Real-time IntraVital Microscopy: In Vivo Cellular-level Imaging of Internal Organs in a Live Animal

Originally broadcast on 08-Jun-23.
Intravital imaging of cellular dynamics in a natural physiological microenvironment can provide unprecedented insights into the dynamic pathophysiology of human diseases. Explore a powerful yet gentle method to image the internal organs of live animals at the sub-micron level.
In this webinar, you will learn:
How intravital microscopy can enable imaging of cellular-level dynamics such as gene expression, cell trafficking, and cell-cell and cell-microenvironment interactions in vivo;
Techniques for cellular-level in vivo imaging of internal organs in live animals to study disease;
The possible applications of IVIM Technology’s All-in-One real-time intravital two-photon and confocal microscopy system.
Intravital microscopy is a unique imaging technique to visualize various in vivo cellular-level dynamics, such as cell trafficking, cell-cell, or cell-microenvironment interactions in a live animal.
Intravital imaging of cellular dynamics in a natural physiological microenvironment can provide unprecedented insights into the dynamic pathophysiology of human diseases that are impossible to obtain through conventional histological observation of ex vivo samples or in vitro culture systems.
During the last decade, intravital microscopy has become an indispensable technique across the biomedical sciences, including immunology, neuroscience, developmental and tumor biology. Notably, in vivo visualizations of gene expression, protein activity, cell trafficking, cell-cell and cell-microenvironment interactions, and various physiological responses to external stimuli have become possible.
It is also a unique tool for developing new therapeutics and diagnostics by providing improved accuracy and reliability for in vivo target validation with delivery monitoring and efficacy assessment. It has been used to directly analyze the delivery and efficacy of new biopharmaceuticals such as antibodies, cell therapy, gene therapy, nucleic acids, and exosome in an in vivo microenvironment.
In this talk, IVIM Technology’s All-in-One real-time intravital two-photon and confocal microscopy system will be introduced. The imaging system has been extensively optimized for in vivo cellular-level imaging of internal organs in live animal models for various human diseases. It can acquire real-time multicolor sub-micron resolution microscopic images in a live animal model with automatic motion compensation, enabling direct imaging analysis of complex cancer immune-microenvironment consisting of various immune cells, stromal cells, vascular cells, and extracellular matrix. Intravital imaging of organs will be briefly introduced.
We will also introduce recent studies that use the real-time intravital imaging technique to investigate dynamic cellular-level pathophysiology of various human diseases and develop novel therapeutics.
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