Is High Protein giving you Heart Disease?!? New study makes waves
Вставка
- Опубліковано 12 тра 2024
- Headlines this week blasted the danger of high protein for the heart. But is the science solid? A look at the new study on protein intake and heart disease making headlines.
Connect with me:
Facebook: / drgilcarvalho
Twitter: / nutritionmades3
Animations: Even Topland @toplandmedia
References:
New study: www.nature.com/articles/s4225...
Animal vs plant protein & heart disease:
www.ncbi.nlm.nih.gov/pmc/arti...
jamanetwork.com/journals/jama...
Fish & heart disease:
www.ncbi.nlm.nih.gov/pmc/arti...
Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.
#NutritionMadeSimple #GilCarvalho
0:00 New study makes headlines
2:03 A 2nd human experiment
3:12 Cell culture
3:42 Mouse arteries
4:20 Protein in mice & humans
6:29 Mechanisms vs Outcomes
7:58 Animal protein to blame?
9:27 Bottomline
Hi everyone, just want to quickly address two FAQs:
1) "Why bother testing anything in animals if we're different from them?"
Mechanistic research in model organisms (yeast, worms, Drosophila, mice etc) is hypothesis-generating and can also fill in mechanistic detail. It does not replace human trials but it does play an important role. Numerous pivotal discoveries in areas such as cancer, pharmacology, neuroscience or circadian biology have stemmed from it. What's erroneous is making the logical leap directly from mouse research to humans without actually running human trials. This error is common in media headlines and social media content but once one is aware of it, it´s easy to see through.
2) "The protein solution contained sugar, oils etc therefore the study is invalid"
As covered in the video, the first experiment in the study used a commercial supplement with multiple ingredients. The investigators then ran a second experiment with common foods where they replicated their findings (see video for full explanation). We should point out limitations of research without falling for facile criticism. This study has several important limitations and does not provide compelling evidence to change guidelines for humans but to dismiss it based on the 1st experiment misses the point that the authors specifically and experimentally addressed its shortcomings. See the full text of the study linked in the description.
thanks everyone for your interest
Gil
"The protein solution contained sugar, oils etc therefore the study is invalid"
- the higher protein solution actually had lower sugars and oils to make up the same calories, so one can argue that the higher sugar, higher oils solution had a better outcome (lower monocytes) than the lower sugar, lower oils solution. HOW COME THE KETO-CARNIVORE-BROS IGNORE THIS FACT?
eXPLAIN Valter Longos findings
First I so appreciate these videos and your non-biased evidence based approach. Huge thanks! Second, a follow up question on animal studies vs human studies. Is there a way to assign a likelihood - perhaps a %% - to whether research would apply to humans in cases where it's unethical or impossible to get good controlled study in human population? For example, if a rare berry was discovered on some island and large animal trials were conducted say across 5 different mammal species including primates and all of them died after eating the berries but for some reason scientists were unable to determine why, I would guess it would be highly unlikely we would be feeding them to humans anytime soon, but seems like there would be a fair likelihood - particularly the more different species that resulted in the same outcome - that the results would translate to humans. I would love to know if anyone has ever tried to put criteria/numbers to this concept? thank you again!
With regards to animal studies, it's also darn near impossible to get a study approved where you're looking for test subjects to either suffer a major health outcome or die. Something about ethics.
Because there is considerable similarity been men and mice and mice experiment can be well controlled and relatively inexpensive.
Thanks for doing this. Good episode. I get SO many requests for protein requirements and it feels like sports nutrition scientists are on one end of the spectrum and longevity researchers are on the other, no?
So far the direct evidence of harm of too much protein seems to be more on the cancer risk side of things. This is the first I hear on cardiovascular risk. If I understand Dr Longo and Greger correctly.
@PlantChompers love you work!
No research reveal what is bad for you individually. Bear this always in mind.
I see both saying high protein is important. Longevity "experts" may be split on it.
If you do an episode on it mention the Australian advice which is different. Our government recommends 0.84 per kg of body mass for those under 70 and 1.07 gm per kg of body mass for those over 70. Another which I have only seen mentioned one time is the rdi/rda is based on body weight so is very problematic, Australians and Americans are mostly overweight and obese, given the advice we are trying to eat heaps of protein to protect our fat cells which doesn't seem appropriate to me. I think the protein advice should be based on height and possibly sex like we do for target weight of non muscly sports people. The RDA's aren't really intended for sports people because energy , protein and some micronutrient intakes will need to be higher.
I like your integrity and emphasis on evidence.
Many thanks, this is by far the best video I have seen analyzing & commenting on this study
I'm really worried about the results of these kinds of animal experiments. What if the mice get too strong and escape containment?
Underated comment 🤣
Untamed Gainzz , who is gonna stop these rats from curling in squat racks all over the world
Oh yeah yeah
Mighty mouse?
It depends if it's Pinky or Brain that escaped containment
I'm glad someone is trying to make nutrition simple, because I'm properly confused.
The researches are confused too it seems. One of the fields of science where there is the often not a consensus but instead views that change every 10 years.
Exactly! Grateful for this channel
Haha that's a nice catchphrase for this channel
you wont find the truth at any one-stop shop
Nutrition is some of the hardest work to do. Most of the effects we are interested in manifest over many years, and if you're working at that kind of time frame it's impossible to do the kind of placebo controlled study you would do to test a drug effect, for example. Or you do it in animals, but mice aren't people. Unfortunately there is also the issue is a lot of nutritional research is funded by entities that have an interest in the outcome.
Another informative, intelligent, and most of all, trustworthy review. Thank you for posting these.
Love your content - so well balanced and measured and evidence based. Keep up the great work.
A long time ago, I was very overweight and went to see a doc. The doc found my BP to be 159/120 (that was my resting BP) He said "Wow! You need to lose weight!"
and dismissed me. That was it. No tests. No meds. No diets. No recommendations. I've learned way more with this channel than my whole life of visiting doctors. All this to say that I really really! appreciate what this amazing doctor does for this community.
Hell yeah. Ofc doctors are important and know a lot more than the average joe. But we all know they are still human, some had their degree a long time ago and don't continue their research and studies, and some simply have biases and aren't as professional as they should be. I personally believe that EVERYONE should know some basics about nutrition and how the body works. I mean, it's our body, we should make sure we learn about it's functions and the scientific consensus around the things that matter in our nutrition. And if we know some stuff, then we can also advocate for ourselves to our doctors.
Eat lots of veggies, cut calories, 3 meals a day preferably within 8 hours, get enough nutrients especially vitamins and Omega 3 fatty acids, cut yummy bread to 2 slices a day max, no snacks, no nutrition bars and no food that makes you hungry like chips.
Probably meant you had to get a blood pressure monitor and check it out for yourself, if it was staying like that, you need meds.
Yeah…. After seeing my parents and how they were treated towards the end of their lives; I’m thoroughly convinced doctors, and nurse practitioners are perfectly fine with just doing the minimal and just letting you die!
I thought diastolic 110 is dangerous one has to go to hospital right away? 120?
Clear and simple as always. Thank you
Me, who just upped protein intake to gain muscle, sees this video.
Thanks for the analysis Dr Gil.
This is a study on mice. What would happen if you put a dog on a largely vegan diet? Would that mean vegan diets are similarly harmful to humans?
been waiting for this one.
i didnt hear of this great that im hearing this first from you so i dont get misinformed thanks a ton Gil!
Thanks for another great analysis
This seems like an interesting start point for further study. But doesn't really tell us anything beyond that. Unfortunately, I think studies like this are overhyped and used as 'proof' for whatever various groups might want to prove.
0:28 14 human test subjects? This is a “big” study? I don’t think so. Also, who commissioned the study? Why were these “findings so important? Studies don’t just happen. There is always a purpose/desired outcome. Who benefits from these studies? So many questions. Great video. Cheers.
Power analysis, you don’t need a ton of people if the differences are large and consistent. If this study were looking at outcomes, they would need a large number of people. But they were looking at biomarkers and cell counts. Obviously you don’t expect the cells in the 20th or 30th person to be different from the first 14.
Much aligned with this perspective. Also read the study and while I have my concerns about a protein sweet spot in terms of excess driving potential cancer risk and insufficiency driving potential lean tissue loss and frailty, I’m in line with the directionality of Dr. Gil’s conclusions here.
Thanks Gill.
Maybe the mice didn't lift any weights. If they would have maybe the proteins would have been redirected to the muscles.
Super Interesting! Many thanks for sharing Dr. Carvalho
Thank you for actually de-bunking this study in a scientific manner. Hard to find on UA-cam.
He's not debunking the study, he's only asking questions and raising interest in future studies.
I'm not against protein, i eat lots of it
Study hasn't been debunked. It was a solid study which produced valid results. He is debunking sensationalist media headlines that came as misinterpreted results of these studies. Which happens a lot.
Awesome one, Doc!
Excellent analysis
what i get from this is .. stop paying too much attention to new studies (and the headlines that bring attention to them) otherwise you will be convinced that everything causes heart disease and everything also prevents it.
Right. Look into some eastern ancient stuff like yoga which teaches how to get your own harmony and feel what your body needs instead of eating somebodys sh$t in all senses.
What a bizarre consluion to draw. Much more sensible to read thoroughly and seek expert input.
@basiltiffani8850 right, like this whole channel is basically about reading studies thoroughly and critically, not just rejecting them because they're new. Being skeptical but open minded to social media hype is a different matter, and that's probably a good idea.
Expert input is also not saying much. You need to check systematic reviews/meta-analysis of RCTs or well adjusted prospective cohort studies. The problem is most people don't have the scientific literacy to do this.
"experts" @basiltiffani8850
Fantastic, thank you!
An underpowered short duration human study unmatched for SFA,a cell culture study and a mice study. I don't believe it adds any confidence for or against high protein intake. Saying high protein does or doesn't raise CVD risk based on that evidence will just be the equivalent of pulling data out of your nose, or adding a feather on a scale that measures in tons and expecting it to change. Pretty insignificant data for actual humans.
true, yet we all know that's what actually happens.
@@TorbLlorts There's evidence plant proteins being better for CVD than animal proteins ( except fish). No current evidence whether high protein intake by itself ( especially plant protein) is increasing CVD .
Can you provide any benefits of a high protein diet for those over 50? Many are pushing older people to eat 2.2 g/kg. I consider anything over 1.6 g/kg as being high protein. The only thing anyone ever claims is preventing sarcopenia, but their are plenty of studies showing that additional protein does not benefit muscle mass and strength in the elderly, whether resistance training or not. There are more studies than this showing high protein has risks for longevity and disease in the elderly (>50).
According to a 2019 study about half of those over 70 are not even getting the RDA of 0.8 g/kg. And we have people pushing 2.2 g/kg, wow.
true, but it still believe it is the case despite what the evidence has shown yet@@demonfedor3748
@@TorbLlorts I prefer to know with a high enough degree of certainty than to simply believe with no basis. Many things people believed in turned out not to be true. Before cause and effect is established I'll just keep leaning on existing quality evidence without worrying too much about the potential unproven side effects.
Thank you. Interesting but more questions than answers arise from the study.
Does Neu5Gc explain some of the difference between the risks associated with plant and animal protein consumption? This might explain why fish consumption does not appear to increase risk.
DHA/EPA from fish is a confounding factor with established anti-inflammatory effects, so a proper study with fish consumption requires lean fish with the fats taken out vs fatty fish with the skin on. Neu5Gc might only play a role with people who are susceptible to it and it would be great to have more studies on it, but unfortunately Neu5Gc is not getting enough attention it deserves, mainly due to the lack of awareness and the carnivore-bro UA-camrs.
Love the nuanced discussion. You not pushing the vegan agenda makes you so much more credible in my eye. Keep up the excellent work!
Same here - the minute anyone starts pushing an agenda of any kind, I tune out. Gil is a breath of fresh air looking at diets objectively and purely based on science.
Eventually you will see that the healthiest diets are plant based. No agenda...people on that side just want you to be informed. Take it or leave it.
Very interesting. I have seen with my own patients that increasing protein per meal (>2.0 grams per kilogram of body weight) in fit, healthy young men without a h/o of ASCVD risk, can dramatically increase LDL cholesterol with a slight uptick in triglycerides and a dip in HDL. Most of these guys do intermittent fasting BUT have very low fiber intakes. After fasting for 10-12 hours, they eat lots of chicken (lower in saturated fat) and hamburger meat (higher in saturated fat). This artifact could be related to the beef intake but other patients do just chicken/fish/plants and NO beef. Mechanistically, could this be because not all protein is used by the body and the rest is broken down to amino acids and recycled to glycogen and other carbon chains to be used as TGs→fatty acids→VLDLs→LDLs (or higher APO-B)......all leading to a higher plaque burden in the arterial walls? Could this be the driver here? Any thoughts or counter arguments would be appreciated. Thank you.
To my knowledge water soluble plant fibers reduce LDL and increase HDL, so it might be due to the lack of fibers and not increased Protein.
Additionally i think fat increases LDL more than protein.
Are we sure it's not just high saturated fat consumption and low fiber? That's probably the answer. I think bodybuilder and PhD Layne Norton eats about 50 grams of fiber and 200 grams of protein. The only way I keep my protein high enough is with whey, if I had to get it from whole foods, I'd probably exceed the AHA recommended intake for saturated fat of about 20 grams daily. I haven't had blood work in years, but I rarely exceed 10 grams of saturated fat daily
I'm no doctor so please correct me if I'm wrong, couldn't also the balance of vitamins k2 and d3 be a factor in these diets? Since they help removing plaque? Also the way the food is cooked, as most people cook their meats in oils or generally less healthy ways than fish and plants. Thank you
I think you are spot on. The protein intake and its direct impact on Insulin, combined with the growth (TOR) driven by Leucine might be the clue here. Athletes or people with high caloric output (especially compound movers like farm/construction workers, cross-fit athletes etc.) might still use the extra protein to regain lost glycogen during the day. Every other person can't which will trigger the fat production.
Another interesting point would be the effect of Leucine on fat cells, therefore on Leptin mechanism.
Very intriguing indeed.
Count me among the people who’ve experienced sharply increased LDL and decreased HDL while on a high protein, whole food diet. It’s really troubling.
Speaking of heart disease I am currently participating in something I call "The apoB challenge". The goal is to lower it as much as possible with diet excercise weight loss and other healthy habits. I currently slip up a lot in my diet,but I'm still trying to go at least 2 weeks with no cheat meals and close to 0 saturated fat and proccessed carbs. After that I can finally measure my apoB to see how low it drops with no medication. Depending on the results I might choose to add low dose medication later ( that's my choice,you might choose otherwise) . Would be glad if the community here supported that challenge as well,if you can and want of course. Wish me luck.
Good luck!!
Can you please give us an example of your typical day of eating ?
Thanks and good luck
What do you mean by zero saturated fat? Almost all food has some, so it's very hard to get to zero even if you eat a diet that has no added fats from oils, animal products, processed foods, and higher-fat whole plant foods (nuts, seeds avocados, etc.). Oatmeal consumption has been shown to lower cholesterol, yet contains at least a fair amount of saturated fat. It also contains a decent amount of insoluble fiber, which helps to decrease lipids. I'm not suggesting you start eating bacon cheeseburgers, but I also think that trying to get to zero saturated fat is a bit of a pointless battle. If you can keep your saturated fat to 2-3% of calories, that's huge. Going lower than that I don't think will make much difference. Reducing processed foods and increasing soluble and insoluble fiber are going to be just as helpful. I'm not sure about APO-B, but at least as far as LDL, it's rare to see anyone get below, maybe 55-60 without some medication, even with an extremely low-fat diet (10% or less total fat, 1% or less saturated fat).
Interesting aim. Good luck
Blessings on your better health!
Thanks for the video. I do wonder if *how* animals are raised is a factor. For example, cattle used to be raised on grass, but now, they are fed a slurry of grain and other ingredients that are not part of 5heir natural diet. Does that practice change the fat balance in their meat?
Farmers think so. My husband tells me that the farmers where he lived would take their grass-fed cows off pasture and bring them back to the barns to be finished. And by that, they meant several months worth of eating corn as their primary calorie source. This is what results in significantly noticeable amounts of fat marbling in steak. I have no idea what the research says about this. But if farmers believe that the additional fat made their steak sell better than their expertise being linked directly to money is probably valid.
Agree entirely with your assessment. Good video, Gil!
I found out for myself that too much protein can be bad for the heart. I have hypertension, palpitations, localized chest pain (twinges) between my heart and sternum, and atherosclerosis.
For at least a month I consumed 1-2 packages of Natreve Mooless protein drinks, usually with soy milk. I started noticing a significant increase in my blood pressure. I stopped in within a few days my BP dropped back down.
A few weeks later, I tried again but only one package per day. After about a month I started experiencing generalized pain to the left of my heart. Thus stopped within a few days of stopping. I got rid of the rest of it.
How much protein per kilo of your body did you consume?
@@painting3daniela13 One packet has 20 g of protein. The soy milk (from Aldi) has 7g/cup and my Magic Bullet can hold 24 ounces, so 21g. Also, the protein from Natreve Mooless is primarily protein isolates (from plant sources), which right there is problematic. So, the first time around I was consuming ~61g from JUST that drink, not to mention the tofu and other plant sources of protein. I eat incidental amounts of animal protein. On some days, because I am a food reviewer, I consumed isolates in products I reviewed, such as protein rich bars and drinks, which generally contained 10-20g.
The second time, thus, I was consuming about 41g from the drink.
Given my body weight of 165 lbs, I should be consuming no more than about 60g/day based on the RDA (which is designed to meet or exceed the needs of 97% of the population) of .8g/kg of body weight.
Interesting! There may have been something else in those drinks though that caused your symptoms, not just the protein - or even just the stress and anxiety associated with taking a new supplement if you suffer from health anxiety like many of us interested in this subject do!
@@GlennsFastReviews I thank you
@@ZsuzsaKarolySmith there are a lot of possibilities. No disrespect to Gil but other experts have weighed in on proteins and isolates. One study isn't definitive, but it's pretty clear that excessive protein consumption is not good no matter the source.
I was not anxious about the supplement and, honestly, once I figured out how to make them taste good, it was disappointing that I couldn't keep drinking them. I had to get rid of over $60 of it. 😞
It aligns with results of studies that show low protein diet extends life span in mice. I have seen anecdotal evidence of this in humans when I briefly worked at an assisted living facility back home in India. It would be interesting to study this further.
I would like to see whey protein vs vegan protein powder, as there is a big difference in mTOR activation.
Is there?
@@Pseudonyymi568100% whey protein products are roughly 10% leucine. Vegan sources are typically 30% less leucine and 50% less Methionine. Both are key in MTOR and IGF-1. pubmed.ncbi.nlm.nih.gov/35034170/
I've seen some studies where they compared whey with soy protein. When matched for leucine there was no difference in muscle protein synthesis. IIRC correctly 28 g of whey are equivalent to 36 g of soy protein in leucine amount.
The whole point of whey is to get the maximum effect from least amount. Whey is factually more potent than almost anything else gram for gram. You could also match potato protein for leucine content and get same result, so what?! Who could eat that much potato? Potato and corn protein isolate are awesome though, but scarce.
I think It depends on how much Leucine you get. Of course, animal protein; especially in people with a leaky gut; might trigger more inflammation and more plaque.
An acute rise in mTOR isn’t very interesting or unexpected, The question is, do we have down regulation periods mTOR. I’d be more interested in a study of balanced circadian cycling of mTOR, and AMPK pathway management compared to mTOR overstimulation and the results from no mTOR stimulation, (looking at factors are such as sacrapenia ). My hypothesis would be people that don’t cycle which suffer various health problems from either extreme. The question is is a 24 hour circadian cycling appropriate or should it be in the form of every few weeks?
I appreciate the new developments and perspectives. However: I am wondering how to access certain journals/articles without the overpayment for the journal. Rather credit or source the writers of this makes sense 🤔
Thanks for the best nutrition info I've ever found. Regarding heart disease, do you have any input for your audience regarding blood pressure, including current guidelines. Are the newest, more conservative guidelines trustworthy (I've heard there was possibly a conflict of interest in their establishment)? And, what should we do when our blood pressure is on the borderline? Thanks for your consideration. Billy, Dallas, TX
Just think about the protein percentage in the human milk... We don't need too much protein to grow
Human milk is designed to be as insulinogenic and fairly obesogenic as possible to get maximum growth in babies. That does not translate well to what adults want or need.
I'm trying to becone better at researching do you have any videos on how to breakdown a study? What questions to ask yourself? How to think more critically?
I am curious how any or all of this relates or applies to someone who is on an mTOR inhibitor medication. I realize my question is very nuanced but it's something that's very much of interest to me. Thanks
I would love to hear your analysis of the new niacin study.
Hey Gil:
As always, learned something from you. What are your thoughts on Methionine restriction? Greger points out in, “How Not To Age,” this is the key to slow down disease, etc. Fish is by far the highest in this.
your question already lays out the strongest challenge to that idea :)
(as covered in this video re: fish)
Great Video!
Leucine and TOR have been the subject of much hand-wringing. Good or bad? Short-term studies seem to indicate that leucine improves muscle anabolism, but long-term outcome studies don't seem to show a sustained benefit. Similarly, high-leucine proteins (whey, etc.) don't actually seem to produce long-term outcomes better than low(er) leucine proteins like pea and soy. As for cancer, there seems to be some indication that too much leucine/TOR early in life isn't a great thing, but later in life mightn't be a problem. It is all very confusing.
Cancer thrives on Glutamine, not leucine and on Glucose/Fructose, and cancer cells are also extremely endowed with insulin receptors.
@@unassailable6138 There are cancers that thrive on glutamine,glucose,palmitate and other sources. And no you cant starve off any of them,they will suck every source dry if they can. Palmitate you have almost unlimited supply unless you have 0 body fat=dead,glucose can't go lower a certain point without killing you so liver will desperately start making more,same for glutamine. Dropping any of the substrates to zero will kill cancer along with you.
@@unassailable6138
source
Dr. Carvalho, would you consider making a video about wild game meat and its impact on the human health issue? Cheers!
I wonder if it's the EFAs in fish that help reduce plaque and inflammation
I so enjoy these videos. What I get from this is that it's probably beneficial to avoid excessive amounts of protein, especially animal protein. I'm not an expert, but from all I've heard and read, avoiding excessive amounts of any single nutrient is generally a good path to take.
A good path to what?
Exactly! The poison is in the dose - too much of anything will kill you. This just circles back to the mainstream advice - everything in moderation.
Can you posit more on Omega 6 Omega 3 ratios regarding Cardiovascular Disease based on this factor? Much appreciated
Leucine in protein causes calcium carbonation reaction, therefore too much protein may be bad for the cardio vascular sysyem
What’s in those liquid protein drinks tho? What carbs did they eat. We need this info
I don't think all proteins and/or amino acids are equal in animals just like the proteins from legumes. The protein from the red meat would be different from the chicken meat. I strongly believe that the protein coming from the fish would be vastly different. It could easily be that the fish oil plays an important role in reducing heart disease.
Dr Carvalho, I'm surprised you are skeptical of animal protein intake itself being associated with cardiovascular disease given its linkage with several aging pathways, including mTOR, insulin, and IGF-1, not to mention a range of studies highly consistent with that association. Fish probably buck the trend due to their high omega 3 content, combined with the fact that people generally don't (nor do they need to) eat a lot of fish to get a significant dose of omega 3s.
I would think the high protein drink would have most of the fat removed and therefore controlled for that variable.
All I can say is I do WAY better weight loss-wise and energy-wise eating more protein and healthy fats and less carbs. Even somewhat healthy carbs. But everyone is different Great video!
I have a friend who says she 'does better' with lots of meat in her diet. She's slender and moderately active. But now she's developed metabolic syndrome. Her doctors suggested she cut way back on the meat and load up on vegetables instead. No actual discussion about protein per se.
What ever the case is I workout and to minimize too much mtor I try to fast for 16-20 hours OR ... only 20 g of protein (more than 25g stimulate mtor) for 16-20 hours and then get the rest of my protein 100+ for about 4 hours, seems to have been better for me.
Nature metabolism is a top publication. They vet these scientific articles using experts on the field.
Dude! Dr. [Dude], I have to laugh. Whoever puts together your expressions on the titles of your videos does a great job. 😆 Great production.
This study reminds us some of the conclusions of the China study.
Exactly!! Follow the evidence!!
Thank you for this evaluation. Are animal proteins bad for the kidneys?
Thank you
I haven’t done the maths but these sample sizes seem very low, first 14 and then 9 people split into two groups.
I would be curious to see a study composed of bodybuilders and find out if their high protein intake coupled with their intense training would yield similar or different results!
Something on Dairy and prostate cancer would be good
I have read that Too much Dairy causes BPH
Agreed. My dad passed away not along from metastatic prostate cancer.
Do protein supplements on sale at the drug store proivde all the amino acids we need?
Yes if it’s whey or some mix of pea and rice
Gundry reckons neu5g is a culprit, opt for non neu5g proteins, although he reckons eating more than 30 grams of protein a day goes to fat. I find hemp and pea protein great, but if I eat the massive amount of protein some say I should I feel too heavy. Question is how much am I absorbing vs eating, what should I aim for in grams?
Very interesting, as Gil says, but I'd love to see a much more large-scale study. 14 people does not give much scope to select a varied test group in terms of age, gender, and ethnicity. A study of 30, 000 people say, with 3 different levels of protein consumption over a period of months, at least, would give rise to a more complete study.
As for me, eating too much protein gives me kidney pain, demonstrating once again, that one size does not fit all when it comes to nutrition.
Thanks
I've read the liquid meal they consumed was Boost Plus which is full of sugar, was the intake identical in both groups?
Finding honest science nowadays is near impossible. Anyone can set up a science experiment to confirm one's biases.
@MB19ap yeah especially w diet. It's always tainted
No, the high protein group had less sugar than the low protein group because for the same amount of calories they upped the protein content and kept fat constant.
I agree with his conclusion. I think a better study would be to study people on lower, medium, high, and really high levels of protein. My prediction would be that those with really high levels of protein would show some problems. Maybe I'm wrong, but that's still my prediction.
Dear sir,
Does ACV destroy vitamin supplements if taken with them together?
ACV - apple cider vinegar?
@@TTR83 yes.
How about a video about too low protein intake? many, elderly especially, don't get enough and doctors often don't know the simple cause of the symptoms.
We've now got studies saying fats/oils, protein, sugar/fructose, gluten, lectins, starches, nightshades, sodium, artificial anything, any preservative, any pesticide, etc, etc are bad for you. Is there anything left to eat?
lol
If you bear in mind that the dose makes the poison, then all the above can be eaten.
Don't get scared off by certain influencers looking for views announcing "Never eat X!!!" because they're full of shit.
In fact, when titles like that crop up in your UA-cam suggestions, just click the three dots and select "Do not recommend channel".
Diary of a CEO and What I Learned Today are both channels that are packed with bullshit designed as information, so bin those two off for starters.
And anything with Paul Saladino.
Ice ! but make sure it from water that has been reverse ozmosis & re minderalised
Whole fruits and vegetables are still good. Also, no studies say plant protein is bad.
Only eat fish, anything else is death
Prof Valter Longo advise to keep mTor low for longevity and health.
Greger has a video going over studies that show that animal protein increases CVD risk and all cause mortality independently of animal fat content. Have you seen those studies?
love him. esselstyn. campbell.
Hah! I was just writing a comment saying, wait! this is a mechanistic study, not an outcome study! when Dr. Carvalho said the same thing. :D
Can you do a video on Chloremquat in food supply mainly oats and oat based cereals? “A Pilot Study of Chloremequat in food and Urine from Adults in the United States from 2017-2023”
What I'm thinking is a somewhat high protein diet thats low in saturated fat. Whole grains for carbs. Plenty of vegetables, have fruit for dessert. Basically focusing on lean protein like fat-free Greek yogurt, chicken and turkey breast and fish. The fat you do have would be mostly unsaturated. I'm thinking fiber and protein for fullness. It would be somewhat higher protein than normal for a strength training exercise routine. Thoughts?
Yeah, I tend to agree. I'm not a big fan of fat-free dairy though - nor the full fat ones - I settle for something in between. I've also started substituting some of the dairy I consume with plant based options - that way I don't consume too much of one or the other - sort of like best of both worlds. Protein needs vary from person to person based on age and life style.
Needs more beans & more plant protein, imho
Also look up the portfolio diet.
My other question is it a spike or temporary thing
I guess if someone constantly overeats protein it would be a permanent elevation not just a spike. Definitely warrants further investigation to examine long-term implications.
These studies are small and riddled with problems. Would like to see you critique the Fructose Survival Theory, a much more ambitious academic endeavor.
anyone know a study that shows better outcomes for plantbased, without weightloss? starting to believe that its all a question of total energy intake.
Search in Google Scholar for studies that adjust for BMI. Feel free to ask again if you have problems finding any.
I'd be curious to know what the participants' activity levels were like.
Still not clear on why given same diet and lifestyle one person gets calcified arterial plaque and another person doesn’t? Have asked quest before here and on other UA-cam pages and have received no response. Thanks in advance if you respond.
Genetics. Some people may have significantly higher predetermined lipoprotein production or significantly lower clearance of lipoproteins or some combination of both( like people with familial hypercholesterolemia),or other factors like diabetes,inflammatory conditions etc. Incomplete answer,I know,but good enough I hope.
Like my Doctor says. We're not lab rats
Might be genetics, amount and type of exercise or some other habit. I read that for example dogs are practically immune to atherosclerosis but can get it if their thyroid is removed. I'm also interested in why many other animals don't suffer from it, it would be nice if if we could transfer that benefit to humans some how, like with some magic enzyme pill or similar.
Ok, I'll attempt an answer of sorts. I'm sure you've heard of genetic variability, right? That is definitely one potential reason. Another is that arterial calcification is a multi-factorial tendency. Not just genes and diet, but also other lifestyle factors like exercise, sleep, smoking, stress, relationships, even pollution levels. Then you have other more theoretical factors like the microbiome, which may be influenced by whether you had a c-section birth or a normal one, how "clean" your childhood was (were you exposed to more dirt, and so got a greater variety of bugs), whether you had pets growing up. There are so many different potential factors out there that it can really account for a lot of potential variability outside of simple dietary choices alone.
It can possibly be different for a number of reasons. Genetics, the level of stress, the gut biome, a similar diet but the amount eaten may be different, the amount of exercise, sunlight and sleep,etc. Nutrition is still in its infancy and many things that were once believed are now found to be flawed.
Would you ever consider making a video on what you eat in a day or some simple recipes you like?
Isn't too much protein bad for kidneys
Only if you already got Kidney disease
I’m sure if I was eating bugs for my protein in excess of 50% the study would show I was enlightened
My understanding was Plaque is a response to arterial wall inflamation / damage. It's a protective coat that the body puts there. It happens with any diet that is inflammatory, due to a poorly balanced diet, like a diet full of sugar, high GI carbs, too much protein or a low fibre diet without much veg or a ton of processed omega 6 oils with hardly any omega 3s. All this causes inflammation hence protective layers of plaque.
I don't like to make conclusions about protein consumptions based on percentage in diet, because it doesn't scale with calories.
We should rather look at it from perspective of hard numbers. For most people it would be either around 0.9-1g of proteins per kg of bodymass or 75-100g a day with average light activity for health.
So, it doesn't really change in relation to calories intake. Regardless if you want to lose weight or maintain bodymass. It also should be calculated based on optimal BMI rather than bodymass, because you can be as well obese or overweight and you don't need that extra proteins per kg of fat bodymass.
Da-lhe Gil!
Uhh, are Dr. Gil implying the researchers didn't account for differences in intake of saturated fat content in the low vs high protein group?
If so, that seems pretty much like a joke in a new study on nutrition, as sfa is established to be a factor for accelerated plaque build up.
But there have lately been a general increase in focus on recommending higher protein and leucine intake, by the online health and fitness influencers....I wonder if this study is a response to this "movement"? 🤔😉
It would also be in response to research on longevity that suggests high protein intake increases cancer risk.
I really think you should learn using the CAP key in your keyboard. Reading your subtitles is difficult.
Would like to see a video about effects on the body induced by Flouride in toothpaste
8:30 The thing is that fish intake is also likely just a marker for a healthier dietary pattern.
Good topic to discuss! Most of my patients feel like they need to get more protein, even when they aren't athletic and already taking in excess.
And what is excess according to you?
@@cyberfunk3793According to the science, excess protein is converted into glucose if your glycogen storage is low, and after that all protein is turned to fat.
Fat people eating excess protein that will just be turned into more fat is probably what he is talking about.
@cyberfunk3793 It's very person dependent but the average 120 lb female doesn't need 150 g of protein everyday and I see many people this size striving for numbers like that. The more is better mentality is not always best.
@@2DocsandTheFoxThey keep wanting to increase a relatives protein (82F), but in excess it messes with her glucose numbers. That’s doesn’t make sense to me. Too much of a good thing can be bad.
I'm 134 pounds. I get anywhere from 80-130 grams protein per day. Is this good enough? Not too much is it?
Gil: Here’s a bunch of studies, along with some critical appraisal.
Dude in comments: Yeah well here’s my unsupported opinion.
And you should see how some even less competent YT channels are trying their worst to dismiss Dr Carvalho's work.
Oh, well, (relatively) free speech comes with its own drawbacks, I guess.
Did you not hear his conclusion?
That's our job as viewers.
I eat around 1 gram per pound of body weight, so that’s around 185 grams of protein per day. Any risks with that? Thanks
No. And as he said, this study can’t even answer the question. But that’s on the high end of what’s suggested for those doing intense workouts like pro-bodybuilders. If you are not doing intense weight lifting or the equivalent, that’s likely much more than you need. 0.8 g per pound is plenty for being very physically active.
Always do your own research and ask good questions. Studies like this can easily over simplify situations. A good question to ask is "what does the TOR pathway do in the body". Lots of things it turns out and the FEAR pushed by this research (remember fear sells) isn't even on the list! Not saying its not a thing. But it isn't one of the main implications of the TOR pathway!
So what is the best diet for longevity. Can anyone explain
Nothing is guaranteed. Keeping stress down and working out regular will help though
I believe that would be plant based, or at least avoiding dairy. It is very unnatural for an adult mammal to consume dairy which is designed to help an infant maintain growth.
@OM617a That's really unfounded. Being 'natural' has absolutely nothing to do whether something is healthy. Vaccines, hygiene products, and antibiotics are all unnatural, where as snake venom and infectious diseases are fully natural.
Dairy *might* be unhealthy, especially in excess, but it being unnatural or natural doesn't really say anything. We have after all, been using dairy for 10,000 years, roughly the same time as fruits have been cultivated.
Purely for longevity from data I would say pescetarian with a lot of variety in plants, low egg consumption and no unfermented dairy.
Fermented dairy in moderation and fish (even though I ethically don't agree with it) seems to have positive effects for longevity or/and health span.
Not the "Western Diet." I think everyone agrees on that.
The good doctor failed to mention that fish has lower Leucine levels than chicken and especially lower than beef.
But it's true, plant-based proteins are lower than any of the 3.
Legumes and seeds can have a really high amount of Leucine as well :)
@@7Mango033
I guess I have to spell it out for people, although it's right in cronometer:
10 oz of beef = 7.5 g Leucine
10 oz Chicken = 6.6 g Leucine
10 oz Salmon = 5.9 g Leucine
10 oz Whitefish= 5.6 g Leucine
10 oz Sunflower Seeds = 4.7 g Leucine
10 oz Walnuts = 3.3 g Leucine
10 oz Oats = 2.8 g Leucine
@7Mango033 which ones are low?
Not close to most animal protein, doesn't matter unless ur an athlete@@7Mango033
@@7Mango033Fish has between 5x and 10x the leucine of beans!