COSMOS DB: A New Database of Toxicological Information to Support Knowledge Discovery (Feb 2014)

COSMOS DB is a new database bringing together access to chemical structures, an inventory of cosmetic materials, and toxicological information. The first public release of COSMOS DB (December 2013) contained 12,538 toxicological studies for 1,660 compounds. In addition, it provided access to 44,773 unique chemical structures including the European Union Inventory of Cosmetic Ingredients (CosIng) and the USA Personal Care Products Council (PCPC) inventories. Two separate datasets within COSMOS are available: US FDA PAFA and oRepeatToxDB. More data(sets) will be added in future updates. The PAFA dataset contains 12,198 studies across 27 endpoints including both repeat dose and genetic toxicity data. Data harvesting efforts within the COSMOS Project have resulted in the assembly of the oRepeatToxDB dataset. This has resulted in the collection of 340 in vivo repeat dose toxicity studies for 228 chemicals. The oRepeatToxDB study records contain the full plethora of observed toxicological effects together with the corresponding sites at which the effect occurred. Free access to COSMOS DB is available from cosmosdb.cosmos.... The capabilities of the database will be demonstrated in the webinar, including how to search COSMOS DB for information on a specific chemical structure, extract knowledge, how the information is being used to support the development of thresholds of toxicological concern, in silico models, and grouping approaches for read-across.
Acknowledgements: The COSMOS Project is funded by the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement number 266835 and the European Cosmetics Association Cosmetics Europe. The US FDA PAFA dataset has been generously donated by the Office for Food Additives Safety (OFAS) at the US FDA Center for Food Safety and Applied Nutrition. More information on the COSMOS Project is available from www.cosmostox.eu.