Jesus, finally someone explained this properly. this is the 10th clip I watched and now can understand this end replication problem. thank you for sharing.
just reading about histone codes and the histone sequence in human. is very complex for me. that is about heterochromatin, euchromatin and histone tails, x chromosome deactivation, methylation and acetylation of histones affecting epigenetic and genetics. I wish you was here to read this with me.
Woow .. interesting topics ... I will try to speak about them in my coming videos maybe next week .. so stay arround ;) .. this week I am working on PCR and rt-PCR the video will be up tomorrow I think ...
There's quite a few things missing in this video. Especially, since we're talking about the end replication problem, there is a need to mention that the lagging strand and its template strand never really fully get replicated, there's always a part of the extended DNA that doesn't get replicated. The telomere essentially has both double stranded and single stranded regions, the single stranded region of the telomere loops around and forms a knot in the telomeric region which stabilizes the ends of DNA.
If replication of large eukaryotic chromosome is initiated at multiple origins of replication ( replication bubbles) the end replication problem should probably happen on each replication bubble. Why it only happens at telomere?
@@hyderali692 I think it's because each replication fork eventually runs into a replication fork running in the opposite direction (they meet). So all of the DNA is replicated there.
@@haykojan6590 if you don't care about learning material as close as accurate, as possible, I am sorry. If I had the academia and time to create a video, I would. However, I am no one to do so, just like you. Just stating an opinion based on what I have learned from professionals. If you don't like my comment and are offended, then maybe science is not for you. There is a lot of criticism and people, just like myself make and learn from mistakes! That is the beautiful thing about science. God bless you and best of luck in your path to success.
Like other students, I finally found it explained correctly and logically after a lot of unuseful videos. The most convincing explanation of telomeres. Thanks alot.
thank you for this explanation, I've been trying to get my head around this for hours but every other explanation on the internet is awful, so thank you for saving me!
Thank u so much. This is the best video on UA-cam explaining the end replication problem and its solution by telomerase enzyme. Really very helpful video for students. God bless u !!
This is the best explanation I have ever seen on this topic.Finally I have clear my doubts regarding this topic.Thank you so much for clearing my doubts . I wish you will keep it up always.
Thank you for the nice explanation. I am wondering why only lagging strands are facing telomere shortenings, why not the leading strands as they also had primer at their starting points and there is no way to replace it with DNA? Could you please explain?
Thanku so very much ma'am ...I have so much confusion regarding this topic...Bt by the help of your video my every confusion gets clear.again TSM...ma'am
Hi! Thank you so much for uploading this! I am just very confused about one thing - why would this not happened on BOTH the lagging AND leading strand? In both cases there is no OH for the new nucleotide to be added to when filling in primers at the end. Afterall wasnt the leading strand also started with a primer as well? Why can that one get filled in easily but the one at the end of the lagging strand cause such a problem? Thank you so much for you help in advance!
In the leading strand there is only one RNA primer at the beginning of the daughter strand. At the end of DNA replication this RNA primer is removed nucleotide by nucleotide and each removed nucleotide is replaced by a DNA nucleotide using an enzyme called DNA polymerase (I), this sequence of DNA which replaces the removed RNA primer is then linked with the rest of the daughter strand using the enzyme Ligase. Now you may ask why this does not happen in the lagging strand? the problem is that the mechanism of replication is totally different in the lagging strand, because there are many RNA primers, each one of them has a different sequence, these RNA primers are removed all at once, then the gaps are filled normally with DNA polymerase starting from each OKAZAKI fragment, but this enzyme usually forgets to replace the last RNA primer because of the missing of -OH, so this enzyme does not sense the absence of the last strand which is rather sensed by the enzyme telomerase which in turn fixes this issue. I hope I answered your question.
Jesus, finally someone explained this properly. this is the 10th clip I watched and now can understand this end replication problem. thank you for sharing.
Oh thank you for your comment, I will try to keep making such videos. And if you have suggestions for other topics, it would be nice to hear them :)
just reading about histone codes and the histone sequence in human. is very complex for me. that is about heterochromatin, euchromatin and histone tails, x chromosome deactivation, methylation and acetylation of histones affecting epigenetic and genetics. I wish you was here to read this with me.
Woow .. interesting topics ... I will try to speak about them in my coming videos maybe next week .. so stay arround ;) .. this week I am working on PCR and rt-PCR the video will be up tomorrow I think ...
Hey .. I thing that you might appreciate this video .. Check it out ;)
ua-cam.com/video/bNjjAoyWs6I/v-deo.html
I second this. This explanation really tied everything together nicely for me.
There's quite a few things missing in this video. Especially, since we're talking about the end replication problem, there is a need to mention that the lagging strand and its template strand never really fully get replicated, there's always a part of the extended DNA that doesn't get replicated. The telomere essentially has both double stranded and single stranded regions, the single stranded region of the telomere loops around and forms a knot in the telomeric region which stabilizes the ends of DNA.
inaccurate video. sorry
If replication of large eukaryotic chromosome is initiated at multiple origins of replication ( replication bubbles) the end replication problem should probably happen on each replication bubble. Why it only happens at telomere?
@@hyderali692 I think it's because each replication fork eventually runs into a replication fork running in the opposite direction (they meet). So all of the DNA is replicated there.
@@jorgeeduardocarrenozapata4243 if you can explain it better, then create a video that explains it buddy.... otherwise take your comments elsewhere
@@haykojan6590 if you don't care about learning material as close as accurate, as possible, I am sorry. If I had the academia and time to create a video, I would. However, I am no one to do so, just like you. Just stating an opinion based on what I have learned from professionals. If you don't like my comment and are offended, then maybe science is not for you. There is a lot of criticism and people, just like myself make and learn from mistakes! That is the beautiful thing about science. God bless you and best of luck in your path to success.
Like other students, I finally found it explained correctly and logically after a lot of unuseful videos. The most convincing explanation of telomeres. Thanks alot.
I must have watched and read dozens of videos and articles on this topic...I finally get it now! thank you for this video.
this has always been a problem and finally,
you've explained to the best of my understanding
thank you very much for the extremely good work.
Your way of explaining complicated topics in such an easy way is awesome.
Great video! I've been looking for someone to draw out how telomerase works and you did a great job with it! Thank you so much
Oh my god thank you so much, I watched literally every video about this topic and then finally found a good and detailed explanation!! Finally 🤯
you are a real master!! I could understand EVERYTHING at once!! I love it!!
It was a great video which gave me full comprehension of telomerase and DNA shortening. Thank You very much
This is such a perfect and straight-forward explanation - thank you
thank you for this explanation, I've been trying to get my head around this for hours but every other explanation on the internet is awful, so thank you for saving me!
This topic of genetics is so interesting. I hope I'll have the chance to study and research it once I've graduated. :D
Same!
Much appreciated!! I was puzzled with it when reviewing cell biology and now I get it!
Thank u so much. This is the best video on UA-cam explaining the end replication problem and its solution by telomerase enzyme. Really very helpful video for students. God bless u !!
Thank you! Very easy to understand, brief and to the point.
Clearly narrated a beautiful story. Well explained. A layman like me can understand well. Thank you.
This was the best explanation I ever heard 👌that was extremely awesome. Thank you
Best explaination of telomeres and telomerase
Thank you for your comment ... stay around many interesting videos are coming up :)
The best explanation so far... I would not have understood it without this video... God bless the teacher
The best explanation I have ever found related to this topic,, I mean she made it more interesting.
This is the best explanation I have ever seen on this topic.Finally I have clear my doubts regarding this topic.Thank you so much for clearing my doubts . I wish you will keep it up always.
i swear to God, am blown away... this is so amazing!!!
best video ive seen so far explaining this topic!!
Only video in the whole UA-cam to explain the concept properly
A very big thanks to u .....after half an hour waste....found u and now it's clear
This is the best explanation i found. Thank you very much.
One of the best video for Telomerase explaination
Thank you so much for clarifying the telomere issue.
My teacher uses imagens from your video to teach about telomers in molecular biology, great job.
Best video for the DNA replication! Thank you
Thank you for the nice explanation. I am wondering why only lagging strands are facing telomere shortenings, why not the leading strands as they also had primer at their starting points and there is no way to replace it with DNA? Could you please explain?
Thank you! Finally!! By far the best video I’ve seen.
Thanks for your intellects explanation about the Telomerase and the end replication problem.
this is the best explanation i have found. thank you!
Finally someone can explain it good job👏
Thank you for the comment ... stay tuned :)
VERY CLEVER; WELL DONE, THE PROBLEM IS WHEN THE PRIMERS ARE REMOVED THE END LAGGING STRAND IS NOT "COVERED DOWN"...now i got it; good job ma'am:)
Thanks god I patiently watch till the end and finally get sth from u
I really don't know how to thank you, you helped a lot.
Your videos are phenomenal! Thank you & keep it up!
WOW, thank you .. such a comment encourages me to keep up :)
wow...your explanation is great. Just what i needed. Thank you.
thank you so much...i struggled to understand this in class but now i totally get whats going on
Finally after looking for so many videos...understood well....thanks a lot👌👌👍👍👍
this really simplified it for me, thank u so much
Wow👏👏🙌🙌👏👏🙌🙌👏👏🙌🙌 Thank you Soooo sooo much, I didn't understand this the whole semester... But thanks to you I finally do 🙌❤️
thanks a lot for explaining complex idea in simple manner. your diagrams are easy to visualize. beautiful
Thank you :D
Great video, you explained it really well! I finally got it
Thank you ... stay tuned :)
Thank you so much for this video, seriously I was so lost but this saved me before my exam😭❤️
Finally someone explained it correctly, nice and easy
thank you so much for this amazing explanation! i finally understand it! more videos !!
Thank you for explaining why replication can go only one direction. :)
Thank you so much for keeping it simple 🙌
Yup it was interesting... Thank you for explaining it so well ❤️
Oh my god thank you!! I finally found a detailed explanation 🤯
Finally someone could help me understand this!!!
Great video, it's really helpful, thank you.
Very helpful .Thank YOU!
Amazing explanation ma'am ... Thank you so much .... Understood very clearly 😊😊
Also Thankyou so much, this is a great description!
What a clear and wonderful explanation...
Keep up the good work, this was really helpful
Many thanks! It is very helpful!!
great job / thank you for sharing this with us
Very helpful, thank you so much !!
Thank you, this video is amazing.
U deserve the world
this is very beautifully explained
Amazing explanation, thank you ... I subscribed to this channel hoping to encourage you do more amazing videos like this.
Very cool and simple explanation thank you!
Thank you 🙏. You are the best
Thanku so very much ma'am ...I have so much confusion regarding this topic...Bt by the help of your video my every confusion gets clear.again TSM...ma'am
Thank you very much for the great video. It was a huge pleasure to watch it and to take notes. Where are you from?
THANK YOU FOR THIS!
This video is awesome. finally finally finally!!!
Great! simple and to the point
Nice Explained. Respect from India🇮🇳🇮🇳🇮🇳
Hi! Thank you so much for uploading this! I am just very confused about one thing - why would this not happened on BOTH the lagging AND leading strand? In both cases there is no OH for the new nucleotide to be added to when filling in primers at the end. Afterall wasnt the leading strand also started with a primer as well? Why can that one get filled in easily but the one at the end of the lagging strand cause such a problem? Thank you so much for you help in advance!
In the leading strand there is only one RNA primer at the beginning of the daughter strand. At the end of DNA replication this RNA primer is removed nucleotide by nucleotide and each removed nucleotide is replaced by a DNA nucleotide using an enzyme called DNA polymerase (I), this sequence of DNA which replaces the removed RNA primer is then linked with the rest of the daughter strand using the enzyme Ligase. Now you may ask why this does not happen in the lagging strand? the problem is that the mechanism of replication is totally different in the lagging strand, because there are many RNA primers, each one of them has a different sequence, these RNA primers are removed all at once, then the gaps are filled normally with DNA polymerase starting from each OKAZAKI fragment, but this enzyme usually forgets to replace the last RNA primer because of the missing of -OH, so this enzyme does not sense the absence of the last strand which is rather sensed by the enzyme telomerase which in turn fixes this issue. I hope I answered your question.
Ok so good video. Now how do we extend them. How or what can be used to stop the shortening ?
Best explanation on YT
Looking forward to more videos on molecular genetic's topics i.e fundamental processes
Good explanation i have ever seen about telomarase
thank you... this is really good.
I would recommend this video. it makes bio 221 concepts easy
Thank you for your comment ..
Perfect explination 💙 thank you 💙
Great video. Thank you so much.
good job...you explain the actual reason behind this telomer problem
Wonderful explanation. Thank you
Thanks very much I hope you continue
thank u so much very well explained 👏 !
Thank u so much its really helpful
Thank you so much, the video was very helpful
Yeaaah finally got it, Thank u soo much !✌🏻✌🏻✌🏻
Tthank you so much you help me with my studies for the exams
Thanks very much
That was really good
Thank you so much, so intelligible
thank you so much , it is well explained !!
Beautifully done ♥️♥️♥️
Your the best you saved me thnx so much
I Love you 😍😍
Best teacher ever
Wow it was great..... Thank you..