How the Body Absorbs and Uses Medicine | Merck Manual Consumer Version

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Absorption affects bioavailability-how quickly and how much of a drug reaches its intended target (site) of action. Factors that affect absorption (and therefore bioavailability) include:
-The way a drug product is designed and manufactured
-Its physical and chemical properties
-Other ingredients it contains
-The physiologic characteristics of the person taking the drug
-How the drug is stored
A drug product is the actual dosage form of a drug-a tablet, capsule, suppository, transdermal patch, or solution. It consists of the drug (active ingredient) and additives (inactive ingredients). The active ingredient is the chemical substance (the drug) that is taken to produce the desired effect (such as lowering blood pressure). The additives (inactive ingredients such as diluents, stabilizers, disintegrants, and lubricants) are mixed with the drug to make it easier to swallow or help break it up in the gastrointestinal tract. For example, to make tablets, the active/inactive ingredient mixture may be formed into small grains and compressed into tablet form. The type and amount of additives and the degree of compression affect how quickly the tablet disintegrates and how quickly the drug is absorbed. Drug manufacturers adjust these variables to optimize absorption.
Because drug products that contain the same drug (active ingredient) may have different inactive ingredients, absorption of the drug from different products may vary. Thus, a drug’s effects, even at the same dose, may vary from one drug product to another. Drug products that not only contain the same active ingredient but also produce virtually the same blood levels at the same points in time are considered bioequivalent. Bioequivalence ensures therapeutic equivalence (that is, production of the same therapeutic effect), and bioequivalent products are interchangeable.
A number of other factors may affect the absorption and bioavailability of a drug taken by mouth. Physiologic characteristics include:
-How long the stomach takes to empty
-What the acidity (pH) of the stomach is
-How quickly the drug is moved through the digestive tract
-Other factors include a person's age, sex, level of physical activity, and level of stress.
Food, other drugs, and digestive disorders can affect drug absorption and bioavailability. For example, high-fiber foods and calcium supplements may bind with a drug and prevent it from being absorbed. Laxatives and diarrhea, which speed up the passage of substances through the digestive tract, may reduce drug absorption. Surgical removal of parts of the digestive tract (such as the stomach or colon) may also affect drug absorption.
Where and how long a drug product is stored can affect drug bioavailability. The drug in some products deteriorates and becomes ineffective or harmful if stored improperly or kept too long. Some products must be stored in the refrigerator or in a cool, dry, or dark place. Storage directions and expiration dates should be strictly adhered to (complied with) at all times.
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