I love this channel. It's awesome being able to see up to date research information on this field, I don't understand most of it, but I like hearing an expert talk about it. You strike that perfect balance between high level expertise and low level laymen explanations. The implications for humanity in the (hopefully) near future seems amazing! I'm already getting in the mindset where I'll be disappointed if I don't live past 200. Perfecting this field means starting a new era for humanity.
Amazing you could keep your focus this past week. Could scientists figure out what is happening during embryogenesis? Is it just OSKM in there? I'd guess there is a lot more going on?
The data we have so far IMO is a superb progress in comparison to past years. Current knowledge already makes it possible to offset bio age at least 20 years back - it just takes a power of will to stick to certain protocols for life, which are in fact available free of charge. Plus discovered molecules / supplements most probably as well will extend life/health span, plus cell repro in future, which will add years again. I am super positive.
The real fun times will be once we have gene editing that will carry all of us to supercentenarian. Probably genetically-modified babies first. Who can smoke, drink and eat trash, but still getting relatively healthy to age 110+. We've already seen such people. Now we have to fast and live like a nun, but most likely will still not even get close to age 100. We should be able to enjoy life. ;)
@@markveen1373 Hmm, IDK about enjoying life part. At least in my case operating on ketones gives tons of emotional benefits to survive in this world. While on glucose I was always depressed, weak, afraid, devastated by the fact of being alone, all this negative crap. In ketosis all those emotions are gone and only some sort of primal aggression is left which fuels me on daily basis. On carbs, I did tons of booze as well as basically a consequence of feeling like crap to escape and couldn't make any substantial money, now I am a millionaire focused on a fighting every day. At least in my case this is how it is.
Which protocols? Any links? From what I know, the only study that has results in humans is TRIIM. And that involves some stuff like HGH that I don't want to mess with yet.
Thank you for this video. I... think I got the general idea. One episode of OSKM activation is not enough to effectively rejuvenate aged mice. Is that it? They did show signs of... um, reprogramming (and that was the point of the experiment, to show what reprogramming cells looks like mechanistically), but there was no reduction of cellular senescence. So to really do the job right, you'd need some degree of OSKM activation and a way to remove senescent cells. Boy I hope that made sense.
6:13 - hmm, I think we don't need to reprogram senescent cells. We need to get rid of them, not allow them to multiply again. Cellular senescence is a cancer-protection mechanism. Senescent cells usually have badly damaged DNA (hence cell cycle arrest).
Musing speculation on Altos strategies: Animal models to test diverse therapeutic methods like OSKM & senolytics to idenitfy organ/system most benefitted to address human disease to most quickly begin human trials? Cardiovascular most likely? Then generalize to whole organism (patient) rejuvenation? I'd guess prioritizing heart, then brain, then peripheral nervous system.
Carbon 60 by reactivating the mitochondria in senescent cells induces apotheosis, which are replaced by stem cells.. Long tern users of Carbon 60 see average telomere length increase significantly. The FOX-04 tests in Switzerland were even more impressive and treatments are now only available to those of significant wealth.
Superb presentation. Having stage 5 chronic kidney disease and connective tissue disorders, I am very interested in the potential of this cellular reprogramming technology. Am already doing what I can through diet, exercise and supplements to induce/enhance autophagy and stem cell regeneration.
@@KJ-um1gq I do ketogenic, 12-15 hr, intermittent fasting. Working up to long fast to induce autophagy Just started TruNiagen to address NAD+ deficiency. Have 20+ year hx of taking standard medicine for severe resistant hypertension, autoimmune connective tissue disease, and now long-covid. To put it succinctly: not a single gooddamn medication has had any positive benefits, but loads of adverse ones. some very serious. Doctors don't know what they are doing - just following whatever the FDA/BIG PHARMA Cartel tells them to do without any analysis of the data or alternative options. Sorry to be so negative, but I am over the bullshit. Not sure yet if NAD+. and other strategies working yet - need another few months to assess
Trimethyl-Lysine interacts with Phosphate/Acetyl-Phosphate to regulate IGF and Insulin. It plays a role in modern day western diet and chemical exposure driven metabolic disorder.
Since SASP is a thing that can even make nearby cells senescent, I wonder if combining osk rejuvenation with proteomic cleansing ala Harold Katcher might do the trick to reverse senescence.
Would you have any interest in making a video giving a reasonable sense of what we might expect from biotech in the next 5, 10, or 20 years? As a layperson I find the recent history of biotech fascinating but also baffling and frustrating. I can't even count the number of "massive breakthroughs in cancer treatment" that I've seen announced, only to never hear about them again. Futurists keep predicting an imminent biotech age that will dwarf the information and industrial ages with respect to societal impact. But outside of your channel, when I try to learn more about biotech, the only two types of information seems to be 1) breathless announcements in the mainstream media that cancer/alzheimers/etc. has been cured yet again or 2) grindingly technical minutiae that wields jargon like a shield against understanding by anyone outside their sub-field. Some questions I haven't been able to find the answer to: Why, despite the very high expectations for biotech companies and research over the past 10 to 20 years, it seems there have been very few breakthrough biotech products taken to market? The Human Genome Project was supposed to revolutionize everything. CRISPR was supposed to revolutionize everything. Sub $1000 genomes were supposed to revolutionize everything. Is the biggest part of the problem the replication crisis? Secrecy of research done by for profit companies? The constraints of doing ethical research on human beings? Something else? Is there any reason to think the rate of biotech progress will improve soon?
@@TheSheekeyScienceShow Hello, I am a new self learner of biochemistry and topics related to it. Your video is amazing and you show real understanding of this matter. I wasn't fully sure about the conditions for the doxycycline to work. Thanks for clarifying. Do we remain with a way to induce the OMSK factors in humans? Can the same genetic medications made to mice be made to human so the drug has the same effect? Regards,
Thanks for watching!
What do you think about the ongoing TRIIM-X trial?
I'm turning 40 next month. I need some rejuvenation fast!
2 late, you a gonner
I love this channel. It's awesome being able to see up to date research information on this field, I don't understand most of it, but I like hearing an expert talk about it. You strike that perfect balance between high level expertise and low level laymen explanations. The implications for humanity in the (hopefully) near future seems amazing! I'm already getting in the mindset where I'll be disappointed if I don't live past 200. Perfecting this field means starting a new era for humanity.
Amazing you could keep your focus this past week. Could scientists figure out what is happening during embryogenesis? Is it just OSKM in there? I'd guess there is a lot more going on?
The data we have so far IMO is a superb progress in comparison to past years. Current knowledge already makes it possible to offset bio age at least 20 years back - it just takes a power of will to stick to certain protocols for life, which are in fact available free of charge. Plus discovered molecules / supplements most probably as well will extend life/health span, plus cell repro in future, which will add years again. I am super positive.
The real fun times will be once we have gene editing that will carry all of us to supercentenarian. Probably genetically-modified babies first. Who can smoke, drink and eat trash, but still getting relatively healthy to age 110+. We've already seen such people. Now we have to fast and live like a nun, but most likely will still not even get close to age 100. We should be able to enjoy life. ;)
@@markveen1373 Hmm, IDK about enjoying life part. At least in my case operating on ketones gives tons of emotional benefits to survive in this world. While on glucose I was always depressed, weak, afraid, devastated by the fact of being alone, all this negative crap. In ketosis all those emotions are gone and only some sort of primal aggression is left which fuels me on daily basis. On carbs, I did tons of booze as well as basically a consequence of feeling like crap to escape and couldn't make any substantial money, now I am a millionaire focused on a fighting every day. At least in my case this is how it is.
Which protocols? Any links? From what I know, the only study that has results in humans is TRIIM. And that involves some stuff like HGH that I don't want to mess with yet.
Brilliant as always Sheekey.
Thank you for time-stamping your excellent videos!
Thank you for this video. I... think I got the general idea. One episode of OSKM activation is not enough to effectively rejuvenate aged mice. Is that it? They did show signs of... um, reprogramming (and that was the point of the experiment, to show what reprogramming cells looks like mechanistically), but there was no reduction of cellular senescence. So to really do the job right, you'd need some degree of OSKM activation and a way to remove senescent cells.
Boy I hope that made sense.
Thats what I got from the video, watched it in slower .75 view time to really listen.
6:13 - hmm, I think we don't need to reprogram senescent cells. We need to get rid of them, not allow them to multiply again. Cellular senescence is a cancer-protection mechanism. Senescent cells usually have badly damaged DNA (hence cell cycle arrest).
Musing speculation on Altos strategies:
Animal models to test diverse therapeutic methods like OSKM & senolytics to idenitfy organ/system most benefitted to address human disease to most quickly begin human trials? Cardiovascular most likely?
Then generalize to whole organism (patient) rejuvenation?
I'd guess prioritizing heart, then brain, then peripheral nervous system.
Carbon 60 by reactivating the mitochondria in senescent cells induces apotheosis, which are replaced by stem cells.. Long tern users of Carbon 60 see average telomere length increase significantly. The FOX-04 tests in Switzerland were even more impressive and treatments are now only available to those of significant wealth.
Superb presentation. Having stage 5 chronic kidney disease and connective tissue disorders, I am very interested in the potential of this cellular reprogramming technology. Am already doing what I can through diet, exercise and supplements to induce/enhance autophagy and stem cell regeneration.
What type of diet do you eat to achieve good results with CKD?
@@KJ-um1gq I do ketogenic, 12-15 hr, intermittent fasting. Working up to long fast to induce autophagy Just started TruNiagen to address NAD+ deficiency. Have 20+ year hx of taking standard medicine for severe resistant hypertension, autoimmune connective tissue disease, and now long-covid. To put it succinctly: not a single gooddamn medication has had any positive benefits, but loads of adverse ones. some very serious. Doctors don't know what they are doing - just following whatever the FDA/BIG PHARMA Cartel tells them to do without any analysis of the data or alternative options. Sorry to be so negative, but I am over the bullshit. Not sure yet if NAD+. and other strategies working yet - need another few months to assess
Glad you’re feeling better. Have you seen your eGFR numbers improve?
@@KJ-um1gq Actually not yet feeling better, and GFR still declining, just starting this new fasting, NAD+, etc. protocol
I would try going plant based. Animal protein is rough on the kidneys
Good as usual, thanks! 🐭
Trimethyl-Lysine interacts with Phosphate/Acetyl-Phosphate to regulate IGF and Insulin. It plays a role in modern day western diet and chemical exposure driven metabolic disorder.
any other random unrelated info you can vomit up?
@@Holypikemanz It's totally related, you just lack the cognitive function, or data analysis skills, to understand how.
Thanks for the video.
Do you think the usage of senolytics by itself can be enough to "reverse" skin damage?
Since SASP is a thing that can even make nearby cells senescent, I wonder if combining osk rejuvenation with proteomic cleansing ala Harold Katcher might do the trick to reverse senescence.
how do you do proteomic cleansing? I have a hair brush...
Have they tested the effects of supplementing those metabolites?
Oh thank god
If senescence promotes reprogramming, wouldn't we want to keep senescent cells? Maybe I'm misunderstanding that paper you show briefly around 6:40.
Its pros vs cons, the cons of senescent cells are higher than the pros. Besides we can reprogram without senescent cells now so why keep them?
Would you have any interest in making a video giving a reasonable sense of what we might expect from biotech in the next 5, 10, or 20 years?
As a layperson I find the recent history of biotech fascinating but also baffling and frustrating. I can't even count the number of "massive breakthroughs in cancer treatment" that I've seen announced, only to never hear about them again. Futurists keep predicting an imminent biotech age that will dwarf the information and industrial ages with respect to societal impact. But outside of your channel, when I try to learn more about biotech, the only two types of information seems to be 1) breathless announcements in the mainstream media that cancer/alzheimers/etc. has been cured yet again or 2) grindingly technical minutiae that wields jargon like a shield against understanding by anyone outside their sub-field.
Some questions I haven't been able to find the answer to:
Why, despite the very high expectations for biotech companies and research over the past 10 to 20 years, it seems there have been very few breakthrough biotech products taken to market? The Human Genome Project was supposed to revolutionize everything. CRISPR was supposed to revolutionize everything. Sub $1000 genomes were supposed to revolutionize everything.
Is the biggest part of the problem the replication crisis? Secrecy of research done by for profit companies? The constraints of doing ethical research on human beings? Something else?
Is there any reason to think the rate of biotech progress will improve soon?
So, how much doxycycline do I need to take to do this?
Absolutely none. [the mice were genetically modified so that doxycycline induced the expression of the OSKM genes]
@@TheSheekeyScienceShow
Hello, I am a new self learner of biochemistry and topics related to it. Your video is amazing and you show real understanding of this matter.
I wasn't fully sure about the conditions for the doxycycline to work. Thanks for clarifying. Do we remain with a way to induce the OMSK factors in humans? Can the same genetic medications made to mice be made to human so the drug has the same effect?
Regards,