Immune Response, Toll Like Receptors (TLR) Pathway - IMGENEX

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  • Опубліковано 1 тра 2011
  • Watch The second Video in the TLR Series!!!! - Don't for get to Like and Follow!
    • Innate Immunity: Viral...
    www.imgenex.com
    Toll Like Receptors: The GateKeepers of Innate Immunity
    Innate immunity as the first line of defense
    The innate immune system is an ancient host defense mechanism found in almost every multicellular organism from plants to humans. In invertebrates it is the sole mechanism of defense against pathogens but in higher vertebrates constitutes the first line of defense. The role of the innate immune system is not an insignificant one; not only must it discriminate between self and non-self as well as distinguish between pathogenic and non-pathogenic microbes, it also plays an important role in triggering and optimizing the adaptive immune response. This remarkable system allows an immediate non-specific response against microorganisms whereas the adaptive immunity mounts a specific response against the invading pathogen during the late phase of the infection.
  • Наука та технологія

КОМЕНТАРІ • 395

  • @killpy12
    @killpy12 4 роки тому +66

    Absolutely horrifying and inscrutable. I love it, thank you

  • @litojonny
    @litojonny 9 років тому +313

    this is what id imagine what studying immunology high must be like

    • @melthompson9487
      @melthompson9487 8 років тому +3

      litojonny that is exactly what I was attempting to do and I felt that my needs were tended to. 10/10

    • @mroosie7488
      @mroosie7488 5 років тому +14

      This IS what studying immunology is like... it's horrific.

    • @matthewludivico1714
      @matthewludivico1714 4 роки тому +5

      While listening to techno music

    • @widyawidya5752
      @widyawidya5752 3 роки тому +3

      Medicine faculty be like

    • @gregorykarimian3813
      @gregorykarimian3813 2 роки тому +1

      LOL

  • @Guihlopez
    @Guihlopez 10 років тому +56

    This video is absolutely amazing. Immunology completely makes sense after watching it. Congratulations to whoever made it.

    • @matthewcurry3565
      @matthewcurry3565 Рік тому +4

      I think someone poisoned me with literal LSD. What is happening?

  • @Airhockeylirare
    @Airhockeylirare 10 років тому +401

    So this is what happens when microbiologists take LSD...

    • @joeshellhammer
      @joeshellhammer 9 років тому +11

      I thought the very same thing when I first watched it, even though I really liked it. But, wow, what an imagination! Pretty impressive. I thought it would have been appropriate to have this video set to "Lucy in the Sky with Diamonds".

    • @prasadbotheju5682
      @prasadbotheju5682 6 років тому +1

      I'm researching relieving sarcoidosis condition naturally and found a great website at Remission Crusher Tactic (google it if you are interested)

    • @thenaturalsourceofourhealth
      @thenaturalsourceofourhealth 5 років тому

      hahahahahahahahah

    • @rittenbrake1613
      @rittenbrake1613 5 років тому

      Nina Borodinskaja 😂😂😂😂😂😂👍🏻

    • @giannis101
      @giannis101 4 роки тому

      Hahaha

  • @rickyroko1
    @rickyroko1 8 років тому +86

    This is the greatest ANIMATION i've ever seen in immunology! lots of love

    • @qingzheng7485
      @qingzheng7485 4 роки тому

      me too

    • @kingsleyuduehikingsleyudue1494
      @kingsleyuduehikingsleyudue1494 3 роки тому

      I want to thank Dr ehime herbs for the help he has rendered to me by getting Rid
      of my (HIV). I was Diagnosed in July 2018 but after the Usage of Dr ehime herbs
      Herbal Medicine, I was cured from (HIV) and the virus was completely gone
      from my body. The Symptoms of the (HIV) Virus is completely Gone.. So
      anyone who is having the virus should contact Dr ehime herbs to give you the
      herbal medicine to cure yourself. HERPES, You can contact on Instagram @dr_ehime_cure2 or contact WhatsApp number (+2348144387765) or email (drehimecure325@gmail.com)
      He cures all this illness,.
      1 cancer cure
      2 diabetes cure
      3 ringing ear
      4 herpes cure
      5 warts cure
      6 HPV cure
      7 Hiv
      8 get your ex back
      9 pregnancy herbal medicine
      10 prostate enlargement
      11 Hepatitis B
      12 Dysfunction...

  • @leticiacuellar6474
    @leticiacuellar6474 6 років тому +11

    Kudos to the producers for making this TLR series funky fun!

  • @yeshitellaaleme4419
    @yeshitellaaleme4419 3 роки тому +5

    I watched this 6 years ago and I wanted to watch it again then my mom put out a UA-cam video and it popped up I'm crying tears of joy!!

  • @101Phase
    @101Phase 11 років тому +15

    Believe it or not, I'm currently writing an essay on Toll-like receptor signalling for a coursework and this was the most accessible summary I've found so far. Excellent work!

  • @dr.salmanriaz1468
    @dr.salmanriaz1468 8 років тому +26

    what can u expect more than this?...
    lovely...thousands of heart loving kisses to the one who created

    • @rashaessam9426
      @rashaessam9426 5 років тому +1

      Dr.Butterscotch certainly great effort

    • @kingsleyuduehikingsleyudue1494
      @kingsleyuduehikingsleyudue1494 3 роки тому

      I want to thank Dr ehime herbs for the help he has rendered to me by getting Rid
      of my (HIV). I was Diagnosed in July 2018 but after the Usage of Dr ehime herbs
      Herbal Medicine, I was cured from (HIV) and the virus was completely gone
      from my body. The Symptoms of the (HIV) Virus is completely Gone.. So
      anyone who is having the virus should contact Dr ehime herbs to give you the
      herbal medicine to cure yourself. HERPES, You can contact on Instagram @dr_ehime_cure2 or contact WhatsApp number (+2348144387765) or email (drehimecure325@gmail.com)
      He cures all this illness,.
      1 cancer cure
      2 diabetes cure
      3 ringing ear
      4 herpes cure
      5 warts cure
      6 HPV cure
      7 Hiv
      8 get your ex back
      9 pregnancy herbal medicine
      10 prostate enlargement
      11 Hepatitis B
      12 Dysfunction...

  • @russelmiller7311
    @russelmiller7311 7 років тому

    vivid explanation on the topic. Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.

  • @HassanKhan-sx1nt
    @HassanKhan-sx1nt Рік тому

    content like this derived people's on youtube to clear concept such videos make study very easy so there is no excuse for no learning

  • @juliaskripka-serry2537
    @juliaskripka-serry2537 9 років тому +90

    Welllll peeing my pants laughing is definitely not the outcome I was expecting when I youtubed TLR videos today

  • @p3natrator
    @p3natrator 7 років тому +1

    Great video! I am a visual learner so it really helped me to put faces with all these things.

  • @tropicantei5550
    @tropicantei5550 5 років тому

    WAAAAW THANK YOU. YOU JUST SAVED MY FINALS x))))

  • @ita14
    @ita14 12 років тому +1

    B7 molecules are B7.1 (CD80) and B7.2 (CD86). They both bind CD28 to sustain T cell activation.

  • @edwardhaughney9665
    @edwardhaughney9665 3 роки тому

    Rather stunning presentation. Pictures are more powerful than words. Keep up the good work. Don't usually care for music accompaniment but this seems to work.

  • @esra11102010
    @esra11102010 11 років тому

    This is amazing. Keep up with the good work, I like them all

  • @bangtanbeau2131
    @bangtanbeau2131 7 років тому

    VERY GOOD ANIMATION. Thankyou! It helped me a lot!

  • @brazilian777able
    @brazilian777able 11 років тому

    This is a very creative ingenious video. Excellent!!! I love the end with the showing of the cast. LOL

  • @marvahkhalid5060
    @marvahkhalid5060 3 роки тому

    wow this is soo amazing!! thankyou for your efforts in creating this

  • @anujapatil2902
    @anujapatil2902 7 років тому

    very thoughtful, thanks, guys for uploading this video!

  • @Peter7beardmaster
    @Peter7beardmaster 11 років тому

    this is exactly how Kuby's describes the process..you just won a like and subscription, thanks a lot

  • @dezafeatle
    @dezafeatle 11 років тому +2

    Very helpful video. Helped me understand my immuno-biology class a lot better.

  • @_SankalpaBhusal
    @_SankalpaBhusal 5 років тому

    It was like a complete review for me!!! Great job...🙌✌🙌

  • @savi263
    @savi263 4 роки тому

    Superb animation to understand the TLR biology! Thanks

  • @username7445
    @username7445 3 роки тому

    The cast is very well chosen! Congratulations😂

  • @Prettyspeck
    @Prettyspeck 10 років тому +2

    Wish everything could be explained in this way. zthis is Amazing

  • @aishabhat2358
    @aishabhat2358 6 років тому +4

    This is toooo cute,never seen anything so interesting and creative related to my studies.
    Thank you so much for this animation❤

  • @jaquelinemanuel5716
    @jaquelinemanuel5716 10 років тому +1

    cute, entertaining, and interesting! I hope more videos on immunology and other topics in med will come soon! Thanks!

  • @uzmakhan9264
    @uzmakhan9264 6 років тому

    Truly it made my topic easy to remember !!THANKS😊

  •  11 років тому

    interesting animations you got there.
    Keep up the good work!

  • @nechamarakow3922
    @nechamarakow3922 9 років тому

    the best way to study! its really a difficult war going inside our bodies.

  • @leonstellander8602
    @leonstellander8602 3 роки тому

    I will never forget this

  • @kakhangchungpanmei8205
    @kakhangchungpanmei8205 11 років тому

    So helpful. wasnt sure about PPR an TLR, now i know , ur website is really helpfull. kip up the good work.

  • @stemked
    @stemked 10 років тому +1

    Very nice. I'm going to use this video in my Immunology class.

  • @sophiabang7868
    @sophiabang7868 3 роки тому

    When you leave no room in your budget for sound lol. Honestly though great video for visualizing TLR system and MHC II antigen presentation. Makes things make more sense as you read.

  • @kandrew5v5
    @kandrew5v5  12 років тому +3

    @Mjhond Thanks, I appreciate it! We are working on more videos as we speak.

  • @ekimzaga
    @ekimzaga 12 років тому

    hell yeah, a video that is speaking in my terms!! house music, animation, and not dumbed down! =)

  • @rrintan9140
    @rrintan9140 5 років тому

    W000WWW omg. thank you so much for creating this creative animation! this will definitely help me so much to pass the exam :)

  • @bharathraj5862
    @bharathraj5862 4 роки тому

    Great work!!
    Easy to understand and thank you.

  • @kandrew5v5
    @kandrew5v5  12 років тому +1

    @PastelitaVelys Do you mean our TLR book? Or another resource? Thanks!

  • @neerajpatil3735
    @neerajpatil3735 10 років тому +2

    Hey! You have uploaded a really nice video. But changes should be made in the names of all component cells and proteins. One can not see properly the names in lower resolutions.

  • @aleenajamil7495
    @aleenajamil7495 10 років тому

    Really good explanation and animations!

  • @hgsnk333
    @hgsnk333 11 років тому

    Please (and thank you) make one for CLRs, RLRs and NLRs!!!

  • @EdwardCullenBby
    @EdwardCullenBby 12 років тому

    Love this video!! Just what I needed to help me study :)

  • @Racheal700
    @Racheal700 6 років тому

    This is awesomeeee....things like this make it so much easier

  • @Toughtriples
    @Toughtriples 7 років тому

    its amazing keep uploading such type of videos

  • @karleffertz
    @karleffertz 12 років тому

    Great video!! when are 2 and 3 coming out??

  • @Mai0211
    @Mai0211 11 років тому +3

    love the animation! makes it much more fun to watch, especially for someone with a short attention span like me who's trying to study. But you should have someone explaining each process instead of music, that would be much better :D someone with a good cartoon voice.

  • @kandrew5v5
    @kandrew5v5  12 років тому +1

    @bundawartini We tried to show as much information as we could. There are still many areas in which this video does not cover. We are releasing a 2-3 part series following up on these areas.

  • @kandrew5v5
    @kandrew5v5  13 років тому +2

    @gutrp Thats Great! If I only I had videos like this through school, it would have made immunology a lot easier to digest!

  • @ashithak6268
    @ashithak6268 3 роки тому

    Excellent. The video says it all....

  • @kandrew5v5
    @kandrew5v5  12 років тому +2

    @jennyEvansmd Thanks for the comments, we are working on 2 additional videos that expand on this presentation. The new videos should fill in some of the gaps ins the sequence that is currently shown.

    • @giannis101
      @giannis101 4 роки тому

      Go on ! You are the best ( greetings from Greece )

  • @nav5679
    @nav5679 10 років тому

    incredible video! one of the best ways to learn this stuff :)

  • @marleneiradukunda4618
    @marleneiradukunda4618 9 років тому

    Great video!
    It's so easy to understand :)

  • @priyankagorai6549
    @priyankagorai6549 Рік тому

    This is absolutely amazing

  • @02luvtrack
    @02luvtrack 9 років тому

    This is amazing. Thank you so much

  • @Ozinco
    @Ozinco 9 років тому

    Genuinely the best signalling animation I have seen to date, bravo sir!

  • @RaviSingh-yz9tx
    @RaviSingh-yz9tx 6 років тому

    Awesome video with excellent presentation

  • @caslandry2847
    @caslandry2847 4 роки тому +8

    This is kinds how it feels when I study for my immunology final after a few too many edibles, and maybe some acid.

    • @kingsleyuduehikingsleyudue1494
      @kingsleyuduehikingsleyudue1494 3 роки тому

      I want to thank Dr ehime herbs for the help he has rendered to me by getting Rid
      of my (HIV). I was Diagnosed in July 2018 but after the Usage of Dr ehime herbs
      Herbal Medicine, I was cured from (HIV) and the virus was completely gone
      from my body. The Symptoms of the (HIV) Virus is completely Gone.. So
      anyone who is having the virus should contact Dr ehime herbs to give you the
      herbal medicine to cure yourself. HERPES, You can contact on Instagram @dr_ehime_cure2 or contact WhatsApp number (+2348144387765) or email (drehimecure325@gmail.com)
      He cures all this illness,.
      1 cancer cure
      2 diabetes cure
      3 ringing ear
      4 herpes cure
      5 warts cure
      6 HPV cure
      7 Hiv
      8 get your ex back
      9 pregnancy herbal medicine
      10 prostate enlargement
      11 Hepatitis B
      12 Dysfunction...

  • @Flush333
    @Flush333 11 років тому

    Wow, this is terrific!

  • @katherinehume5058
    @katherinehume5058 10 років тому

    Excellent work!

  • @drshwetalokwani3690
    @drshwetalokwani3690 Рік тому

    Thank you for making it easier

  • @jessicakorupolu8190
    @jessicakorupolu8190 8 років тому

    thanks for the great video! It helped alot and really adorable.

  • @chuepheng
    @chuepheng 12 років тому

    LOVE THE VIDEO!!

  • @vionagunawan5938
    @vionagunawan5938 10 місяців тому

    Wow this is so cool, and I can understand it immediately

  • @saumyaranjansatrusal764
    @saumyaranjansatrusal764 4 роки тому

    an amazingly interesting video i have ever seen..hats off to the creator, epic imagination...

  • @Saul_GC
    @Saul_GC 12 років тому

    there are soooo many things other than what appears here that i must learn, may god have mercy on my soul, and on your souls if you are/will be in this situation

  • @capriccioso35
    @capriccioso35 12 років тому

    @gerbilinatube CD 80 is another name for B7 and yes it links with CD28 as a costimulator for T cell ( in this case, CD4 , helper T cells) activation

  • @kandrew5v5
    @kandrew5v5  12 років тому +1

    @willamricard Thanks alot! More videos are on the way

  • @user-kx6gr6ky4b
    @user-kx6gr6ky4b 7 років тому

    this is awesome and imaginative! well presented 😉

  • @mozarliszt
    @mozarliszt 12 років тому

    Very good video, so comprehensive!I love it.

  • @nuarma
    @nuarma 7 років тому

    This was amazing.

  • @kensani
    @kensani 8 років тому

    This, is beautiful!

  • @11nicolalbamamanimerlo18
    @11nicolalbamamanimerlo18 2 роки тому

    Bonito video que compartes, estubo muy interesante muy bonito gracias. En invertebrados es el único mecanismo de defensa contra patógenos pero en vertebrados superiores constituye la primera línea de defensa . GRACIAS me ayudó bastante💅🥰

  • @friedrichbaumgarten8886
    @friedrichbaumgarten8886 8 років тому +1

    Danke schön

  • @Ashwin_official
    @Ashwin_official 3 роки тому +1

    So accurately and well explained

  • @azeemnaeem6720
    @azeemnaeem6720 3 роки тому +1

    Lovely inspiration for immunology

  • @MrTimothy250
    @MrTimothy250 12 років тому

    Well, in fact, there is two types of B7 proteins. B7-1, which is CD80, and B7-2, also nammed CD86. Both can fix CD28 or CTLA-4, respectively stimulating or inhibiting the lymphocyte T CD4+ cell.

  • @alwaysambitious
    @alwaysambitious 4 роки тому

    So cool! I love it.

  • @zeeto_k
    @zeeto_k 4 роки тому

    this video is more helpful more than my prof.

  • @Hellos.5
    @Hellos.5 3 місяці тому

    I can only imagine a game designer and a doctor collaborating on this 😂. It’s a wild ride.

  • @dianachin8001
    @dianachin8001 10 років тому

    This is so cute ! Thanks for doing such a helpful video

  • @NLNikoleta
    @NLNikoleta 12 років тому

    i am using anti-TNF inhibitors and i like your video so much!

  • @jorgearmandomejiatobar6482
    @jorgearmandomejiatobar6482 5 років тому

    wonderful work I love it

  • @wellyd44
    @wellyd44 11 років тому

    Yes CD80 and CD86 are B7 molecules expressed by the APC upon TLR activation. CD80 is B7.1 and CD86 is B7.2. The B7 nomenclature is old whereas the CD nomenclature is more modern.

  • @walidsong2255
    @walidsong2255 4 роки тому

    Please explain the work of the enzyme 5 alpha reductase in changing the male hormone, and where it is produced. Thank you.

  • @adrijanacabric332
    @adrijanacabric332 11 років тому

    Predivna animacija, jasno u potpunosti.

  • @Spremke92
    @Spremke92 11 років тому

    Amazing,well done!!! :)

  • @habibehk
    @habibehk 4 місяці тому

    Saved it, and sent the link to my kids- Cool, fun and creative animation! If you can, please share the link(s) to your other work(s) in the reply to comment section.

  • @ranaalhelaby5718
    @ranaalhelaby5718 7 років тому

    that was so helpful. thank you

  • @gerbilinatube
    @gerbilinatube 12 років тому

    Cool, thanks Mr Timothy, that's good to know.

  • @khimbahadurale7079
    @khimbahadurale7079 8 років тому

    Really an interesting way of learning!!

  • @expertgov.musically287
    @expertgov.musically287 5 років тому

    Great work.

  • @ashwinishinde64875
    @ashwinishinde64875 3 роки тому

    Please upload more videos ..... This is so easier to understand everyone ..... I have never see like this animation 😂🤦😍😍

  • @imegatrone
    @imegatrone 12 років тому

    Nice Video That You Share , So Very Nice Thanks You . In invertebrates it is the sole mechanism of defense against pathogens but in higher vertebrates constitutes the first line of defense

  • @kandrew5v5
    @kandrew5v5  13 років тому +2

    Also check out Imgenex's new apoptosis detection tool called pSIVA

  • @MadrassaDzOubahMed
    @MadrassaDzOubahMed 5 років тому

    Hi ...thank you very much for your videos ..
    could you tell me please the name of the program that can make that animation style ... thanks again

  • @xiaohanjiang749
    @xiaohanjiang749 4 роки тому

    Very wonderful!

  • @Patricia-vf4sn
    @Patricia-vf4sn 7 років тому

    WOW! Amazing!!!