Cause of Multiple Sclerosis. Neurologist Explains When We Will Find It
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- Опубліковано 1 жов 2024
- What is the cause of MS? For decades, the cause has eluded scientists. Here, I discuss attempts to look for a singular cause such as Nitrates, Saturated fat and dairy, Vertebral artery abnormalities, Thymus overactivity, Amalgam toxicity, Chronic yeast infection (candida overgrowth), and CCSVI.
I then discuss risk factors for MS such as EBV, Diet, Vitamin D levels, Sunlight, genetics, sunlight exposure
I then give my opinion on whether we will find a cause of multiple sclerosis.
Article on CADASIL: www.nytimes.co...
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: • Video T
he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.
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Its not easy to communicate science to laypersons like you do in these videos. Everyone with MS should greatly appreciate your efforts
Thanks
@@DrBrandonBeaber it's so interesting that you just did this video because it's trending today that a recent study seems to have found good evidence that EBV is the leading cause of MS. Obviously, EBV has been suspected for a long time but this study may actually be the proof? I would like to hear your thoughts on this! Thank you for all the hard work you do!
@@gracevallery5296 I will probably do a video on that specific article shortly
@@DrBrandonBeaber looking forward to it!
Thank you for this video! I agree that Ms is a complicated disease, and most likely multifactorial. I am currently learning about the aces study around childhood trauma and how that could lead to inflammation and problems later in life. I would like to see more research involving trauma in childhood, and autoimmune diseases.
I remember reading that study about MS association with childhood CNS injury between ages 11-20 yrs. It looks very possible & explains multifactorial cascade of disrupted blood brain barrier allowing viruses, yeast, bacterias, toxins, fat particles, vaccines etc to enter. Then immune system is trying to kill infected CNS cells. MS relapses therefore are often triggered by any immune activation, like surgeries, infections, vaccinations, stress, childbirth etc. I have no scientific back up for any of the above, just think this could be happening 😀
I’m convinced it’s caused by stress, which can form in a multitude of ways, physical or psychological.
Personally I believe the cause of MS is just an unfortunate case of multiple issues merging and creating the disease. And I want to use a very crude analogy, so people can understand my theory.
I think people with MS have a weaker body and it can't deal with all of these issues thrown at it, which then makes it malfunction....
Analogy: so imagine the worlds best oven mitt, you can confidently stick your hands in an oven and come out unscathed. However people with MS (btw humans are the oven mitt) have an oven mitt made out of inferior material (less sun exposure vitamin D)it might have a small hole somewhere (imagine that being something genetic) then there is a stain (previous illness) on it which interferes with it's structural integrity. Then when that goes in the oven it you don't come out unscathed.
Hope that makes sense lol.
I like you theory, agree with you
I would add oly one factor, stres
Dr Baeber, your knowledge and time is so much appreciated. Thank you so much 🙏🏼
I’d be interested in learning more about how/If trauma/stress plays a role, many of the success stories I see of people living a somewhat normal life with MS tend to have meditation/yoga/stress-reduction tools that they lean on. Curious about ur thoughts on stress management in people with ms.
I have had patients doing well from all walks of life including those with type A personalities with high-stress lifestyles. That being said, I am a proponent of mindfulness and stress management. Many people with MS experience worsening symptoms during periods of stress.
Most likely multifactorial, then triggered by a specific event like an ordinary infection or physical trauma like a car accident, or a highly stressful event.
All the factors you identify impact the veins. A lot of specialists see MS as a vascular disease
I sometimes wonder if the fact that we see numbers on the rise, or that more people are diagnosed with MS in the "west" is because at this point we as a society are more aware of what MS is, and the medical community as a whole has faster and more sure was of diagnosis. While still marked as "rare", everyone seems to know someone who suffered from MS in the age prior to ethical and effective DMTs, and not treating things on a escalation model. Also considering the average diagnosis is a woman in her 30s, how many cases of reported MS issues where swept under the rug as "female issues". I know in college I attempted to go to the doctor to report fatigue and that my legs randomly felt like they where caught in wet cement. The man who saw me just asked "What med are you looking for?", chalked it up to "work out more", and that was it. Five years down the line, I was admitted to the ER and then they took my reported condition seriously.
Not that there is any way to test this, but I do wonder if these factors play a roll in why we are (luckily for the patients) finding more people with MS sooner then latter or not at all.
I agree that better diagnosis of "mild" MS is part of the increase in prevalence
Excellent! When I think about some of the risks of MS I think they don’t apply to my situation at all. My childhood was spent outside with plenty of sun ( no sunblock at that time) , exercise, and I was a scrawny not overweight kid. Never smoked, drank plenty of milk…
No family history or mono, but growing up as a military kid had plenty of exposure to solvents as contaminants at base housing.
My sister in law also was diagnosed with MS and that is her only link too. At least from our unprofessional opinions.
Keep hunting for the cause and fix!!! 😊
That is really interesting!
Have you done Hepatit B vaccine?
@@arr2820 yes
Had to have because I was a health care worker.
I would love to see more studies on if emotional or other mental trauma contributes to MS. My gut says yes.
Great video. In fact as a MS patient living with the disease over 15 years I agree that a healthy & active lifestyle together with proper MS trearment helps me to improve my life quality and so reduce the rate of perceived cognitive MS sideeffects and reduce the rate of new MS attacks.
As video suggestion I would love to hear from you what you think about the use of probionic acids in the form of probionic salt. There has been a trial study in Germany by Prof. Dr. med. Aiden Haghikia.
Thank you and best regards from Switzerland
Thanks for the suggestion. I'll look into to this.
Thank you so much for this information, Dr. Beaver! I agree with you that MS is a complex disease with multifactorial risk factors. I am just curious to know more about the connection on how stress and a traumatic episode may have triggered MS in someone's life? I have read so many stories, as well as mine, that have that in common.
Absolutely needs to be looked into also. I had zero signs of MS until a series of traumatic events happened from age of 41 to 45, diagnosed at 45 1/2 yrs old. Completely feel it is trauma related in my case.
I use a tanning bed for vit D and as far as I know the UV heels the immune system too. UV alone, without the protective wavelengths that come with sunlight, such as red light, is not great for the skin but I am willing to sacrifice my young skin for better health.. what would be great, is if someone invented a full spectrum therapy bed that was exactly like the sun because so many of us do not have sun for part of the yr. What is interesting, is that I feel better in the sunny months. I think sun exposure is a lot more important for disease percentile than we realize.
My thoughts exactly, and I’m not a dr. That’s why some treatments seem to work better than others for different people. This is also speculation on my part. Now stubborn people like me that are quite tired of shots are a different matter. If they come up with a shot that cures and fixes MS, I would do that! But otherwise I’m tired of shots. I think my MS trigger was standing outside in the heat probably a bit dehydrated. I have no direct family history. No my diet and exercise is nowhere it should be, so that is also possibly a trigger, but less likely. I’m not a smart person and I don’t know all the research going on, but if they haven’t found a certain root cause for MS by now, there might not be one.
Wow, this is a really great summary of this topic. Thank you!
I agree there must be multiple environmental factors versus a singular cause. I definitely believe that EBV plays an important role in the development of MS. Maybe it's the trigger?? Idk. In my experience I developed infectious mono when I was 25 years old. 3 year's later I started developing symptoms of MS. My only other risk factor was low vitamin D levels, for which I took supplements for. Other than that I don't have any other known risks factors. There is not a single person in my family that has been diagnosed with MS. It's definitely a complicated disease.
Looking at various MRIs it appears MS lesions originate from the circulatory system. This indicates exacerbations originate from a ("leaky" or) weak portion of the endothelial layer of the circulatory system in the brain.
The root cause appears to be multi-factorial because the number of assaults and nutritional deficits (we know B12 is one of them) that can cause endothelial cell breakdown is large. However by focusing on the root cause (potentially breakdown of endothelial junctions) we may be able to finally eliminate MS.
At this time the best known ways to maintain the integrity of our endothelial functions throughout our bodies using nutrition is explained in writings of Dr. Terry Wahls MD, MD, George Jelinek, MD (both of which have been diagnosed with MS), Dr. Roy Swank, MD, Dr. John McDougall MD and Dr. Michael Greger, MD.
Sometimes even very complex problems have simple solutions. You just have to know where to look. Suppressing the immune system alone will not work for many of us. I applaud to what Atara is doing and hope that many companies will try a different angle for this horrible disease.
I failed ATARA188 and had to withdraw due to progression. Could have been placebo though...
@@NestingInNashville Sorry to hear that. Hope you are OK
Great video! Do you think the root causes (even if multifactorial) of various autoimmune diseases are likely to be distinct and vary based on their pathways of effect? For example, medications for MS tend to differ from Crohn's or diabetes drugs as they may target different cells within the immune system that may be typically implicated in each disease. However, we do have evidence that the gut biome, vitamin d, sunlight, stress, viruses, etc are all common risk factors amongst autoimmune diseases generally, even though each disease will be distinct in it's pathology and immune pathway. We also know that autoimmune diseases generally on a macro level have been increasing with these risk factors in the developed world primarily. If a person has all the risk factors for autoimmune disease generally which seem to be common across all from what I understand, but no family history for a certain condition, what determines if they get MS versus say diabetes or Crohn's? (I appreciate this is possibly more of an immunology question, our knowledge of which on the grand scale is rather limited)
Even though there are some shared risk factors and some similarities in immune physiology, there are meaningful differences as well. For instance, many people once believed MS is simply rheumatoid arthritis of the brain. However, TNF-alpha drugs which are beneficial in RA can worsen or even cause MS. Unlike RA, MS is not strongly associated with other autoimmune diseases.
Tysabri is both used for Crohns and MS
@@DrBrandonBeaber That's interesting, I hadn't realized there was a sort of scale of association in that regard between them with MS being considered more distant in that regard. Thank you!
Dear Dr Beaber, thanks again for a great overview video. I agree with you that likely there is not a single "simple" cause of MS, otherwise we would have found it already. I am wondering what type of research is out there using statistical analyses that accounts for interactions between different risk-factors. In particular, I think that there must be several systems (be it immune, on the level of mitochondria, or what not) failing simultaneously that eventually result in MS. I guess research that looks into interactions between genes and environmental factors might provide some useful insight. It may be interesting to find people who share a genetic risk to get MS and then to study epidemiologically the differences between those who get the disease and those who do not. I guess this might be more fruitful (but also MUCH harder) than comparing people with MS with the general healthy population. Most likely somebody came up with this idea - if I did without any medical education sitting in my armchair, then med specialist who are paid for doing this type of research surely have done this as well. :D
Stay healthy and thank you. Greetings from Germany!
Great video! I watch all of them you post.
Awesome content. As a science teacher and MS patient I always struggle with trying to find the cause and I’ve spent more time then I care to admit trying to figure it out 😂. Hopefully someone much smarter than me can put just one more piece of the puzzle together!
I am also waiting for someone much smarter than me to figure this out so I can take the credit ;)
What about testing every patient at the start of their diagnosis their vitamin D levels.
My daughter's vitamin D level was 17 nmol which was extremely low. She was only tested with my insistent and even then her neurologist wasn't concerned.
I appreciate that you and Dr Boster talk about diet and importance of good vitamin D levels. Her treatment with Mavenclad in the last two years seems to be successful so far.
Thank you for all your educational videos.
@@michaelwhite5255 Don't forget about the potential benefits of sunlight which in my opinion has even stronger evidence than vitamin D: ua-cam.com/video/f0DqKB_L6-o/v-deo.html
Help me. I suffer peripheral toxic neuropathy after Pfizer vaccine
I'm so sorry... ❤️
I'd love to see a presentation on progressive MS in older folks. Most of us were diagnosed before DMT's were routinely prescribed. Are there recommendations for tx?
How do you differentiate between loss of function due to aging and disease progression. How do you know if your DMT is the right tx for you. Recommendations for improving quality of life when insidious progression does not subside. Need a reality based prognosis.
Thank you from Morocco a girl struggling with Ms
Great talk today. My son was originally dx with Addison’s Disease. Now we know Adrenal Hypoplasia Congenica. No males lived long in previous generations.
We will find a cause of ms and I believe we find a cure. Probably the genetic component can be manipulated in the future. Hopefully to cure my sons disease as well as ms.
It seems to be multifactorial. At least I couldn't pinpoint a single cause from my history and from others having MS. Things might triggered mine probably were using a lot of antibiotics in childhood, having an autoimmune tendency from my mother side, and consuming a lot of trans fats and coke during my teenage years. The saddening part is that no matter you take care of your health afterwards don't do much once the die is cast. I guess all autoimmune diseases are complicated and they occur after certain amount of dysregulation in the body/immune system. That being said, quest for finding cause(s) would be a good effort nevertheless in terms of detecting risk factors and preventing the disease.
About finding cures, I get more and more sceptic. It feels like MS treatments will come to a point in which patient condition could be almost completely stabilized and maybe even a bit improved.
I really appreciate your honest analysis on MS. You don't give false hopes to people like me by staying completely objective and scientific. Thanks Dr. Beaber!
What about gut microbiome and gut health?.I have since my childhood problems with gut.I am lactose,gluten and histamin intolerance.I am pretty sure this is a risc factor too.And i think this is the cause why i have MS,Just thinking.There are many studies about microbiome and MS.Greetings from Germany
The mention of mercury toxicity was interesting. Has there ever been any sign that an old pesticide like dieldrin might be implicated in developing MS?
Years ago I read about a researcher who was certain that MS was linked to past head injuries, but I haven't heard anything further about it. Have you heard anything about that?
Everytime I get a MS flair I get pain in the area of my carotid artery and ice pick headaches. It directly correlates with my progression of symptoms. I'd love to know more about the vascular part of MS.
I used to feel that way when walking. I'd get quite lightheaded. Now I'm in a wheelchair 95% of the time {because of my legs, not the dizziness). No more lightheadedness though. So that's one way to solve a problem I guess. Probably not the best way though...
A complex array: vitamin D needs to be >80ng for sure.. also B complex especially B1,6,9, & 12 for remyelination. But we can't be deficient in iron or copper or zinc either!
Great video. I personally cut out land animals and dairy from my diet about a year after my diagnosis. I pretty much follow OMS and am pretty much symptom free . I think processed and refined foods play a huge role in a lot of health issues. And pesticides. We should not be eating chemicals, I don't buy food with ingredients.
Is there any evidence that you can be genetically pretty disposed to get an autoimmune disease? My Father and Grandmother also had an autoimmune disease but we all have a different one. I don't think we will discover a cause for MS anytime soon. I do think multiple cases are probable.
I agree that it's definitely multifactorial. There must be several different risk factors that when brought together, cause a perfect storm for a MS diagnosis. I had mono at age 14, had low Vitamin D when tested, grew up in Toronto ON, lived in a house where both my parents smoked, I never smoked thankfully, but I ingested enough second hand smoke, put a lot of salt on my food...However, I was always fit and exercised. Who knows? All I know is that MS blows but having an informative channel like yours, makes it better to cope with and understand. I give you my continued gratitude for your content and time.
My diet is really good, I try to keep myself fit and healthy and there are no known people in my family with MS but I did have Epstein-Barr virus around six or seven years old. I have absolutely no other avenues to lead down other than Epstein barr
This is such a helpful over view. Your videos are always unbiased and reasonable. I really value your expertise. Thank you 🙏🏻
I'd be interested to hear what research there is, if any - I personally have a theory - to do with MS or autoimmunity and a general genetic high-sensitivity... which might include emotional, sensory, psychological sensitivity.
Thanks again for your work.
Another excellent video. While I seldom ask "why did I get MS" as I don't think, as you agree, that it was any certain thing that I have done, my husband continues to contend it is due to the chemical exposures I have had in my life. Primarily I grew up on a farm (so certain chemical exposures are higher) and I have had perms and color treated my hair. He has UC and controls it through diet and life style- he contends that with a better diet I could improve my MS and possibly avoid taking Ocrevus. It is hard to deal with these arguments constantly- maybe this video will help- thanks
I am Kaiser patient and they have said that i have suffered from white matter disease mini strokes and differential ms diagnosis.. is there any way you can help rule out MS, I also had CSF done and cerebral angio etc done but I am still on basic blood pressure cholesterol meds
Terrific video Dr Beaber! I completely agree with your thoughts that this is a complex disease that will not have one definitive cause. It is more of a syndrome that is a result of the various risk factors you have discussed in my opinion. Hopefully we will just gain a greater understanding of autoimmune conditions in general and that will provide is with better treatments. I think the most compelling evidence is that the gut microbiome and health of the gut highly influences the development of autoimmune conditions. I believe this could be the next big step in our understanding of this disease and many others!
Interesting Video. What do you think about Moderna has dosed the first subject in the Phase I Eclipse clinical trial of its Epstein-Barr Virus (EBV) vaccine candidate.
Excellent video! Lots of interesting information. I had a very bad case of mono when I was 16 and I've always been suspicious that it was somehow related in some way. Thank you for taking the time to make these videos!
i got MS after waering heavy heaphones for 2 years, which pressed on the sides of my face, combined with stress, ate a lot of sugar and animal milk this time, nearly no fish and much saturared fats, usually cheap pizza, döner kebap, after i left my parents home, the quality of food become lower, all fast food over 2 years, i was kept from sleeping since over a year, i heared, that omega3, calcidiol and calcitriol are important to Immune system
HIV---> "And the Band Played On: Politics, People, and the AIDS Epidemic" by Randy Shilts
If in a carnivore diet there anecdotal evidence of it reversing Type 2 Diabetes, could there something to this for treatments for MS? There was a Harvard study done in 2020 about it
awesome video i think your right they are to many variables to consider and in my opinion since we are all so different its most likely a bunch of different things working in conjunction to cause the ms ..... like for me it runs deep in my fam my mom had an uncle and a cusion with it and for some reason all of my moms children developed ms thats including me .... these increase in chance and obesity and high cholesterol in childhood plus smoking at a young age are the main contributing factors to why i developed ms and really obesaty in childhood i think is what made all of my moms children really have a higher chance since it was already so prodomament in our family line but like i said and you said these groups of contributing factors .....what ever they might be for the individual is what makes it so they developed multiple sclerosis
what about niacin supplementation? didnt researchers find out that niacin/b3 apparently helps in myelin recovery/repair? are there any studies on that?
Dear Brandon, you are such a giver to humankind. We love u and appreciate you sharing your knowledge and joie de vivre
bad microbiome and bacterial epsilon toxin may be the cause MS.
current studies show that there is a 32x risk with epstein bar Virus to fall into MS gap
There is a respectable neurologist who told me that multiple sclerosis is a clot that affects one of the main vein, which causes the blood to not reach properly to the nerve, so white dots appear on the MRI, and not treating that clot properly leads to the symptoms That you mentioned in this video. please clarify At this point, I am confused as to whether I have MS or a Clot!
Thank you.
I have a video on CCSVI which is probably what you are referring to: ua-cam.com/video/sqoK9BkI6g0/v-deo.html
Were there ever studies trying to link increased risk of MS with stress?
Very informative thank you. Could it be stress related?. I strongly believe my ppms was triggered in my early 50’s with an overload of it.
I've read articles about that...like the immune system so overactive to manage an unknown (virus, pregnancy, stress, trauma etc) after the threat is gone immune system continues to work at that level and causing some type of autoimmune disorder including arthritis.
Great video, and love your channel. My husband has late-stage MS. Probably. He was diagnosed like 40 years ago and has the attitude "I don't need no stinkin' doctor" so I'm not 100% convinced. Thank you for talking about interesting topics in language that mortals understand. Nice video production, too.
Thanks Cynthia.
Dr. Beaber, have the MS researchers looked at microscopic parasites IN the brain and cerebral spinal fluid?
Yes. There is no known parasite known to cause multiple sclerosis. In fact, a study published in JAMA showed that hookworms could actually TREAT MS. jamanetwork.com/journals/jamaneurology/fullarticle/2767084 Epstein barr virus is likely part of the cause of MS: ua-cam.com/video/3bkEXWg3kTw/v-deo.html
I was wondering what your recommendations are for tumorfreactive MS
I could do a separate video on this. For people with very aggressive onset and debilitating symptoms, I would often use strong chemotherapy drugs such as cyclophosphamide and prednisone together. It depends on the situation.
Hello Dr. Beaber,
I have a question regarding MS. Last zear in June I recieved COVID Vaccine first dose. Two weeks after I felt numbness in two parts od my leg and since I am a neuroscientist I was worried a bit because it was associated with two different nerve roots. So I could say that it is not a nerve compression. After few days it stopped to develop. After two more weeks, I went to vaccination center to receive second dose and I told them about it and they deny any association with the vaccine and said that vaccine cannot cause it. So I went for it. After two days everything started to get worse, So spasticity was added to Hypoesthesia. At first the brain and spine MRI were clean. Then after two weeks they saw only a lesion in T10/11 and nothing in the brain. So they went for transverse myelithis. After 4 weeks there was a new lesion in Amigdala. I was forcing them to perform plasmaphresis and longer cortisone shock therapy. I was also proposing immunomodulation therapy since I was seeing it caused by the vaccine. At first they didn't accept but nothing else could stop or delay the relapses, almost every 2-3 weeks I had a new lesion. On December, finally they gave me a diagnosis of MS most probably caused by the vaccine and they started immunomodulation therapy. It is getting better but I want to know that if this is caused by the vaccine, can it be reversible? By the way, OCBs were 7 bands and I want to ask them to perform another Lumbar to check it. I think if it is reversed, OCB should go back to
Sorry. I can't comment on your specific situation. In the United States VAERS data for the pfizer, moderna, and J&J vaccines, the rate of multiple sclerosis and transverse myelitis have not been reported to occur above background rates. There are case reports of MS and transverse myelitis after covid-19 vaccination and infection.
@@DrBrandonBeaber thank you so much Dr. And do you think that there is any possibility that it is reversible, or it cannot be reversible?
My cat was ok one day, and the next day she died. We don't know the cause. After that, I developed the worst flu symptons ever.
One year later: my first flare. Can cats transmit EBV or other virures like that to human? 🤔 I do have antibodies (tested last year). Do EBV activates during an MS flare?
Anyway, definetly ... a multifactorial illness. Recently, my mom told me about my grandma.. she didn't walk for a whole year when she was 50 (before I was born). At that time (1990), they thought it was neurological, but didn't give it a name. Other than that no autoinmunes in my family, just me.
Do you have a video about "the causes" of flares?.. I think that I don't care about the first inmune system "mistake", but why does it continue doing mistakes?
Thanks for the video. Grettings for CR.
MS & Covid got me pure exhausted to leave a full comment. But my gut instinct keeps telling me all these neurotoxic chemicals. Mainly pesticides (think NITENPYRAM) & herbicides (think glyphosates) but also contributing are some of the others added in to food (think of the wine additives) & personal hygiene (think DMDM) & cosmetic products (skin is our largest organ absorbing all sorts of toxins).
Hello Dr. Beaber, just wondering a day later on the 13th of Jan. Science Magazine published an article "Two decades of soldiers’ medical records implicate common virus in multiple sclerosis" what is your opinion on this? Thank you very much for all your efforts and care, best wishes
I am aware of this study and will do a video on it soon. I have another video on EBV and MS if you want to take a look: ua-cam.com/video/nycIHwdWv-w/v-deo.html
@@DrBrandonBeaber thank you, I will watch :)
Anybody have any flare ups or increased symptoms from their COVID vaccine? Seemed to increase my spasms 10 fold while recovering from the shot. I felt like I was in the exorcist.
Just remember, helicobacter pylori (which causes stomach ulcers) was only identified in 1982. It would be arrogant to think that all infectious microorganisms which currently exist have already been identified!
I think it's karma for that candy bar I took from the corner store back in primary school. :) Great video! I feel the same way, too many risks that aren't 100% but it's still good to be aware of them.
Agree, My gut also tells me that there are more connections to viruses. We got exposed to something at some point and our body just didn't respond correctly. MS is a continuation of that malfunction. The fact that I was an overweight smoker just kicked it into high gear.
I heard minimum from 5 neurologists that i have to 99% no MS. They say"6 month ago the MRs of brain, cercival and thoracic were normal and 5 months ago the nervewater was also ok. But now I get much more symptoms but they do not take nervewater again(in 2 clinics). I am sure that I have to 99% PPMS and thats why they did not see it til now. What do you think?
A c.pneumoniae infection actually lowers the vit D level in your blood (a survival mechanism of the bacteria). A c.pneumoniae infection actually alters lipid metabolism. These characteristics of MS (unusual saturated fat metabolism, low vitamin D) are the result of the infection (not necessarily cause of the disease). I can direct you to some papers on this if you need.
another great video! Any chance of covering that Burt study from October? We’re in the throes of considering HSCT, working with UTSW in Texas and would love your take.. people value your unbiased opinions - thanks again ♥️
So are we close to having an EBV vaccine?
Likely far from a vaccine, but I am going to publish a video on ATA188 next week. It is an anti-EBV neurogenic t-cell therapy being developed by Atara Biotherapeutics
Some Sources
ATA188 - Atara Biotherapeutics: www.atarabio.com/pipeline/ata188/
Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple Sclerosis (EMBOLD): clinicaltrials.gov/ct2/show/NCT03283826
Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV+ PTLD) After Failure of Rituximab or Rituximab and Chemotherapy (ALLELE): clinicaltrials.gov/ct2/show/NCT03394365
A Study to Evaluate Tabelecleucel in Participants With Epstein-barr Virus-associated Diseases: clinicaltrials.gov/ct2/show/NCT04554914?cond=A+study+to+evaluate+tabelecleucel+in+participants+with+Epstein-Barr+virus-associated+diseases*&draw=2&rank=1
ECTRIMS presentation: ectrims2021.abstractserver.com/program/#/details/presentations/505
ATA188 data from Atara: d1io3yog0oux5.cloudfront.net/_700bd03f8ec0f45e123f64a8f50976c9/atarabio/db/640/5463/pdf/EAN_052620_ATA188_FINAL.pdf
In my personal experience I had a football injury at fourteen with a diagnosis of a vascular necrosis. I have had multiple x rays and surgeries.over my lifetime at sixty four. So my hypothesis is the multiple x rays in my lifetime had something to do with my diagnosis.
This is a great channel. Subbed. Thank you
Thanks!
PPMS is not good to treat. Unfortunately. Only Ocrevus can MAYBE help a liitle bit
There have been studies that showed exposure to solvents was a risk factor. I was a graphic designer before we transferred to digital. I and used rubber cement glue and solvent for it, permanent magic markers and other chemicals.
I've heard many possible causes of MS, but I don't fall under many of these possible causes. I was born in Barbados, I came to Boston when I was 17 and diagnosed with MS 7 years later. I'm the only person in my family with MS. I don't drink or smoke and personally I believe MS is linked to something transmissible through sex
Have hormones been studied? My cousin and myself both have had hormone issues and are MS sufferers, as well as a close friend. Wondering?
There was no MS in the Faroe Islands, then British troops set up bases. A few years later there was an epidemic of MS.
Great presentation. Thank you.
My first MS symptoms occurred almost 40 years ago. I was diagnosed 32 years ago with "benign " MS and SPMS 22 years ago. I have always been acutely sensitive to fragrances, lead based paint, potpourri, cleaning agents, etc. I suffered migraines. 45 years ago I had my car rust proofed with a product called Ziebart. The toxic smell of Ziebart coming from my car's heating system was horrific. I believe I was genetically susceptible to MS and Ziebart toxicity was the trigger. Not sure of the chemical contents of Ziebart but I'm sure it is not meant to be inhaled.
There must be a connection to environmental stress on our olfactory system and auto immune diseases. Welcome your thoughts.
Thanks
Thank you once again for such a well explained video. I know that the reason for what happened to me is multi factorial and that alternatively, the reason for me getting to good health is also multi factorial. The idea that there is a cure for such complex conditions does not make sense to me. Having said that, I am very encouraged by all the exponential progress being made in understanding more about the condition .
There’s no agreement amongst neurologists that MS is an autoimmune disease. I can direct you to papers on this.
What about Hepatit B vaccine? There were studies in France about that
Give it to us good Doc Beabs… the Elusive cause…of MS.
#Sharingiscsring
Great video. Can't speak on what causes MS. What about the genetic part about MS. Myself believes it is in the X chromosome. I believe that about 75% of MS patients are female. Math lines up. Also I have MS (male diagnosed 03) my Aunt (diagnosed in 60's) and Great Aunt (20's or 30's) had MS. We are all only linked through the X chromosome. I have not seen much about the genetic pathway. Thank you for sharing your knowledge. Very informative information.
I paused video to leave comment. You do talk about X chromosome. Thanks
What are your thoughts on the new EBV and MS study from Harvard. Does this study advance our understanding of the correlation between EBV and MS or does it really just confirm what we already know?
I think it confirms what we already know, but it is very convincing evidence that EBV is part of the causal pathway of MS.
Stess and emotional trauma
Wow was that all one take?? You're a rockstar, doc
Hi,
Is it common to go more than 10 years without an attack ?
The first episode was a major foot drop and numbness on the complete left side.
I couldn’t walk for almost 3 months.
I was 18 with the first major attack and now 28 going on 29 and there has been no more attacks just little issues here and there from the main attack over 10 years ago.
Yes. This happens all the time. I have a patient who had optic neuritis at age 30 and did not have another MS symptom until her mid 60s when she had subtle walking difficulty, a ~35 year remission
@@DrBrandonBeaber thank you
I also have heard of others going that long but didn’t know it was common with such a major first attack that impacts mobility.
I have been on no mediations.
What do you think about the recent study that found a causal relationship between EBV and MS? Could that be the cause of MS, like the study suggests?
I think there is strong evidence ebv is part of the causal pathway of MS. I have a video on this topic: ua-cam.com/video/nycIHwdWv-w/v-deo.html I will do a video on the article you mentioned soon.
@@DrBrandonBeaber Thank you for the reply and thank you for all the interesting videos!
It could be a mixture of EBV and having specific genes.
These are definitely both factors. Here is my video on EBV: ua-cam.com/video/nycIHwdWv-w/v-deo.html Here is my video on genetics of MS: ua-cam.com/video/ZaJK6nFXV0w/v-deo.html
Just viewed your saturated fat video on MS. I was wondering how much saturated fat should you limit yourself to? I like my fatty nuts and I feel like they help with my brian fog. Also L-serine has seen positive results with progression of ALS and also alzheimer's I was wondering if there's any potential benefit for MS.
You may appreciate my video on Dr. Roy Swank's book: ua-cam.com/video/RS6wlSbCu_c/v-deo.html He recommended
@@DrBrandonBeaber thanks! Your videos are very informative. I appreciate the time and effort you put into these.
@@Kc-di7vj :)
Mono?
Never mind ..u answered at lol 4:16
@@stardustshorty More info on the connection between EBV and MS in this video: ua-cam.com/video/3bkEXWg3kTw/v-deo.html
@@DrBrandonBeaber Ty so much . Very appreciated .and honored u answered me