The next software revolution: programming biological cells | Sara-Jane Dunn
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- Опубліковано 14 жов 2024
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The cells in your body are like computer software: they're "programmed" to carry out specific functions at specific times. If we can better understand this process, we could unlock the ability to reprogram cells ourselves, says computational biologist Sara-Jane Dunn. In a talk from the cutting-edge of science, she explains how her team is studying embryonic stem cells to gain a new understanding of the biological programs that power life -- and develop "living software" that could transform medicine, agriculture and energy.
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If Google was the one researched it, there would be ads at the corner of my vision.
:D
Ummm.... Might be better, we know what resources we need, how to get it, and how much we should pay it and choose any available option that more suitable... Idk maybe... But any ads would be silly though... 😅
There are ads in the corner of your vision everywhere in “real life” 😂😂 go walk down any street
Some take-aways : 1 Math is the language to uncover and understand patterns; 2. Everything can ultimately be reduced to physics; 3 System dynamics is far more useful than its typical application in engineering.
physics can be reduced to mental concepts and sense data, which can be interpreted as personal experience.
love the term 'wetware'...… I am a software developer, I loved this ted talk.
"Please pay $999 to upgrade your immune system"
@Hugh Jones you wish
you already pay for vaccines to upgrade your immune system LUL
Varun Kumar Velidandi oh we can see this coming a mile away lol. Capitalism, man.
At least it's more useful than an apple stand
@@felipeXinfi No I don't, vaccines are free.
i'm currently a first year student majoring in Bioinformatics and for some reason, this course makes me think twice whether should i continue on pursuing in this course or not because it's kinda hard for me tbh. but after watching this i feel like i got a whole new overview and perspective about my course. definitely going to study hard so that i can be one of these great minded people in the future 😃
Continue doing it.
@@julioalexo i can't even remember leaving a comment under this video, but i just want to let you know that i'm still doing it and currently a final year student, majoring in Bioinformatics. it might be little but your comment motivates me to keep grinding and be one of those great minded people in the future, thank you :)
@@sitisyazwani4658you graduated yet? Congrats!
@@sitisyazwani4658 Has it been worth it? I'm one month into my major and I'm also doubting whether this is for me or not
I can't wait to run my Microsoft-designed kids in for patch Tuesdays
Service key
Please no
I thought of this 15 years ago and my teacher at the time said I was crazy lol
1 year here.
I believe you 😬
Probably because you sounded childish and unsophisticated when you said it. Btw people have conceived of this for a loooong time buddy, actually do it is very different because its complicated.
Dude that’s life
Thought about something like this after learning about the basics of cell signalling from a friend. Knew about the idea of biological computers from and article 4yrs ago. Computer programmer.
Dare I say, what a beautiful (extraordinary) explanation, and presentation.
It's been long since having the pleasure of experiencing such intellect, and expert articulation. And that, in parallel. Inspiring. Thank you for sharing Sarah-Jane.
r/iamverysmart
That's probably why it's on the TED channel and not TEDx xD
Thank god this research is being done by Microsoft -- what could possibly go wrong?
I wonder how the blue screen of death will be expressed in a biological system 🤔
@@dumbledoor9293 you mean literal death
as opposed to the government? lmao.
😳😳😳idk about that 😂
But seriously am a huge fan of this
Funny! :) Jokes aside, not only are most of the advanced research centers running on Windows with a flavour of Linux for supercomputing, but also Microsoft is heavily invested in the space with some brightest minds working for them. I know, it's scary but the company is huge and diverse.
Hello youtube community. My Name is Ed im 25 years old from Illinois. I lost my Job about 2 months ago, Ive applied to over 100 jobs and had so far 2 interviews no calls or emails. I get anxiety sometimes...I pray and I hope that ill get a job offer, but here I am 2 months later and still no job. Even with all of the effort I put in I feel like its still not enough. I just have to keep my head up, tomorrow is a new day.
If you read this I hope you have a blessed day.
Get a taste of social engineering, they can't have jobs for anyone, but want to "program your cells", go figure what these mad people are up to !
Ed, all I can do is to wish you good luck.
Best of luck for the future Ed & try your hand at something different perhaps, something you really want to do. Have a good day brother
Omg..
I just quit my job today...
And I have no f**king idea.. what's Next!!
Maybe sleep till I'm decayed...
That was thirsty AF dude but hang in there
This is an extremely interesting and deep topic. We're creating computers while our bodys are working similarly. I regret not studying IT harder
Alexi IT would not have helped. You’d need a degree in bio engineering and computer science. CS majors and Engineers fall IT “I tried”. As in they tried to be engineers but failed.
Imagine how the cognitive capitalism of tech giants will shape our future. And with the growing threat of mass surveillance and cyberwarfare, who is left to defend our human rights?
A Brave New 1984 isn't it?
Mass surveillance isn't that much of a threat, focus in global warming.
@@clementlumumba4824 Sounds like someone who isn't facing genocide.
@@clementlumumba4824 Global warming is a completely different issue. Privacy and ownership of personal data, fundamentally belongs to the people, it's each individual's property and it's worth a fortune.
Everyone has something to hide. What mass surveillance does is catching every benign breaches of law and taboo, and since the public is all guilty, the executive part of the government can selectively enforce laws, essentially giving them both judicial and legislative power, infringing on the core principle of trias politica, the separation of powers.
Now do you think the elderly rich and powerful political elite actually cares about the climate? Or maybe they're too focused on manipulating the public for votes and accumulating more wealth.
_"Arguing that you don't care about the right to privacy because you have nothing to hide is no different than saying you don't care about free speech because you have nothing to say."_
-Edward Snowden
I once said in my presentation that bacteria will be the next sustainable USBs and everybody laughed. Look who's laughing now xD
Jeez, why is everybody down here flipping out ? Am I the only one actually looking forward to what they'll be able to do ? Just because it's Microsoft doesn't make it automatically bad, just as an university research lab doing the same isn't automatically good.
7:58 theory shows that automatically checking whether an arbitrary program satisfies a specification is in general as difficult as just executing it, so no, there is no general technology for checking whether a program meets a specification... now, of course, for the simple types of programs we typically write by hand it would be doable to write down or even automatically generate proofs of correctness, but besides maybe NASA and authors of complex distributed protocols (such as for your triply redundant cloud storage), no one does these "formal specification checks" (aka. model checking).
Great talk, but why the incorrect information about biomass solar efficiency? Plants collect sunlight at 2 - 6% efficiency. The current record for human-made solar cells is 46%. Lot's of great applications but learning from high-efficiency plant photosynthesis is not among them... =\
exactly!
This is what I'll research after uni
i want to but I'm stuck in stupid computer science, I want to do masters in computational biology.
@@dreamscapeai7 yooooo I also want to do a master's in computational bio. see you there!
Listen at 1:50
It's more complicated, it reacts to conscience, you are happy and a miracle happens cells react instant.
And then somebody hacks your immune system. LoL.
Well, different bacteria have different methods of avoiding the immune system.
Isn't this hacking?:)
Could be great for immunodeficient individuals? Potential applications in leukemias, lymphomas, multiple myeloma, HIV/AIDS, sickle cell anemia, many chemotherapy treatments, organ and bone marrow transplantation .........
Jesse Cabernel It’s cute that you believe scientists don’t already have the capability to do that in genetic engineering.
John Lamee Such cells exist?? Look up natural killer T-cell immunotherapy in cancer .....
it's call a poison
so inspiring!!!
The problem is that computer codes are running on system that operates at the speed of light while biological codes will have to run on biological/chemical processes that operates at the speed of a snail. You write your "Hello World" codes and sit there for hours or days to know if you got it right. Your code-run-debug cycle takes too long. This will make "biological programmers" productivity a lot lower than computer programmers.
The faster computers can simulate it before you try irl.
Testing Testing... I can see my comment but no one else can. Weird. Is this a UA-cam bug or some kind of censorship feature? hmm... No clue.
We must understand the programming language that created the genome sequence in order for us to repair, modify and reproduce an organism. Computational Biology is IT.
Very interesting work.
What has been discovered about nerve repair?
Has anybody used living neurons to interface severed human nerves?
A multidisciplinary group at UC Berkeley and an institute in China have been researching biological computation since the 1970's. Read "The Body Electric" by Dr. Robert Becker to understand the interface with the living creature.
And then someone creates malware for it.
wouldn't really help given there's no network to spread it across.
You mean like bioweapons. We already have that.
"As a computational scientist in biology, my goal is to identify the necessary abstractions to develop predictive, explanatory models of the biological programs that govern cellular behaviour." That's from her profile at Microsoft. Heady stuff...and a little terrifying. Are we sure we want that kind of power?
this seems to me to just be GMO dressed up with AI
@John Lamee I see your point about treating diseases like cancer, but where do we draw the line.
If a cancer is untreatable then that's just how the person dies. Saving lives is a good goal, but this level of treatment is rapidly approaching immortality.
Is death to be avoided at all cost? Is death not just a part of life? I for one plan to die when it's my time, just as God and nature intended.
@John Lamee That's a very valid response. I don't disagree with any of that. Thanks for responding. That gave me some more perspective. Sometimes my first reaction is to see the most worrisome aspects of a topic. What I meant by my time to die was that time when, despite all attempts, no amount of effort or medicine is enough. I value my life, but not enough to defy God to keep it is all.
@John Lamee AI = MAXIMUM RESULTS OVER EVERYTHING ELSE!!! ignoring safety nearly entirely unless the constraints are well defined. The important part is understanding the output, but in terms of understanding genetic syntax, we are pretty much just blind.
There is nothing abstract about biology. Their analogy will only go this far and they will learn through some hard lessons if they have not already. Abstractions are used by human mind not biology. Reality does not function under abstraction and it does not need to. You can't enforce abstraction on biology without compromising on its robustness.
wait aren't we in a simulation already
🙂🙂
why would you ask here then?
It's called the internet lol
Yeah, but you still upgrade your character in the simulation :P
Its amazing that every cell in you is replaced and only your conscious stays the same.
This could be that through water somehow it transfers the information or might actually be on the quantum level.
I have been doing research on this for years, and you are on the right track. RNA/DNA, or any living cell activity does not work without water, and there is more involved than chemistry. Enzymes are not just molecules, they are alive -- but water must be present.
your consciousness technically isn't same the more time passes the more you change from this moment including your personality and core values
@@colinkelley6493 or isn't it because nature loves everything free, and thanks to water, diffusion of important molecules is easier ?.. your lungs work by using diffusion too to exchange CO2 from your blood with oxygen in the bronchites, since they initially have higher concentration of each initially when u take each breath, they diffuse into the lower concentration counterpart.
Fascinating and a bit scary too but as with any frontier of knowledge it’s well worth pursuing - we must be very aware of the risks tho’.
Finnaly a concious comment that isn't apocaliptic
Love the yellow trousers! A TED revolution.
الامل في مستقبل أفضل كل الإحترام و التبجيل للعلماء الشرفاء .
Devastatingly simple! Perennial annuals?
Very Interesting!! Thank you..
Not mentioned is that once perfected it would be the pathway to physical immortality.
This is amazing! Always thought about this when i was in highschool, glad that they're researching it
I'm currently in high school & learning about the same thing! Cheers
Yes, then I can achieve immortality!
I thought millennials were suicidal
@@vve2059 and your sure that I'm a millennial?
*Immortality is a curse*
@@M.G.R... it depends...
@@M.G.R... There's a clear distinction between biological immortality and genuine immortality. I can't believe you're so thick that this must be explained to you.
Insight : Biology is like kids, you have to dominate it carefully with care, nurture it, guide it without being harsh. Plus, you and your intentions have to be very pure, like parents approach towards kids. Then only Biology will work in your favour, otherwise adversely. Domination should be enchanting, not brutal. Also, Biology works as a team, this should be considered too. One literally has to use emotions to program Biology.
Edit: scope of Biology could be beyond cell level to global level, like a global consciousness or emergence. This is because of millions of years of evolution and connections at quantum level. This needs to be considered too. As of now it behaves like grumpy kid locally.
great video
Fantastic! Bring it on!
The absolute WORST thing we could do with all this CRISPR-type stuff is rush into it. Humanity isn't ready for it, but unfortunately it does exist so lets not repeat the mistakes made during the software/internet revolution
Technology better be in harmony with nature.
Where is the ordering or structure ? What is the process ? Scan a persons DNA , Then model them in a computer, Make DNA edits in the computer and model the outcome, Finally make the DNA edits to person with some editing tool ? How long do the edits last, What order should the edits be made such as should I regrow a third set of teeth at 40 or should I first try to regrow my tendons and restore my skin to youth ? Seems impossible but we could go as far as modelling a human into one of those quantum computers maybe you could be able to move forward with the theory of editing a person.
To hear such enthusiasm for the potential of this technology with only a brief mention of it's dangers is kind of terrifying. Perhaps I only find this Ted talk disturbing because I have been made aware of some EXTREMELY unethical things happening in this area of research RIGHT NOW. I wonder if we will see Sara at the next Nuremberg trials.
🦋I’ve learned to keep things simple- as humans we have a tendency to over complicate things
Usually in my expereince it is the other way round. We tend to go with the simple answer and miss out how complicated things really are. Especially when it goes into predicting how things would turn out to be. I am not a chess genius so predicting 2-3 turns ahead i think is rather usual, but what happens in causalities 7, 10 or more cause and effect actions down the line? For example i see so many people being hyped about science into immortality, but not many questioning how systems not built for it would turn out to behave. Do you want immortal politicians if they are not of your party? What about immortal billionares ... ? Over complicating to me means not coping with reality, but struggling to understand. The yearning for simplicity is human and understandable, but with all the technologies upcoming it is often a luxury we may not have when judging how those should work. On the other hand if you talk about how to keep your private systems running simple so you can overview them quickly and decide fast, that is very economicly efficient and often leads to either more spare time a leaner work flow and being more relaxed while managing your life overall, which i guess you were hinting towards.
I also like to keep things simple, yknow, like, not having generalized cancer or AIDS or something. This could do the trick. They aren't speaking of growing another pair of arms.
Descamps Etienne 🦋having MS & being a mom know first hand that keeping things simple is so important
truly inspiring
Very interesting and very well presented.
But the limitations are there: turn a cucumber into a earthworm.
More plausible than you think, over time genetic therepy while keeping cells alive through the transition. I'm sure that more radical transformations than cucumber->earthworm are physically possible.
I find this fascinating!
Especially in the area of agriculture seeing the impact it can have on general food supply worldwide. I see greater yields, improved quality, improved shelf life for storage, ease of processing and more products that can be discovered.
This can help overcome the problem of hunger in different parts of the world.
My concerns are usually around how these innovations can be regulated. In the quest of improving life on Earth, we shouldn't distort the existing systems too at the same rate. We must seek balance in all of these.
Nonetheless, I love the Biology and Tech combo. Cool.🙂
Nice information! Great presentation!
These are the mad scientists we watched movies about as kids.
Thank you for sharing. =)
I found her discussion illuminating and intelligible to the lay person. However, despite this, I am disturbed by her casual optimism with regard to "bio-ethics" . Is she completely blind to current events? Did she fail to recognize climate change? Is she oblivious to the immense divide that exists economically between nations and within nations? Is she ignoring the political and social divides that are destabilizing the world? Who is going to benefit from this technology? The pitchforks are at the doors of the governments and corporations of this planet! Good luck, lady!!
now someone's gonna write some JS framework for this thing too...
This came to my mind too: D lol
6:00,,couple of videos ago, They were talking about interfacing AI with the neurotransmitters of the human brain,,,talk about regulating
This all sounds great but we are still in the experimental stage. We need to see practical daily use.
I want to know when someone will port Doom or Quake to run on my rosebush.
Excellent
Sara-Jane, are low income people going to have access to life extending technologies?
Sadly no, rich people would also become poor after spending on it though.
Awesome and not imaginable for us
What could possibly go wrong......
I'm studying biology, the topic biochemistry is useful to our field but it is much harder to study than the living things such as plants, animals and humans itself.
This subject is the reason why I'm failing my class. If anyone can give me an advice about this, please do. I really need it.
Biochemistry requires you to understand the biological processes in a chemical manner which involves reaction mechanisms, enzymes their regulation by a lot of factors ranging from feedback inhibition to second messengers and so you must devote sufficient time to this subject and try to enjoy the learning process although it gets boring at some stage. Refer Lehninger-Principles of Biochemistry and take assistance from UA-cam channels like Khan Academy, Crash Course Biology, Bozeman Science and MIT OCW, which would help you in developing interest in this subject. In the end, you need to put a lot of hard work and have the patience that with time your understanding of the subject matter would become strong.
@@AbhaySingh-wi4qu wow! I was just going to recommend that she drop the class and wait.
@@thucydidesvonschlieffen893 Hey I don't wanna drop class 🤣
@@AbhaySingh-wi4qu I will! Thank u so much💗
@@jeweljimenez715 then don't drop, and study hard.
That was awesome
Love is always a demonstration - not just a set of words or a feeling.
This is why I love Ted talks ♥️
Ah yes, *No views* , 252 likes, 7 dislikes and 36 comments. 🙄
good to know
Now that is really cool.
This was a pretty pumped up talk! Nice!
Anyone got DOI sources on that research?
2021 , Most people think I'm delusional. They say it is not possible. I say it is only the matter TIME.
I want to design a machine will destroy the doctors and their need.. I hate doctors and I want to destroy them by designing a machine which will perform their work . I know this seems impossible today but I will make it possible when I will grow up currently I am a jee aspirant and I have started building my foundation since class 6 and now I am in class 9 and I am now completing the jee syllabus!!
That's not a sort function, that's a comparator function.
"Biology" is not a material. Very weird wording.
Why is everything so focused on maintaining a growing population? Lack of resources aside, it's literally lowering the general quality of life. No one enjoys living on top of one another dude.
Humans are maladapted to abundance, and thus will blindly defend a pro-natalist stance in the face of consequential devaluation of human life and massive over-consumption of resources. It's effectively insane.
@@SolarScion More people means more smart people.
150 person tribes couldn't invent smartphones. Maybe 12 billion people is what it takes to develop faster than light travel.
Don't be so pessimistic.
At the end of the 6th day, God looked and said it was good. On the 8th day people started using the climate as an excuse to kill each other and try to make others eat bugs for sadistic entertainment. How about we view people as inherently valuable.
This a revolutionary, highly challenging idea that may help
The difference is that any living cells exist by creation, hence its perfect. perfectly understanding the working of it might not be possible. Secondly there should be zero error in its implementation since it's dealing with life of a beaing.
Software engineers generally are unable even to get a zero bug computer program. Then how is this going to be logical
But I think it may help to fix certen level of biological issues , if succeeded
We could...
I dreamt that yesterday and hence I searched it on UA-cam.
In the various wisdom traditions of the world huge emphasis is placed on ethics and conduct. Goodwill for others is encouraged while greed is discouraged. Patience is always a virtue. Through applying these principles we come to see the utter beauty and perfection of things as-they-are. Musicians of profundity, especially classical but of all traditions express these things through their music for those with the patience to listen.
There is a natural balance but it has no place for excessive greed.
Note there is no awe or amazement expressed here about how biology is operating just as it is. How is has served and is serving us.
Like Francis Bacon who spoke of stretching out mother nature on a rack and forcing her ro reveal her secrets the only concern here is how to squeeze out more, how to build human created things bigger and better. No concern is expressed at all about any form of limits or constraints.
We just go our greedy way ahead and program biology to serve us with no appreciation whatsoever for what is since it's all godless anyway.
There's another way and many know it. It's called love, gratitude and appreciation. Meet you there!
More then 50 years ago I read a book named "The biological bomb" that described how biological science was advancing sooo fast that in 50 years the world would have totally changed. Well here I am more then 50 years later and today many of us has lost our faith in artificial medicine/biology. (I did not watch the video to the end...)
Remember there have been incredible advances in biotechnology in that time. Antibiotics have saved millions of lives. Synthetic insulin has reduced the price and increased the availability of the drug. Vitamin A enriched rice deployed in regions undernourished has the ability to prevent unnecessary blindness. The list is actually very extensive.
@@mariannehaines4982
Those advances You mention has certainly not changed the world in a spectacular way as promised in that old book or in this TED Talk.
The world has no doubt been somewhat modified due to biotech applications from the severely corrupt biotech industry However the advantages and disadvantages of that is a controversial debate:
While I agree that some natural antibiotics like penicilline and tetracycline, has saved many lives in the modern world, they are not really the product of biotech but by other organisms that ancient cultures understood to use. But we don't.
microbiologysociety.org/members-outreach-resources/outreach-resources/antibiotics-unearthed/antibiotics-and-antibiotic-resistance/the-history-of-antibiotics.htm
Further we know today that modern antibiotics may create more harm then health. In fact it is quite usual.
"Synthetic insulin has reduced the price and increased the availability of the drug"
If You believe synthetic (bio-engineered from bacteria) insuline is a biotech advancement/human advantage You REALLY need to read this article from Independent diabetes thrust: www.iddt.org/diabetic-commonsense/the-great-debate-natural-animal-or-artificial-human-insulin?cn-reloaded=1
c) Golden rice (=GMO) may be golden for the manufacturers but involves many serious risks to health and here is a quote from Greenpeace (VAD= "vitamin A deficiency):
"Dietary diversification addresses multiple deficiencies, and in the case of home gardens empowers people to diversify their own diet. By looking at the root causes of the problem, a range of projects such as home gardens and diversifying farms can eradicate not only VAD but also tackle all other nutrients and malnutrition in the same instance. Sustainable solutions to VAD and other micronutrient deficiencies are proven and in use. The real need is to ensure that these solutions are rolled out to the people who need them"
Further, if poor people are fed with GMO food their health will deteriorate. In stead we must solve some social problems incl inequality such that they are able to apply the solutions Greenpeace recommends.
The biotech industry is severely corrupt and do not care about poor people's health except as an opportunity for enrichment.
The vaccine industry is a particularly illustrious example on harmful biotech industry with negative human value.
Having noted the above, I am convinced that more and better education and research indeed are the solution to our future problems if we only can remove corrupting incentives from the the society.
Wait can you program real life computer virus?
That blows my mind...
"programming biology is not going to be something you are going to be doing in your garden shed".. doubt this quote stands the test of time. Recall a recent Netflix series... dude in shed with crisper. Not same techniques, but still.
You mean Altered Carbon ? While I do doubt that this won't become widespreaded at some point, just because it is doesn't mean everyone can do it that easily.
Descamps Etienne “unnatural selection” on netflix
@@haffordj Oh well, that did look like Altered Carbon from your description. My bad.
Sounds like: biological computing will not overpower the current conventional computers in every aspects, they will only be good in some aspects, is that so? so, in the future, binary computers, quantum computers and biological computers will coexist forever? None of them will be obsolete?
Imagine a simple "hello world" program in wetware. What would it look like??
Get Bloomberg to invest in this instead of his presidential campaign.
About this technology, I somehow think China has far more knowledge and experiences than other countries.
I like to think of the genome, or dna, as a long ribbon, with codes along the ribbon being utilized from birth (start of genome, start of code) to death (end of genome, end of code)…. 2,500,000,000 genes is approximately 1 gene being executed each second.
Manipulating our genome is one thing. The fuel our genome burns, and its consequences is another.
What’s the word that I was looking for
Ah yes kernel, what’s the kernel for biology programming?
Ray Kurzweil predicted this over 11 years ago. It will happen.
A child licking a light switch may think it's interesting, they may be amazed by their ability to light a room and then make it dark again, they may feel like master of that room.
But it's not the lack of understanding that makes this situation dangerous, it's being smart enough to think there are no consequences in nature.
Human nature is to lose respect for all things we 'understand'.
“Operating system that runs living software” sounds like biblical system of the Beast.
And then, someone creates ransomware for it and asking for bitcoin.
I’m waiting for my smart biological phone.
soon enough people will be immortal fr
Imagine going to best buy to get an upgraded arm
Sara said something which I have been suspecting for awhile now: DNA is holographic, running under quantum principals. If so, that would explain the incredible entanglement of the helix it's self. Which hints to the reason why our brain is so crevassed, and as one becomes more intelligent, more so it becomes.
Being said, that would give rise to truly living, functional, "Created" beings as such as we are, but being silicon instead of a carbon based entity. . ?
Knock-knock. . . "Good to see you friend!. . Come in, come in!.. Welcome to dinner! Would you like a bowl of sand with a glass of some hot, freshly squeezed D.I. water? Maybe an arsenic biscuit too??"
You know I am waiting for biological evolution from 2010. It has been 9 years now but no groundbreaking evolution in biology 😣😥😢.
2020, Do you still have questions?
@@cynthiaherrera1714 🤣🤣🤣 Are you directing my attention to Covid-19.
Love from INDIA
That function should be called, compare(a,b) or signOfDifference(a,b), NOT sort(a,b), just saying - I would reject your pull request...