The clock in our genes and in every cell of your body | Joseph Takahashi | TEDxSMU 2013

Joseph S. Takahashi, Ph.D. is the Loyd B. Sands Distinguished Chair in Neuroscience, an Investigator of the Howard Hughes Medical Institute, and Chair of the Department of Neuroscience at the University of Texas Southwestern Medical Center in Dallas. His research interests are the molecular mechanism of circadian clocks, neuroscience, and the genetic basis of behavior. Dr. Takahashi pioneered the use of genetics in the mouse as a tool for discovery of genes underlying neurobiology and behavior. His awards include the Honma International Prize in Biological Rhythms Research in 1986, W. Alden Spencer Award in Neuroscience from Columbia University in 2001, Eduard Buchner Prize from German Society for Biochemistry and Molecular Biology in 2003 and Outstanding Scientific Achievement Award from the Sleep Research Society in 2012. He was elected a Fellow of the American Academy of Arts and Sciences in 2000, and a Member of the National Academy of Sciences in 2003. He was a co-founder of Hypnion, Inc., a biotech discovery company in Worcester, Mass., that investigated sleep/wake neurobiology and pharmaceuticals (now owned by Eli Lilly and Co.), and is a co-founder of ReSet Therapeutics, Inc., a biotech company that works on the role of clocks in metabolism.
About TEDx:
In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)

[@marckdan2508]

It's interesting how our biology is so closely tied to the natural rhythm of the earth; how all life is orchestrated by the 24hr period that makes up the full rotation of the earth around its own axis. We were, indeed, made FOR this planet, BY this planet, and made OF this planet. I have confidence alien life will not survive here. We've earned our right to exist on this rock. We've learnt to cope with the many microbial life forms that could otherwise threaten our existence. We've evolved (in symbiosis) WITH this rock, to survive & thrive here........Does it then not make all it all the more illogical that we continue to threaten, maim, and destroy this rock -- not for survival, but for greed that does nothing to prolong our transcient individual existences?

[@aaronlaitner4343]

"We become what we behold. We shape our tools and then our tools shape us." - Marshall McLuhan

[@albussd]

All of that is fine but I certainly would not say that we earned our right to exist on this rock. Too much entitlement is assumed with that statement.

[@hosoiarchives4858]

4:05 internal biological clock
8:49 gene animation, “cell clock”
11:53 SCN
14:40 chimera

[@Johanna-qf1yx]

Very well done

[@vasantipunchoo3699]

Volume low. Wish cd have the text to read

[@sourbhrankawat8454]

I'm working in circadian biology field and I feel sad about Sir Takahashi he was close to getting the Nobel prize for his discoveries of clock mechanism in mice eventually the Nobel award was given to a fly chronobiologist.

[@gregorymullins8873]

where circadian biology intersects with tcm body clock theory is really really interesting

[@shiks800]

He should have been the winner. His work opened a lot doors in determining when we even dose drugs!

[@RoyalW1979]

Profound!

[@walterscott2286]

Can't hear. Volume is too low to be able to follow comfortably.

[@youkyung-yi9857]

thank you. awesome work !

[@dcscccc]

hi. an interesting question: according to evolution fly and mosquito split off about 250 my ago. fly
generation is about less than one month. so even if one generation mean
only 1 new mutation we will need only 10^8 month to change his entire
genome. or about less than 10^7 years. so fly and mosquito are suppose
to be different in about their entire genomes from each other. far from
reality.

[@AlexWatts1992]

You are forgetting that any mutation may be covered by mating with a genetically dissimilar mate - an event that is MUCH more likely to occur than mating with a genetically similar individual

[@forwardfamilyfarmer]

My dear, most of the mutation is harmful. hence during natural selection, most of the mutation is discarded.
and repair system is also repaired mutation.

[@geofffeltham6363]

Sell Human Centric and this was a fantastic presentation. I thought I knew a lot before but this elevated my knowledge to a new level.

[@Acidoverwrite]

What type of Lights energy do we use to regenerate?

[@Atravick]

So how do the master clock cells in the brain interact with all the other cells in our body?

[@liutasx]

Through hormones released by brain parts connected to masterclock. Also organs have their own clock.

[@XKong-wf5yt]

By Hormones, feeding behaviors, temperature fluctuations . But this question still has no confirmed answer

[@saxenaryan]

You can listen to Andrew huberman podcast he explores actionable protocols for these concepts

[@riteshmahajan5209]

just to hear the last four words, I watched this whole talk

[@jmahtab]

And then there was shift work.

[@BijouBhaskarPadinjaraChira]

🌸🌸🌸

[@willycat7445]

Volume so low

[@susydyson1750]

try putting the volume yr phone up

[@juanconeo]

I'm the second mouse... Fml

[@Medinalegend]

Arabic translate ?