One can only hope your calm, rigor, candor, nuance, and open-mindedness sends a wave of inspiration to the rest of the YT community through your success. Thanks for doing what you do.
Thank you for translating him, it really brings the epidemiology down to the body physiology brilliantly, to explain why TMAO may not be the causal factor we think it is.
I remember Dr. Greger did a video on TMAO, where in the study he presented, plant-based individuals who were eating choline through cruciferous vegs or legumes were not producing TMA because they hadn't fostered a gut microbiome to make that conversion, where people with more meat in their diet did and were producing TMA.
I'm not even sure this completely matters though because it's such a paradox about what choline does for us. Choline can act as a carbon doner via Betaine to convert Homocysteine back to methionine. Elevated homocysteine levels are associated with cardiovascular risk so choline mechanistically could improve that. But as we just saw, choline can also be converted to TMA via a gut microbiome. The problem with this though is again mentioned in the video that Fish contain a lot of TMA and TMAO which we do absorb and eliminate. We skipped the entire conversion of choline to these compounds and ate it directly yet still find cardiovascular benefit of eating fatty fish. It is a pretty confusing marker. It's worth mentioning though, most choline is not converted to TMAO since it's so crucial to cell membrane integrity, methionine recycling and also as a precursor to the neurotransmitter acetylcholine. So again, it is a wonder why two diets can both be rich in choline yet that choline follows (or seems to follow) different fates.
I WOULD LOVE an interview with someone about choline, specifically addressing 1. if it's really that essential and 2. if vegans or others with plant-based diets should worry about it. PLEASE.
18:20 good point: any food can be claimed to be bad based on some isolated components. 19:20 the effect of sodium on blood pressure is relatively small, but the dash diet is overall good to reduce blood pressure.
Thank you for your videos, I have recently found the channel and learned a lot by looking through your videos. I feel much more informed in making decisions about my health. I'm glad that I know where the information comes from in the linked studies, and the videos present the information in a more understandable and accessible way.
I would argue, let me know if you agree, that although we can be more pragmatic and stick to health outcomes associated to foods/food patterns, we still are interested in knowing if it is a particular element of the food that is more interesting, so maybe we can enhance it through technology or whatever technique that proves to be effective for modifying the composition of some foods. For example, if it is proven that it's just the amount of EPA DHA in fish that results in protective effects, then maybe we should consider supplementing EPA DHA (from algae for example), instead of eating the fish that might also be a source of bad outcomes (because of microplastics, heavy metals, or TMAO in this case). What do you think?
Thanks for another informative video ! I eat a lot of eggs and fish, so I get a good amount of choline. I've lost over 110 lbs at a safe rate if around 1.75 lbs a week. Before I started my "health kick" I was miserable. Hypertension barely under control with three meds, borderline type II diabetes, obese, and copd requiring use of a rescue inhaler. Today I'm down to 2 meds from 9, my a1c is 5.3, blood pressure averages around 128/78, bmi is in the normal range, and I haven't had to reach for my inhaler for over two years. My blood work is near optimal across the board. One other positive. After my most recent colonoscopy, the doctor recommended I make an appointment to deal with my hemorrhoids which had bothered me for years. Switching to a whole foods diet with plenty of fiber took care of them, thus sparing me of the need for surgery. I feel really good, so as far as TMAO, I'll just mention it to my doctor next visit. In the meantime I will carry on with my current diet.
TMAO precursors are everywhere and health promoting as well. One key may be preventing the oxidation of TMA. Please keep on top of peer reviewed publications on this. Thanks for all your efforts to improve everyone's health.
"TMAO is a nerd's wet dream!" 🤣 Good reminder to not get too hyper-focused on isolated nutrients. (except for vitamin B12 and a few others...) Stay tuned for further research on TMAO, and follow a health dietary pattern. Thank you so much for these succinct, illuminating videos! ~ Marian
There is no evidence suggesting that eating local and seasonal fruits is more health promoting, than eating various fruits, all year long. I would say, it's the opposite.
That it may be wise to be careful about those foods (all animal-based, including "real" ones) which increase TMAO, particularly those who don't have good proven pros on their side - till research knows more.
@@jannier9766 OK? What would some 1-2-300 years ago living in your region be eating? I’m just saying that we should be better connected with our natural environment. Does your local wildlife eat imported food? And I bet they’re overall a heck of a lot healthier than the local humans.
Are wholegrains really associated with better health? Isn't that just when compared to refined grains? But not when compared to whole intact foods, legumes, colourful vegetables and fermented plants.
LOVE your work!! Could you please make a video about KOMBUCHA? I know it's a probiotic, but since it can contain a little percentage of alcohol I would like to know what the effect is on our health. Thank you!!
Took a little while to dial in to the parlance and pace of your guest's presentational style if im honest. Took two watches to grasp. And your interjection(s) were helpful. As with most things nutritional science, a complex topic with many confounders making defining whether TMA(O) is a problem or not.....somewhat problematic.
I don’t pay attention to the carnivore reductionists’ claims that lectin is bad so don’t eat beans. By the same principle, I also don’t pay attention to vegan reductionists’ claims that TMAO is bad so don’t eat fish (or, whole grains).
Esselstyn made a big deal about TMAO in fish and behaved as if it was the _coup de grace_ counterargument to those who advocating eating it. I'll continue with my wild caught Salmon. But is there a way to know if you are a TMAO outlier and have high levels in your blood? Is there a reasonable cost, patient ordered lab test available to check?
Excellent discussion and explanations of the unresolved subject of TMAO. IMO, TMAO is likely a surrogate at all normal physiologic levels. However, at some to be determined supraphysiologic level it can become causative of CVD. Like everything the dose makes the poison.
Question : Is choline an important, necessary B Vitamin ?? Furthermore, Choline is an important part of phosphotytlecholine which is an important precursor to acetylcholine, a very important neutrotransmitter that can prevent and or delay Elderly Dementia (maybe Alzheimer's ?? ). Phosphotytlecholine a good ingredient in Lecithin. Anyone confused ??
I was on a 100% whole food plant based diet and my TMAO was STILL HIGH. I chatted to Joel Kahn and he's seen the same thing in other #WFPB. I keep my ldlc < 35 and apoB
Nutrition Made Simple! was closer to Nutrition Made Difficult! with this topic. It's nobody's fault since there is no clear evidence for this. I appreciate the honesty and not pushing for one way or the other as a majority of nutrition channels are heavily biased and cherry pick data to support their biases.
Now that genetic information is readily available, I am very excited about future generations being able to isolate individual genetic abnormalities in order to tailor diets for better health. I never believed calorie restriction made total sense as a catch-all answer. Now we are learning individual genetic variables heavily influence individual dietary needs for optimal health. Personally, 23andMe says I have an rs5082 CC/GG abnormality, which appears to increase obesity with saturated fats, which may increase likelihood of atherosclerosis and type 2 diabetes. A carnivore diet with high saturated fat intake may be highly detrimental to these people. Apparently close to 50% of people have this abnormality with the exception of East Asian (only around 16%). I believe these genetic variables likely need to be factored into dietary choices.
Interesting would be a video about animal-based, potentially semi-essential nutrient supplements like taurine, carnitin, carnosin, DHA, ... - particularly for plant-based diets.
Do we know how much does whole grains raise TMAO levels vs meat/dairy/fish? I got from this video that if TMAO levels should be regulated (i.e., they are a causal factor) and if they should be regulated by diet then knowing how much each type of food raises it might indicate if the dose determines the poison. I’d love some clarification on this. Excellent comment on TMAO and excretion levels could be an issue and not diet. Thank you for pointing that out. I’d love to see another video on this subject as studies continue to be done on TMAO.
I'm considering taking l-carnitine as a supplement but I'm still on the fence. The absorption rate is really low, you have to take 3-5 grams of L-carnitine so the body can absorb 0.5 grams. I wonder what happen to the stuff that doesn't get absorbed. I also read that you can eat garlic to prevent the negative effects of TMAO.
The question is even though I primarily eat vegetarian with occasional fish, chicken yet I do take few supplements with choline like CDP choline and Alpha GPC to improve my cognition. And these sources can also make TMAO so also L-Carnitin supplements
Any multifactor component like fish have can have X number of factor that are bad for Heart health and Y number of factors that are good for Heart health. It is the net effect that is important. For example, lets say increased intake of Omega-3 could be a +80 on a scale of -100 to +100, and TMAO could be -10. Just looking at these two factors in isolation means a +70 net effect. Multifactor components are complex in their effects on the bodies health, so recommendation for the general population should be based on the net effect, while at the same time specific circumstance may change the recommendation such as perhaps a person with severe Kidney disease may have to be more cautious about TMAO intake, as the normal negative effect of -10 could rise to -80 or higher negating the positive effects of Omega-3.
Hmm, so conclusion is = TMAO may be indicative of a negative effect in the body, if it gets above a certain thresshold, which unfortunately currently is unknown....and likely also individual. Dr. Gil> Is TMAO a blood marker, that is easily ordered through ones local MD? Have you personally an opinion on a general "theoretic max threshold " of TMAO, people should probably try to stay under? 🙂
This is exactly the same example that can be used to explain the new EU research showing blood tests with high Xylitol is associated with higher cardiovascular events.
TMAO helps the body deal with high osmotic pressures. Same as fish. If you have circulation issues, arterial issues, or kidney filtration issues, the body will create TMAO to aid in circulaton. Studies show us that people who have the highest level of TMAO tend to have better survival from heart attacks.
I lean more toward it's just or mostly a marker of what you eat. In the general population higher TMAO, likely comes from eating lots of red meat and eggs which come with higher doses of saturated fat and/or cholesterol. Either way, given all the confounding factor, it seems extremely unlikely it will ever be a maker your GP checks and says you need to change your diet to lower it.
Who wants to smell fishy too? It would be interesting to figure out what bacteria would hopefully help to repopulate and remove bacteria that create TMAO. Probably bacteria that doesnt prefer meat/sulphur. Although there are brussel sprouts and such. Everyone eating tins and tins of sardines should be aware.
Once again, eating predominantly vegetables, fruits, lean meats, nuts, seeds, and legumes, is associated with the best health outcomes. Fixating on one food item or component is typically a waste of time. We know limiting saturated fat keeps cholesterol low and limiting refined carbohydrates improves health and longevity.
@@paulabranson6530 Black beans are a legume, not a refined carbohydrate. They would be the least of my worries. People trying to sell you something will say anything to get clicks or buys.
Saturated fat (and probably a lot of other things) will always be controversial and heterogeneous until researchers are able to separate people by genetic variants. Some people are simply more genetically tolerant and less harmed by saturated fat than others. For all the years I was doing French cooking and eating large amounts of butter, cream and duck fat, I had low cholesterol (except high HDL). Years later I had my genome done; lo and behold I tolerate higher amounts of saturated fat. My family jokes I got the French genes!
@@paulabranson6530If you eat legumes, nuts, seeds, vegetables, fruits, whole starchy carbs, like yams, potatoes, grains, etc, you will get all the fiber that you need.
It's not a difficult argument to make... processed red meats < red meats < fish < plant based. Fish was just better than those, doesn't mean it was healthy. Standard understanding of health has evolved over the years, and now the health community just needs to say the same. Fish is better than meat, but if yoy want to do even better than that. Avoid fish and go more plant based.
Perhaps a bold statement, but since choline is everywhere in many foods, if TMAO would be a really important issue, evolution would have taken care of it, or ... of us, besides of other aninals. We are still here, so it's effect can only be on longevity.
There are a couple issues with this view even though it sounds compelling at first. the first is that, thought of as an optimizing function, it’s “goal” is reproduction. Selective pressure operates on a timescale for producing and raising offspring that survive. So if TMAO had negative effects at age 50 on, that wouldn’t matter much from a natural selection standpoint. You can see the same thing with saturated fats. We can survive eating large amounts of them well into middle age, past reproductive “success” before cardio risk starts to turn into cardio events. The second issue is that evolution isn’t directed, so just because something would make sense, it doesn’t mean evolution will have had the opportunity to select for that path (say for example a beneficial mutation never even arises).
Remember though, evolution is about being around long enough to reproduce, not longevity. So higher TMAO levels might only matter in an evolutionary sense if it negatively impacted to an extent where it kept enough humans from reaching their sexual procreative maturity.
@@HidingFromFate And therefore researchers should best focus attention to effects, if any, that become predominant in middle-aged and somewhat elderly age groups.
Whether or not TMAO is causal of heart disease, I say, "Neener, neener, neener!" because I eat whole food vegan. You guys worry about it or make excuses for eating unhealthy foods. LOL
Grammar police here. Why do all you BRILLIANT health advocates say "less" instead of "fewer?" It's so easy to correct. I'm no brainiac and I did it. Once you get it you'll never go back.
I get your point, however, most Americans can't get it right, and you do expect non-native English speakers to always use all aspects and nuances of their 2nd or 3rd or 4th language? I mean, most Americans speak one language, American English, and a good percentage of them are not really eloquent or grammatically correct in their speech and writing.
It doesn't matter. Language is a living thing and if most people understand something as correct, then it is highly likely to become the standard over time. Grammar is important up to a point.
Heres something to ponder: What is the purpose of distinguishing between continuous and quantized comparison? Why can we say more when a comparison is greater, but need to use less or fewer when a comparison is, well, lesser?
Linguists make a distinction between prescriptive or “standard” grammar and descriptive grammar, which describes the current actual language. Standard grammar is constructed after the fact and often doesn’t represent the living language. Most native speakers no longer make this distinction so the grammar will be changed in the future to reflect the change in usage. In other words, you’re fighting against the tide.
Good Luck with that . If your 30 and want to look and feel like your 80 and toothless Eat fruit and nothing else and you'll be on the fast-track to ill health.
Fruitarians are the group that keep making vegans look bad. There are fruitarians that seem to manage for decades, but you're just complicating your life and limiting yourself.
One can only hope your calm, rigor, candor, nuance, and open-mindedness sends a wave of inspiration to the rest of the YT community through your success. Thanks for doing what you do.
Unfortunately, the algorithm rewards outrage and sensationalism. This is literally a case of the 'system' being rigged against people.
Thank you for always searching for the truth of the topic.
I really like this kind of nuanced discussion. Science in action!
Thank you for translating him, it really brings the epidemiology down to the body physiology brilliantly, to explain why TMAO may not be the causal factor we think it is.
Please cover EPA/DHA - more news saying it increases risk of heart issues
But Rhonda Patrick and many other talk about the benefits
I remember Dr. Greger did a video on TMAO, where in the study he presented, plant-based individuals who were eating choline through cruciferous vegs or legumes were not producing TMA because they hadn't fostered a gut microbiome to make that conversion, where people with more meat in their diet did and were producing TMA.
I'm not even sure this completely matters though because it's such a paradox about what choline does for us. Choline can act as a carbon doner via Betaine to convert Homocysteine back to methionine. Elevated homocysteine levels are associated with cardiovascular risk so choline mechanistically could improve that. But as we just saw, choline can also be converted to TMA via a gut microbiome. The problem with this though is again mentioned in the video that Fish contain a lot of TMA and TMAO which we do absorb and eliminate. We skipped the entire conversion of choline to these compounds and ate it directly yet still find cardiovascular benefit of eating fatty fish. It is a pretty confusing marker. It's worth mentioning though, most choline is not converted to TMAO since it's so crucial to cell membrane integrity, methionine recycling and also as a precursor to the neurotransmitter acetylcholine. So again, it is a wonder why two diets can both be rich in choline yet that choline follows (or seems to follow) different fates.
Dr. Gil is a gift, make us think critically 🙏
I WOULD LOVE an interview with someone about choline, specifically addressing 1. if it's really that essential and 2. if vegans or others with plant-based diets should worry about it. PLEASE.
NutritionFactsOrg has got a few episodes on it
@@ChickenDelight-m3p Buddy, if NutritionFacts is your source of scientific health information you gotta rethink everything you know.
@@Teneablmao
This is a perfect illustration of "it's complicated"
Indeed!
The captions here are accurate and exceptional for that.
I'm a fan of captions, so I see a LOT of bad ones. I agree that these were good. I can only assume that many YTers don't check the captions.
It's mostly the YT autogenerated captions that often do a hilariously bad job😧
18:20 good point: any food can be claimed to be bad based on some isolated components.
19:20 the effect of sodium on blood pressure is relatively small, but the dash diet is overall good to reduce blood pressure.
Thank you for your videos, I have recently found the channel and learned a lot by looking through your videos. I feel much more informed in making decisions about my health. I'm glad that I know where the information comes from in the linked studies, and the videos present the information in a more understandable and accessible way.
Thanks for jumping in to explain in real time.
Brilliantly presented Gil
I would argue, let me know if you agree, that although we can be more pragmatic and stick to health outcomes associated to foods/food patterns, we still are interested in knowing if it is a particular element of the food that is more interesting, so maybe we can enhance it through technology or whatever technique that proves to be effective for modifying the composition of some foods.
For example, if it is proven that it's just the amount of EPA DHA in fish that results in protective effects, then maybe we should consider supplementing EPA DHA (from algae for example), instead of eating the fish that might also be a source of bad outcomes (because of microplastics, heavy metals, or TMAO in this case).
What do you think?
Thanks for another informative video !
I eat a lot of eggs and fish, so I get a good amount of choline.
I've lost over 110 lbs at a safe rate if around 1.75 lbs a week. Before I started my "health kick" I was miserable. Hypertension barely under control with three meds, borderline type II diabetes, obese, and copd requiring use of a rescue inhaler.
Today I'm down to 2 meds from 9, my a1c is 5.3, blood pressure averages around 128/78, bmi is in the normal range, and I haven't had to reach for my inhaler for over two years.
My blood work is near optimal across the board.
One other positive. After my most recent colonoscopy, the doctor recommended I make an appointment to deal with my hemorrhoids which had bothered me for years. Switching to a whole foods diet with plenty of fiber took care of them, thus sparing me of the need for surgery.
I feel really good, so as far as TMAO, I'll just mention it to my doctor next visit. In the meantime I will carry on with my current diet.
TMAO precursors are everywhere and health promoting as well. One key may be preventing the oxidation of TMA. Please keep on top of peer reviewed publications on this. Thanks for all your efforts to improve everyone's health.
Great video! Thanks for sharing What a nuanced conversation looks like.
Choline is essential for brain functions and cell membranes. This is far more important than dubious speculation about TMAO. In my opinion.
"TMAO is a nerd's wet dream!" 🤣 Good reminder to not get too hyper-focused on isolated nutrients. (except for vitamin B12 and a few others...) Stay tuned for further research on TMAO, and follow a health dietary pattern. Thank you so much for these succinct, illuminating videos! ~ Marian
what's wrong with b12?
Fantastic video.
Take home message? Who the hell knows anymore. That said, eat real food, in small amounts and infrequently. Fruit local and seasonal.
Yeah, and mix it up at much as you can. Variety is important.
There is no evidence suggesting that eating local and seasonal fruits is more health promoting, than eating various fruits, all year long. I would say, it's the opposite.
That it may be wise to be careful about those foods (all animal-based, including "real" ones) which increase TMAO, particularly those who don't have good proven pros on their side - till research knows more.
I live in the Midwest. If I only ate local fruit, I would never eat oranges, pineapple, lemons, mangoes. . .
@@jannier9766 OK? What would some 1-2-300 years ago living in your region be eating? I’m just saying that we should be better connected with our natural environment. Does your local wildlife eat imported food? And I bet they’re overall a heck of a lot healthier than the local humans.
Are wholegrains really associated with better health? Isn't that just when compared to refined grains? But not when compared to whole intact foods, legumes, colourful vegetables and fermented plants.
In general, the quality of the comments reflect the quality of this channel's content. ❤
LOVE your work!! Could you please make a video about KOMBUCHA? I know it's a probiotic, but since it can contain a little percentage of alcohol I would like to know what the effect is on our health. Thank you!!
Just something else to worry about. Something we can do little to change.
Took a little while to dial in to the parlance and pace of your guest's presentational style if im honest. Took two watches to grasp. And your interjection(s) were helpful. As with most things nutritional science, a complex topic with many confounders making defining whether TMA(O) is a problem or not.....somewhat problematic.
I don’t pay attention to the carnivore reductionists’ claims that lectin is bad so don’t eat beans. By the same principle, I also don’t pay attention to vegan reductionists’ claims that TMAO is bad so don’t eat fish (or, whole grains).
Esselstyn made a big deal about TMAO in fish and behaved as if it was the _coup de grace_ counterargument to those who advocating eating it. I'll continue with my wild caught Salmon. But is there a way to know if you are a TMAO outlier and have high levels in your blood? Is there a reasonable cost, patient ordered lab test available to check?
All the plant based influencers do that. It's a religion; facts don't matter. They're as bad as the carnivore crowd.
I wonder if seasonal eating helps reduce the production of TMA, as the bacteria would die back after periods of choline/carnitine absence.
Next video by another equally qualified doctor a month from this video: TMAO CURES heart disease!!
I've never really worried about it, because I only heard about it 5 minutes ago! I do eat eggs and liver, so I will pay attention thanks👍
Excellent discussion and explanations of the unresolved subject of TMAO.
IMO, TMAO is likely a surrogate at all normal physiologic levels. However, at some to be determined supraphysiologic level it can become causative of CVD. Like everything the dose makes the poison.
Thank you Gil! Will you be doing a review of the new Ornish study for Alzheimer's??
Question : Is choline an important, necessary B Vitamin ?? Furthermore, Choline is an important part of phosphotytlecholine which is an important precursor to acetylcholine, a very important neutrotransmitter that can prevent and or delay Elderly Dementia (maybe Alzheimer's ?? ). Phosphotytlecholine a good ingredient in Lecithin.
Anyone confused ??
I was on a 100% whole food plant based diet and my TMAO was STILL HIGH. I chatted to Joel Kahn and he's seen the same thing in other #WFPB. I keep my ldlc < 35 and apoB
How high was your TMAO if I might ask? Mine is 900umol/g and I don't know if I should be worried
@@nikolausbarnas wow ... mine was flagged at 10uM.
Choline, Choline, Choline, CHOLINE...
Please don't give me cancer
Just because you can....
Please explain, does it really give one cancer
@@davidford8539 That's what Dr. Parton seems to be saying.
@@davidford8539 Parton me?
@davidford8539 everything gives cancer in excessive amounts
omg hahahahahaha
Nutrition Made Simple! was closer to Nutrition Made Difficult! with this topic. It's nobody's fault since there is no clear evidence for this. I appreciate the honesty and not pushing for one way or the other as a majority of nutrition channels are heavily biased and cherry pick data to support their biases.
Now that genetic information is readily available, I am very excited about future generations being able to isolate individual genetic abnormalities in order to tailor diets for better health. I never believed calorie restriction made total sense as a catch-all answer. Now we are learning individual genetic variables heavily influence individual dietary needs for optimal health. Personally, 23andMe says I have an rs5082 CC/GG abnormality, which appears to increase obesity with saturated fats, which may increase likelihood of atherosclerosis and type 2 diabetes. A carnivore diet with high saturated fat intake may be highly detrimental to these people. Apparently close to 50% of people have this abnormality with the exception of East Asian (only around 16%). I believe these genetic variables likely need to be factored into dietary choices.
Interesting would be a video about animal-based, potentially semi-essential nutrient supplements like taurine, carnitin, carnosin, DHA, ... - particularly for plant-based diets.
Heard lots of discussion about carnitine and choline, but I missed the parts about lecithin... is sunflower lecithin safe?
Do we know how much does whole grains raise TMAO levels vs meat/dairy/fish? I got from this video that if TMAO levels should be regulated (i.e., they are a causal factor) and if they should be regulated by diet then knowing how much each type of food raises it might indicate if the dose determines the poison.
I’d love some clarification on this.
Excellent comment on TMAO and excretion levels could be an issue and not diet. Thank you for pointing that out.
I’d love to see another video on this subject as studies continue to be done on TMAO.
Please Dr. Gil, can you make a video about this study? "Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality"
Thanks .
I'm considering taking l-carnitine as a supplement but I'm still on the fence. The absorption rate is really low, you have to take 3-5 grams of L-carnitine so the body can absorb 0.5 grams.
I wonder what happen to the stuff that doesn't get absorbed.
I also read that you can eat garlic to prevent the negative effects of TMAO.
cruciferous vegetables lower FMO3.
The question is even though I primarily eat vegetarian with occasional fish, chicken yet I do take few supplements with choline like CDP choline and Alpha GPC to improve my cognition. And these sources can also make TMAO so also L-Carnitin supplements
Any multifactor component like fish have can have X number of factor that are bad for Heart health and Y number of factors that are good for Heart health. It is the net effect that is important. For example, lets say increased intake of Omega-3 could be a +80 on a scale of -100 to +100, and TMAO could be -10. Just looking at these two factors in isolation means a +70 net effect. Multifactor components are complex in their effects on the bodies health, so recommendation for the general population should be based on the net effect, while at the same time specific circumstance may change the recommendation such as perhaps a person with severe Kidney disease may have to be more cautious about TMAO intake, as the normal negative effect of -10 could rise to -80 or higher negating the positive effects of Omega-3.
I have IGg food sensitivity, and the top 3 are dairy, eggs, and beef. So I wonder if TMAO is somehow involved.
Hmm, so conclusion is = TMAO may be indicative of a negative effect in the body, if it gets above a certain thresshold, which unfortunately currently is unknown....and likely also individual.
Dr. Gil> Is TMAO a blood marker, that is easily ordered through ones local MD?
Have you personally an opinion on a general "theoretic max threshold " of TMAO, people should probably try to stay under? 🙂
@@danieljrgensen133 what is your facebook id
I eat fish. I'm confused. Should I stop?
18:21 fantastic !!
This is exactly the same example that can be used to explain the new EU research showing blood tests with high Xylitol is associated with higher cardiovascular events.
TMAO helps the body deal with high osmotic pressures. Same as fish.
If you have circulation issues, arterial issues, or kidney filtration issues, the body will create TMAO to aid in circulaton.
Studies show us that people who have the highest level of TMAO tend to have better survival from heart attacks.
Eating a vegan diet, is a choline supplement needed?
I take a garlic supplement to block some of the conversion as a precautionary measure, since garlic is good for the heart outside of that already.
I lean more toward it's just or mostly a marker of what you eat. In the general population higher TMAO, likely comes from eating lots of red meat and eggs which come with higher doses of saturated fat and/or cholesterol.
Either way, given all the confounding factor, it seems extremely unlikely it will ever be a maker your GP checks and says you need to change your diet to lower it.
Who wants to smell fishy too? It would be interesting to figure out what bacteria would hopefully help to repopulate and remove bacteria that create TMAO. Probably bacteria that doesnt prefer meat/sulphur. Although there are brussel sprouts and such. Everyone eating tins and tins of sardines should be aware.
Put Omega 3 and atrial fibrilation on your next topics list please 😊
If fish is a massive source of TMAO, but still healthy for the heart (netto outcome), then I dont really care about TMAO at all.
Kidney function. Something trying to surface in my memory about the effect of kidney function on TMAO impact.
and what about cancer and TMAO?
Once again, eating predominantly vegetables, fruits, lean meats, nuts, seeds, and legumes, is associated with the best health outcomes. Fixating on one food item or component is typically a waste of time. We know limiting saturated fat keeps cholesterol low and limiting refined carbohydrates improves health and longevity.
I totally agree what about fiber intake? I love black beans but high in carbs and it's like everyone says no carbs how does folks get their fiber?
@@paulabranson6530 Black beans are a legume, not a refined carbohydrate. They would be the least of my worries. People trying to sell you something will say anything to get clicks or buys.
Saturated fat (and probably a lot of other things) will always be controversial and heterogeneous until researchers are able to separate people by genetic variants. Some people are simply more genetically tolerant and less harmed by saturated fat than others. For all the years I was doing French cooking and eating large amounts of butter, cream and duck fat, I had low cholesterol (except high HDL). Years later I had my genome done; lo and behold I tolerate higher amounts of saturated fat. My family jokes I got the French genes!
@@paulabranson6530If you eat legumes, nuts, seeds, vegetables, fruits, whole starchy carbs, like yams, potatoes, grains, etc, you will get all the fiber that you need.
@@paulabranson6530 You don't need to avoid any macronutrient, including carbs. Just eat a whole food balanced diet.
In a blink of an eyes if there is a catastrophic event. I'm eating bugs if need be😮 Any ideas for accessing clean H2O in acgua fits?
Well, that's a pretty out of left field question for this video topic.
I had to google TMAO to work out whether to watch this video
It's not a difficult argument to make... processed red meats < red meats < fish < plant based. Fish was just better than those, doesn't mean it was healthy. Standard understanding of health has evolved over the years, and now the health community just needs to say the same. Fish is better than meat, but if yoy want to do even better than that. Avoid fish and go more plant based.
Why does this viseo have access only with link? I find this topic pretty interesting
how did you get the link a month early?
All I care about is people who eat healthy(fruit and veg) have little to no health issues.
My arthritis went away went I went vegan. Could be from the drop in TMAO.
"The predominant predictor of TMAO is fish. " Please don't associate fish with whole grains.
Nerd's wet dream. I love it! :D
Perhaps a bold statement, but since choline is everywhere in many foods, if TMAO would be a really important issue, evolution would have taken care of it, or ... of us, besides of other aninals. We are still here, so it's effect can only be on longevity.
There are a couple issues with this view even though it sounds compelling at first. the first is that, thought of as an optimizing function, it’s “goal” is reproduction. Selective pressure operates on a timescale for producing and raising offspring that survive. So if TMAO had negative effects at age 50 on, that wouldn’t matter much from a natural selection standpoint. You can see the same thing with saturated fats. We can survive eating large amounts of them well into middle age, past reproductive “success” before cardio risk starts to turn into cardio events. The second issue is that evolution isn’t directed, so just because something would make sense, it doesn’t mean evolution will have had the opportunity to select for that path (say for example a beneficial mutation never even arises).
Remember though, evolution is about being around long enough to reproduce, not longevity. So higher TMAO levels might only matter in an evolutionary sense if it negatively impacted to an extent where it kept enough humans from reaching their sexual procreative maturity.
@@HidingFromFate And therefore researchers should best focus attention to effects, if any, that become predominant in middle-aged and somewhat elderly age groups.
Whether or not TMAO is causal of heart disease, I say, "Neener, neener, neener!" because I eat whole food vegan. You guys worry about it or make excuses for eating unhealthy foods. LOL
Carnitas
Grammar police here. Why do all you BRILLIANT health advocates say "less" instead of "fewer?" It's so easy to correct. I'm no brainiac and I did it. Once you get it you'll never go back.
I get your point, however, most Americans can't get it right, and you do expect non-native English speakers to always use all aspects and nuances of their 2nd or 3rd or 4th language? I mean, most Americans speak one language, American English, and a good percentage of them are not really eloquent or grammatically correct in their speech and writing.
It doesn't matter. Language is a living thing and if most people understand something as correct, then it is highly likely to become the standard over time. Grammar is important up to a point.
Heres something to ponder: What is the purpose of distinguishing between continuous and quantized comparison? Why can we say more when a comparison is greater, but need to use less or fewer when a comparison is, well, lesser?
I could care fewer about your grammar
Linguists make a distinction between prescriptive or “standard” grammar and descriptive grammar, which describes the current actual language. Standard grammar is constructed after the fact and often doesn’t represent the living language. Most native speakers no longer make this distinction so the grammar will be changed in the future to reflect the change in usage. In other words, you’re fighting against the tide.
Nerds wet Dream😂
Yeah he was wrong about that . My wet dreams are something else
LMAO can cause breathing problems.
Im thinking fruits is all one needs
Good Luck with that . If your 30 and want to look and feel like your 80 and toothless
Eat fruit and nothing else and you'll be on the fast-track to ill health.
@@vince7349 stop spreading lies
Someone died on a fruit only diet since youre missing key nutrients and insufficient calories
Fruitarians are the group that keep making vegans look bad.
There are fruitarians that seem to manage for decades, but you're just complicating your life and limiting yourself.
you also need legumes, nuts&seeds, and leafy greens and mushroom.