A 3D animation of mismatch repair in E. coli

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  • Опубліковано 8 вер 2024
  • Made using Blender 2.75 as part of my third year Practical Project (BSc Medical Biochemistry).
    March 2016

КОМЕНТАРІ • 140

  • @Gamelover882
    @Gamelover882 Рік тому +20

    My professor recommended this video and I see why. It's quick, in plain English, well animated and accurate without over complicating things. Thank you!

  • @DendyJungle
    @DendyJungle 7 років тому +95

    dont know why you are giving this away for free but i am glad you are. Usually have to pay for really good educational videos

  • @hoshi1599
    @hoshi1599 2 роки тому +5

    Beautiful. I didn't realise there was going to be a bend with mutH while studying. This clears up so much .

  • @truth2power528
    @truth2power528 6 років тому +14

    Great video Sam. This helps tremendously in visualizing the process and makes it easier to understand.

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому +1

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @peednas711
    @peednas711 2 місяці тому

    Bro I have a professor in molecular cell biology. He's been a professor there for 10-15 years. And still, you were able to explain this mechanism better than him. Good job to you. This is your calling

  • @johnhenry4389
    @johnhenry4389 8 років тому +7

    That was one of the best videos of DNA-enzyme interaction I've seen.

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому +2

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @parth2615
      @parth2615 3 роки тому

      @@samarrowsmith1396 I was studying for my molecular genetics course, I couldn't visualize the mismatch repair system so I searched "DNA mismatch repair" on youtube. This was the second recommendation.
      PS. It's a great video. I recently learned the basics of blender, I will also try making such nice little animations just for fun.
      Hope this was helpful.

    • @factualbiology7769
      @factualbiology7769 2 роки тому

      ua-cam.com/video/iO32xJF1cTk/v-deo.html

    • @Ragunath21
      @Ragunath21 4 місяці тому

      ​@@parth2615 now it's first in recommendation

  • @samarrowsmith1396
    @samarrowsmith1396  6 років тому +106

    If anyone enjoyed this video and would like to see another of the sort, please suggest your ideas! I'm looking for suggestions for the next topic to animate!

    • @axellir
      @axellir 6 років тому +3

      The video really helped me to visualize the process! Thanks! How about an animation about homologous recombination?

    • @holden2966
      @holden2966 5 років тому

      DNA techniques ?

    • @blandon93
      @blandon93 5 років тому

      How dna polymerase select nucleotudes in replication. Does it take nucleotides freely or they stick?

    • @singhmilandip
      @singhmilandip 5 років тому +3

      I would like to see SOS response...

    • @srikantadash4603
      @srikantadash4603 4 роки тому

      Transcription Translation post translational modification

  • @trudyandgeorge
    @trudyandgeorge Рік тому +1

    Went looking for explanations on cyclical redundancy checks and wound up here. So Mother Nature did it first! Bravo 👏

  • @holden2966
    @holden2966 5 років тому +11

    Wow! This great! Made perfect sense in just 3 minutes. Great animation! Keep it up Sam

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @holden2966
      @holden2966 3 роки тому

      @@samarrowsmith1396 I just searched it up

  • @sliceofnoob2885
    @sliceofnoob2885 4 роки тому +1

    Thanks the best vid I've found on mismatch repair....a real life saver

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @Lillith9008
    @Lillith9008 3 роки тому

    This is one of the most aesthetically narrated biology videos I have seen. Thank you :D

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @factualbiology7769
      @factualbiology7769 2 роки тому

      ua-cam.com/video/iO32xJF1cTk/v-deo.html

  • @adityakale6064
    @adityakale6064 5 місяців тому

    It was so simple to understand and you saved me for my exams

  • @a.i892
    @a.i892 3 роки тому

    One of the best educational videos i've ever seen

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @carlosalbertolararojas3610
    @carlosalbertolararojas3610 3 роки тому

    Thank you for this video I was trying to study methods of DNA respiration and I could not visualize this in my mind , you made it a lot easier for me many thanks.

  • @hafsaamzim1901
    @hafsaamzim1901 2 роки тому +1

    It’s amazing and very clear. Thank you a lot.

  • @satabdideka8832
    @satabdideka8832 3 місяці тому

    Ahh, you made it so easy! Thanks a lot

  • @nitukharsel3625
    @nitukharsel3625 Рік тому

    A well animated vdo 😊. I liked it very much .please animate mor topics of Molecular biology😢

  • @pulgimole5
    @pulgimole5 8 років тому +6

    Very helpful! thank you

  • @shivamverma2754
    @shivamverma2754 2 роки тому

    wow so much wow ... great job Sam

  • @harvey2733
    @harvey2733 3 роки тому

    Such an amazing presentation. Loved it.

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @nikitamaurya6644
    @nikitamaurya6644 6 років тому +2

    Thank you so much,it helped me a lot.

  • @lisarichards3217
    @lisarichards3217 7 років тому +2

    More science videos! This is well done.

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @DL551997
    @DL551997 8 років тому +2

    extremely helpful. thank you very much!

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @niharikagovindjha8919
    @niharikagovindjha8919 6 років тому +2

    it's really good but a bit more clarity about methylation and also references to RecJ and endonuclease VII would have been great

  • @twisampatidas9965
    @twisampatidas9965 5 місяців тому

    Awesome brother

  • @noorulhassankhan
    @noorulhassankhan 3 роки тому

    Wonderful video, thank you so much!

  • @malekmohamad4815
    @malekmohamad4815 2 роки тому

    that was epic..my regards from syria

  • @maryamsediqi3726
    @maryamsediqi3726 Рік тому

    Awesome, thank you so much

  • @litchfirmian7562
    @litchfirmian7562 2 роки тому

    This is really helpful, thank you, sir.

  • @hayilee9601
    @hayilee9601 2 роки тому

    you just saved me! thank you so much :)

  • @feliscatus4921
    @feliscatus4921 2 роки тому

    this is an informative and useful video!

  • @lapetiteloutre9345
    @lapetiteloutre9345 5 років тому +1

    Great video, thanks a lot :)

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @Ssalma6338
    @Ssalma6338 11 місяців тому

    About the DNA polymerase , is it polymerase III which is responsible for the resynthesise of the new strand or the Polymerse I ? I get confused

  • @arvindshankar7679
    @arvindshankar7679 5 років тому +1

    Good work fam, this is helpful.

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @wealllovelina
    @wealllovelina 3 роки тому

    awesome animation! thanks!

  • @Mk-hc9jm
    @Mk-hc9jm 3 роки тому

    Legend, thank you so much

  • @ayeshaqamar5972
    @ayeshaqamar5972 5 років тому

    Thank you so much for the video

  • @zuhaltatar935
    @zuhaltatar935 5 років тому +2

    İts very helpfull! Thank you so much :)

    • @SURESHKUMAR-gt7eo
      @SURESHKUMAR-gt7eo 5 років тому

      Hello

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @corvette724
    @corvette724 5 років тому

    well done Blender job

  • @ubaldogennaromastrominico786
    @ubaldogennaromastrominico786 2 роки тому

    Great job!

  • @musicspeaks0101
    @musicspeaks0101 6 років тому +1

    thank you so much!!!

  • @7mikepd
    @7mikepd 8 років тому +12

    i think it's dna polymerase I that fills in the nucleotides before ligase fills in the nick.

    • @camelliaxie9381
      @camelliaxie9381 7 років тому +8

      Pol I is for proof reading and Nick translation (replacing RNA primers between Okazaki fragments). Pol III is for elongation, so the video is correct.

    • @zsusanner
      @zsusanner 7 років тому +2

      The video is correct. It is DNA polymerase III that fills the gap

  • @superiorslush5147
    @superiorslush5147 3 місяці тому

    every good 3d biochemistry animation has a british accent

  • @matthewgrammatico8434
    @matthewgrammatico8434 7 років тому +1

    thanks mate. great video!

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @matthewgrammatico8434
      @matthewgrammatico8434 3 роки тому

      I was doing a genetics module at the university of Nottingham and just searched mismatch repair on UA-cam. It's a great video because of the visual aspect.

  • @wasifullahdawar6962
    @wasifullahdawar6962 3 роки тому

    Thank you

  • @adammiah235
    @adammiah235 5 років тому

    It is a very good video.......thanks ....

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @asifhamid9676
    @asifhamid9676 6 років тому +1

    Superb.....

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @blancaparraga3006
    @blancaparraga3006 3 роки тому

    Thank you so much

  • @shafiamobasheri830
    @shafiamobasheri830 3 роки тому

    The best ever

  • @katarinala
    @katarinala 7 років тому +1

    THANK YOU, it was so confusing in my book!

  • @reviewsbymithy8532
    @reviewsbymithy8532 3 роки тому

    Question please
    Why Dna is looped out in search of nearest d(GATC) methylation site?

  • @user-hq8mx7mn3u
    @user-hq8mx7mn3u 6 років тому

    Infinitely helpful

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @ryanisber2353
    @ryanisber2353 2 роки тому

    So good

  • @anilk1241
    @anilk1241 7 років тому +2

    great video !!
    - a medical student

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @zaynas2100
    @zaynas2100 7 років тому

    It's a very good video thanks

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @aisheebhattacharya4228
    @aisheebhattacharya4228 5 років тому +1

    Wht abt uvrD helicase?

  • @atanasatanasov9036
    @atanasatanasov9036 7 років тому

    Awesome! Thanks

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @kalpanamurmu3776
    @kalpanamurmu3776 5 років тому

    Thanks you sir .

  • @abhiriseagain9303
    @abhiriseagain9303 4 роки тому

    awesome vid thank youu

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому +1

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @abhiriseagain9303
      @abhiriseagain9303 3 роки тому

      @@samarrowsmith1396 Hey thank you so much for your video. I searched for DNA repair and your video came up in search results..I watched many , this was the best one. For me this video was very beneficial in understanding the topic easily. And the animation was amazing, gave a clear picture. These are the topics which confuses some, so people tend to search for this kind of videos maybe thats why and you did a great job with the video.

  • @wassmmd8521
    @wassmmd8521 4 роки тому

    Very nice

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @saja4887
    @saja4887 4 роки тому

    Thanks a lot :)

  • @user-de3qh4os7s
    @user-de3qh4os7s 7 років тому +1

    thank you...... please how can download this video

    • @Ahnzhie
      @Ahnzhie 7 років тому

      1. Go to www.keepvid.site/
      2. Copy the link of this video and paste it on keepvid site
      3. Click download and you can find more options down :)

  • @elnazzeinali3240
    @elnazzeinali3240 Рік тому

    Thats good tnx

  • @nareshsheoran2298
    @nareshsheoran2298 6 років тому

    Very nice sir

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @AlessandroDonaggio
    @AlessandroDonaggio 3 роки тому

    hope you got a first for this!

  • @stephenhawking9155
    @stephenhawking9155 2 роки тому

    How can i pay you. You just saved me ❣️❣️❣️

  • @maheenejaz360
    @maheenejaz360 5 років тому

    Kindly tell mismatch repair of e. Coli and eukaryotes differs? Pls answer as soon as possible.

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Hi Maheen, I realise this is a VERY late reply on my part so I can only apologise. I imagine my hesitation to answer this question is because I don't fully know the answer myself. There are analogues of the mismatch proteins across life, but the difficulty comes of looking at things within the chromatin environment. Making an accurate animation of the movement of histones and unzipping the DNA strands that have been exposed would be a comparative nightmare (for me anyway, there are probably skilled animators who could try making a representation of this). The wikipedia article for mismatch repair has a basic outline of the analogues: en.wikipedia.org/wiki/DNA_mismatch_repair

  • @eugenealice6839
    @eugenealice6839 5 років тому +2

    nice

    • @NT20817
      @NT20817 5 років тому +1

      rlly nice

    • @aliceeugene6871
      @aliceeugene6871 5 років тому +1

      Hey what’s up Nate ?

    • @NT20817
      @NT20817 5 років тому +1

      Alice Eugène chillin like a villain, n you?

    • @aliceeugene6871
      @aliceeugene6871 5 років тому

      Cool, not me, I’m an hard worker today !

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому +1

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @JamSlapper
    @JamSlapper 5 років тому +1

    MutS and MutL are heterodimers not homodimers, good vid though

  • @ej_stories
    @ej_stories 3 роки тому

    👌👌👌

  • @mcpba3857
    @mcpba3857 5 років тому +3

    1:15

  • @priyasultania8943
    @priyasultania8943 6 місяців тому

    Dam good

  • @agri_lover_boy1292
    @agri_lover_boy1292 3 роки тому

    Please apki volume high kordo

  • @muskanpathan7623
    @muskanpathan7623 6 років тому

    Wow!!!!

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @Futurescientist_
    @Futurescientist_ Рік тому

    This is wrong first step hemimethylated GATC pe

  • @sanauzma6192
    @sanauzma6192 3 роки тому

    pleas sir be lauder i cant heat uhh

  • @user-hf9wy5jp6x
    @user-hf9wy5jp6x 3 роки тому

    перевод на русский

  • @jinglingu3465
    @jinglingu3465 7 років тому

    旺德福!!!

  • @theeducationtree8272
    @theeducationtree8272 5 років тому +1

    AMAZING!! THANK YOU.

  • @crazyfilms6562
    @crazyfilms6562 6 років тому

    Very nice

    • @samarrowsmith1396
      @samarrowsmith1396  3 роки тому

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @crazyfilms6562
      @crazyfilms6562 3 роки тому

      Sir it's been 2 years now and I was in 12th standard at that time, after watching your video It made me easier to understand the concept and visualization makes it more memorable, now sir I am doing mbbs and hopefully became a doctor.🙏

  • @tarannumkhatoon5070
    @tarannumkhatoon5070 6 років тому

    👌👌👌