Vitamin D deserves S tier, you undersold it's effects so hard. Maybe it's boring from a chemical standpoint, but from biochemical and endocrine it's not.
Fun fact about Vit K - it is given routinely to babies right after they are born (usually via IM injection or occasionally oral supplementation) because they are naturally low in it and don't yet have the gut bacteria that produce it which as explained in the video can affect blood clotting. It reduces the rate of intracranial haemorrhage which can cause brain damage - particularly important for babies who have had more traumatic births (i.e. vacuum or forceps assisted births).
@@roddydykes7053that's terrible. Sounds like they screwed that up. I don't think you're supposed to suck a baby's skull on a vacuum to point you can pull him around even when stuck! Or wrap bbq tongs or forceps or whatever around its face and yank him out. I bet it feels like being constipated except there are no farts to help push it out
Dude I love how science content creators are using trendy UA-cam stuff to teach science. I am easily baited into science videos with titles like "Vitamin tier list" "Are giraffes OP?" "Scientific theory iceberg"
Biochemistry is a wonderful middle ground. Enzymes catalyze some amazing reactions through interesting mechanisms. Biomolecules also have very interesting characteristics and structural motifs.
"this is the more complicated part" is THE funniest shit. you lost me immeditaly the moment you started talking and, 5 minutes into an endless string of chemical names, you say "now it gets complicated" Perfect. i love this channel so much
*Ascorbic acid* is actually used to make a rocketry propellant! It's called crimson powder and I believe it's primarily used in ejection charges as a more potent, cooler burning, alternative to black powder.
There's funny way to memorize the vitamins soluble in fats in Czech language - the word for butt (which contains fat) is "ZADEK" and If you take out the "Z" you get the vitamins soluble in fat - "ADEK" :D
In Brazilian Portuguese, "keda" sounds exactly like "queda", which means falling. So I memorized it as "if you slip on it (cause fat is slipper), KEDA"
Just wanted to say these videos are amazing to watch for me as an undergraduate chemistry student. It introduces me to aspects of chemistry I haven’t learned about yet and helps me be somewhat familiar with some things before I even learn about them in classes.
You can also get Vitamin-E from Eggs, just like Vitamin-B1, B2, B5, B6, B12, Biotin, Choline, Folate, Vitamin-A, D, E and K2. Along with (And I know these aren't Vitamins, but still..) Iodine, Iron, Phosphoprus, Selenium, Sodium and Zinc. They're literally a perfect food.
@@ssgoko88 quality of and egg....depends on the quality of the chicken....the quality of the chicken depends on the quality of its lifestyle. simple borskie....not sure what you asked me to be honest.
@Pera 'D i think they were confused about "not just any eggs" and might have assumed you implied eggs from other animals lacked some of the qualities of chicken eggs, since you specified "chicken eggs" earlier in the comment, so they asked you to elaborate on that. I might be wrong tho.
@@MondayAgainBip gotcha..talking about chicken only here....but regardless my point of the animal and its living condition = quality of the egg. don't change. but thats the same for any good food tbh.
As someone who’s just getting off of accutane myself, I think understanding the chemical processes behind why my skin excessively dried out and my dozens of nose bleeds would be interesting to see! As always thank you for the effort you put into these videos!
@Max R Read any of Grant Genereux's three free ebooks on vitamin A. Grant Genereux has been on a low vitamin A diet for +8 years. Too bad you have been damaged by a high dose retinoic acid in accutane.
Whoa they still make accutane? I thought it was lawsuit'd out of existence Fun story: out of shameful habit, I went to pop a zit while on my first month of accutane. The dry skin under my fingertips just slid off instead
This some of the best-summarized versions of biochemistry that we (basic medical science ie. doctors, dentists, medical science, etc.) have to learn in my country for this particular topic. We just basically remember all the B vitamins as (1-PPP, 2-FAD, 3-NAD, 5-CoA, 6-transaminase, 7-CO2 transporter, 9-nucleotide synt, 12-Cobalt version of heme). Usually, we only got the text with some pictures but not the whole pathway (only the significant one) to study not to mention that every vitamin plays a role in understanding how our body works (you need to understand the basic pathway of metabolism first + heme synthesis). It is a fascinating topic and I admire how you presented it in an easy-understandable way for a topic that is mostly oversimplified to good-bad benefit.
Please please please please make a detailed video on Acutane! I've read countless articles and research about how to works on a cellular level and I still can not connect all the pieces, however from what i did understand the drug is genuinely miraculous! I just got off two cycles and the symptoms were extremely wacky but I was left with perfectly clear skin at the end and my acne has not returned since. I had extreme dryness in my eyes, lips, skin, hair as well as joint pain in my knees and hips, tightness in my hips and pain in my lower back. I noticed i was far more injury prone and I even took longer to heal from injuries while I was on it. Really hope you take this suggestion into consideration as I think its near impossible detailed information on the drug even though its so widely used and talked about amongst teenagers struggling with acne. Love the videos and thank you so much!
Nixtamalization of corn was also explained in Tasting History: Unwrapping Aztec Tamales as well as SciShow: Corn Shouldn't Be Food, But It Is. A walk-through of the full process can be found on Rose Red Homestead: How to Nixtamalize Dent Corn.
I have said before how your videos are really improving, but this one is like none other before. The visual support is clean, the memes are funny and the information is easy to comprehend. Amazing job!
Niacin was originally called nicotinic acid because it can be created by the oxidation of nicotine with nitric acid. However, people knew nicotine as the addictive chemical in tobacco, so the name niacin was used instead. Niacin comes from the words NIcotinic ACid vitamIN.
One cool thing about biotin is its interaction with avidin. More specifically, the binding affinity of avidin to biotin is among the strongest non-covalent bonds. It's pretty much non-reversible without denaturing the avidin.
Regarding finding local edible plants with needed vitamins... I would assume that in most places humans have lived for an appreciable length of time, people have pretty much figured out what plants are edible pretty effectively. Finding an edible plant that's also palatable and cultivatable and fills a gap in human needs in an area, that nobody knows about should be exceedingly rare.
As soon as I read the words "vitamin lore" I knew this was gonna be good, maybe I would've actually chosen that biology course if it was taught like this
Adding one thing, Umetaro Suzuki was working on vitamins but originally term "vita-aminy" was created by Casimir Funk in 1912 who created concept of vitamins
Hands down the best chemistry content on youtube. I really like that you touch on adjacent topics like psychopharmacology as well. Thanks for all your hard work!
Something that fascinates me is how essential amino acids like phenylalanine and tryptophan have cyclic carbon rings that arent formed in animals bodies. We are reliant on plants and microorganisms for the building blocks of our bodies.
@@nolanhanson5743 it's a mix of blender, wavefronts from RCSB pdb's, and chemdraw. Those usually are consistent but honest we would use anything as long as it shows what we would like to show effectively.
so in hungary (where I live) there is a big thing about vitamin c, because one hungarian scientist got the idea of extracting it from peppers and he did so succesfully. So apart from citrus fruits, peppers (as in paprika) should be good too. (go look it up if you want it’s Albert Szentgyörgyi and it’s a whole thing, there aren’t a lot of hungarian contributions to science so the ones we did make are super hyped up in every school)
There are MANY Hungarian scientific contributions. Ignaz Semmelweis is the reason many many babies have survived being born. Just one significant example. Szeresed magad, koszonom.
Greetings to my Hungarian brother from Poland 😉 As for vitamin C there is a misconception that citrus fruits have a lot of it, while in fact some other fruits and veggies have much more of it. Camu camu and acerola are the most abundant in it, and paprika is also more rich than citruses.😂
Hungary is well known for a lot of important scientists and artists compared to population. Szentgyörgyi, Neumann János, Teller Ede, Szilárd Leó etc etc
Based on what you said about B12 maybe this changed, but folic acid was usually recommended to pregnant women in part to help prevent neural tube defects.
Its both, folic acid has been known for a while, but "recently" b12 was also shown to independently reduce the risk. Nature Reviews Endocrinology volume 5, page 354 (2009)
Fun fact about the whole non-bioavailable niocine in maize: indigenous populations had known about this in some way or another for centuries, and knew to 'nixtamalize' (what a beautiful word) it long before European colonisers came and took the stuff as-is and shipped it all over the world. While our forebears were scratching their heads over why everybody else was getting sick from their cheap maize-only diets, the locals laughed it up and threw some more volcanic ash on their corn flour. For another fascinating take on the tortilla story, Tasting History's got a couple great videos about it!
Even though I don't understand half of this stuff I do generally get the idea. I just love these kinds of videos because I get to appreciate how beautifully complex nature is.
Hey, I know I’m a little late to the video but if you see this by any chance could you start adding the IUPAC names under the graphics of molecules? Especially the hydrocarbons. I’m in grade 12 chemistry right now on the organic chemistry unit and it would be a massive help in reinforcing what I’m learning
Fun Fact about Vitamin A - One piece of a polar bears liver about the weight of 500 g has an about 9 million IU of vitamin A and acute human toxicity will occurs at around 300,000 IU. A danish scientist once tried to convice some to Greenland natives to try to eat Polar Bear Liver and almost died from a single bite :D
As someone in a biochem program, your stock exchange analogy actually confused me for a brief moment lol. I had to use my knowledge of coenzymes to understand the analogy rather than the other way around. This was a fun video. More bio stuff please!
I would love one about all the skin stuff like even comparing the different chemicals and stuff or whatever in each retinitoid also that’s cool they don’t cause photosensitivity is there a way maybe to make acutane do that? I though photosensitivity was becasuw it made skin cycle faster so it was new skin which is easy to burn
Would totally like a video on astaxanthin been reading all the NIH and pubmed studies. Trying even to ask chatgpt3 how to achieve that orange colored skin that can happen with astaxanthin as well. I did 100mg daily for a few months from 2 different brands and didn't achieve that orange result. My eyesight improved along with taking Sulbutiamine and Astaxanthin from negative 1.25 to 0.75 (fR sighted) along with (convuluted with rather) eye exercises daily. Over the course of 1 year, going to try and add NMN to get back to not needing to wear contact lenses. Also added bacopa and lions mane extract to the mix, 2 grams and 5-10 grams respectively. (Also increased potassium (Kiwi, greens) and magnesium glycibate due to sulbutiamine utilizing more uptake).
This is definitely the best video about vitamins I have ever seen, it was really detailed and I loved every second of it, have you thought about doing similar video about minerals?
@@That_Chemist Geology Hub frequently refers to the chemical composition of lava, typically silica vs alkali metals, but geologists in general have their own rather odd way of categorizing minerals (felsic vs mafic). Toss in the the weirdness of clay minerals and you've got lots to talk about.
I have a lot of health anxiety and thus, have a hard time appreciating my body. This video helped me change my attitude - if my body can do all these crazy biochemical reactions and conversions, it deserves some respect. Thank you for your content. I appreciate it and the team a lot.
Very curious about acutane. I took that when I was a teenager and although it was the only thing that actually cured my acne it had some marvelously horrible effects on my skin, like a desiccated piece of flaky jerky covered in cold sores. Like my entire lips were just one big cold sore. Never had one after that nor before.
It may be rare, but in my 20s I actually had mild scurvy for some time. It caused my gums to bleed whenever I brushed my teeth. It got to the point where I just had to make a partial vacuum in my mouth, and it would start bleeding. It stopped when I took Vitamin C supplements for a while.
Its definitely not thwarted its still supported by private investment, but it does stand that nutritionally it wasn't better than normal rice it was evaluated twice by the FDA. But new generations of it will likely be introduced eventually and reevaluated. But at the time it was brand new and didn't deliver on promises at least in America. In Asia it was political resistance maybe somewhat anti GMO but more anti western influence.
Putting them all in a tier list really helped me differentiate and remember them and their roles in the body. Absolutely genius video formatting thank you!!
A year out from my BS in biochem , and I'm glad you brought up how yellow flavins are! Was the first quality my professor mentioned in intermediary metabolism and I was thinking, "wonder if E&F knows". Thank you for the great content!
I would really appreciate the video on Vit A, specifically accutane. As I think about starting a course but I'm terrified of nose bleeds more than anything else.
i started on accutane relatively recently, id love to see a whole video about the vitamin a-esque (retinoids? im in the first year of my undergrad in chem lol, i dont know ANYTHING) even if i am a bit late to the party. the packaging alone on accutane is no joke, every surface reminds you about the birth defects. its interesting that compounds so similar can be used topically and ingested orally for acne
Riboflavin has given me quite a scare because if you consume an excess it come out in your urine and Riboflavin is astrobright yellow. (I don't think it's underrated in the tier list). I think he was entirely too clever with vitamin C and think he may have been influenced to put it into C tier because it was Vitamin C. It obviously is S tier given its important role in history.
As a doctor i cant agree with you on the tier list chemistry >Biology 😂❤ The information given is super crisp , valuable and presentation is on " S tier" 🙏
Your channel is amazing. Even for amateur viewers who will probably never be in a lab (like myself), it's still just so interesting to learn about this stuff.
Your animation and overlay work is getting amazing, really adding the the draw of the content. The visible complexity of the spinning enzymes involved in the Krebs cycle drives home how amazing that machinery is as a whole without saying a word. When looking at inputs and outputs it seems all too simple, but it's a ladder of the same complexity as the mitochondrial electron transport chain.
Thanks! We have some more cool changes coming in the next tierlist we will be posting (hopefully in the next few days, definitely before the end of May)!
As an undergraduate biologist I can say that Vitamin B7 is actually useful for detection experimental procedures in biology, since it forms complexes with avidin and maybe for that reason it should have been higher on the list (maybe D tier). But sulfur does suck and it does stink indeed. Anyway, I love how far your channel has come and the quality of your content has improved dramatically. Your videos are always extensively detailed and I thoroughly enjoy them. Even though I chose biology as my major, I do love chemistry and your videos remind me of how fun chemistry is while also enhancing my current knowledge.
It’s so weird… we’re so averse to managing farms that are biodiverse that we’d rather go through all of that genetic modification to rice instead of just farming a second plant.
I wish I had waltzed upon this video before submitting my multi-vitamins literature review! Trying to academically put that there is no standardised, regulated definition was a task and a half. This video definitely cemented how much I enjoy biochemistry, but the stress of studying higher-level chem past the required foundational level has me hesitating on it. It also means I need to study a level 200 chem unit before I reach the level 300 biochem units, so I at least have a year and a half, two years max before then if I want to get serious about it. Thanks again to you and your wonderful team! My brain has been most satisfied! :)
I read an entire book on Vitamin K2 and the surrounding studies. Something about it as a coenzyme for proteins that transport calcium from and to tissues in the body, apparently really important in preventing atherosclerosis and reshaping bone during pregnancy and childhood growth. Book is called Vitamin K2 and the Calcium Paradox. They also cover some interactions between all the fat soluble vitamins. I'd love to see you tackle the chemistry behind these studies. Thanks for all you're doing here. 🤜🤛
This is so complicated for a tier list man... I feel like I need to be a biologist to understand. Wish you had simplified to make this more accessible.
"Fat soluble vitamins are less likely to cause deficiency" me having a severe vitamin D deficiency last year and having to take a lot daily because I'm allergic to sunlight ☺
Vitamin B2 is pretty cool for people with a MTHFR gene mutation… For these people it basically cures anxiety and depression (although other nutrients are sometimes needed as well, but B2 is key), as well as fixing elevated homocysteine, inflammation and a long list of associated health risks. Also Vitamin D deficiency remains extremely common and causes a range of health issues… including susceptibility to severe COVID. However the most severe form responsible for rickets is less common.
Maybe you have a video on this, I think it would be really cool to talk about the role micronutrients play in our gut biome and the key role they have with the bacteria that lives in our bodies
Hrngh. These biologists, misnomering chemicals ánd these nutritionists claiming that food is good or bad. Did you see how the egg went from being healthy to being unhealthy to being healthy again to being unhealthy to being healthy now in a span of 40 years? Crazy stuff.
I am in the gym and I want to get bigger. This biology and chemistry and good stuff is oddly intriguing bc I think it feels like it’s gonna help me get more gainzzz
Can confirm, I'm watching this and deficient in most B vitamins, due to malabsorption related to Crohn's disease. :P Great vid, would love one on retinoids if only so that I can hear about how developmental toxicity from retinoids actually works.
A really decent percentage of the population have a genetic defect (on the MTHFR gene) that almost completely inhibits methylation of THF in the liver. It's a major cause of depression misdiagnosis.
This dude made a golden shower joke at vitamin a but didn't *once* mention that riboflavin literally turns your pee into a fluorescent neon highlighter
Vitamin D deserves S tier, you undersold it's effects so hard. Maybe it's boring from a chemical standpoint, but from biochemical and endocrine it's not.
Low mood, low energy, low test etc
Yep, can't take the video seriously.
100% agree. Most people are vitamin D deficient now. It was also proven people who were affected by COVID the most had severe vitamin D deficiency.
@@ayushkanekar5698keep cope boss, vitamin D improves thyroid which has direct conection with testosterone and GH
@@Adderkop88exactly and he puts the the chemical structure in the tiers instead of the name. What a fail.
Fun fact about Vit K - it is given routinely to babies right after they are born (usually via IM injection or occasionally oral supplementation) because they are naturally low in it and don't yet have the gut bacteria that produce it which as explained in the video can affect blood clotting. It reduces the rate of intracranial haemorrhage which can cause brain damage - particularly important for babies who have had more traumatic births (i.e. vacuum or forceps assisted births).
Interesting fact, thanks for sharing!
Oh yeah I got vacuumed out of my mom’s cnut. Hardly ever hear anyone bring that method up
@@roddydykes7053that's terrible. Sounds like they screwed that up. I don't think you're supposed to suck a baby's skull on a vacuum to point you can pull him around even when stuck! Or wrap bbq tongs or forceps or whatever around its face and yank him out. I bet it feels like being constipated except there are no farts to help push it out
These comments are.. awful.
on the 8th day the baby begins producing its own, hence why jewish people wait until the 8th day for circumcision
I have no background in chemistry. I know very little about chemistry. However, your videos are a joy to watch
I hope you learn something useful from the videos :)
@@That_Chemist good evening sir, can you recommend a chemistry fundamentals textbook? especially organic chemistry
@@othman3049 Clayden is pretty good, especially if you find mechanisms to be helpful - chemlibre texts is another free online resource
Dude I love how science content creators are using trendy UA-cam stuff to teach science. I am easily baited into science videos with titles like "Vitamin tier list" "Are giraffes OP?" "Scientific theory iceberg"
Same😭😂😂
people use techniques lie this all the history
vitamin A the new meta bro get with the motion no cap
They gotta appeal to the mass so its genius
I'm starting to like biology... and it scares me
same tbh
Biochemistry is a wonderful middle ground. Enzymes catalyze some amazing reactions through interesting mechanisms. Biomolecules also have very interesting characteristics and structural motifs.
Just wait until you find sacred geometry. Pretty patterns got me enjoying MATH 😂
What if I told you, biology is a great field parallel to computer science?
one of us.. one of us...
The colored functional group atoms makes my brain feel good. You did an amazing job with this. Excited for the one.
I can't take all the credit - it is only possible thanks to the whole team!
@@That_Chemist Then you have an amazing team.
Carnivore diet is the best
you’re putting out some of the best chemistry content on youtube right now. thank you.
I will share your kind words with the team :)
😳🥰
The best of course being Nile green.
You are welcome 😊
@Ayo or adsorb.
"this is the more complicated part" is THE funniest shit. you lost me immeditaly the moment you started talking and, 5 minutes into an endless string of chemical names, you say "now it gets complicated"
Perfect. i love this channel so much
What on earth was complicated for you
lol don't worry about this ^
i felt the exact same hahaha
@@chaldoone9656 it turns out, when you are learning things, you might start out confused. Not everyone is familiar with stuff you may find elementary
Speak more biochemistry, please. This video is so satisfying.
Now we need a sequel by Ex&F on how to make explosive vitamins :D
"what's the healthiest explosive"
@Explosions&Fire I love you, Tom. No homo. Nice collab with Cold Ones, it reminded me just how much I miss new uploads from you.
@@ExplosionsAndFirewe need an answer
@@ExplosionsAndFire nitroglycerin is used as a medicine so maybe its that one
*Ascorbic acid* is actually used to make a rocketry propellant! It's called crimson powder and I believe it's primarily used in ejection charges as a more potent, cooler burning, alternative to black powder.
🤩 Thank you so much for mentioning my video! I appreciate you!
I appreciate your videos a lot - keep up the incredible work!
@@That_Chemist Thank you 🙏
There's funny way to memorize the vitamins soluble in fats in Czech language - the word for butt (which contains fat) is "ZADEK" and If you take out the "Z" you get the vitamins soluble in fat - "ADEK" :D
The really important thing is to remember that the fat-soluble vitamins are not R, D, E and L.
In German too we memorize them by EDEKA a common grocery store here
"Zadek" is also a word for butt in Polish language
In croatian DEKA means blanket so it works
In Brazilian Portuguese, "keda" sounds exactly like "queda", which means falling. So I memorized it as "if you slip on it (cause fat is slipper), KEDA"
Just wanted to say these videos are amazing to watch for me as an undergraduate chemistry student. It introduces me to aspects of chemistry I haven’t learned about yet and helps me be somewhat familiar with some things before I even learn about them in classes.
Great to hear!
You can also get Vitamin-E from Eggs, just like Vitamin-B1, B2, B5, B6, B12, Biotin, Choline, Folate, Vitamin-A, D, E and K2. Along with (And I know these aren't Vitamins, but still..) Iodine, Iron, Phosphoprus, Selenium, Sodium and Zinc. They're literally a perfect food.
from a organic, actual free range, good diet having chicken you may yes. not from just any eggs.
@@perad1895 could you explain how an egg could even be made without these essential materials
I'm pretty sure it's any egg.
@@ssgoko88 quality of and egg....depends on the quality of the chicken....the quality of the chicken depends on the quality of its lifestyle. simple borskie....not sure what you asked me to be honest.
@Pera 'D i think they were confused about "not just any eggs" and might have assumed you implied eggs from other animals lacked some of the qualities of chicken eggs, since you specified "chicken eggs" earlier in the comment, so they asked you to elaborate on that. I might be wrong tho.
@@MondayAgainBip gotcha..talking about chicken only here....but regardless my point of the animal and its living condition = quality of the egg. don't change. but thats the same for any good food tbh.
As someone who’s just getting off of accutane myself, I think understanding the chemical processes behind why my skin excessively dried out and my dozens of nose bleeds would be interesting to see! As always thank you for the effort you put into these videos!
Same
Same
@Max R
Read any of Grant Genereux's three free ebooks on vitamin A. Grant Genereux has been on a low vitamin A diet for +8 years.
Too bad you have been damaged by a high dose retinoic acid in accutane.
Don’t take that shi
Whoa they still make accutane? I thought it was lawsuit'd out of existence
Fun story: out of shameful habit, I went to pop a zit while on my first month of accutane. The dry skin under my fingertips just slid off instead
This some of the best-summarized versions of biochemistry that we (basic medical science ie. doctors, dentists, medical science, etc.) have to learn in my country for this particular topic. We just basically remember all the B vitamins as (1-PPP, 2-FAD, 3-NAD, 5-CoA, 6-transaminase, 7-CO2 transporter, 9-nucleotide synt, 12-Cobalt version of heme). Usually, we only got the text with some pictures but not the whole pathway (only the significant one) to study not to mention that every vitamin plays a role in understanding how our body works (you need to understand the basic pathway of metabolism first + heme synthesis). It is a fascinating topic and I admire how you presented it in an easy-understandable way for a topic that is mostly oversimplified to good-bad benefit.
Thank you! It really helps when people share it so that it can reach as many people who would benefit as possible :)
Please please please please make a detailed video on Acutane! I've read countless articles and research about how to works on a cellular level and I still can not connect all the pieces, however from what i did understand the drug is genuinely miraculous! I just got off two cycles and the symptoms were extremely wacky but I was left with perfectly clear skin at the end and my acne has not returned since. I had extreme dryness in my eyes, lips, skin, hair as well as joint pain in my knees and hips, tightness in my hips and pain in my lower back. I noticed i was far more injury prone and I even took longer to heal from injuries while I was on it. Really hope you take this suggestion into consideration as I think its near impossible detailed information on the drug even though its so widely used and talked about amongst teenagers struggling with acne. Love the videos and thank you so much!
Nixtamalization of corn was also explained in Tasting History: Unwrapping Aztec Tamales as well as SciShow: Corn Shouldn't Be Food, But It Is.
A walk-through of the full process can be found on Rose Red Homestead: How to Nixtamalize Dent Corn.
I have said before how your videos are really improving, but this one is like none other before. The visual support is clean, the memes are funny and the information is easy to comprehend.
Amazing job!
Your production in videos has gotten a lot better over time (not saying your prior videos are bad). This is S tier content.
Poggers
Niacin was originally called nicotinic acid because it can be created by the oxidation of nicotine with nitric acid. However, people knew nicotine as the addictive chemical in tobacco, so the name niacin was used instead. Niacin comes from the words NIcotinic ACid vitamIN.
Thank you
One cool thing about biotin is its interaction with avidin. More specifically, the binding affinity of avidin to biotin is among the strongest non-covalent bonds. It's pretty much non-reversible without denaturing the avidin.
Regarding finding local edible plants with needed vitamins... I would assume that in most places humans have lived for an appreciable length of time, people have pretty much figured out what plants are edible pretty effectively. Finding an edible plant that's also palatable and cultivatable and fills a gap in human needs in an area, that nobody knows about should be exceedingly rare.
Mineral tier list?
Vitamin K2 supplementation has been found to be effective in preventing osteoporosis and some heart problems.
As soon as I read the words "vitamin lore" I knew this was gonna be good, maybe I would've actually chosen that biology course if it was taught like this
Adding one thing, Umetaro Suzuki was working on vitamins but originally term "vita-aminy" was created by Casimir Funk in 1912 who created concept of vitamins
And then Funk was credited with the discovery of B1...despite likely discovering B2.
I really appreciate the conciseness and precision of the script, some of the best ive seen in youtube educational content.
thank you!
And he speaks so clearly and quickly. Tons of information in an interesting format even if I'm only able to comprehend some of it.
Hands down the best chemistry content on youtube. I really like that you touch on adjacent topics like psychopharmacology as well. Thanks for all your hard work!
Something that fascinates me is how essential amino acids like phenylalanine and tryptophan have cyclic carbon rings that arent formed in animals bodies. We are reliant on plants and microorganisms for the building blocks of our bodies.
??? No they dont.
Yes thats how omnivores work
Carnivores: Reeeeeee
Amazing production on this one. Your team is amazing
They are indeed :)
@@That_Chemist What program is used to make the structures (and can I also make color coded letters with it?)
@@That_Chemist yes! Whoever makes your graphics is doing an incredible job. Loved the TCA cycle one
Maybe even his best vid so far
@@nolanhanson5743 it's a mix of blender, wavefronts from RCSB pdb's, and chemdraw. Those usually are consistent but honest we would use anything as long as it shows what we would like to show effectively.
so in hungary (where I live) there is a big thing about vitamin c, because one hungarian scientist got the idea of extracting it from peppers and he did so succesfully. So apart from citrus fruits, peppers (as in paprika) should be good too.
(go look it up if you want it’s Albert Szentgyörgyi and it’s a whole thing, there aren’t a lot of hungarian contributions to science so the ones we did make are super hyped up in every school)
There are MANY Hungarian scientific contributions. Ignaz Semmelweis is the reason many many babies have survived being born. Just one significant example. Szeresed magad, koszonom.
@@Yarmox *Austro
Greetings to my Hungarian brother from Poland 😉
As for vitamin C there is a misconception that citrus fruits have a lot of it, while in fact some other fruits and veggies have much more of it. Camu camu and acerola are the most abundant in it, and paprika is also more rich than citruses.😂
Hungary is well known for a lot of important scientists and artists compared to population. Szentgyörgyi, Neumann János, Teller Ede, Szilárd Leó etc etc
Based on what you said about B12 maybe this changed, but folic acid was usually recommended to pregnant women in part to help prevent neural tube defects.
Its both, folic acid has been known for a while, but "recently" b12 was also shown to independently reduce the risk.
Nature Reviews Endocrinology volume 5, page 354 (2009)
Fun fact about the whole non-bioavailable niocine in maize: indigenous populations had known about this in some way or another for centuries, and knew to 'nixtamalize' (what a beautiful word) it long before European colonisers came and took the stuff as-is and shipped it all over the world. While our forebears were scratching their heads over why everybody else was getting sick from their cheap maize-only diets, the locals laughed it up and threw some more volcanic ash on their corn flour. For another fascinating take on the tortilla story, Tasting History's got a couple great videos about it!
Even though I don't understand half of this stuff I do generally get the idea. I just love these kinds of videos because I get to appreciate how beautifully complex nature is.
I have to put the video in x0.75
I stg I learn more from UA-cam than I ever did in high school + college combined
I really like that new style of presentation going with the classic That Chemist voiceover
1:48 Which kind of acid is the safest? The answer is Folic Acid-it’s totally benign
Ooo Im excited! I love the production quality on these and ive been super curious about vitamins, Perfect combo!
Hey, I know I’m a little late to the video but if you see this by any chance could you start adding the IUPAC names under the graphics of molecules? Especially the hydrocarbons. I’m in grade 12 chemistry right now on the organic chemistry unit and it would be a massive help in reinforcing what I’m learning
Fun Fact about Vitamin A - One piece of a polar bears liver about the weight of 500 g has an about 9 million IU of vitamin A and acute human toxicity will occurs at around 300,000 IU. A danish scientist once tried to convice some to Greenland natives to try to eat Polar Bear Liver and almost died from a single bite :D
As someone in a biochem program, your stock exchange analogy actually confused me for a brief moment lol. I had to use my knowledge of coenzymes to understand the analogy rather than the other way around.
This was a fun video. More bio stuff please!
Lol
Oh, and I'm so up for a video about various retinoids, especially how newer generations like adapalene are causing less/none photosensitivity in skin!
I would love one about all the skin stuff like even comparing the different chemicals and stuff or whatever in each retinitoid also that’s cool they don’t cause photosensitivity is there a way maybe to make acutane do that? I though photosensitivity was becasuw it made skin cycle faster so it was new skin which is easy to burn
Would totally like a video on astaxanthin been reading all the NIH and pubmed studies. Trying even to ask chatgpt3 how to achieve that orange colored skin that can happen with astaxanthin as well. I did 100mg daily for a few months from 2 different brands and didn't achieve that orange result. My eyesight improved along with taking Sulbutiamine and Astaxanthin from negative 1.25 to 0.75 (fR sighted) along with (convuluted with rather) eye exercises daily. Over the course of 1 year, going to try and add NMN to get back to not needing to wear contact lenses. Also added bacopa and lions mane extract to the mix, 2 grams and 5-10 grams respectively. (Also increased potassium (Kiwi, greens) and magnesium glycibate due to sulbutiamine utilizing more uptake).
This is definitely the best video about vitamins I have ever seen, it was really detailed and I loved every second of it, have you thought about doing similar video about minerals?
I haven't thought a ton about minerals (rocks), but in terms of biominerals we could definitely do something like this in the future
@@That_Chemist Geology Hub frequently refers to the chemical composition of lava, typically silica vs alkali metals, but geologists in general have their own rather odd way of categorizing minerals (felsic vs mafic).
Toss in the the weirdness of clay minerals and you've got lots to talk about.
I have a lot of health anxiety and thus, have a hard time appreciating my body. This video helped me change my attitude - if my body can do all these crazy biochemical reactions and conversions, it deserves some respect.
Thank you for your content. I appreciate it and the team a lot.
I would absolutely love a video on carotenoids, beta carotenes, acutane, etc. Thank you for such educational and informative content!😊❤
Very curious about acutane. I took that when I was a teenager and although it was the only thing that actually cured my acne it had some marvelously horrible effects on my skin, like a desiccated piece of flaky jerky covered in cold sores. Like my entire lips were just one big cold sore. Never had one after that nor before.
It may be rare, but in my 20s I actually had mild scurvy for some time.
It caused my gums to bleed whenever I brushed my teeth. It got to the point where I just had to make a partial vacuum in my mouth, and it would start bleeding.
It stopped when I took Vitamin C supplements for a while.
Also, wasn't Golden Rice also better yielding in other nutrients? And I think it was thwarted by anti-GMO scare-tactics in developing countries...
I think is was also super hardy and able to grow in a variety of conditions, including during periods of less water.
Absolutely, greenpeace destroyed a lot of crops due to their purist views that put "not GMOs" over stopping preventable loss of human life
ב''ה, the full story is that apparently business reasons killed it
@@josephkanowitz6875 ב"ה?
Its definitely not thwarted its still supported by private investment, but it does stand that nutritionally it wasn't better than normal rice it was evaluated twice by the FDA. But new generations of it will likely be introduced eventually and reevaluated. But at the time it was brand new and didn't deliver on promises at least in America. In Asia it was political resistance maybe somewhat anti GMO but more anti western influence.
i’m on accutane and there’s so much misinformation out there but it still kinda scares me. would love a video on it (:
What s that ?
@@yahia9481 gets ride of acne, has many side effects
or consider not being on a poison
moreplatesmoredates and leo and longevity covers accutane
@@feelinghealingfrequences7179 your name is "feeling healing frequencies" you probably think 5G is deadly sit the poison talk out
There've been some exciting results in aging reversal in lab mice using niacin derivatives.
Damn i watched one of the best chemistry video on UA-cam. Great video bro
Thank you!
Putting them all in a tier list really helped me differentiate and remember them and their roles in the body. Absolutely genius video formatting thank you!!
yes please do make a video on Accutane so I can know what exactly it did to my body during and post treatment
it's basically Vitamin A
A year out from my BS in biochem , and I'm glad you brought up how yellow flavins are! Was the first quality my professor mentioned in intermediary metabolism and I was thinking, "wonder if E&F knows". Thank you for the great content!
It gives a nice color to your pee after eating liver :D
I like how you've updated your visual presentation! Your slides are colorful and fun to look at.
I would really appreciate the video on Vit A, specifically accutane. As I think about starting a course but I'm terrified of nose bleeds more than anything else.
This is such a good thumbnail. Nice one fr
Man I'm liking all the chemistry details in the editing. I'm a huge fan, and someone who really likes the videos you put out
I appreciate the kind words!
i started on accutane relatively recently, id love to see a whole video about the vitamin a-esque (retinoids? im in the first year of my undergrad in chem lol, i dont know ANYTHING) even if i am a bit late to the party. the packaging alone on accutane is no joke, every surface reminds you about the birth defects. its interesting that compounds so similar can be used topically and ingested orally for acne
Riboflavin has given me quite a scare because if you consume an excess it come out in your urine and Riboflavin is astrobright yellow. (I don't think it's underrated in the tier list). I think he was entirely too clever with vitamin C and think he may have been influenced to put it into C tier because it was Vitamin C. It obviously is S tier given its important role in history.
Vit c is tasty, should be up top on that alone.
As a doctor i cant agree with you on the tier list chemistry >Biology 😂❤
The information given is super crisp , valuable and presentation is on " S tier" 🙏
I really like the new new format like a bit of info and I also like the new colours
I thoroughly enjoyed this. You put so much detail and effort into this video and I love it! keep it going
Your channel is amazing. Even for amateur viewers who will probably never be in a lab (like myself), it's still just so interesting to learn about this stuff.
Thank you :)
Your animation and overlay work is getting amazing, really adding the the draw of the content. The visible complexity of the spinning enzymes involved in the Krebs cycle drives home how amazing that machinery is as a whole without saying a word. When looking at inputs and outputs it seems all too simple, but it's a ladder of the same complexity as the mitochondrial electron transport chain.
Thanks! We have some more cool changes coming in the next tierlist we will be posting (hopefully in the next few days, definitely before the end of May)!
I don’t make these by myself anymore, but rather we have a team of people who are dedicated to working on it :)
As an undergraduate biologist I can say that Vitamin B7 is actually useful for detection experimental procedures in biology, since it forms complexes with avidin and maybe for that reason it should have been higher on the list (maybe D tier). But sulfur does suck and it does stink indeed. Anyway, I love how far your channel has come and the quality of your content has improved dramatically. Your videos are always extensively detailed and I thoroughly enjoy them. Even though I chose biology as my major, I do love chemistry and your videos remind me of how fun chemistry is while also enhancing my current knowledge.
Thank you for your kind words :)
It’s so weird… we’re so averse to managing farms that are biodiverse that we’d rather go through all of that genetic modification to rice instead of just farming a second plant.
This is amazing. Would love to see more biochemistry content here!
I wish I had waltzed upon this video before submitting my multi-vitamins literature review! Trying to academically put that there is no standardised, regulated definition was a task and a half.
This video definitely cemented how much I enjoy biochemistry, but the stress of studying higher-level chem past the required foundational level has me hesitating on it. It also means I need to study a level 200 chem unit before I reach the level 300 biochem units, so I at least have a year and a half, two years max before then if I want to get serious about it.
Thanks again to you and your wonderful team! My brain has been most satisfied! :)
I read an entire book on Vitamin K2 and the surrounding studies. Something about it as a coenzyme for proteins that transport calcium from and to tissues in the body, apparently really important in preventing atherosclerosis and reshaping bone during pregnancy and childhood growth. Book is called Vitamin K2 and the Calcium Paradox. They also cover some interactions between all the fat soluble vitamins. I'd love to see you tackle the chemistry behind these studies.
Thanks for all you're doing here. 🤜🤛
Apologies if someone has already pointed this out, but there is a graphics error at 37:05, where it should show D2 for the plant based form, not D3.
B12 is so cool, it’s also an antidote for cyanide poisoning!
In response to @1:00, you said:
Vitamin: 251 times
Vitamins: 50 times
I've been dealing with nutrition in a macro sense for many years, and until today I had no idea Vitamin B12 was a Cobalt complex.
more about the carotenoids please and their ability to stimulate collagen growth in the skin along with protect from UV damage and what not please.
This is so complicated for a tier list man... I feel like I need to be a biologist to understand. Wish you had simplified to make this more accessible.
Your channel alone just got me super obsessed with biochemistry. Awesome stuff
Thanks for the kind words! It is amazing how intricate the natural world is
i love the new glow-y theme! it helps make my favorite subject even more mesmerizing, thank you!
I will let David know :)
wow I just love watching such long, in depth videos and finishing the video- forgetting every last detail learned
"Fat soluble vitamins are less likely to cause deficiency" me having a severe vitamin D deficiency last year and having to take a lot daily because I'm allergic to sunlight ☺
My first job with a biology degree was a conjugation chemist and sulfur earned a special place in my heart
DACs gotta conjugate
My winter depression was largely a crippling vitamin D deficiency spiced up with ADHD and general anxiety disorder 😂
Same
Most people are deficient in vitamin D today
Eyyy SAD-ADHD-anxiety gang
les goooo
Those vitamins look like little creatures when drawn like that
Vitamin B2 is pretty cool for people with a MTHFR gene mutation… For these people it basically cures anxiety and depression (although other nutrients are sometimes needed as well, but B2 is key), as well as fixing elevated homocysteine, inflammation and a long list of associated health risks. Also Vitamin D deficiency remains extremely common and causes a range of health issues… including susceptibility to severe COVID. However the most severe form responsible for rickets is less common.
nice video bro. Helped so much
This video is so well made. Even though I am a finance student and have no relation with chemistry, here I am watching a 45 minute video 😀
Glad to hear it :)
Maybe you have a video on this, I think it would be really cool to talk about the role micronutrients play in our gut biome and the key role they have with the bacteria that lives in our bodies
Hrngh. These biologists, misnomering chemicals ánd these nutritionists claiming that food is good or bad. Did you see how the egg went from being healthy to being unhealthy to being healthy again to being unhealthy to being healthy now in a span of 40 years? Crazy stuff.
imo it's because most people don't understand the complexity of biology - hopefully they will after some more of these biochem videos 😎
BuT cHoLeStErOl
Am i just imagining stuff or eggs have been healthy for like all my life probably like the definition of one of the healthiest foods
I am in the gym and I want to get bigger. This biology and chemistry and good stuff is oddly intriguing bc I think it feels like it’s gonna help me get more gainzzz
tbh the answer is usually 'people are taking some sort of steroid'
Can confirm, I'm watching this and deficient in most B vitamins, due to malabsorption related to Crohn's disease. :P
Great vid, would love one on retinoids if only so that I can hear about how developmental toxicity from retinoids actually works.
consider buying sub lingual B vitamins
KAL brand is good quality
Bro this video is actually so fking good, thx for such a detailed and educational video
Thank you!
Thank you for making some stuff easier to understand; I am taking intermediate metabolism and have an upcoming test this week.
You can do it! Give it your best!
This is my favourite type of videos: chemistry in biomedical context
This video is a perfect balance between comedy and informative content. All shown in an easy to understand way.
A really decent percentage of the population have a genetic defect (on the MTHFR gene) that almost completely inhibits methylation of THF in the liver. It's a major cause of depression misdiagnosis.
can you do a video on vitamins and minerals best for testosterone tierlist?
Vitamin D, Calcium, Zinc and Iron.
@@iskander07 could you explain why iron? i can only think of promoting healthy blood flow that can help testosterone circulate
boron too
I am watching this high and my mind is blown lol i never knew vitamins could be so cool
Bill nye the chemist guy
This dude made a golden shower joke at vitamin a but didn't *once* mention that riboflavin literally turns your pee into a fluorescent neon highlighter