Will his ‘rejuvenation alternative’ beat ageing? | Dr Aubrey de Grey (SENS Foundation)
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- Опубліковано 23 лип 2024
- We have a “respectable chance” in the foreseeable future of using the “rejuvenation alternative” to reach a point where someone’s age will not determined their health, according longevity expert Dr Aubrey De Grey.
The chief science officer at the SENS Research Foundation - a non-profit which funds scientific rejuvenation therapies - argues the way to increase human longevity is not to attack the pathologies of old age but rather to use a “common-sense maintenance approach”.
The biomedical gerontologist claims “the problem is that we’ve been trying to go after the health problems of old age with geriatric medicine all this time.”
“We’ve got to be more preventative,” he says.
“The maintenance approach says basically let’s actually let metabolism generate damage at the rate that it naturally does so, but then step in every so often and repair some of that damage, just eliminate it from the body, so that even though it is being generated it does not reach this pathogenic level of abundance,” he explains.
“Unlike pathology, this approach does make sense.”
De Grey has classified all the “damage” associated with ageing into seven categories.
This means, he says, we can describe a corresponding generic intervention that implements the common-sense maintenance approach.
He offers cell loss as an example of how his classification and associated maintenance approach works to tackle “damage” associated with age.
According to De Grey, as cells are lost and not replaced with ageing, the “obvious fix is stem cell therapy… to replace the cells the body is not replacing on its own.”
He continues to outline how through this “rejuvenation alternative” we are going to see “quite a big increase in longevity”.
De Grey was speaking at the second in a three-part series entitled ‘Debating Ageing: A Transdisciplinary Engagement Forum.
Also taking part in the lecture were Professor Emma Teeling, UCD School of Biology and Environmental Science, and Professor Liam Delaney, UCD School of Economics.
The ‘Debating Ageing’ series is jointly presented by The UCD Humanities Institute, the UCD Centre for the History of Medicine in Ireland, the UCD Conway Institute, the UCD Institute for Discovery, the UCD Geary Institute, and the UCD HRB Ignite Connect Programme.
Dr. Aubrey de Grey is the biomedical gerontologist who researched the idea for and founded SENS Research Foundation. He received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively.
He is Editor-in-Chief of Rejuvenation Research, is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organisations.
UCD Twitter: / ucddublin
UCD Facebook: / universitycollegedublin
UCD Instagram: / ucddublin
UCD Homepage: www.ucd.ie
This Man. (Dr. Aubrey de Grey)
Is one of the most Caring, Intelligent, & Important people in the whole - wide World.
Such promising technologies. Hopefully we will see them come to fruition soon, say 20 years, less than that even better. I want to be able to celebrate my sons' 500th birthdays :-)
I'll be 62, October 2023. I went back to school in 2010 to do graduate work in Gerontology. I WISH I could have seen Dr. Aubrey de Grey speak, but never have. I think this guy is brilliant. I was hired (at USC) to work on the tail end of a 40+ year longitudinal study on Alzheimer's (a tragic cognitive disease). I was responsible for cognitive testing (and some gofer work being new in the field at 49 - lol). This guy is my hero as I've always had a fascination for longevity and immortality. I wrote a successful award-winning memoir in 2022 called "Alive After Dying" (not about life after death) and will be releasing book 1 of a sci-fi trilogy incorporating some of Dr. de Grey's theories called "Her Immortal Menagerie" literally this weekend (Sept. 2023). I would never have thought about releasing it if it hadn't been for this amazing man. Dr. de Grey just turned 60 on April 20, 2023. He delights in looking old. It's his modus operandi. :-)
I love this. Very promising technologies. Reversing aging will become reality within 20 years.
It's not that easy. Daydream can't be realized.
Sike
You wish
@JosephMQ You bet I am. But I would settle for slowing aging for now, which we already can do. Give me 80 healthy years on this planet and we'll see what's possible in 2060.
@@squamish4244 nice response
I love you Aubrey.
I know right! Me too :) do you currently take any life extension therapies by chance?
How about gong to their website sens.org and seeing their research accomplishments?
Of course you are right but where do we go to get the right pills
He was in Dublin and I didn't know about it.
Sorry you missed another great talk by him.
Povijest…...I had heard about it only once or twice in the past month so it was easy to miss> At least it's available here. :) I know Aubrey goes all over the world all the time.
damnnn I drove him home once :) do you currently take any life extension therapies by chance?
thanks to science-based and all who have given info for my mom.
@@USAtoElsewhere hello Sherry. NR from Elysium basis is promising and safe life extension supplement. Talk to your doctor about taking metformin. It's very cheap and very strong very safe and lots of human studies. The good stuff is expensive. Ask your doctor about IVing NAD+ and mesenchymal stem cells. The latter is the most powerful. There is a place in Texas that do it for 6K and much credible place does it for 20k to 100k. It's in Panama City, Panama. Google Dr. Neil Riordan. Get your mom's genome sequenced of course :)
Hurry up. Aint gettin any younger :)
This will become a very profitable industry. I am willing to pay all my money for more youth and time on earth.
This seemed like an updated version of the type of talk Aubrey gives to newcomers (to his work). This is not on the topic of direct anti-aging but I think related to it -- Today I saw a tv commercial for living donors for (human) liver transplantation. The end of the ad showed two people next to each other in hospital beds shaking hands. Wondering if anyone else on here knows about this? I have not yet researched this treatment.
Ray Kurzweil is involved with a company already 3d printing organs which he predicts ( and he is usually conservative) will be accessible within 5 years and with little chance of rejection as they use the person's own cells.
Anyone with enough money will be able to get these treatments very soon outside the US.
@@murrayflewelling1258 Sounds fake to me.
@@mattheww797 If you think the printing of organs is fake I suggest you use google for 5 seconds. It is not knew news.
@@murrayflewelling1258 Yes I think it's fake. Because if it was real they wouldn't need organ transplants. PERIOD.
@@mattheww797
First -Mathew please do not vote for Trump again.
Second we can repair backs with stem cells and that's still in clinical trials ....period lol
Third- at least try to know whats happening around you.............
techcrunch.com/2018/06/25/implantable-3d-printed-organs-could-be-coming-sooner-than-you-think/
Implantable 3D-printed organs could be coming sooner than you think
www.sciencedirect.com/science/article/pii/S2214785317301220
physicsworld.com/a/print-me-an-organ/
Crap! Also can't believe I missed him in Dublin.. opportunity missed :(
damnnnn I drove him home once :) do you currently take any life extension therapies by chance?
@@increasemaximumlifespan2502 Science-Based species Just regular supplements and intermittent fasting really. This Vicki person in the comments does make a good point. Got into it when Aubury first started.. been a long time since. Dont usually listen to FUD but point taken..
@@cliddily I've only been following age reversal science for 2 years and it's clear that Vicki has no idea what she or he is talking about. There r many treatments for aging already and at the rate of progress it is very clear that we will achieve the LEV in our life time. Honestly just don't listen to Aubrey unless they make a break through bc he really doesn't say anything objective. It's annoying
@@increasemaximumlifespan2502 Hey, It´s been a while since you made this comment, but I wanted to make you a question. Who do you recommend to listen to in order to learn about aging or some advice to get closer to LEV?
Aubrey is pretty frickin popular now. Why doesn't he ever talk about IVing mesenchymal stem cells? Or NAD+ precursors. He has one video about metformin and does not articulate well. There are a lot of powerful life extending tech out their rn. He barely ever talks about xenotransplantation and 3d bioprinting. WTF
"Or NAD+ precursors."
David Sinclair has that well covered. Look up his talks.
tottally get what you mean
Always interesting to hear to the Wizard of Oz
Great speaker. Unfortunately what he talks about will probably be usable in the next generation if not further.
Not sure about the analogy he makes of the human body & a car, I suspect that Sinclair is more on the right track. Cars are made of inanimate objects & don't have the capacity to self-repair damage, the human body does contain such mechanisms for self-repair & maintenance, which is where research should be focused, I suspect.
The repair mechanisms of the body are at the absolute core of what he's talking about. It's essentially augmenting those mechanisms, dealing with the areas where they're inefficient or ineffective . I think you should maybe watch some more of his talks or read the SENS website to get a grip of what he's actually saying.
Yep, I agree. Humans would like to be able to live longer and with lots of health too. That is understandable, but like you said, to compare that to inanimate objects is rather futile.
Yes. That was a weird analogy with cars.
I am a big fan of the SENS research platform, but honestly I think the European group has a far better approach to telomerase.
What are you talking about? I know what telomerase means but do you mean scientific or clinical or..?
@JosephMQ they have done tons of work. Check the website and sign up for the news letter. They are cutting edge.
Then it was the other video, playing on my words I wrote. My fault on this one. I change it to the other video.😃😃😃😃😃🤩🤩🤩🤩🤩
no
It's just amazing how the body ages so fast in just a few years. Aubrey has gotten really old now. God, aging never stops. It's just a never-ending process of decaying. People need to really accept that aging needs to be stopped. I can't work for 20 more years in a decaying vessel. Take me home Jesus, please.😇😇😇😇😇😇
The cost of sequencing will be less than a dollar, within five years, and will give us a powerful cheap research tool. I think we could end aging in ten years.
Oh yea! do you currently take any life extension therapies by chance?
@@increasemaximumlifespan2502 These therapies will start with senescent cell clearance in 2023. They go through about five years of testing which seems ridiculous when they are targeted specifically at the aging population. They would be administered in a hospital or clinic as they could be dangerous. I would take these when they become available. They will be like everything else, expensive then the price will drop over time. It will be interesting to see how countries with free medical treatment ( like the UK) treat these therapies. Senescent cells and mitochondria cause a lot of damage so going after these makes a lot of sense.
@@higreentj you don't take metformin, NR, or stem cell therapy?
@@increasemaximumlifespan2502 I am taking metformin but nothing else.
@@higreentj awesomeee
Past
Three years to ending aging in mice, cats, and dogs while humans die while waiting for safety checks to be performed.
Any progress?
@@mid7699 We have a vaccine for SARS COV 2 COVID 19 now but it has to go through safety trials. It is the same with anti-aging therapies they get stuck in safety trials.
@@higreentj What is your opinion about people that are teenagers today, is there any chance they will reach longevity escape velocity?
@@absoluteunit3885 Teenagers will definitely reach longevity escape velocity. There are other possibilities with Neuralink where you download your memories into a computer and create a digital you. neuralink.com/
@@mid7699 This is a good source of information on the SENS approach to ending aging. www.fightaging.org/
Why does he look better than his 13 years old ted talk. Where he has the same exact beard and much more wrinkles.
stardolphij2, I'm certain of it because that man can't even get passed one interview without chugging alcohol. That in itself tells me he's a pretty bad alcoholic. I'm certain of it because it's been over twenty years, and sens doesn't have a single treatment that reverses aging. Not one simple treatment. I'm certain of it because if Elizabeth Holmes es company cannot come up with a simpler way to just take blood, then this man for sure I not reversing all the decaying aspects of a human body. I'm certain of it because I have common sense.
He doesn't have nearly the funding of other ventures. And yes, he is an alcoholic, as have been numerous scientists and innovators who changed the world.
Daddy!
Peter Sellers, I'll be in a nursing home in twenty years, no hope for me. Aubrey wants to do too much to reverse aging. Replace organs, that in itself is scary. The simple injection of Gene therapy seems to be the way to go. Everything is dangerous to the body. The body sure does get tired though. Aging stinks, me thinks
Im sorry you wont get to see it,how old are you now if you dont mind me asking? you will be in nursing home are you like 50 or 60 right know?
@@twinface1081 , Mark my words, you'll be in one too. In the. Link of an age you'll be old.
@@twinface1081 , Let me tell you, I was your age when this man first said nobody would grow old over 20 years ago. You will grow old, just enjoy your life.
@@vickybiagini8623 I cant grow old i will not grow old.You wont either your not gonna get old.Aubrey De Grey i believe in him we just have to hold out a bit longer just give it another 10 to 15yrs or 20yrs maximum and then i believe we will all have the cure to old age nobody will grow old in the coming decades i dont think so.I dont want to see anyone in a nursing home not mee or you or anyone,i hate seeing ppl suffer from getting old it sucks,its not fun to watch it.The cure to old age is coming soon ik it.It takes time to get these therapies out,alot of testing and things so in 10 to 20 yrs i believe we will have a cure to old age .
@@twinface1081 , Believe me, I hope you never feel the effects of aging. With the passage of time people we love die also. Theres alot of sad stuff in life, just enjoy the good while you can. Life goes by very fast, and time will become ones worst enemy. Theres beauty in life, but also sadness. One needs to grasp both, and realize neither lasts forever. I hope you get your wish in life, and never age.
man, I am sure you are on the right track, you look like a 1000 year old :D
If I actually look like that at 1000, I'd call it a win...
🤣
is Aubrey wearing a mouth-guard?
aubrey de grey, biological age 56, apparent age due to his beard and outfit like 130 years
He drinks a lot. A LOT.
He’s looked like that since he was 20 years old. All that heavy English beer.
六丸の人ｗｗｗ
This bearded old man himself why not younger?Who
I think the motivation behind all of this research is to get rid of his beard
No
stardolphij2, I'm glad you want to stay in your ever decaying body forever. I personally don't want to just work, pay, bills, and decay. For the people who think that's a great life, all the power to them. I think it's a horrible existence.
We will upload our brain before this comes along.
Johnny Thomas I agree.
it's pretty much already here. do you currently take any life extension therapies by chance?
We have senescent cell clearance therapies now but for some unknown reason they have to go through five years of safety checks. In five years sequencing the human genome will be less than a dollar and exaflop computers will be available but expensive.
Sherry Von, let me tell you about Bill Andrews. I've been following him for about eight years. Betty White should have been 24 again, six years ago from him so called telomerse lengthening pill he's been coming up with for the past eight years. Now he has failed in his own right to reverse any aspects of human again. So he has jumped on the Elizabeth Parrish gene therapy bandwagon. He's even taken some credit for it in a recent video I've watched with him Jesus will walk on water again before he turns Betty White 24. He's 67 now, and looks every bit of it. I really wish something could come about to save people, but even Aubrey admits there's nothing to even slow aging at this point in time. At least he's honest about it, unlike Bill Andrews whose been lying for a decade in his videos. God Bless
Sherry Von, I plan on being dead by twenty years because Aubrey even admits these therapies aren't for thirty to a hundred more years . There's nothing right now to reverse human aging. I'm 44 and already am feeling what aging entails. Honestly since hitting my fourties, I've literally been living on aspirins everyday. Plus I've lost people I've loved a lot. I have another aunt who is 68 and smokes like a chimney. She will probably be gone in her seventies. I'm sure you have kids and want to live. I don't, so I'm ready to die by fifty I'd say. I'm not afraid of death because I've been interested in the metaphysical for over twenty years. I know that we exist after death in some form or another. Whether it's reincarnation, heaven, hell that's all speculation until it happens to us personally. I'm leaning towards reincarnation since I've read a lot about it over the years. I know in my physical body I possess now that I will die one day. I'm just honestly more afraid of ending up in capable of taking care of myself in a nursing home. I'd rather die with the music still in me, somewhat🤗🤩😃😅😜
Nah man, fight against the night
"I'm sure you have kids and want to live. I don't, so I'm ready to die by fifty I'd say. "
I'm 65, childfree, and quite willing to see tomorrow, thanks...
I've heard him say that he believes that there are some who have already been born who will live to see 1000 years, sans climate change not killing us off first.
He sends me into a panic attack
????
Guess he'll get to buy a noble prize as well. Too bad way things are going it will be post-humorously.
@@Khannea Who ?
@@Khannea
They don't give nobel prizes for over babbling.
@@cineblock224 Just to let you know, he is not babbling : - ).
His beard is muffling his voice
He has a speech impediment.
Tl:Dr. I dunno. Prolly just the beard and long hair but he looks pretty old for a dude in his mid thirties
Given that he’s 55, that’d be the reason.
MC Woodworks, where the heck did you get the info that Aubrey is in his 30's? Hope that was a typo. Aubrey looks around his age but he may look as old as he does because he repeated says he doesn't get much sleep. I dont get enough sleep either so I know the toll it takes.
And believe me I hate aging, and am not against a cure for it. My rational mind takes over after twenty years with not one treatment at all. Not even reversing hair loss.
He's been giving this same speech for years. They have nothing.
Actually - they are curing alzheimers and diabetes 2 now , and quite a lot of info about how to prevent osteoporosis and such is coming out so I figure I shan`t have to be weak and fragile and dementia when I turn 80 in 30 years ... I am quite hopeful really
@@peteralund Oh, they are curing alzheimers? I must have missed that part since they haven't cured anything.
Senescent cell clearance will be the first. Unity Biotechnology have completed phase 1 trials and Oisin Biotechnology start phase 1 trials this year.
Vicky you're all over life extension youtube video comments
He's drunk
Sherry Von, you also said you don't want surgery. Aubrey talks about replacing every organ in our bodies practically. This guy is Looney with how he thinks recersing aging will happen. Replacing body parts, some injections, maybe young blood, stem cells. He's talking like we are a physical car, and it's so easy to replace our organs. You can't compare a human to a car. Humans aren't meant to last more then sixty or seventy years. You can keep a car going forever if you have the money. TgmGod shortened our lifespans so much because of sin, and that's a fact. Just look up the case of Christopher Watts and see what he did. Then tell me we deserve to live forever. Humans are an evil breed.
" TgmGod shortened our lifespans so much because of sin, and that's a fact. "
Okay, appeal to divinity. There's little else to be said to you.
Except perhaps there are various other gods that people observe, you might get a second opinion...
MrCarcappa16, you're obviously very young and can't rationalize the difference of building something that has one day the capacity to fly, to actually reversing the accumulated damage done to a human body. These are two totally different accomplishments. The first one was feasible, the second one isn't. We lose everything with age, bones, skin, organs, hair, our capillaries get much smaller, blood flow is not as it was. My advice is enjoy your youth because it goes fast. This man isn't hasn't done anything in over twenty years but flap his gums. They have to keep up the charade so money keeps flowing in from investors. I'm 44, and dying of aging. Everyone over fourty is. As far as being much dumber then alcoholic Aubrey goes, he can't spell this, Supercalifragilisticexpialidocious. But seriously, aging will be the worst thing young people face. It's really painful.
What about telemerase induction using a viral vector delivery method? Or cas 9 gene editing? These are just several very promising and rapidly advancing methods to bring improved health and longer life to people. Exponential progress seems slow in the beginning...not much happens. 30 years ago this was the case. But when initial breakthroughs are made, the rate exponentially increases. The human genome project has enabled the biological sciences to be transformed into a information technology. We can now, and are more effectively able to manipulate our DNA as we can computer code. Look at the progress computers made since the 1950s. Imagine now that kind of exponential progress in biology. In 20 years we will most likely be able to reverse up to half of the accumulated damage we had received from aging. There are companies now, including Google's calico and bioviva that are working on these therapies.
"These are two totally different accomplishments."
There were those who were totally certain that heavier-than-air flight was completely impossible.
"The first one was feasible, the second one isn't."
Why? There are reasons for all the conditions you go on to list. Why are you certain that they are beyond repair?
"This man isn't hasn't done anything in over twenty years but flap his gums. "
Then you've not paid attention...
@@stardolphin2 your correct. Biotech has become a technology. This is a game changer. Gene editing is already changing medicine. If a technology works then we can take advantage of it!
I don't get it. Why do people not want us to die? Death is just part of life. I don't think it's something we need to defeat.
cual es la diferencia de vivir eternamente y morir eternamente
he is 55 and looks like he died a very long time ago. i like what he does, but i wouldn't bet on this horsi.
So much B.S...this hippie Audrey de Grey (he has a idiot B.S. name )) he looks old he can't find a cure for himself to look young? ..B.S. talk !
he wants money selling B.S. Books..another scam artist !
Dunno what to think about Aubrey, he could be legit working on somthing, or just scamming people out of their money for reaaserches he knows are leading no where.
all it takes is to do some research on him. do you currently take any life extension therapies by chance?
Like going to the Moon, far too many people are involved to maintain a 'scam...'
@@increasemaximumlifespan2502 You keep saying that on like every comment. That exact wording, too. What even *are* these therapies you're talking about
@@increasemaximumlifespan2502 from where we can get these therapies?
@@revolrz22 I should have said geroprotectors. More evidence for their gero effects in humans than we have for lifespan extension bc no one has done the experiments yet. Lifespan extension has only been validated in animal models, but many of them are taken by life extensionist bc they have been heavily tested in humans against multiple different diseases. Talk to ur primary care physician about taking 300mg of EGCG/day. Go check out my YiuTube channel to learn about other great ones also
Why does it look like scam
Are you kidding?....he is over 200 years old..
Shooting holes, at least you have some common sense with comparing these Scientists to Elizabeth Holmes. If Theranos can't come up with a simplified way to take human blood, this man sure as heck isn't coming up with therapies to reverse the decay of a whole body. He said it's easier to repair damage then to suppress it. Have you seen a seventy year old lately? There's no way you can take a seventy year old with all the damage accumulated over five decades, and revert them back to age 25. Everything changes about an individual in fifty years. Our heads get smaller or larger,. Ears and nose keep growing. Bone loss is rampant at that age. We shrink, can he give us back height? They can't even regrow a bald spot now. He's going to regrow hair back to when a person was 25. It's easier to prevent damage I would think for sure. So I agree, he's a scammer. Along with Bill Andrews who should be 24 by now along with Betty White.
Sherry Von, I've never even heard of leaf. Let me tell you something, I have every right to my opinion just like you do. I'm a deathist you say. We are all dying everyday. If you're waiting on Aubrey to save you at 66 years old, you'll be waiting till you're 120. This man nor Bill Andrews has done nothing for aging. Aging is a horrible, horrific thing to endure, but he's not curing it, that's for sure. Let's wait for David Sinclair's pill to come out possibly in thirty years. Lol. I laugh at people who think their living forever. Not happening, sorry. Get right with God is all I can say. He is the only one that can help. And that's the truth. I used to believe this crap until aging started.
Unity biotechnology and Oisin biotechnology should have anti aging therapies by 2024. Why they have to go through five years of safety checks, when they will only be used by the elderly, is beyond me.
Luke Perry just died at 52, and Aubrey is curing aging. We can't even live 5 decades. Wow, life is short and brutal. R.I.P Luke. Hurry up Aubrey, we are all dying. Stop drinking and start thinking. Damn
He's already made significant contributions to mathematics and biology; he deserves the rest -_-
The only thing in need of "rejuvenation" is his speech. The same speech for the next 20 years without changing a single word.
His PhD is from Cambridge, awarded for his landmark contribution to the mitochondrial theory of aging. I don't know what you are talking about.
@@RationalAnimations
Prove it
@@RationalAnimations cine block is a conspiracy theorist who'll demand proof, and reject the evidence, only to then run away because he's a coward. I'm familiar with him and there's no getting through to him, so please, don't waste your time with him like I did.
@@cineblock224
Noone cares about you, stop hindering discourse.
@@Pyriphlegeton
You both proved that you actually care by commenting.