To be fair, at the height of the Cold War where NBC (nuclear-biological-chemical) warfare could break out any day, such an awareness was necessitated. The times called for it.
I would love to see an episode about protective suits and the special lab equipment and techniques used to protect yourself. I know you love safety Professor, and I'm sure Neil wouldn't mind wearing the suit.
When I was a kid I took our dog, a huge black poodle, for a walk on a foggy night. For some insane reason I wore an old gas mask too. We met a man out for a walk. He screamed, jumped over a hedge and ran into a garden. Gas and gas masks are not funny. I'm still slightly ashamed. And smiling - slightly.
Speaking about the gas mask I once did a university placement studying Radon; and again it was found that activated charcoal made from coconut shell is the most efficient absorbent. Even more so when cooled by liquid nitrogen. A cryogenically cooled-gas-mask may function even more effectively than a standard one. Interesting stuff.
I would suppose that the reason it is more effective is because of thermal shrinking within the fine ground coconut carbon making the gaps between the carbon molecules even smaller.
***** I know this is a bit of an old video to be commenting on. But this was a great visual for me. We learned a lot of this chemistry during one of my paramedic classes. Mark I and Mark II kits used for field treatment of nerve agents, or organophosphate poisoning also included Atropine. We no longer carry Pralidoxime and our protocols change to an Atropine only treatment. Could you explain the chemistry behind how Atropine alone works to counteract nerve agents or how the combination of the two work together. I'd also love to see more videos about the chemistry behind more of the medications I use in the field. The way you format videos gives a visual and I feel helps immensely.
Miles McDonnell The end result of acetylcholinesterase inhibition is an excess of acetylcholine within the synapse. To counteract this, anticholinergic drugs lie atropine are used and it works by blocking the receptors that acetylcholine binds to. So while it doesn’t directly decrease the amount of actylcholine , it will lessen the negative effects by blocking its binding.
I once heard that the antidote for a nerve agent ( I can't recall if it was sarin or VX ) was lethal if the user had not actually been exposed. Is this true? I started wondering about this when the explanation for the chemical interaction of the sarin antidote was given.
+Josh Bonds Partially true. Atropine - the common antidote to nerve agents (e.g. VX) - can be toxic if the dose is high enough. The auto-injectors issued to NATO troops is said to contain enough Atropine to cause an adverse reaction if the patient hasn't in fact been exposed to a nerve agent.
I'm sure there must be some sort of omninutrient packages available already. Total Parenteral Nutrition exists, basically being fed through an IV, which is a sad necessity for many people.
These videos are improving my background chemistry no end. You guys make it interesting and easier to remember! Love them! From an environmental scientist :)
Its main purpose is supposed to be smoke screening if I remember correctly. If you need a smoke screen now if not sooner a WP grenade will do that. Which is why tanks have white phosphorus launchers on them, so they can instantly have a means of hiding. I wasn't aware that it was flatly banned for use against combatants; I thought as an incendiary weapon it was only banned for aggressive use when civilians are nearby. (per the Geneva Convention on Certain Conventional Weapons).
12:30 Indeed, considering that you combat troops ARE equipped and protected I would say that it is civilians, rather than solders, who are the INTENDED targets of chemical weapons. This is most likely why they were not used in WWII and their use, even in modern warfare is so limited. Now I can see the use of such weapons as a detraction, if the enemy troops are busy caring for civilian casualties they can't attack you. I think it's clear they are meany to harm civilians more than troops.
+Eric Taylor True. But not every army in the world has every soldier equipped with the proper defensive gear needed to protect against alpha-bio-chemical attacks.
Check Tokyo subway sarin attack, even in most favorable conditions spending several million dollars on production launching attacks in 5 places at once, only 12 people were killed, while same results were accomplished by one suicide bomber in Russia. Previous, extremely well prepared attack, releasing sarin from refrigerator truck , killed 7 people while just driving truck in Nice terrrists killed 86 people. What makes sarin most worthless weapon of all. probably kitchen knife will be more dangerous.
sarin is an organophosohate, VX works in a very similar way with different sidegroups on the phosphate. the distinction in G and V-series is mainly historic aside from Vagents being more potent by weight and more persistent after release
It works in the same process, it is just better at it. I can't specifically say what is better about it or how it does it better, as I am not as good at chemistry as the creators of this video, but it does work in the same way.
It depends on the dosage of the gas, in a confined space nerve agents can kill within minutes if that, however you're correct that getting a small lethal dose in a ventilated area would lead to a very long drawn out death which I assume would be agonizing Nerve gas really is a terror weapon much like nuclear weapons and biological weapons, it's more effective against civilians than soldiers and works best in concentrated urban areas.
How in the world could evolution make such a complex system, even if it took billions of years. It's unfathomable the amount of complexity that goes into the simplest action of a human body. Not to mention every single animal and omant. I'm in awe.
To my knowlege, the first time that poison gas was used in warfare, was in the U.S. Civil War. The gas was phosgene. I read about this in the book, "Chemical Process Industries," published by McGraw-Hill in the 60s.
+Clyde Wary Chemical warfare, on the large scale tactical and strategical level, was first used by China since 3000 years ago with arsenical gas, mustard(plant) gas, lime bombs(tear gas equivalent) and other type of poison and toxin delivered in a huge variety of manner, even by artillery and rockets, even till today.
Used by the Sassanids against Roman 16 soldiers in a Zoroastrian temple underground, caving in the entrance after burning sulphur sulphur crystals to sulphur dioxide. Use of chemicals by Zoroastrian/(Iranian) priests was recorded by Greeks when they were still a thing.
I have seen an old video that I am guessing was shown to US troops in Vietnam and it had a live demonstration of nerve gas being used on a goat. It looked like one of the most painful ways to die.
All modern warfare is horrendous. Say what you want about Saddam Husseins evil in Iraq, but in the course of the most recent Iraq war, about a quarter of a million people died, and the few of them were soldiers, and that was a war waged by one of the most advanced militaries of the world, the US. There's one United Nations institution we are desperately lacking, and that is one that specializes in counselling warring parties to tame the effects of armed conflicts, and providing publicly accessible military research for how to avoid civilian deaths in military confrontations. We need a United Nations Institute for Civilian Safety.
The UN has a security council where they attempt to set up diplomacy between the parties and whenever there is a war or civil war or insurgency etc. The UN does it's best to send help to those in the crisis that are not particularly involved in the crisis on a military level. The core principals of the UN during times of war is to promote peace and to secure safety for citizens.
'Most recent iraq war" Thats not the most recent war, the battle against isis is a war, just because your country is barely involved doesnt mean it doesnt deserve war status.
I live in Utah and the Dugway Proving grounds where much of this stuff is stored is less that 200 kilometers away. Much or most of this stuff has been destriyed at Dugway.
One little nitpick at 5:29. Without AChE your muscles stay in contraction I believe. Thus your arms and legs would always stay in flexion (foetal position) and your lungs would stay in inhalation (diaphragm contracted breathing in) and you couldn’t exhale. Hence convulsions. It is worse medically because you can’t do artificial respirations as well (without suction). Sorry if I’m wrong but I believe lack of acetylcholine would cause the described action (Botox). But closer at 8:35 in the description of the inability to hydrolyze. The other thing that happens is the immediate overproduction of fluid (saliva and watery sputum) so the lungs fill with fluid and gas exchange becomes impossible - and again, artificial resps don’t help.
What a coincidence...I talked about this on my first day of class (today) with my first year chem students. I made up a Powerpoint last week and I also used Pacman for a sarin representation! I thought it was a really clever idea...guess I wasn't the only one! :)
2:00 No, that is simply wrong. There was rampant chemical weapon use in Asia, most notably in China, by the Japanese. That fact that nobody, at least as far as I can tell in the comments section, has brought it up in seven years is kind of scary from an educational perspective.
Not really, sure if you pluck out the sentence "luckily there was no chemical warfare what-so-ever in the second world war" that's incorrect. But given the context of him talking about "the allies" and "the Nazis" and how he's specifically talking about the development of chemical weapons by those powers, his statement was correct, as neither of those sides used chemical warfare what-so-ever in the second world war. Now, you are right about the japanese using chemical chemical weapons during ww2, but he wasn't talking about them.
That chemical detector isn’t so far removed from the kit I learned in the military, late 90s early 2000s, called they RVD (residual vapour detector) great vid 👍🏻
Brady, I'm not sure which channel this idea would be best suited to but I think it'd be an interesting video subject, radiation. Explain exactly what radiation and radioactive decay are, how atomic bombs cause and leave it behind. Onto why it affects our bodies, what is it exactly that gets inhaled and the process that causes damage etc... The topic has been brought up briefly in many videos but it'd be nice to have one video dedicated to it. Thanks.
Thanks for the informative video Brady and also to Professor Poliakoff and Stockman for the information! Haven't seen a gas mask like that in years but I'll bet it wouldn't have been nice having to wear one for a while, especially in a blackout.
It isn't pointless, you just have to stay calm and keep to the point. If they insult you, ignore it. If they say something that is wrong, don't insult them, tell them why they're wrong. It's that simple. I've had many debates/conversations that have started ugly but ended happily simply because I stayed respectful towards the other person even if they insulted me.
+Mr Msan worse, or at least equal, and way more insidious. You can survive a nuclear attack(given the distance) with proper knowledge and improvised protection, chemical weapons instead require proper special protection, know-how, decontamination procedures, etc., ... if you ever see it coming...
Not many UA-cam channels are cross-cutting in the professional manner that this channel is. Every unresolved cutaway makes me lean in more lol like its lord of the rings or something 😂 The soundtrack is chosen well and perfectly mixed too. The only audio issue is the inconsistent dialogue levels. Only in some videos, not all. Could just be the on-site mixing, no much you can do if it isn't proper. The rest is seamless. Y'all got a real editor on your hands. Fantastic work. Are there film/television post-production students working on these?
Pralidoxime is but one treatment, and its use is limited to admin within a certain time frame, depending on the cholinesterase inhibitor. Past a certain point, "ageing" occurs where the irreversible binding of ACheI to cholinesterase is too much, and only supportive treatment is sufficient. Atropine is used instead and is the first line treatment in emergencies until access to pralidoxime is available; because as an anticholinergic it can compete with ACh and reduce the excessive signalling.
“Now that’s vinegar now” I liked that illustration. So many Americans don’t understand the way that chemistry actually changes the identity of substances, they mistake it for something like a cake recipe where the inputs remain. Though in the animation not sure why they didn’t just depict the sarin molecule as a Pie wedge filling acetylcholine pac-man’s mouth.
you said around the 6:05 minute mark that the molecule thst is broken off is vinegar. but what happens to that vinegar molecule? is there a hidden vinegar reserve somewhere on your body for whenever you're eating sallad hehe? ;)
I might be a teacher one day. Hopefully I can major in chemistry. I've been teaching myself so when I go to class I'm way ahead and I wanna stay that way on top
I really like Rob Stockman. He explains things so simply and yet with great clarity. Those models are great to see too and he seems to know a lot about human biological/chemical processes and molecules. What is his specialisation? I'm also curious - It's obvious why it's illegal to produce, but is there any non-toxic use for this Sarin molecule? Are there any legal applications for it? Is it ever allowed for research? It seems odd that there would only be self-destructive uses. Thanks guys. :)
The Wikipedia article on HCN says that the US and Italy both used it in WW1. Dunno the details. HCN is on schedule 3 of the CWC: (somewhat) usable as a chemical weapon but also produced on an industrial scale for legitimate uses.
The fluorine is considered a "leaving group". It leaves the sarin molecule so that spot can bind tightly to the active site on the cholinesterase molecule. I'm not sure what happens to it, it probably rebinds to a nearby hydrogen atom in a water molecule and makes HF. That bond is pretty strong, which is why HF is a weak acid (see recent Mythbusters episode). BTW, it doesn't have to be fluorine, it can be a pseudohalogen like CN- as in tabun.
Forgive my chemistry errors beforehand: If you drank flouridated water like we have in the U.S. Would traces of that show up in a hair sample? Would it show up as the same element in the hair sample of a sarin gas victim? If the same, would the concentrations found allow one to conclude one way or another whether the source was flouridated water or sarin?
Have you read the relevant law? As an incendiary, WP is banned for use in civilian areas or on civilians, but incendiaries ARE allowed for use on combatants in the field of battle. There is no regulation against large bullets (although the Hague Convention bans expanding or exploding bullets under 400g weight). WP's main use is as a smoke screen, not as an incendiary, however. There are much deadlier incendiaries out there.
Please be aware that the green capsule on the front contains asbestos, these often leak due to age. I also remember playing with these in the 70's as they had potassium permanganate.
Pralidoxime is injected. A soldier carries a "nerve agent antidote" kit that contains two auto injectors - one filled with atropine, the other with pralidoxime which in the US Army is called "2-pam chloride."
Really interesting video! Now I have a doubt. A person with myasthenia gravis would have more tolerance to the gas? The excess of acethilcolinesterase is the main cause of their symptoms.
Not much details in public-domain but I did ask someone who works in a government chemical-weapons laboratory (they test gas masks and how to detect gas attacks like we've seen in Syria) and he confirmed being exposed to Nerve Agents like Sarin is LITERALLY the most painful thing as all your pain receptors are jammed "on" you literally feel the worst of every sort of pain, burning, freezing, tearing. And your suffocating, paralysed by seizures and totally blind.
I just think it's interesting to see how the route makes such an enormous difference in toxicity. Most of that seems as expected, e.g., the volatiles like sarin are most hazardous in inhalation while vx is hazardous on contact. Botulinum is fortunately a huge molecule that doesn't come through the skin, but if it does get inside a very little can cause a lot of damage. And plutonium seems nowhere near the top of the list...
Very interesting! Thank you once again periodicvideos for such a good and informative video. Really like this channel and therefor I've been subbed for a long time :)
I'm having trouble finding updated articles, so thanks for the information. That's the Blue Grass Army Depot in Kentucky? What about the Pueblo Chemical Depot on Colorado? The destruction deadline was in 2012, wasn't it? They seem to have a good safety record destroying this stuff at other US sites so it's not like there are still a lot of unknowns left. At least it *can* be destroyed just with chemistry, unlike heavy metals and radwaste.
Even as a kid, the Professor was already a chemist.
His first word was not ma-ma, it was car-bon. Cause mommy was made of carbon.
He was a professor at birth. Later in life he completed his doctors tesis ;)
I love this guy lol
To be fair, at the height of the Cold War where NBC (nuclear-biological-chemical) warfare could break out any day, such an awareness was necessitated. The times called for it.
@Tom R Him
I would love to see an episode about protective suits and the special lab equipment and techniques used to protect yourself. I know you love safety Professor, and I'm sure Neil wouldn't mind wearing the suit.
+Tunechi I hope this gets more attention and eventually gets noticed by Prof. Poliakoff
+Tunechi Lee Invite CGP for commentaries and I'll even pay to see that.
Someone start emailing because that's a great idea
+Tunechi Lee I would like to scan that QR code but I'm afraid of doing it
Tunechi Lee I WANNA se that too!!
I've got a molecule of sarin here
Not real sarin?
NO I HAVE ONE SINGLE MOLECULE OF GAS HERE WOULD YOU LIKE TO SEE?
This made me laugh harder than it should have.
quite funny
Brits...... They are cheeky
Well i can see where it was.
I'm your 1000th like
I love how Rob clearly explains how molecules work.
That tie is brilliant.
I need to find that!
That is the best tie ever made! 😂
I want one.
"Just let me warm up the neurotoxins." -GLaDOS
Gladiolus Tatum 90 percent of Humanity is Poisioned ,Operation Paperclip...
So the cake wasn't a lie. It was just cooking with neurotoxins.
I really love that old guy, I could probably listen to him for days.
If you watch all his vids end to end it could take a couple of months possibly
You mean sir martyn poliakoff?
@@gollumtheartisticnewt1028 he loves him SO much, he never bothered to remember his name.
We are all now on the NSA list, thanks youtube
@Evi1M4chine thank you fbi agent
Prof. Rob has the most soothing pleasant voice to listen to.
harmless professor in gas mask = stuff of nightmares
stan blammerson lol
When I was a kid I took our dog, a huge black poodle, for a walk on a foggy night. For some insane reason I wore an old gas mask too. We met a man out for a walk. He screamed, jumped over a hedge and ran into a garden.
Gas and gas masks are not funny. I'm still slightly ashamed. And smiling - slightly.
agree
Harmless? He knows 1000 ways to poison you and then another 100 ways to get rid of all the evidence 😈
As a chemist, I found this extremely interesting. Thank you for making this video, guys!
i do to
I met him when I attended one of the University open days, he's as humble as he seems in the videos!
The first thing that came to mind right before I clicked this video was “this is how you end up on more watchlists”
Speaking about the gas mask I once did a university placement studying Radon; and again it was found that activated charcoal made from coconut shell is the most efficient absorbent. Even more so when cooled by liquid nitrogen. A cryogenically cooled-gas-mask may function even more effectively than a standard one. Interesting stuff.
I would suppose that the reason it is more effective is because of thermal shrinking within the fine ground coconut carbon making the gaps between the carbon molecules even smaller.
***** I know this is a bit of an old video to be commenting on. But this was a great visual for me. We learned a lot of this chemistry during one of my paramedic classes. Mark I and Mark II kits used for field treatment of nerve agents, or organophosphate poisoning also included Atropine. We no longer carry Pralidoxime and our protocols change to an Atropine only treatment. Could you explain the chemistry behind how Atropine alone works to counteract nerve agents or how the combination of the two work together. I'd also love to see more videos about the chemistry behind more of the medications I use in the field. The way you format videos gives a visual and I feel helps immensely.
Miles McDonnell The end result of acetylcholinesterase inhibition is an excess of acetylcholine within the synapse. To counteract this, anticholinergic drugs lie atropine are used and it works by blocking the receptors that acetylcholine binds to. So while it doesn’t directly decrease the amount of actylcholine , it will lessen the negative effects by blocking its binding.
This is top shelf comment section. Right on!
Atropine, also, if too much is given, can cause horrendous hallucinations
For the same reason too -- by turning off too many acetylcholine receptors
Thanks to these videos I actually have a better visual understanding of how molecules interact and react with eachother.
That was enlightening
I once heard that the antidote for a nerve agent ( I can't recall if it was sarin or VX ) was lethal if the user had not actually been exposed. Is this true? I started wondering about this when the explanation for the chemical interaction of the sarin antidote was given.
+Josh Bonds Partially true. Atropine - the common antidote to nerve agents (e.g. VX) - can be toxic if the dose is high enough. The auto-injectors issued to NATO troops is said to contain enough Atropine to cause an adverse reaction if the patient hasn't in fact been exposed to a nerve agent.
Adverse effects from atropine will happen regardless if person is exposed to nerve agent or not
thats the big needle you have to stick into your heart right?
Jonathan S Gerard Most autoinjectors recommend that you place the thing against your thigh muscle. Doesn't go in to your heart.
i was thinking of atropine
I wish I had you guys for science classes. I've learned more your videos, than I did in class😂😅
When will I be able to have ATP shakes and replace food altogether?
U dont only need atp
You also need nadp and nad and many many aminoacids and lipids basically you always need food
ap2pat you still need to take in vitamins, minerals, proteins, lipids etc. ATP alone isn’t enough, even for a single celled bacterium.
Atp cant cross cell membrane so it will be useless to take them in. Unless you can somehow transform atp to glucose or other compounds
I'm sure there must be some sort of omninutrient packages available already. Total Parenteral Nutrition exists, basically being fed through an IV, which is a sad necessity for many people.
dude this is the perfect place for ALL discussions, including and especially politics. its certainly the right time as well.
this video was so fancy, lovely work and lovely chemistry!
This is by far the coolest Periodic Videos I've ever seen.
These videos are improving my background chemistry no end. You guys make it interesting and easier to remember! Love them! From an environmental scientist :)
Its main purpose is supposed to be smoke screening if I remember correctly. If you need a smoke screen now if not sooner a WP grenade will do that. Which is why tanks have white phosphorus launchers on them, so they can instantly have a means of hiding. I wasn't aware that it was flatly banned for use against combatants; I thought as an incendiary weapon it was only banned for aggressive use when civilians are nearby. (per the Geneva Convention on Certain Conventional Weapons).
12:30 Indeed, considering that you combat troops ARE equipped and protected I would say that it is civilians, rather than solders, who are the INTENDED targets of chemical weapons. This is most likely why they were not used in WWII and their use, even in modern warfare is so limited.
Now I can see the use of such weapons as a detraction, if the enemy troops are busy caring for civilian casualties they can't attack you. I think it's clear they are meany to harm civilians more than troops.
+Eric Taylor True. But not every army in the world has every soldier equipped with the proper defensive gear needed to protect against alpha-bio-chemical attacks.
@@RevCode alpha-bio-chemical
wtf is alpha? A in ABC stands for Atomic.
@@LockenJohny101 Yes, and thats where the alpha is for (Alpha Radiation). At least in my native language thats what it was abbreviated as
@@RevCode But an atomic bomb radiates alpha and gamma. That a stuipid name.
@@LockenJohny101 Not my name; I guess the reasoning was that the dust has a big part of alpha emitters?
Now I am really afraid of chemical warfare... Sarin is scary!!
ewauvwas the scary thing is that it is much more applicable than atomic or bio weapons
Have you seen the military test videos of sarin? You'll really be amazed.
Check Tokyo subway sarin attack, even in most favorable conditions spending several million dollars on production launching attacks in 5 places at once, only 12 people were killed,
while same results were accomplished by one suicide bomber in Russia.
Previous, extremely well prepared attack, releasing sarin from refrigerator truck , killed 7 people while just driving truck in Nice terrrists killed 86 people.
What makes sarin most worthless weapon of all. probably kitchen knife will be more dangerous.
ewauvwas says you when you're wearing a Burhka
Ask for PAAM. :P
One dude giving us a molecular class...the other guy is messing around with a very old gas mask. And the cuts between each of them are hysterical.
"guy messing around"... Though, I really shouldn't expect too much from a shirtless avatar...
sarin is an organophosohate, VX works in a very similar way with different sidegroups on the phosphate. the distinction in G and V-series is mainly historic aside from Vagents being more potent by weight and more persistent after release
It's hard to hear what he says cuz his hair is too mesmerizing
I know I'm late but this comment is gold. 😂😂😂😂
So is your beard!!
It works in the same process, it is just better at it. I can't specifically say what is better about it or how it does it better, as I am not as good at chemistry as the creators of this video, but it does work in the same way.
Very interesting video. I've been wondering how Sarin affects the body/nervous system since I read about the Aum attacks in Tokyo in 94/95. Thanks :)
this is the best video i've watch for a long time on UA-cam. Probably since the enigma-encoder one!
Brilliant video - thank you for a level-headed, riveting, and sobering discussion.
It depends on the dosage of the gas, in a confined space nerve agents can kill within minutes if that, however you're correct that getting a small lethal dose in a ventilated area would lead to a very long drawn out death which I assume would be agonizing
Nerve gas really is a terror weapon much like nuclear weapons and biological weapons, it's more effective against civilians than soldiers and works best in concentrated urban areas.
I came to be scared and fascinated, but as usual was simply charmed by the little child hiding in the Professor.
How in the world could evolution make such a complex system, even if it took billions of years. It's unfathomable the amount of complexity that goes into the simplest action of a human body. Not to mention every single animal and omant. I'm in awe.
“The thing that you breathe through”
That's what it is, though. There's no need to be technical in this context, I'm sure the words simply escaped him at that moment.
The best channel on UA-cam.
To my knowlege, the first time that poison gas was used in warfare, was in the U.S. Civil War. The gas was phosgene. I read about this in the book, "Chemical Process Industries," published by McGraw-Hill in the 60s.
+Clyde Wary Chemical warfare, on the large scale tactical and strategical level, was first used by China since 3000 years ago with arsenical gas, mustard(plant) gas, lime bombs(tear gas equivalent) and other type of poison and toxin delivered in a huge variety of manner, even by artillery and rockets, even till today.
Used by the Sassanids against Roman 16 soldiers in a Zoroastrian temple underground, caving in the entrance after burning sulphur sulphur crystals to sulphur dioxide. Use of chemicals by Zoroastrian/(Iranian) priests was recorded by Greeks when they were still a thing.
I have seen an old video that I am guessing was shown to US troops in Vietnam and it had a live demonstration of nerve gas being used on a goat. It looked like one of the most painful ways to die.
All modern warfare is horrendous. Say what you want about Saddam Husseins evil in Iraq, but in the course of the most recent Iraq war, about a quarter of a million people died, and the few of them were soldiers, and that was a war waged by one of the most advanced militaries of the world, the US.
There's one United Nations institution we are desperately lacking, and that is one that specializes in counselling warring parties to tame the effects of armed conflicts, and providing publicly accessible military research for how to avoid civilian deaths in military confrontations.
We need a United Nations Institute for Civilian Safety.
The UN has a security council where they attempt to set up diplomacy between the parties and whenever there is a war or civil war or insurgency etc. The UN does it's best to send help to those in the crisis that are not particularly involved in the crisis on a military level. The core principals of the UN during times of war is to promote peace and to secure safety for citizens.
'Most recent iraq war"
Thats not the most recent war, the battle against isis is a war, just because your country is barely involved doesnt mean it doesnt deserve war status.
Mister Dinner sorry but it isn't a war if a document isn't signed. It's just America idiotically deploying troops.
I believe he was referring to when the gas was used during war
The United Nations is a toothless tiger.
I live in Utah and the Dugway Proving grounds where much of this stuff is stored is less that 200 kilometers away. Much or most of this stuff has been destriyed at Dugway.
"Esquire;" lol... so British
One little nitpick at 5:29. Without AChE your muscles stay in contraction I believe. Thus your arms and legs would always stay in flexion (foetal position) and your lungs would stay in inhalation (diaphragm contracted breathing in) and you couldn’t exhale. Hence convulsions. It is worse medically because you can’t do artificial respirations as well (without suction). Sorry if I’m wrong but I believe lack of acetylcholine would cause the described action (Botox). But closer at 8:35 in the description of the inability to hydrolyze. The other thing that happens is the immediate overproduction of fluid (saliva and watery sputum) so the lungs fill with fluid and gas exchange becomes impossible - and again, artificial resps don’t help.
Switching between the prof's gas mask and neurotransmitter explanation a bit too frequently.
What a coincidence...I talked about this on my first day of class (today) with my first year chem students. I made up a Powerpoint last week and I also used Pacman for a sarin representation! I thought it was a really clever idea...guess I wasn't the only one! :)
2:00
No, that is simply wrong. There was rampant chemical weapon use in Asia, most notably in China, by the Japanese.
That fact that nobody, at least as far as I can tell in the comments section, has brought it up in seven years is kind of scary from an educational perspective.
Not really, sure if you pluck out the sentence "luckily there was no chemical warfare what-so-ever in the second world war" that's incorrect. But given the context of him talking about "the allies" and "the Nazis" and how he's specifically talking about the development of chemical weapons by those powers, his statement was correct, as neither of those sides used chemical warfare what-so-ever in the second world war. Now, you are right about the japanese using chemical chemical weapons during ww2, but he wasn't talking about them.
That chemical detector isn’t so far removed from the kit I learned in the military, late 90s early 2000s, called they RVD (residual vapour detector) great vid 👍🏻
This video predicted spidget finners
Baran Hekimoglu the symbol used for Sarin gas IS a fidget spinner. Just as annoying as nerve gas...
Brady, I'm not sure which channel this idea would be best suited to but I think it'd be an interesting video subject, radiation.
Explain exactly what radiation and radioactive decay are, how atomic bombs cause and leave it behind. Onto why it affects our bodies, what is it exactly that gets inhaled and the process that causes damage etc...
The topic has been brought up briefly in many videos but it'd be nice to have one video dedicated to it.
Thanks.
Are you my mummy?
Now that Doctor Who quote really scared me!
I thought the exact same thing ...
Don't know ask Jeremy Kyle. ;-)
Muummmyyyyy
@@RustyDust101 saaammme
Very well explained. Sarin stops the body’s on/switch leaving it on thus stopping breathing.
That gas mask has to be worth some cash money
it can. but he'll never sell it
I wonder how much my grandmothers South African passport from the 1930s is worth, its in mint condition in my parent's room.
ZOMG Gaming! in Australia it would be worth alot!
BEST VIDEO YET - it is pertinent, historical, chemical and well-made. good job.
This is suddenly very relevant!
Desert Shield we were instructed in the use of Atropine and 2 PAM Chloride.
THEY PREDICTED FIDGET SPINNERS
Good to see Rob Stockman back on our screens.
"Are you my mummy :c"
Subscribing you to you was a great idea. I feel like I can become smarter and work toward making a difference with my major.
5:47 "Are you my mummy?"
Man this video has made all the crazies come out the woodwork...
You are now breathing and blinking your eyes manually.
Thank You for your videos. I am very fortunate to have found your channel!
Alright if nobody else is gonna say it I guess that means I'll have to
The thumbnail kinda looks like a fidget spinner
tommy karrick Yep
we all know
Thanks for the informative video Brady and also to Professor Poliakoff and Stockman for the information! Haven't seen a gas mask like that in years but I'll bet it wouldn't have been nice having to wear one for a while, especially in a blackout.
We want you to know the chemistry so you can make it yourself... I mean... that it's bad. yah. XD
This is one of your best, Brady and Bunch!
It just got used to harm civilians in Syria. :(
It isn't pointless, you just have to stay calm and keep to the point.
If they insult you, ignore it. If they say something that is wrong, don't insult them, tell them why they're wrong.
It's that simple. I've had many debates/conversations that have started ugly but ended happily simply because I stayed respectful towards the other person even if they insulted me.
Still not as bad as the most indiscriminate mass weapon of all; the atomic bomb.
+Mr Msan worse, or at least equal, and way more insidious. You can survive a nuclear attack(given the distance) with proper knowledge and improvised protection, chemical weapons instead require proper special protection, know-how, decontamination procedures, etc., ... if you ever see it coming...
+Andrea Tomassini "decontamination" how's cleaning up that atonic bomb site going m8?
Lorcan O'Brien much easier and less dangerous than decontaminate a binary nerve agent aerosol, no doubt about it
Lorcan O'Brien especially if that "atomic bomb" was an airburst
kuck hoa kuck, heh
Not many UA-cam channels are cross-cutting in the professional manner that this channel is.
Every unresolved cutaway makes me lean in more lol like its lord of the rings or something 😂
The soundtrack is chosen well and perfectly mixed too. The only audio issue is the inconsistent dialogue levels. Only in some videos, not all. Could just be the on-site mixing, no much you can do if it isn't proper. The rest is seamless.
Y'all got a real editor on your hands. Fantastic work. Are there film/television post-production students working on these?
Pralidoxime is but one treatment, and its use is limited to admin within a certain time frame, depending on the cholinesterase inhibitor. Past a certain point, "ageing" occurs where the irreversible binding of ACheI to cholinesterase is too much, and only supportive treatment is sufficient. Atropine is used instead and is the first line treatment in emergencies until access to pralidoxime is available; because as an anticholinergic it can compete with ACh and reduce the excessive signalling.
“Now that’s vinegar now” I liked that illustration. So many Americans don’t understand the way that chemistry actually changes the identity of substances, they mistake it for something like a cake recipe where the inputs remain.
Though in the animation not sure why they didn’t just depict the sarin molecule as a Pie wedge filling acetylcholine pac-man’s mouth.
I love periodic table videos you always teach me amazing things, thank you so much for all that hard work! I'm a big fan. Greetings from Colombia.
Daniel Manrique how can i learn english please help me coz i love this language.
you said around the 6:05 minute mark that the molecule thst is broken off is vinegar. but what happens to that vinegar molecule? is there a hidden vinegar reserve somewhere on your body for whenever you're eating sallad hehe? ;)
one of the best videos of you guys. I would appreciate more videos about organic chemistry!
Thank you for teaching me! Namaste I know you have worked very hard for the knowledge and wisdom you contain
I might be a teacher one day. Hopefully I can major in chemistry. I've been teaching myself so when I go to class I'm way ahead and I wanna stay that way on top
I really like Rob Stockman. He explains things so simply and yet with great clarity. Those models are great to see too and he seems to know a lot about human biological/chemical processes and molecules. What is his specialisation?
I'm also curious - It's obvious why it's illegal to produce, but is there any non-toxic use for this Sarin molecule? Are there any legal applications for it? Is it ever allowed for research? It seems odd that there would only be self-destructive uses.
Thanks guys. :)
The Wikipedia article on HCN says that the US and Italy both used it in WW1. Dunno the details.
HCN is on schedule 3 of the CWC: (somewhat) usable as a chemical weapon but also produced on an industrial scale for legitimate uses.
thank you for keeping this channel going, so much useful science on this channel :)
these videos are so interesting, thank you..I feel bad I messed up school so much
Coconut shells/Charcoal is still used as a filtration agent in Diving/breathing air compressors
one of the best episodes I've seen.
Thank you !
The fluorine is considered a "leaving group". It leaves the sarin molecule so that spot can bind tightly to the active site on the cholinesterase molecule. I'm not sure what happens to it, it probably rebinds to a nearby hydrogen atom in a water molecule and makes HF. That bond is pretty strong, which is why HF is a weak acid (see recent Mythbusters episode).
BTW, it doesn't have to be fluorine, it can be a pseudohalogen like CN- as in tabun.
Forgive my chemistry errors beforehand:
If you drank flouridated water like we have in the U.S. Would traces of that show up in a hair sample?
Would it show up as the same element in the hair sample of a sarin gas victim? If the same, would the concentrations found allow one to conclude one way or another whether the source was flouridated water or sarin?
Have you read the relevant law? As an incendiary, WP is banned for use in civilian areas or on civilians, but incendiaries ARE allowed for use on combatants in the field of battle. There is no regulation against large bullets (although the Hague Convention bans expanding or exploding bullets under 400g weight). WP's main use is as a smoke screen, not as an incendiary, however. There are much deadlier incendiaries out there.
Everytime the video reverted to Prof, I would die of laughter with his gas mask comments
Please be aware that the green capsule on the front contains asbestos, these often leak due to age. I also remember playing with these in the 70's as they had potassium permanganate.
as long he wont break it he will be fine. asbestos is only dangerous once you free the fibers.
Is the 'Super Reactive Water' Pralidoxime drinkable? If not, how would you administer it as a cure?
you can drink it but it is bad for you
...
How the fuk is pralidoximine a type of water?!?!?!?
Just because he says it is like a super water, does not mean it is. n00b
Pralidoxime is injected. A soldier carries a "nerve agent antidote" kit that contains two auto injectors - one filled with atropine, the other with pralidoxime which in the US Army is called "2-pam chloride."
10:02 all I hear is "it sucks " hahaha can't fall into sleep anymore.
Really interesting video! Now I have a doubt. A person with myasthenia gravis would have more tolerance to the gas? The excess of acethilcolinesterase is the main cause of their symptoms.
This has been a really interesting episode.
Not much details in public-domain but I did ask someone who works in a government chemical-weapons laboratory (they test gas masks and how to detect gas attacks like we've seen in Syria) and he confirmed being exposed to Nerve Agents like Sarin is LITERALLY the most painful thing as all your pain receptors are jammed "on" you literally feel the worst of every sort of pain, burning, freezing, tearing.
And your suffocating, paralysed by seizures and totally blind.
The cuts are brilliant
Great now we would be most obliged if you did a video on VX organophosphate nerve gases
I just think it's interesting to see how the route makes such an enormous difference in toxicity. Most of that seems as expected, e.g., the volatiles like sarin are most hazardous in inhalation while vx is hazardous on contact. Botulinum is fortunately a huge molecule that doesn't come through the skin, but if it does get inside a very little can cause a lot of damage.
And plutonium seems nowhere near the top of the list...
So informative and I really liked the editing too
Very interesting! Thank you once again periodicvideos for such a good and informative video. Really like this channel and therefor I've been subbed for a long time :)
Every once in a while I watch some videos again. It makes me feel much better.
I'm having trouble finding updated articles, so thanks for the information. That's the Blue Grass Army Depot in Kentucky? What about the Pueblo Chemical Depot on Colorado? The destruction deadline was in 2012, wasn't it?
They seem to have a good safety record destroying this stuff at other US sites so it's not like there are still a lot of unknowns left. At least it *can* be destroyed just with chemistry, unlike heavy metals and radwaste.