Homology-dependent double strand break repair

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  • Опубліковано 16 вер 2024

КОМЕНТАРІ • 55

  • @reeseymeimei
    @reeseymeimei 9 років тому +797

    I will take my genetics exam and remember this man whispering about double strand break repairs.

  • @uneloutredeuxloutres
    @uneloutredeuxloutres 6 років тому +235

    Is this oxford press ASMR?

    • @leenasa2286
      @leenasa2286 5 років тому

      Lise Rose MAURIN 😭😭😭😭

  • @gingerrmoe
    @gingerrmoe 7 років тому +411

    Snape, you gotta move away from the microphone when you breathe.

    • @Ethentent
      @Ethentent 7 років тому +6

      I thought the same thing! But yeah, it sounds like he's trying to make an ASMR video xD

  • @daniellaschaening4470
    @daniellaschaening4470 6 років тому +50

    Wow! I didn't know I could speak parseltongue, but I understood everything this guy just said!

  • @misterphuzz
    @misterphuzz 7 років тому +54

    I don't care about the voice. At least I can understand the words he speaks, unlike many other big-time science video producers. And the visuals were so helpful.

  • @karstenlane6864
    @karstenlane6864 9 років тому +39

    This was incredibly helpful. To see this animation done with DNA looking structures, as oppose to just lines, made a world of difference. Thank you millions :D

  • @taylorbrady4213
    @taylorbrady4213 9 років тому +152

    This guy should be a Bond villain.

    • @k.j.b.h5245
      @k.j.b.h5245 8 років тому +1

      +Taylor Brady Jajaja i thought the same when first listened his voice.

  • @omrisinder5602
    @omrisinder5602 8 років тому +208

    whats going on with that man voice??
    does anyone else feel discomfort with that??

    • @Kjonesa
      @Kjonesa 7 років тому +34

      literally only went to the comments section to see if anyone else noticed that, lol.

    • @skarpengland
      @skarpengland 5 років тому +2

      his voice is awesome. Funny part of learning for oncology.

  • @adrianbulfon8430
    @adrianbulfon8430 10 років тому +8

    One of the best videos Ive seen to date!

  • @roveradamus
    @roveradamus 9 років тому +67

    Good video. But the narration made me uncomfortable. Please record the audio away from the microphone please!

  • @simonbaker9909
    @simonbaker9909 9 років тому +9

    Valuable animation, but could use some more explanation, such as: 1) under what conditions is the homologous dsDNA conveniently located nearby, and how is the physical coordination/matching of regions initiated; 2) other references (wikipedia) mention two different paths to resolving the bubble, one involving cross-over, the other not -- is this true, or is this video more accurate information showing only the non-crossover way; 3) how does the bubble know when it has synthesized enough new DNA on the invading strand to match the other hanging end of the broken DNA?
    Why is the description of the video seemingly wrong ("Published on Aug 12, 2014
    In this animation, we explore how a transposon moves as a consequence of DNA cut-and-paste transposition. ")?

  • @karenn.8810
    @karenn.8810 8 років тому +13

    good animation and well explained ! this was very helpful

  • @anubhavdas2095
    @anubhavdas2095 5 років тому +8

    Really nice video, I got goosebumps

  • @MrCharanthej
    @MrCharanthej 6 років тому +1

    Great video.....Both videos on Homologous repair and Non homologous repair are nice...Thankyou.....

  • @sym2988
    @sym2988 6 років тому +1

    even though you whispered through this whole thing this was a great visualization aid, thank you

  • @ImperialGoldfish
    @ImperialGoldfish 6 років тому +3

    Incredibly helpful explanation, thank you

  • @dinosaursgorawrish
    @dinosaursgorawrish 8 років тому +61

    its worse because when you turn up the volume you can hear his heavy gasp for air in between sentences

  • @kufuffin47
    @kufuffin47 6 років тому +1

    Amazingly helpful animation. Thank you!

  • @moonju0116
    @moonju0116 9 років тому +49

    Why is this guy whispering?

  • @murg526
    @murg526 6 років тому +3

    That voice will be haunting me

  • @AMillionOs
    @AMillionOs 7 років тому +6

    His voice makes you automatically think he knows what he's doing

  • @Dornatum
    @Dornatum 8 років тому +1

    I don't understand how the C region is entirely newly synthesized DNA. I thought the endonucleases only removed one strand of DNA from the site of damage. At 0:36, I still see a single strand of C. How is that removed later on?

  • @xx8113
    @xx8113 6 років тому

    brilliant video---!love the animation!

  • @turma85medicinaepm7
    @turma85medicinaepm7 6 років тому

    very comprehensive, thank you.

  • @oglow100
    @oglow100 9 років тому +7

    Thuderf00t is that you?

  • @DeemahAd
    @DeemahAd 10 років тому

    Did you mention that the nuclease digests 5' ends???

  • @sebastianaguiarbrunemeier9192
    @sebastianaguiarbrunemeier9192 6 років тому

    Well explained

  • @goldenyuusha
    @goldenyuusha 7 років тому +2

    this was like asmr

  • @SrirachaPilsner
    @SrirachaPilsner 6 років тому +1

    why is werner herzog explaining homologous repair to me rn

  • @peishitan2519
    @peishitan2519 9 років тому +1

    Hmmmmmm Where did the homologous strand come from? Did it come from its sister chromatid?

  • @7azem3mad
    @7azem3mad 7 років тому

    great

  • @MrMetalHead1100
    @MrMetalHead1100 6 років тому

    it looks like it created a repeat in the DNA

  • @bongwhanyeon9584
    @bongwhanyeon9584 9 років тому +2

    It sounds like Jigsaw

  • @ldnt1698
    @ldnt1698 7 років тому

    This is probably a really stupid question but the other name for this method of repair is Homologous Recombination, Right?

    • @ldnt1698
      @ldnt1698 7 років тому

      and micro homology - mediated end joining is the other video, the Holliday junction resolution.

  • @NH-px6vj
    @NH-px6vj 5 років тому +3

    This boy seriously needs to learn how to use his voice effectively when presenting something to people. I can’t focus at all because his voice is like a noise. He’s gotta speak clearly

  • @zackfairthepuppy
    @zackfairthepuppy 7 років тому +4

    Bio ASMR

  • @maria11135
    @maria11135 8 років тому +5

    With this voice. NO!!!

  • @Sannoon93
    @Sannoon93 6 років тому

    am i color blind or the "pink" strand is actually purple hahaha men! just kidding :P very useful video narrated by the a guy who is extremely dehydrated yet congested and should narrate the villain in a movie or something!!

  • @omerfaruksimitcioglu3190
    @omerfaruksimitcioglu3190 9 років тому

    içinden konuşuyo sanırım

  • @jschoong94
    @jschoong94 9 років тому

    Narration can be improved.

  • @rakeshbam9883
    @rakeshbam9883 9 років тому +8

    confusing as heck

  • @isabelshelton07
    @isabelshelton07 6 років тому

    thanks for the video but creepy voice

  • @00the00virus00
    @00the00virus00 8 років тому +3

    Horrible voiceover.