DNTNF_moa

Dominant Negative TNF (DN-TNF) is a novel biologic designed to disrupt soluble TNF trimers and insert itself into a newly formed heterotrimer containing at least one DN-TNF monomer and up to two solTNF monomer(s). The DN-TNF---solTNF heterotrimer does not bind TNFR. As such, DN-TNF effectively neutralizes solTNF, thereby attenuating inflammation.