Love to know how this information can help people with Autoimmune? So many people suffer and all that’s available are drugs with loads of side effects that suppress the whole immune system. Please make another video if your aware of available treatments that have been successful.
Great video. Can you explain why aren’t RA sufferers not being injected with primed C4+ IL2 & Th1 +TGF B (ex vivo) and re injected CAR-T style? Or induce Teff with a CCP receptor to deletion in periphery? Also Teff needs IL2 to survive, otherwise they die of signal deprivation eg when Treg binds all the IL2, so I guess the conversion has to be ex vivo
Hey there. You are bang on. FOXP3, CD25, CD4 are how we identify typical Tregs. FOXP3 is a transcription factor. So it binds to, and turns on, many of the genes associated with being a Treg.
Love to know how this information can help people with Autoimmune? So many people suffer and all that’s available are drugs with loads of side effects that suppress the whole immune system. Please make another video if your aware of available treatments that have been successful.
Great video. Can you explain why aren’t RA sufferers not being injected with primed C4+ IL2 & Th1 +TGF B (ex vivo) and re injected CAR-T style?
Or induce Teff with a CCP receptor to deletion in periphery?
Also Teff needs IL2 to survive, otherwise they die of signal deprivation eg when Treg binds all the IL2, so I guess the conversion has to be ex vivo
Hey, i have a question. What is the structure of the Tregs ( is it FoxP3+/CD25+/CD4+?) and what is the function of FoxP3+? Amazing video btw!!
Hey there. You are bang on. FOXP3, CD25, CD4 are how we identify typical Tregs. FOXP3 is a transcription factor. So it binds to, and turns on, many of the genes associated with being a Treg.