Islet cells: A cure for Type 1 diabetes? | Eelco de Koning | TEDxBoerhaavedistrictStudio
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- Опубліковано 7 чер 2024
- Can type 1 diabetes be cured? In this talk Eelco de Koning takes us on a journey through time. He explains what type 1 diabetes is, how it is currently treated and what the future for patients could look like.
Credits and thanks to: Recording studio sponsor @ University of Applied Sciences Leiden. Graphic design by Esmé Postma, Ire Oyekan and Sheila Herron. Intro music Birds by Scandinavianz | / scandinavianz Creative Commons Attribution 3.0 Unported License creativecommons.org/licenses/... Eelco de Koning is Professor of Diabetology at the Leiden University Medical Center (LUMC) in the Netherlands. He coordinates the national islet transplantation program in the Netherlands and he is medical director of the human islet isolation and transplantation unit at the LUMC. He also heads the LUMC Diabetes Center focusing on person-centred diabetes care. His research aims at a better understanding of human islet biology, islet regeneration and preservation, and novel sources for insulin-producing-cells. He is principal investigator of the regenerative medicine consortium RegMedXB and the international stem cell consortium reNEW that are focused on developing novel islet replacement strategies for type 1 diabetes using pluripotent stem cells.
This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx
My greatest hope is to live to see a cure happen for my son and others suffering from this terrible disease
Yes it's bad.
Me too!
Me too
I have been following research on T1 since my first child developed T1 in 1993. Since then, I had two other children develop T1 and then I got it when I was 59. I remain hopeful for my children that they will experience a cure in their lifetime. I also agree with one of the other commenters that we T1 people need to enjoy the life we have now too. It is hard work but resistance is futile. My tail is still wagging.
Fellow tail wagger Tom, Rock on.
God bless you all I got it at 23 and my uncle's son at my age yet he got it when he was less than 1 year old and my cousin's son got it too. I did read lots of research on this topic and we get diagnosed with this autoimmune disease. It is genetic and there are some environmental triggers that cause it to occur, even parents' anxiety can be transferred to their kids if parents faced trauma or an accident. The story has more to it yet I cannot mention that in a comment. As you said sir enjoy your life as T1d or paralyzed or healthy nothing deserves to be sad about:)
I got T1 when I was 57. It is believed that people over 30 can only develop T2. If there is a cure for it, it won’t be in our lifetime. I hope this cure is around for your kids.
I got T1D in 2006 at the age of 34 (now I'm 51). In all that time the only way I've found to successfully manage my blood glucose and insulin intake is to be on a keto diet. Even my doctors say "don't do that you need healthy carbs" and to them I say no, you're telling me to eat the food that makes me need more insulin and have out of control BS and feel ill.
Until we have a successful cure, like what Prof. de Koning is talking about, I will cut as many carbs as I can to remain healthy and have good diabetes control.
To be fair, if I do ever get this cure I will stick to a keto diet forever.
Please make this happen, I’ve struggled with type 1 for over 20 years, I was only 10 when I was diagnosed.
I’ll be honest, I still hate living with it, I’ve tried so hard to have better control of it but I never have and I’ve recently started paying the price by losing most of my vision in my left eye.
I’m worried about the next few years, it’s taken a toll on my mental health now too, also there’s now 4 people in my family that have type1.
I’d give anything to live the rest of my life diabetes free. I hope there’s a cure before my time is up
Don't worry dear there will be cure😘
It’s really an understatement to say that we can understand the pain it causes you my brother, we pray to Allah to ease your pain and equip you with the strength and recovery, Bi’izni’Llah.. hopefully one day Insha’Allah we will find the right cure for everyone enduring this pain and suffering in silence, amidst us. May Allah reward your perseverance.(tawakkul) aameen❤️
@Positive vibes no there will not, you're dreaming. Too much money to be lost.
@@bslomof-1901 exactly what i was thinking, eliminating cancer and diabetes from the world would leave big pharma struggling like the rest of us, it’s true, think about it.
@@type1dyl24 yes,sad but true...
I was diagnosed at age 3 and now I'm 45. They've been talking about this stuff the whole time, with next to zero progress so far.
great talk, I enjoyed it.. Thank you
Thank you so much Dr Obulor @youtube, for your full dedication to your work and knowledge you compose to save lives. Keep up the Good work sir🙏
when my granddaughter was diagnosed at 3 years of age, we imagined she might see a point where diabetes could be a thing of the past. Now 20 years old, perhaps it will be a distant memory within the next decade...
"her brain can relax" sums it up really 💚
Slow progressing type 1, that was my second diagnosis last week from my endocrinologist, after suffering from dka back in late June. Was diagnosed as a type 2 back in 2017. Insulin therapy is a whole different ballgame.
Good job
Thanks🙏!!
Seems exciting! Though it would take decades then to be available to patients in developing countries.
Thankuu you so much sir you most valuable deep disease research and past example also again thankuu you so much sir🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏
Thanks for the information, several years ago the U of M did this to 100 patients. Would like to find the follow up results on that group. My daughter just “celebrated” 20 years with this bummer of a disease. Yes, people can live with it but the constant reminder is very depressing for the patients. We keep praying and donating towards a cure🙏
I was lucky enough to be enrolled in a few of their studies! They changed my life for a few years. The effects of my study wore off after an average of 2 years, mine went for 4
@@EpicWarBoy Thanks for the reply! Do they have any plans for follow up procedures for you? My daughter is 22 and would love to “get on a list”
Life is a bummer disease with the constant reminder of suffering, diabetes or not, if you so chose to live that way. My diaversery of 47 years is coming up soon. While i appreciate your prayers and donations, we still have to live, thrive, and adventure right now!
Please, Science, solve this terrible disease!!!
God willing 🙏♥️
All diseases are horrible. There are much worse ones than type 1 diabetes. Don't let it stop you from doing anything!!!! So thankful for the tech we have today with type 1. -Brian. Type 1 for 47 years and counting.
Lets HOPE that our suffering ends soon
@@parmeetsingh7705 The suffering stops, the second you chose not to suffer anymore.
@@OneTakeSunday i try my best though , thank you for your advice
I'm Jane. Waiting and waiting.
Eagerly waiting for a cure for type 1 diabetic ...🙏
Alslam alikm
Thank u for u work
Please cure this …. I don’t want it anymore 😢
Using the body’s own stem cells seems like the best solution, due to the lack of need of immunosuppressive drugs.
I hope that medical miracle will happen soon
Restrict carbs to no more than 6grms for breakfast and 12grms for every other meal. This eliminates the need for fast acting insulin. Slow release should still be taken. This regime works very well for my son of 16 with type 1. Every now and then he can have a treat measured with a dose of insulin. Not quite Keto but close.
My mom had two of these transplants and second one worked. Was a brittle diabetic
Is it done?
we suffering with diabetes type 1 please doctors do something for us
Thank you for talk!Every one must to control Diabet and most those that have member with Diabetic in Family😍🌏
Sweet indeed. My daughter may be able to enjoy a somewhat normal quality of life. It's a tough world even for those without T1D.
Yes!!! Everyone struggles!!! We all have right now. -Brian, Type 1 Diabetic for 47 years and counting!
@@OneTakeSunday and here's to a cure plus 47 more! Bravo
Please help me sir 🙏 my son five years type 1 daibetic problem
I've been living with type1 Diabetes for 2 years still waiting for the cure
While I commend the work on stem cells (my 2 children fight type 1), I'd suggest we also need to undertake a retraining of the immune system (opposite of immunotherapy used to treat cancer) to remove the need for immunosuppression drugs. We can't move from one drug dependency (insulin) to another (immunosuppression).
Hey t1d community, what is the most effective way for you all to learn about these complicated themes related to cure research and clinical trials? I am working on the impact campaign for the feature documentary, The Human Trial, and am exploring ways to better educate t1d patients about the power of clinical trials. Any thoughts?
what are the requirements to get accepted to receive? Our daughter was 35 when she was first diagnosed with Type 1.5. she is now 40 and is doing well, but as the pancreas diminishes the numbers vary. how do we explore this treatment?
Merci
Please let this be! My precious daughter has suffered for so many years.
Don't fight diabetes, accept it, thrive with it; every human has struggles. Today is a great day to be alive. Thank God (and Banting!) that we have insulin and closed loop systems as co-pilots. Brian Type 1 diabetic for 47 years and counting.
@@OneTakeSundayhow can i cope with the anxiety of getting complications later in life? I'm 13 and ive had diabetes since I was 7, but my sugar was very out of control for about 3 years (2019-2022) but now I'm doing way better and my average blood sugar is 5.8 mmol. I'm worried if it has permanently damaged my organs. I've had no symptoms of any disease/bad eyesight and nothing bad show up in blood tests, but I'm scared that my past terrible management lowered my life span and quality of life. It's really hard dealing with this disease and i dont think a cure will be here any time soon so im trying my best to control it. If i keep managing my blood sugar well will i be able to avoid complications and have a normal life? Thank you :)
@@cindysvibes9895 Hi Cindy! Always a pleasure to meet another type 1 🎉!! If you live in the future, you are anxious, if you live in the past you are depressed, if you stay present, you are at peace. There has been far worse control than you, or I, have been through (check out the book: “Breakthrough: Elizabeth Hughes, the Discovery of Insulin, and the Making of a Medical Miracle”. Elizabeth didn’t even have insulin available to her for 3 years, because exogenous insulin wasn’t derived yet, and she lived a fantastic life!). If you feel yourself trying to predict the future, get some tools to come back to the present. When I find myself worrying about my kidneys shutting down again (they got damaged when I was 14 years old, and not diabetic related when they shut down for 3 months) I will feel my surroundings; I will feel what my chair I am sitting on feels like with my hands, I will notice how my toes feel, I will feel my pillow against my cheeks, and if it gets really bad, ill grab an ice cube and just meditate with it, trying to hold it for as long as I can. I also pray, a lot. I will pray for you as well, my young friend. I’ll leave you with this question though, who is going to have the best quality of life of these four scenarios(rate them in order from best to worst): 1)The person that worries all day they will develop diabetic complications, and do develop them. 2)The Person that sees the future as one with a cure, hope, and delight, and develops complications, 3)The Person that sees the future as one with a cure, hope, and delight, and gets the cure. 4)The person that is happy and grateful to be alive right now; the person that is on a walk, listening to the birds chirp, or a loud jet plane, or feeling the cold, fluffy, carpet, with a layer of warmth trapped between their socks and the ground.
@@OneTakeSunday FU.
@@vincentwiese8414 Seeing as how it is Palm Sunday, not even gonna bite. I forgive you. Even though you're now blocked, i wish you well.
How are these stem cells preserved? I have low islet, but my body does not attack my islets. I do need insulin though. I had a stone in my bile duct and the acids went to my pancreas. So I have low islets. Seems this could be good.
شكرا جزيلا لتعليق الخاص بك ... هل هناك اسباب اخرى لانحفاض الانسولين
@@abdullahalzaben8200 Unfortunately I can’t read in this language. Maybe my daughter can. She speaks Hindi fluently. Don’t know what language this is in. Will try to decipher it though. Thank you.
@@abdullahalzaben8200 I don’t know if the question about low insulin is for my personal health. But as for me, when the stone blocked my bile duct, the acids went to my pancreas, and liver. My liver is good now since it’s been over 13 years ago but my pancreas is about 40 % of what it was. Funny at the time I was still not diabetic until 2 years afterwards. My doctor says I still produce some insulin but not enough to control my sugars.
Watching a loved one to deal with TD 1 every day 24/7 with no breaks is heartbreaking. A person with TD1 takes the challenges of dealing with the disease on , because the alternative is dying. I would love to believe this caring doctor but I think that treatment of TD 1 is a billion dollar business a year and pharmaceutical companies will not allow a cure!!!
@jeminaz5644 I so, so agree with you especially in the United States. They're all about making money off of diabetes, cancer, heart disease, just to name a few. I've had T1D for 47 years and when I was first diagnosed, all I would hear from the medical profession was how close they were to finding a cure. I haven't heard that song and dance for decades.
Sweet does not cut it. There is no word for how beautiful that day will be. I have been type one for 45 years. I am now 50 and I’ve been hearing that the cure is five years away since I was five years old. Let’s hope it’s under five years now. The day I don’t have to count. Carbs inject insulin will be a very very beautiful day indeed. 😊 and have no bloody hypos, which I am having right now.
Thank you so much Dr osaye for believing in me and showing me the importance of herbs,your herbal suppliments are a major impact in my life
I am still waiting for Dr. Eelco de Koning to give me a call, which he was supposed to do two years ago, to participate in his research.
The reason I never got the call was probably because I don't use insulin and companies paying for the research don't like that (nor do my doctors).
From the very first time I started seeing testimonies about you Dr Igudia , I always had full confidence in you that even if I had purchased your medicine , my Diabetes test would be tested negative , now I'm so happy that I could finally say thank you so much Dr Igudia . you really are a God sent and i appreciate you a lot
bot
Can a mama give her beta cells to cure her own son of type 1 diabetes? I'm certainly really ready for my youngest grown son to be cured once and for all.
انت ام رائعه ... وانا فكرت بهذا الامر .. اود التبرع بكامل البنكرياس الخاص بي لابني الوحيد .
I can't possibly thank you enough Dr omoruyi for the excellent remedies you produced to your patients ,as a unique gift of love, I want to use this moment to appreciate you, I'll recommending you to the world™™™
I wonder what could have become of me if you weren't the one who came to an interval in my life. Thank you for curing my Diabetes naturally Dr Gboya . I immensely appreciate you. ❤....
I just want to be the Rambo in a possible zombie apocalypse scenario
I have diabetes type MODY, which is a hereditary form of diabetes. My DNA has a mutation that makes it harder for islet cells to respond to high glucose.
My hope is that one day, this mutation can be repaired with crispr-cas9. This is much easier with stem cells in a test tube. If these repaired cells can be turned into islet cells, multiplied, and placed back, I would effectively be cured. The positive point is that my diabetes is not an auto-immune disorder so I don't need to suppress my immune system if the islet cells are made from my own stem cells.
I don’t know what I would have done without your help. Thank you so much for curing my type 2 Diabetes with your herbs Dr Igudia
Please find a cure… my child is diagnosed when she 1 year and 7 months now she 3 years….😭😭😭😭😭😭
🥺🥺🥺😒😒😒😒
Words aren’t enough for me to show how I grateful I am for helping me to get rid of my Type 2 Diabetes Dr Igudia
Why this strategy of organ donor, when you have similar and potentially better products with "pouches" that protects the cells.
what do you mean?
I thank you so much Dr Igudia for sending your Herbs to me which actually cured my type 2 diabetes. Now I’m free and enjoying my new life
The point starts around 08:52.
Rant follows:
Get to the point! 6 min in and he is still talking about something else (history of insulin). Oh, he is starting to get to a point? No, still talking about the wrong stuff but now we are at the organ donor islet transplant stage. 08:52 finally!
He just had to go over the 10min. mark for UA-cam.
Why not talk about the subject the whole 12min?
I understand what you are saying but this is a TEDX talk to inform somebody who may not know anything about it so he wants to inform them about everything, including the history of how it started.
@@Max040fficial He should still cut out the history lesson and get right to the point and rather add more detailed information. If I want a history lesson I search for it.
Drives me nuts too, we all have busy lives, God I wish they would get to the point!
Thanks because i was gonnna turn it off got so bored haha
2023(Gregorian) “Respect and dignity.” Furthermore:
I want to be fixed, I have had this disease since 8th grade
Try keto or carnivore, intermittent fasting , helped alotta people
@@gusc6785 not a cure bozo
💖
@@gusc6785 that would actively kill someone with type 1 diabetes, don't spread that around as a cure
@@gusc6785 That would not help for Type 1 diabetes. Types 1 and 2 are very different.
Yeah I have only had Type 1 for 4 years, and a cure would be nice. I can't complain, but the disease controls your life. Making Insulin affordable for all who suffer from diabetes is a good start too.
THANKS FOR BEING THERE FOR ME MY (diabetes) IS COMPLETELY DONE Dr ogie on UA-cam ✅💕 0:01
Speed up the cure. Please, it is overdue and people will suffer without the cure.
DMSO. 👌🏻
I know I'll never have the chance to benefit from this treatment, but perhaps my son might. Of course, it would not reverse my retinopathy or improve my 30% kidney function.
Right there with you with CKD and type 1 for 47 years. Don't worry about the future, please live for today.
I’m 33 and have retinopathy, recently had 2 eye surgeries in hope of gaining some vision but unfortunately I gained very little, I’m about 70% blind in my left eye now, I’m so worried about losing vision in my right eye, thankfully it’s healthy for now, but the vision loss in my left have affected me in so many ways, it’s very frustrating. I’d give anything to have my vision back.
Times used to be very Challenging, I had the worst days of my life living with Type 2 Diabetes, I appreciate you so much Dr Igudia, You have restored me my life that was lost already . Thank you so much for curing me of my diabetes with your natural Herbs 😊
Words failed me on how to appreciate you for sending your Herbs to me after I place my or order which cured my type 2 diabetes’s Dr Igudia
Words failed me on how to appreciate you for sending your Herbs to me after I place my or order which cured my type 2 Diabetes Dr Igudia.
Does it went permanently. Please help I'm suffering. What is the procedure
Since the moment I first saw Dr osaye,I felt taken well care of,with the smile he wavered at me,the time and efforts he took to listen to my problem and provide me with a soluble answer,I'm sincerely grateful
Paid, fake advertisement. No such thing as cure yet for diabeties.
The beta cell cure is tooo expensive 🥺
Anything that is inaccessible to the poor is neither radical, nor revolutionary.
Insulin costs hundreds of dollars a vial in the US.
Tell me, what will be the price of islet cell treatment?
probably the same amount the pharmaceuticals will lose if they allow a cure.
“Imagine how sweet that will be”.
Yes, imagine. Imagining is the furthest we’ll go, because our clown show of a government will do whatever they can to keep the path to a type 1 diabetes cure slow af.
Tell Brian Shelton to "imagine". We are so close to a cure, but cure or not... we all have right now. Stay present my friend, -Brian Type 1 diabetic for 47 years and counting.
This mama doesn't care about false fake fingernails and acetone in the nail salons. I care about the health and cure for my son's diabetes
Thanks you Dr Igudia on UA-cam for all you do in my life and my family. I went for a test today after taking the medication i ordered from Dr Igudia and I tested type 2 diabetes negative. Thanks doctor I will keep letting the world know about your good work sir
Really???
In 2023 you are still lecturing and summarizing the history of T1D and its potential cures, which have been known for five years at least? What's the point of such presentations? To prolong people's hope once again?
Why not expedite all the efforts, raise tons of money, like they did for the COVID-19 vaccines and other meds? Simply put: WHY SO SLOW?!
Doctor osaye has shown a lot of compassion to his people buy working tirelessly and providing us with a herbal solution to diabetes, we're grateful.
Bro idk what herbs you're talking about but there's not herbal solution for type 1 diabetes...
... the stem cells... 1998 studies... results... come on!*
Just a few more years guys 😂
Words aren’t enough for me to show how I grateful I am for helping me to get rid of my type 2 diabetes Dr Igudia.
...he's talking about a cure for type 1, this wouldn't cure type 2 bc it treats a lack of insulin production, not acquired insulin resistance.
T1D is the worst
Ya perdy dinero me serraron la pajina u akien reclamo
Medicine mafia - can't do that , because they earn money for their customers.
😂😂😂the doctor don't want to understand that diabetes comes because of excessive stress
The human trial documentary, shame the cells wasnt ready for the 100th anniversary of the discovery of insulin. Id be surprised if it can keep blood sugar below 6.5, 117 at all times
it was a great documentary, but i was disappointed that Brian Shelton was mentioned in it. Those cells that he got, first in human islet's developed from stem cells, worked with a 50% load. Also the company that made those stem cells, Vertex, bought Viacyte, the company followed in this documentary. I am close to 117 all the time. -Brian, type 1 diabetic for 47 years and counting.
@@OneTakeSunday They've also struck a deal with gortex. Nice, can't complain about your results, well done for putting the effort in. Will this cure be able to mimic a functional pancreas, itl be hard to cause the food will have a headstart
Sadly it won’t ever be cured as there is too much money companies make off of everyone’s ailment. Been type 1 for 31 years and it’s been the same hype since I can remember.
We sit like brave dogs. Maybe we have to act then
exactly,very sad but true
Please hurry 🙏 my daughter is 12
Don't let a cure stop you and your daughter from doing anything!! With love, Brian. Type 1 diabetic for 47 years and counting.
I am type 1 . Hate it
Don't let it rob you of a happy, adventurous life! Diabetes is a tough thing to accept, but acceptance is key for me. Stay present my friend. -Brian Type diabetic for 47 years and counting.
We all do , we gotta keep pushing through have someone to talk to about this it might help even a little bit - Parmeet Singh t1d for 11 years and beyond
Same. keep going forward dont dwell on it brother :)
Citrus bergamot helps massively
YOU ARE REPEATING YOURSELF!!!
Our Daily Foods Waters Soils
Too Contaminated!
Start THERE .NO MORE FALSE MARKETING!
Proverbs 3:5-6
God Bless
His Righteousness’s Love Truths Discernment’s And Good Common Sense. Each New Day Never The Less.
HalaluYAH
Thank for this awesome educative video I'm happy I made $22k weekly from a very profitable investment platform
How do I join these investment platform so that I can earn?
@@deannasundberg Woah you really was dropped on the head as a child?!?!
Carnivore Diet. Research it.
I highly doubt a "carnivore diet" can cure an autoimmune disease.
this is how to make people not take you seriously.
That helps type 2. Not type 1.
@@Mmax389 ok, thanks. I don't have Diabetes, so I don't really know much. Just have a good success story from my brother. He did carnivore Diet and his type 2 is gone.
@@mozmatt4716 actually. You'd be surprised.
Thank you so much Dr Obulor @youtube, for your full dedication to your work and knowledge you compose to save lives. Keep up the Good work sir🙏
I thank you so much Dr Igudia for sending your Herbs to me which actually cured my type 2 diabetes. Now I’m free and enjoying my new life.