Whenever you see translocations at the BCR (the antibody genes) you should remember that those loci are especially prone to aberrant events because of VDJ recombination and somatic hypermutation - the only process in the body that actually changes DNA sequence. It is also worth noting that we heard here about epigenetic changes contributing to the malignant behavior. I bet that this occurs far more often than we currently are aware, in many tumors, because it is so much easier to look for DNA sequence mutations than to find epigenetic effects. Stay aware of the evolving literature on this.
You might want to consider checking out the cases in Robbins Essential Pathology. I helped create those for the book. There are free-text questions and hot-spotting on images to help you find features in the description.
Very useful information on Myeloid neoplasm
Whenever you see translocations at the BCR (the antibody genes) you should remember that those loci are especially prone to aberrant events because of VDJ recombination and somatic hypermutation - the only process in the body that actually changes DNA sequence. It is also worth noting that we heard here about epigenetic changes contributing to the malignant behavior. I bet that this occurs far more often than we currently are aware, in many tumors, because it is so much easier to look for DNA sequence mutations than to find epigenetic effects. Stay aware of the evolving literature on this.
Could you add some case presentations at the end of these videos to, you know, integrate it all - clinical features, investigations, morphology, etc?
You might want to consider checking out the cases in Robbins Essential Pathology. I helped create those for the book. There are free-text questions and hot-spotting on images to help you find features in the description.
@@PathologyCentral Appreciate your help. Thanks.