JAK Inhibitors - New FDA Approved Treatment!

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  • Опубліковано 23 гру 2024

КОМЕНТАРІ • 107

  • @acquiesce100
    @acquiesce100 2 роки тому +20

    It's been available in the UK privately for a long time. I don't know why people are so obsessed with waiting for FDA approval. It's not about the FDA. It's about the patients and their well being. The USA are behind with the times.

    • @californiadoll6273
      @californiadoll6273 2 роки тому +1

      Exactly! To me FDA approved means nothing. They are crooks and will only pass something after they've made huge profit off it and then after the company pays out they'll 'pass' it

    • @Low_pH
      @Low_pH Рік тому

      Mainly litigation but I agree

    • @stevebellows7314
      @stevebellows7314 Рік тому

      So usa does not do this yet. How can you get the treatment of you live in usa

  • @TheArticulatingAnoraksPodcast
    @TheArticulatingAnoraksPodcast 2 роки тому +18

    Please do a new Oral Minoxidil video following the recent New York Times article

    • @julius930
      @julius930 2 роки тому +2

      Watch the reaction video from hair cafe on it, he is basically completely debunking the article

    • @ramennoodleking
      @ramennoodleking 2 роки тому +1

      @@julius930 the guy from hair cafe is a total quack

    • @Agnes135
      @Agnes135 2 роки тому +1

      @@julius930 3 studies say otherwise, alongside hundreds/thousands of anecdotal reports

    • @julius930
      @julius930 2 роки тому +5

      @@ramennoodleking In most aspects regarding hair loss treatment he is totally aligned with this channel. Regarding oral minoxidil, he is acknowledging the effectiveness (in fact, he has taken it himself for a couple of months with great effect) but he is highlighting the uncertainty regarding significant cardiovascular side effects and the warning label.

  • @_baller
    @_baller 2 роки тому +2

    I wonder how much adrogenic has areata involved as well, I notice a lot of stressed people have hair loss

  • @saifsalim8702
    @saifsalim8702 2 роки тому

    Thank you docs, greetings from USA/ Michigan

  • @amgen1269
    @amgen1269 Рік тому +2

    Going on this week!!

  • @timjonsson8652
    @timjonsson8652 2 роки тому +2

    Could you cover finasterides effect on fertility? It doesn’t look like there is enough information regarding this topic online

  • @jimdandy8996
    @jimdandy8996 2 роки тому +4

    Wasn't there a black box FDA warning last year for serious cardiac effects of JAK Inhibitors? I'd rather be balled.

    • @jokerharley1271
      @jokerharley1271 2 роки тому +4

      I guess be a balled weenie then

    • @jimdandy8996
      @jimdandy8996 2 роки тому

      @@jokerharley1271 Versus a cardiac cripple - or dead 🤓

    • @josephgrmovsekcollaredcons6085
      @josephgrmovsekcollaredcons6085 2 роки тому

      Yet you are Covid vaxxed and boosted and not concerned of the implications for your heart with zero benefit

    • @Senedissak
      @Senedissak 2 роки тому +2

      @@jokerharley1271 lmao

  • @super-super-
    @super-super- 2 роки тому +2

    Can this be used to treat androgenic alopecia? Or is this only for areata?

  • @nazdhillon994
    @nazdhillon994 2 роки тому +2

    How long can JAK inhibitors be taken ? Can they be taken life long ?

  • @iamnoone78647
    @iamnoone78647 2 роки тому +6

    Talk bout fin and dut combination therapy

  • @xerxeszion49
    @xerxeszion49 2 роки тому +1

    Can you take finasteride (propecia) and multivitamins or will one cancel out the other.

  • @nasserwesh
    @nasserwesh Рік тому +1

    In older cases of androgenic alopecia that may not respond well to finasteride, will they be able to benefit from this Jac inhibitor to regrow hair in unresponsive areas?

  • @enigmasolver7779
    @enigmasolver7779 2 роки тому

    Have they spoken about prp injections?

  • @prachetmohare8841
    @prachetmohare8841 2 роки тому +1

    Hi doctor,
    In your previous video you explained about lowering the testosterone to threshold level then how do you know your threshold level and also some studies say that 1mg per day is as effective as 0.5 mg or 0.25 mg per day….could you please clarify.
    I am paranoid about testosterone conversion to estodil so is there a way to manage it and make sure more testosterone is used for other purpose like muscle building or binding with something else so extra testosterone is inert and so not much or a normal amount of T is converted to estrodil
    Waiting for your response
    Thank you doc

  • @elliefrangoulis2228
    @elliefrangoulis2228 5 місяців тому

    Is this not good for androgenetic alopecia? Because I read that it has been very successful for that too but no one mentions this option for AGA.

  • @adnanalkaltham6689
    @adnanalkaltham6689 2 роки тому

    Could u take about the usage of Tretonoin (retin-a) to maximise minoxidil absorption and efficacy?

  • @chasehart6832
    @chasehart6832 2 роки тому

    Creatine and finasteride together? May one who is on finasteride take creatine without fear of adverse effects on DHT levels?

  • @Subbu_is_reinforced
    @Subbu_is_reinforced Рік тому

    Please help me I am dying from this alopecia areata universalis....I am 32 years old with 28 years of this hair loss history....please help me 🙏🙏🙏🙏😭😭😭😭😭😭😭🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏😭🙏😭🙏😭🙏🙏😭😭😭😭🙏😭😭😭😭

  • @anticag
    @anticag 2 роки тому

    Hi could you share the paper/study please?

  • @hj89786
    @hj89786 2 роки тому

    Will cutting a coated 1mg finasteride pill into 2 0.5mg reduce efficacy?

  • @irishmuscle7352
    @irishmuscle7352 2 роки тому +39

    Great news for Alopecia Areata sufferers but not for us Androgenic Alopecia sufferers 😔 Forgive me for probably sounding so selfish.

    • @SonOfBangali
      @SonOfBangali 2 роки тому +3

      There are many treatments for aga in the pipeline . I hope they discuss those. For example CosmeRNA, Breezula etc

    • @irishmuscle7352
      @irishmuscle7352 2 роки тому +7

      @@SonOfBangali I already know about those but I’m trying not to get my hopes up too much in anticipation as we have been let down before after being promised a working treatment.
      The most promising and likely available treatment that I’m watching is Pyrilutamide. Apparently Kintor is releasing their phase two results in early September, fingers crossed all went well 🤞🤞

    • @SonOfBangali
      @SonOfBangali 2 роки тому +1

      @@irishmuscle7352 yeah that makes sense . But I hope since there are many competitors it will make all of them want to get tap the market before the other . Let's see .. I am hopeful within a year or two we will see something. Affordability will be another question all together though .

    • @irishmuscle7352
      @irishmuscle7352 2 роки тому

      @@SonOfBangali Agreed 100%

    • @jockez3581
      @jockez3581 2 роки тому +5

      To me Alopecia Areata sounds like a way worse condition at least the totalis/universalis variants. You can loose your eye lashes, eye brows and all other hairs wich totally changes your face/body.
      We must hope for a cure of both conditions.

  • @chora2858
    @chora2858 Місяць тому

    Does it work on short anagen syndrome or loose anagen syndrome

  • @SunnySharma-ve3jw
    @SunnySharma-ve3jw 2 роки тому

    Sir I am suffering from alopecia universal And suggest me diet for this disease?
    Protein diet is good for me or Not?

  • @goodboySr
    @goodboySr 2 роки тому

    Can you please do a video about the medicine name and how much in the week you should take. Is 7x 4mg necessary, or can you get result with less dosage the week, as like finas taking onky 3x 1mg would be sufficient. I hope to see a video soon about this. Every1 with alopecia areata will be very happy with this. Thank you

  • @harshbhandari9070
    @harshbhandari9070 2 роки тому +1

    What are your thoughts on using beard hair as donor hair for the scalp? Do you do so in your clinical practice? Also, you guys talk a lot about having FUT first and then FUE if needed. What are your thoughts on doing an FUE first and then FUT?

    • @123dweaver
      @123dweaver 2 роки тому +1

      Seems to me it wouldn't look natural. It's a different type of hair.

    • @aspiealpaca1917
      @aspiealpaca1917 Рік тому

      @@123dweaver Beard hair doesn't grow as long as scalp hair (generally), but if you have short hair I think beard hair would look okay.

  • @dansimonds9556
    @dansimonds9556 2 роки тому +3

    Hey guys, thank you for the awesome content. One thing I am wondering is that I am on 1mg oral finasteride and would like to take Tongkat Ali to improve testosterone. Do you think this will render my finasteride ineffective or bring other unwanted side effects (too much conversion to estrogen?) Thank you so much!

    • @ilbro7874
      @ilbro7874 2 роки тому +4

      It will just increase your dht a bit more. I'm using topical RU, minoxidil, tretinoin and when I go on ashwaganda, tongkat and fadogia for testosterone I don't notice an increase in hairloss...but ymmv

    • @dansimonds9556
      @dansimonds9556 2 роки тому +2

      @@ilbro7874 appreciate you sharing your experience bro 🙏

    • @raguseum11
      @raguseum11 2 роки тому

      the guy from" more plates more dates" will know for sure. Ask him

  • @bepo5074
    @bepo5074 2 роки тому +3

    I have a sort of offtopic question but couldnt find any answers on the internet: can i take 5g creatine per day while on 3mg finasteride per week or will this again lead to hairloss cause the dht increase from creatine is to high?

    • @petsuper5636
      @petsuper5636 2 роки тому +1

      Dont worry It wont. Creatine doesnt increase dht nearly as much to cause any noticable hair loss. Considering you are on fin you are safe.

    • @MarcoMadrista
      @MarcoMadrista 2 роки тому +1

      @@petsuper5636 wasn't it over 50% in that experiment? It's quite a lot I think

    • @Cosmic_Code
      @Cosmic_Code 2 роки тому +2

      I will give you a perfect answer. Because people have no idea what they are saying often.
      3 mg Finasteride = equal to 3 times aweek or 0.5 mg per day, will most likely reduce 60-65 % DHT.
      Creatine can sometimes increase DHT with 56 - 70 % of usage with 5 gram per day for longer time or cycles of creatine.
      Why should you listen?
      Because I done Creatine for 28 years on and off and been on Finasteide and Dutaseride. I would no go near Creatine. Its not worth it. I rather take Nandrolone or something extreme as Tren and such, as its less androgenetic converting than Creatine. You can also do a blood test and measure levels in the body and if above 90?. I would not bother taking it. Meaning you got storage enough in the muscles of the body. I been over 90 and 102 while not even taking it and I am 43 years old. I am also a fitness coach and nutrition freak here in Denmark.
      Creatine just binds water into the muscles and makes you 2-3 % stronger. If looks good when at the gym if below 20 % bodyfat and such. But its not the main thing I would consume. I even taken 20 and 30 grams of creative sometimes in the past. Mostly kept it was 2-7 gram per day. I have noticed a direct link between that and loosing hair. It depends on your age and many factors.
      It might be more safe to consume Creatine if on Dutasteride in this case.

  • @ajgomez254
    @ajgomez254 2 роки тому +2

    Please do a video on what dosing should look like when taking duetasteride alone and not in combination with finasteride. The label says .5 every day, but would every three days work just as well?

    • @ratt57
      @ratt57 2 роки тому +1

      I just got prescribed dutasteride. I was formerly on finasteride, and saw a video by these guys that taking it three times a week was just as effective as every day. I'd also like to know if the same is true with dutasteride. I've been looking through their videos and can't find any video that specifically deals with dutasteride only.

    • @ajgomez254
      @ajgomez254 2 роки тому

      @@ratt57 can you please direct me to the video where they say duetasteride thrice a week? Thank you

    • @ratt57
      @ratt57 2 роки тому

      @@ajgomez254 It's a video they did on finasteride, but I don't remember which one. They recommend taking finasteride every other day rather than every day and explain that 3mgs a week is just as effective and why. I'm assuming - and maybe I'm wrong - that I can do the same thing with dutasteride, since it's pretty much the same drug, only stronger.

  • @Whatsup78100
    @Whatsup78100 2 роки тому

    Could you do a Video on the effect of LLysine on hairloss?

  • @RichardoBrit
    @RichardoBrit 2 роки тому +1

    Does this work for Alopecia Barbae on the beard?

    • @Cosmic_Code
      @Cosmic_Code 2 роки тому

      What is that? You have that? Spots you mean or?

  • @oliverf2924
    @oliverf2924 2 роки тому

    A show about scube3 research would be interesting

  • @marcusduff2124
    @marcusduff2124 2 роки тому

    Does it work for non autoimmune hair loss?

  • @ThisVideosHorrible
    @ThisVideosHorrible 2 роки тому

    Hey Dr..Been on 1mg 3x weekly since Aug 1… Dht before starting was 46ng/dl…. Did a blood test on September 10… just got results back.. DHT is only 28 ng/dL thats a 37% reduction.. so not that 70% sweet spot … so i was thinking of switching to name brand Fin as im using Keeps generics or do you think its the frequency of 3x weekly thats not dropping it low enough… or do i need to wait longer or something.. I didn’t take a pill the day of the sept 10 blood test
    Thanks for response in advance!

  • @savopejovic25
    @savopejovic25 2 роки тому +1

    They recently started giving it for Vitiligo as well

  • @mreuronzy9377
    @mreuronzy9377 2 роки тому

    Can you just be on finasteride and get a penile implant if you get ed?

  • @AM-ku8qw
    @AM-ku8qw 2 роки тому

    Im sorry for my english.
    I want to ask something. Is it normal to have shedding After using finasteride?
    I Started 2 month ago with finasteride and i have to much hairloss

  • @TheTalisman515
    @TheTalisman515 2 роки тому

    Question , is it safe to take creatine without hair loss ?

    • @didierdunca
      @didierdunca 11 місяців тому

      i think its not, i do sport too i know

  • @prcption8636
    @prcption8636 2 роки тому

    Does this work for just normal hair loss ?

  • @ernestvasko2472
    @ernestvasko2472 2 роки тому

    thanks

  • @mohammedibrahim2530
    @mohammedibrahim2530 2 роки тому

    Sir
    4 months of finasteride 6 time a week and not seeing any good results nor my hair loss stopped or decreased
    Doctor please and pleassssseee answer me ?

  • @noahjung3286
    @noahjung3286 2 роки тому

    Doctor. I found that I have very early stage DUPA a week ago. Since it's still an AGA, it is still very likely that I can recover with finasteride, right? Can you please do a video about DUPA?

    • @Bendover-tw4ee
      @Bendover-tw4ee 2 роки тому

      Yes dupa responds to finasteride

    • @victornicolaestanciu6575
      @victornicolaestanciu6575 Рік тому

      Hi, what treatment did you pursue and what were your results? I might be in the same situation.

  • @californiadoll6273
    @californiadoll6273 2 роки тому

    My brother takes 1 5mg finasteride in the morning & 1-dutasteride 0.05mg at night because his hair was basically all gone. Has anyone else done that?

    • @ghani6607
      @ghani6607 2 роки тому

      I think he's high dosing, on this show they mentionned before that 1mg 3 times a week is enough.

  • @drunkshooter4156
    @drunkshooter4156 2 роки тому

    I have diffuse alopecia and I am using minoxidil for about 1.5 month but I apply 2ml at once one time per day because 1ml isn't enough to cover. Should I keep applying 2ml at once or try to apply 1ml twice a day but covering less in each application?

    • @Cosmic_Code
      @Cosmic_Code 2 роки тому

      Finasteride or Dutasteride might help you better...

    • @drunkshooter4156
      @drunkshooter4156 2 роки тому +1

      @@Cosmic_Code I started finasteride a month and a half too. So far no side effects

    • @Cosmic_Code
      @Cosmic_Code 2 роки тому +1

      @@drunkshooter4156 Ahh great. good luck then with Minox also. I will just answer you anyhow since I tried it all. I also used Minox 10 % from tugain India. 2-5 % mostly. 5 % Kirkland mainly.
      I will say that you can use 2 ml at once to prevent greasyness. If you get groggy or fog in the head then use 1 ml at the time. I have sometimes used 4ml 10 % with derma-roller and had all the symptoms and such and even heart tightness. I sometimes get tiny dizzy from 2-2.5 ml of 5 %.
      And I am a man over 6 feet and 230 pounds to put it into perspective
      I think between 1-2 ml is best at once. I would just go for 2 ml once aday. Its not going to help a lot on hair loss to do it more than once per day. Otherwise I would tell you. The thing is that if you stop 4 days or more on minox then wears off slowly out of the system and shedding will occur. I use 1.5-2.5 ml aday once in the evening and wash it in the morning. But you can do as you want?

    • @drunkshooter4156
      @drunkshooter4156 2 роки тому +2

      @@Cosmic_Code I don't have the greasy hair problem or itching. I wash my hair every 2 or 3 days and apply minoxidil everyday. Also twice a week I use the derma roller and apply minoxidil but no side effects also. I use minoxidil folcare that is available in Portugal and was recommended by my dermatologist because it causes less itching and greasy hair. Also I take 0.6mg of finasteride everyday (4,2 mg weekly) .Hope to see results in the next 4-5 months. Thank you for the answers and let's beat genetics xD.

    • @Cosmic_Code
      @Cosmic_Code 2 роки тому

      @@drunkshooter4156 let's hope:) Can I ask which NW level you are in? I reversed 3NW into 2.5 NW on half-year on 0.5-1 mg Finasteride aday. I just started Dutasteride 0.5 mg 4 x times a week also. I hope to get it down into a 2 NW level. In the worse case, you only need 1600-2400 grafts to restore an NW3 or NW Vertex (Which is not the case) And you also restore the donor area with Fin or Dut. It has 6000-8800 potential hairs to fix in front of the head or vertex if regretting some later. I am from Denmark. I hear you can buy Loniten at the pharmacy down there. Oral Minox? Is that true? I got it on prescription but they just stopped selling it here. I wanted to take 2.5-5 mg for better results than topical minoxidil. It's a safe dose you take with fin and I have long hair so It's easier to get greasy with 2 ml Minox. If you got less length of hair or short hair as most people do? Then it's easier to apply and also derma role. I can only derma roll my temples because my hair is around 50 cm long. It gets entangled if starting to derma roll it. But derma rolling helps no doubt. Also for the absorption of Minox. I assume folcare is a brand down there? Ever thought of Loniten? I don't have itching either. But, after a lot of research I came to the conclusion that buying a Nizoral shampoo with 60 ml 1 % without prescription and doing 2-4 washes per week for 2 weeks (Wouldn't hurt) They call them the Big 3. Fin or Dut + Minox + Nizoral. Nizoral is just to be safe and get rid of underlying inflammation of the scalp, even if there is no itching or flaking/dandruff or redness, but invisible inflammation some suggest. BTW. I was in Portugal as a kid:) I saw Bullfighting at this stadium. I will never forget it. Nice beaches also.

  • @nickangelovski4358
    @nickangelovski4358 2 роки тому

    Love Rusty 😁

  • @irishmuscle7352
    @irishmuscle7352 2 роки тому +1

    First

  • @AvinashChandraa
    @AvinashChandraa 2 роки тому

    Second

  • @MrDeceptacon88
    @MrDeceptacon88 2 роки тому

    1000th

  • @The_Voice_of_Reason_is_here
    @The_Voice_of_Reason_is_here 2 роки тому +1

    Fifth

  • @traclpackage5075
    @traclpackage5075 2 роки тому +3

    Another disappointed r/tressless user

    • @Bathrezz1
      @Bathrezz1 2 роки тому +2

      Why are you disappointed?

  • @martinm.1967
    @martinm.1967 2 роки тому +3

    The next best thing to hope for is KX826 (Kintor), a strong androgen receptor blocker: en.wikipedia.org/wiki/Pyrilutamide

    • @stephanosss
      @stephanosss 2 роки тому +1

      Yes i agree. Lets see this in action..

    • @Lidemann92
      @Lidemann92 2 роки тому +2

      Get ready to get disappointed

    • @super-super-
      @super-super- 2 роки тому +1

      What are the results of phase 2 trials?

    • @martinm.1967
      @martinm.1967 2 роки тому +2

      @@super-super- Effect Sizes somewhere between Finasteride and Dutasteride.

  • @NovaGeo
    @NovaGeo 2 роки тому +1

    Third