Pharmacology - ANTIBIOTICS - CELL WALL & MEMBRANE INHIBITORS (MADE EASY)
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- Опубліковано 25 чер 2024
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Antibiotics, also known as antibacterials, are a group of drugs used to treat various infections caused by bacteria. Antibiotics work by either selectively killing (bactericidal) or inhibiting the growth (bacteriostatic) of bacteria. This pharmacology lecture covers topics such as classification of antibiotics; cell wall structure of Gram-negative bacteria, Gram-positive bacteria, Mycobacteria; mechanism of action and side effects of Cell Wall Synthesis Inhibitors: Beta-lactams (Penicillins, Cephalosporins, Carbapenems, Monobactams), Beta-lactamases (Avibactam, Clavulanic acid, Sulbactam, Tazobactam), Fosfomycin, Cycloserine, Vancomycin, Bacitracin, Antimycobacterial drugs (Isoniazid, Ethambutol), mechanism of action and side effects of Cell Membrane Integrity Disruptors: Daptomycin, Polymyxins.
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Source of diagram depicting the enzymatic steps involved in S. aureus cell wall synthesis: www.biomedcentral.com/1471-218...
0:00 Intro
2:02 Bacterial cell wall structure
3:02 Beta-lactams & Beta-lactamases
6:18 Enzymatic steps of cell wall synthesis
8:24 Fosfomycin, Cycloserine, Vancomycin, Bacitracin
11:38 Mycobacterial cell wall inhibitors
14:24 Cell membrane integrity disruptors
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Know more about antibiotics in easy way, visit -medicosearch1.blogspot.com/2023/09/Amoxicillin%20and%20clavulanic%20acid%20-%20amoxyclav%20625%20-%20Class-%20Uses-%20side%20effect%20-%20amoxyclav%20in%20pregnancy%20-%20Antibiotic%20-%20%20Beta%20lactamase%20inhibitors%20.html
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Don't forget to watch Antibiotics part 2 -------> ua-cam.com/video/5HQmvQJWzNY/v-deo.html
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great video! the explanations are very clear for why the abx target the enzymes/structures
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Know more about antibiotics in easy way, visit -medicosearch1.blogspot.com/2023/09/Amoxicillin%20and%20clavulanic%20acid%20-%20amoxyclav%20625%20-%20Class-%20Uses-%20side%20effect%20-%20amoxyclav%20in%20pregnancy%20-%20Antibiotic%20-%20%20Beta%20lactamase%20inhibitors%20.html
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Know more about antibiotics in easy way, visit -medicosearch1.blogspot.com/2023/09/Amoxicillin%20and%20clavulanic%20acid%20-%20amoxyclav%20625%20-%20Class-%20Uses-%20side%20effect%20-%20amoxyclav%20in%20pregnancy%20-%20Antibiotic%20-%20%20Beta%20lactamase%20inhibitors%20.html
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Know more about antibiotics in easy way, visit -medicosearch1.blogspot.com/2023/09/Amoxicillin%20and%20clavulanic%20acid%20-%20amoxyclav%20625%20-%20Class-%20Uses-%20side%20effect%20-%20amoxyclav%20in%20pregnancy%20-%20Antibiotic%20-%20%20Beta%20lactamase%20inhibitors%20.html
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Thank you very much Sir. Regarding daptomycin, may I ask why the leakage of potassium causes depolarization rather than hyperpolarization?
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But i have a qusetion about the Daptomycin mechanism. "such as potassium to leak through causing depolarization of membrane" why is depolarzation? positive ion out--> inside more negative than outside --> it should mean repolarization or hyperpolarization. Am i correct or not? Thank you.
Which textbook do you use sir
15:09 how can potassium passage cause depolarization?
5:38 What about Carbapenemases ??
carbapenem antibiotics may dont using with beta lactamases but there is carbapenem resistant bacterias.
1. Are the antibiotic producing isolates sensitive to known antibiotics? 2. If so, what does this tell us about the isolates? How might this relate to the antibiotics they produce?
Is there a part 2?
Yes. I'm currently working on it. Make sure you subscribe and enable notifications if you want to be notified as soon as it's uploaded. Thanks for watching!
Tq man
Thank you in 2024 ❤❤❤🙏🙏🙏
Tq