Single-cell sequencing of circulating tumor cells to predict progression from MGUS/SMM

Irene Ghobrial, MD, Dana-Farber Cancer Institute, Boston, MA, discusses the application of single-cell sequencing of peripheral blood (PB) tumor cells to predict progression from monoclonal gammopathy of unknown significance (MGUS) or smoldering multiple myeloma (SMM) to multiple myeloma (MM). This technique identifies cytogenetic abnormalities and offers a comprehensive assessment of circulating tumor cells that surpasses the limitations of a bone marrow biopsy. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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