As a physician who has a patient population of young adults with fatty liver disease, I find the C15:0 story compelling. Specifically the pathophysiology of the cellular fragility syndrome makes sense. Low levels of sturdy fatty acids like C15:0 in our cell membranes leads to weakened cells, leading to lipid peroxidation, ROS, iron deposition, iron overload and cell death by ferroptosis, leading to accelerated NAFLD/NASH. Further, the clinical trial you mentioned was performed by Dr. Schwimmer, a leader in pediatric fatty liver disease. The way I read his findings is that if you increase your C15:0 levels above 5ug/mL, patients with increased liver enzymes had significant improvements in ALT and AST, which to me means that there is a safe, low risk way to address a condition (fatty liver disease) that has very few treatment options. Exciting (but early) findings.
You are either incorrect or have little evidence that supplements that are antioxidants generally blunt the effect of exercise. You should stop saying this. Some antioxidants do this but not all. We know that there are human studies suggesting that astaxanthin increases muscle strength and endurance. There are mouse studies on curcumin and olive leaf extract that show that each improved muscle mass, strength and /or endurance. I will give you one example, but there are several This human clinical trial on Natural Astaxanthin in 2011 was funded by Gatorade Sports Science Institute. For this study, Gatorade used competitive cyclists, supplementing them with a placebo or 4 mg of Natural Astaxanthin each day for four weeks. From the endurance athlete’s-or for that matter-from any competitive athlete’s perspective, the results were excellent. In a 20 kilometer (approximately 12.5 mile) cycling time trial, the performance of the subjects taking Astaxanthin significantly improved, while the subjects taking placebo showed no improvement. Natural Astaxanthin made these competitive cyclists on average 5% faster in only 28 days. Also, the cyclists taking Astaxanthin demonstrated significant improvement in their power output, which increased by 15% on average over the same 28 day period. As far as I know, Gatorade does not sell, and has not sold, a product containing astaxanthin
@DrBradStanfield I get the impression that the shill selling snake oil is felling threatened by Fatty 15, a product that was going through the pharma route to market, but was withdrawn and released as a supplement because it is a natural product, not needing the approval required for drugs. It is interesting that so many specialists in their fields are doing their own research on C15. And the fact you ignored evidence from populations that naturally consume large quantities of C15 in their diets and have higher health and longevity markers than the rest of the European and American population’s.
I've been critical of your videos in the past due to what I believed were overly negative statements towards some supplements & health interventions that had both positive and negative data supporting their use. In this case, you have redeemed some of my criticism by providing solid information and an educational public service. Thank you for this.
Dr. Brad You are correct in your assessment in regards to fatty 15. If you look at their web site, they list a different address for their returns that they shut down in 2020. Fatty 15 has no actual store front. So where is this product manufactured? Dr. Brad, please keep digging into these unscrupulous vitamin claims.
Most Vitamin C supplements are unstable. Unless they use a stabilized slow release version I don't think anyone knows what it's capable of. Which is sad. No one does the leg work on anything.
Unlike this video here is a valuable comment.. note that if you study the fatty15 site it is targeting the vegans.. aka those who refuse milk and such other foods..
Dr Brad is HUGELY on point here, however, there are molecules that have almost no strong human peer reviewed documentation, yet they have been known over the centuries and in various countries around the world. Thanks, Brad.
There are also many examples of snake oil that have existed for centuries. This is why strong human peer reviewed documentation matters: separating fact from fiction.
What I did after reading all the "C15 papers" I could find - simply make a more concerted daily effort to getting grass-fed dairy products, goat/sheep milk products, and/or grass-fed beef. Near as I can tell, about 2 ounces a day of such cheese or butter, 4 oz of such beef, or a couple cups a day of such whole milk meets the "RDA" (assuming/if such a thing truly exists for C15). Any one of those in nominal amounts each day should do the trick, and since all of those are all healthy unprocessed foods with beneficial Omega 3 profiles as well - as long as I keep it all within daily calorie thresholds there is no downside risk if the whole thing turns out to be bullocks. :)
What about the saturated and trans fat content? What about the associations of animal protein with cancer and autoimmune diseases (established with strong statistical significance in epidemiological studies documented in the China Study?)
What about them? Sure, there are people with allergies or vegan that may wish to avoid. I would suggest anyone that believes proper health maintenance must include 100% avoidance of any level of saturated fat consumption is not fully or properly informed. For example; C15 itself - to any extent it truly is essential - is a saturated fat. And somehow, if the research is to be believed, that saturated fat became “essential” to proper cellular health over the course of at least a few hundred thousand years of evolution (if not millions), despite the absence of a magic pill…
Wonderful comment.. unlike this video.. he miss the point that vegans are the ones lacking and the target is not the suppliment it is the statement that c15 may be an essentially nutritient.. he is a misguided and misleading good information
I'm so glad you go against the mainstream health-UA-cam-channel trend with pushing supplements by sowing fear and instead stick to medical research on humans.
Listen to latest Dave Asprey podcast. The person behind it is on it and mentions where you can get links to research. Up to you to decide then. Don't forget that Dr Brad was pro resvératrol just a few years ago after he'd drunk the David Sinclair Koolaid (as had many of us, admittedly). Even at that time there was research around which dissed it.
Ozempic is a good example of what will happen if someone comes out with something that actually works as well as its advertised. You're gonna hear about it very quickly
I am very skeptical of supplements and medicine what’s popular isn’t working you got to find little known things to get any benifit. They don’t advertise things that help no money in dead people no money in healthy people.
I’m in my 50’s and most of my family has died from Alzheimer’s. Because of this and my age, I started taking neuro hacking supplements a few years ago. I had a full physical about 5 months ago and was told my liver enzymes were spot on for good health. 4 months ago, I added the supplement uridine after watching some videos on it. A month ago I ended up spending several days in the hospital with fatty liver disease. They said one of my numbers is supposed to be under 100, but was now over 2100. I started reading about each supplement I take and found that in some, uridine can cause this. I stopped taking all supplements completely. I feel more clear minded now than I have in years. I’m going to steer clear of supplements for the foreseeable future.
Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden www.ncbi.nlm.nih.gov/pmc/articles/PMC5349792/ Contrary to observations in industrial populations, older adult E4 carriers with high parasite burdens either maintained or showed slight improvements in cognitive performance, whereas non-E4 carriers with a high parasite burden showed reduced cognitive performance. Being an E4 carrier is the strongest risk factor to date of AD and cognitive decline in industrial populations
If you're afraid of Alzheimers then you need good sleep, daily exercise, and a solid diet. If supplements help at all (a big "if"), then their effects are marginal compared to sleep, exercise, and diet.
Actually many ingredients that make a cake taste better also make a stew taste better... Adding black chocolate to the sauce of a beef stew like Daube or Boeuf Bourgignon is an old trick of french cooks, cinnamon also adds flavor. More general, adding sugar to savory dishes in general makes them better, as does adding a bit of salt to many sweet desserts and cakes. Adding butter to both will also make them simultaneously tastier and unhealthier...
creatine is just about the only supplement that matches the hype and I’ve been around for 60 years so few really pan out to your point don’t chase every new thing doctor oz was the biggest offender every week a new miracle, food or pill for me this is a particularly good video thank you
I appreciate the information. I had taken this product before and it did nothing for me. I even put that on a post of this product on facebook. Some had even taken this for a year and it did nothing for them as well. I hope this video makes it around so others know not to take this product.
And if it IS found to be effective, guess what? A pharmaceutical company will say that it is extremely beneficial for a particular ailment and will apply with the FDA for it to be sold by prescription only.
I am glad I waited. I was one of the people that took the information about C15 to heart. But I never bought any. I was thinking a bit in the direction of eating those types of fish those dolphins ate. But I have a question, on your video. You showed white compressed pills, but how can those contain fats?
Summary. It's like: - trying to turn a sketch into a full colo[ur] painting - finding a new ingredient that makes a cake taste better - finding a shiny object on a beach - a polished pitch - a magician performing a trick - a mechanic telling you your car has a made-up problem - selling tickets to a concert - crying wolf
Having taken Fatty 15 for 5 months now my HDL is the highest it has ever been, my before & after blood test prove it. This was the reason I started it. Also fasting Insulin went from 15 to 6.6. I will keep on taking it and will test again at the end of the year. For now my biomarkers are moving in the right direction if that changes then I will change my supplements.
@@MegaWandak True, I feel this way about Brad. Only focuses on single facts about substances that have been studied vastly in many areas like resveratrol.
I have obtained a letter from the National Archives that Stephanie Venn-Watson wrote back in 1977 when she was just 5 years old. She wrote to the United States Congress demanding they modify the dietary guidelines to exclude dairy fat. AND THEY DID JUST THAT! The same exact year, her future husband wrote to Sardian sheep farmers in broken-Italian and asked them to consume adundant amounts of their pecorino cheese to obtain high levels of C15:0. Their plan? 45 years later compare Sardians with high levels of pentadecanoic acid to Americans with almost none, pen some wild story and publish it in a peer-reviewed journal, then create a supplement. And it worked...ALMOST. If it hadn’t been for the New Zealand medical Magnum P.I. (you just need to grow a crumb catcher, Brad) they would have gotten away with it! Thanks for the cracking the case! By the way, I would love to try the supplement you're pushing on your website (the Dr. Brad Stanfield Micro Vitamin for a cool $39.99) in order to reep the "18% smoother skin" benefit. Would you recommend I have my rough skin tested prior to taking it and then again after 3 months? What would that test be, exactly? Thanks, Julian
Yes, supplements must be research science based and have pharmaceutical level quality control, even then they dont work for everyone in the same way, just as drugs don't always too .
What a fantastic and eye-opening video, Dr. Stanfield! 🌟 Your breakdown of the supplement hype cycle is not just timely but essential in a world where "miracle cures" seem to pop up faster than a TikTok dance trend. It's fascinating (and a bit alarming) how the supplement industry has mastered the art of storytelling. They’ve turned marketing into a high-stakes game of "who can sell the most hope." I mean, if I had a dollar for every time I saw a supplement marketed as the "next big thing," I could probably fund my own clinical trial! 💸 Your point about TEDx talks being used as platforms for unvetted claims is particularly striking. It’s like watching a magician pull a rabbit out of a hat-impressive, but you have to wonder where that rabbit came from! 🐇✨ Just because someone is on a stage doesn’t mean they’re not just selling smoke and mirrors. And let’s not forget the irony of it all: we’re often told to "trust the science," yet many of these supplements lack the rigorous research that would make any scientist proud. It’s like being served a gourmet meal that looks amazing but is made entirely of air-satisfying to the eyes, but not so much for the stomach! 🍽 For anyone looking to navigate this minefield, your advice on seeking out supplements with proven health benefits is golden. It’s a reminder that sometimes the best "supplement" is a balanced diet and a good night’s sleep. Who knew that the real miracle cure was just a well-rounded lifestyle? Thanks for shedding light on this important topic, and for keeping us all informed and entertained! Looking forward to your next video-maybe something on the "real" benefits of kale? 😉🥬
Watch: "C15 Fats: What No One is Telling You [7 Studies Later]" and "C15 Fats: Better than Omega-3s? Scientist Explains", by the UA-camr: Physionic Physionic's Credentials: - Ph.D. in Molecular Medicine (Cell Physiology) - Masters in Exercise Physiology - 10 Years Experience in Laboratory Work - Previous American College of Sports Medicine Certification - Non-Degree in Nutrition Science (1.5 years undergraduate education) - Classroom Professor (T.A. in 2015) in Health, Nutrition, and Physiology since 2016
Great video. I bought into the hype because of the interview with Stephanie Venn Watson. She seemed so sincere and the dolphin story and the Sardinian (humans) story. She may be sincere and the marketing people took over and over hyped the product. The fatty 15 people say they have a double blind placebo human trial of 20 people taking their pills and 10 control people taking placebos with good results on the 20 people. I wish Brad had talked some about the Sardinians and the human trials, otherwise it was a great video.
Yes, this aligns with my experience as a consumer. Not a science person but usually curious about things, I like to find the evidence for claims and it is often very much like was described here: “in animal studies …. Scientists found in mice that ….” Listening to many of the presentations you find on UA-cam, there are great leaps in logic. You often read the “10 best foods/supplements for people with (insert condition)” and when you read through said list, it is full of hyperbole, making tenuous links such as Vitamin C is an antioxidant therefore prunes, which are high in vitamin C can reduce3 inflammation. Can sound convincing. Going through a few health conditions myself, I’ve become very alert to the points described here relative to that hype cycle. Some articles look like they have actually made links to scientific research and will provide the links (knowing most people wont read them but just accept the fact that “it must be true then”) that are actually related to something else. The dosage of supplements is also concerning to me. There needs to be regulation of the supplement industry.
There's emerging evidence that creatine may be neuroprotective as well as increase muscle endurance. There's no downside to taking it, and plenty of indications of potential upside, I think everyone should take 5-10 grams/day.
Well it may be my so called placebo effect trait from Ancestry, but on day 32 the hair on my arms is getting thick, sex changes - more ejaculate, slightly better sleep. Better mood. I am 70. Also started taking astragalus though as well. I have looked hard for the papers from 2012, nada. It does make me suspicious about a scientific journey vs. greed. But if it can lower mTor which is unproven, it might escape all those patents and just be added back into milk.🎉 My hearing loss may be improving due to that new form of autophagy. But there are other variables that may be involved.
Almost all from taurine to rapamycin start off and are primarily based on animal studies. The data on dogs who live 12 years more or less is not even out. You too push your own supplements based on the weakest of non randomized trials on multivitamins. And I get it that you too need to get hits for your UA-cam. So you either take a non conflicted educational role or you stop making yourself look better than the others. Everything imho out there is more or less personal opinions that are attempting to be monetized
Also while what makes a cake taste good may make a stew taste better it also may make it worse. Similarly, the supplement may worsen our health. So literally no reason to take it, it gives hope but also risks.
Execellent video, Dr Brad. Cutting through the wellness BS is important work. I’d be interested to know your opinion of naturopathy, a practice that seems to rely on prescribing any number of supplements to treat patients.
Hi brad, don't you offer any discount code from your supplements? I am thinking of switching and putting my trust in you. I usually buy them separately from do not age. Are the compounds from natural foods or plants?
If I had a nickel for every time something called "fatty" tried to scam me I'd have two nickels this year, which isnt a lot but its weird that it happened twice.
Seems like palmitoleate + apigenin could be a healthy combination. Improved insulin response without higher risk of fatty liver, hopefully, with the apigenin added.
The statement about the subgroup analysis doesn’t make sense. You say: ‘even in the subgroup analysis, which is a risky thing to do in a small trial anyway, there was still no statistically significant difference’. Smaller N gives less power. If a result is statistically significant, this is despite small sample size and power. It’s only ‘risky’ in that you need a large effect size to see p < 0.05. And the Kruskal-Wallis p value in the table is 0.01, which is significant at alpha = 0.05. Did they set it at 0.05 or are you referring to a result reported elsewhere?
Hello Doctor - looked at your brand for psyllium husk - is not organic. Some brands indicate organic and third party tested. Is to costly? Or really not needed or benefit if organic brand?
I see that you take psyllium husk for digestive health. Could you comment on recent research that says beta glucans (found in mushrooms, seaweed, barley and oat husks) are even better for gut nutrition than insoluble fiber like psyllium?
I saw an interview with SVW and my intuition red flags were going up. Something about her doesn't feel right. I've been looking at various channels to get more info and appreciate this caution. I eat grass fed butter so I don't think I need a supplement unless it has more human data.
I have taken C15 and C17 several times and it seems to give me a reduction in stress hormones. I find it quite useful after a long day of work. My libido also increases .
Dr. Stephanie Venn Watson is an interesting person with, indeed, great insight. Also notable is her entrepreneur mind. She seems to know how to put the results of her work into an ingenious new business. I understand that when she and her team discovered the role of C15 in the well-being of the dolphins, she attributed the lack of C15 to the changing nutrition of the animals. In other words, according to her, in the past those dolphins would have had sufficient C15 to thrive. Therefore, for millennia dolphins have received all the needed C15 from the right diet. What humans need is to eat a healthy diet rich in saturated fats from dairy. Look at the centenarians of Sardinia. They seem to have enough of the C15 in their system without any supplement. They apparently get all their C15 from eating dairy product from raw goats and sheep’s milk pasturing on the grass of high mountains tops. I modestly believe that we can get the C15 we need from the proper diet rich in dairy saturated fats and the meat of those animals. Just have cheese high in C15 daily, and a rack of lamb regularly!
Not surprising at all. I've noticed that - seemingly - you can find a study that says just about anything you want on the NIH website. The NIH is a participant in all of this. The supplement heroes like David Sinclair have a lot in common with people like "pharma-bro" Martin Shkreli and the rest of the supposedly "legitimate" pharmaceutical industry. They just operate in different channels and they know how much they can bend the rules in each market - pharmaceutical or supplements.
Thank you Dr. Stanfield! I almost purchased their product :( It has been touted on so many podcasts! Honesty and understanding are thoroughly lacking on so many other podcasts!
Hi Dr. Brad. In my country there is a supplement including all these "Kreatin, L- Karnitin, L-karnosin, Taurin, Silimarin ,Pirolokinolin Kinon, Likopen, B1, B2, B5, B7, B9,B12, Vit A, Zinc, Selenium, Manganese". Do you recommend such a supplement for long term use?
Here to see if any one else experienced nausea and vomiting from taking fatty15. I just canceled my subscription. I have had terrible nausea since I started taking this a week ago.
Do you also make videos about medicines produced by pharmaceutical companies, that are allowed to do their own approval trials and which get approved by the FDA based on these 'trials' and which turn out to be extremely harmful (sometimes even deadly) after they are given to patients? This is well documented 'standard practice' in medicine today (I am sure you know). That would make a much more important video than this 'hype' thingie clip. The 'false hope'- scenario is much more valid for many 'approved' drugs, so why this aggrieved excited tone for just another insignificant supplement that probably has no or fewer side effects than those approved medications. Or are you just trying to convince us of something else? Please explain .
I use to sleep 7 hours 50% of the time and 6 hours the other 50 %. Now (C15) I sleep 70% of the time for 8 hours and remaining 30 % I sleep for 7 hours!! THANK YOU FATTY 15!!!!
Well for NMN and other NAD+ booster there have been results for people with very low NAD+ levels, like glaucoma patients with very low NAD+. It very well could be same for C15:0 that it is beneficial in cases were levels are very low. But we would need a longer trial with a lot of people with initial and further levels measured.
I have been sleeping horribly since taking fatty15. I was sleeping quite well before it. So disappointed since sleep is so imperative to good health. I feel even worse now.
i bought the hype, and started adding butter to my coffee, i get the same amount of C:15 that's in the pills and a creamer coffee...i have no idea what this does to my body but my coffee tastes better
Wow buen video, excelente para tener criterio con la industria de la publicidad ( en realidad criterio con todo 😮). Espero que pronto esté excelente canal tenga su versión en español.
Thank you, Brad standfield. You have saved me a lot of money as I quit taking n. M andrez Vera troll as promoted by David Sinclair. I was about to buy this as I had listened to their pitch at least twice. Thank you for your honesty and your help in our journey to stay healthy and live a long life
I tried it. So far it's like snake oil or placebo. I have not noticed any actual impact posiive or negative. Now what about Sinclair? Did Sinclair invent this model of patent backed snake oil? Is it deliberate?
Thanks for a great overview and presentation. We should probably always be careful with new molecules and wait for good human double blind placebo controlled studies.
💊Supplements I Take: drstanfield.com/pages/my-supplements
📜Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap
As a physician who has a patient population of young adults with fatty liver disease, I find the C15:0 story compelling. Specifically the pathophysiology of the cellular fragility syndrome makes sense. Low levels of sturdy fatty acids like C15:0 in our cell membranes leads to weakened cells, leading to lipid peroxidation, ROS, iron deposition, iron overload and cell death by ferroptosis, leading to accelerated NAFLD/NASH. Further, the clinical trial you mentioned was performed by Dr. Schwimmer, a leader in pediatric fatty liver disease. The way I read his findings is that if you increase your C15:0 levels above 5ug/mL, patients with increased liver enzymes had significant improvements in ALT and AST, which to me means that there is a safe, low risk way to address a condition (fatty liver disease) that has very few treatment options. Exciting (but early) findings.
You are either incorrect or have little evidence that supplements that are antioxidants generally blunt the effect of exercise. You should stop saying this. Some antioxidants do this but not all. We know that there are human studies suggesting that astaxanthin increases muscle strength and endurance. There are mouse studies on curcumin and olive leaf extract that show that each improved muscle mass, strength and /or endurance.
I will give you one example, but there are several
This human clinical trial on Natural Astaxanthin in 2011 was funded by Gatorade Sports Science Institute. For this study, Gatorade used competitive cyclists, supplementing them with a placebo or 4 mg of Natural Astaxanthin each day for four weeks. From the endurance athlete’s-or for that matter-from any competitive athlete’s perspective, the results were excellent. In a 20 kilometer (approximately 12.5 mile) cycling time trial, the performance of the subjects taking Astaxanthin significantly improved, while the subjects taking placebo showed no improvement. Natural Astaxanthin made these competitive cyclists on average 5% faster in only 28 days. Also, the cyclists taking Astaxanthin demonstrated significant improvement in their power output, which increased by 15% on average over the same 28 day period.
As far as I know, Gatorade does not sell, and has not sold, a product containing astaxanthin
@DrBradStanfield I get the impression that the shill selling snake oil is felling threatened by Fatty 15, a product that was going through the pharma route to market, but was withdrawn and released as a supplement because it is a natural product, not needing the approval required for drugs. It is interesting that so many specialists in their fields are doing their own research on C15. And the fact you ignored evidence from populations that naturally consume large quantities of C15 in their diets and have higher health and longevity markers than the rest of the European and American population’s.
I wish doctors were as careful about prescribing medications.
I've been critical of your videos in the past due to what I believed were overly negative statements towards some supplements & health interventions that had both positive and negative data supporting their use. In this case, you have redeemed some of my criticism by providing solid information and an educational public service. Thank you for this.
Ditto!
ditto
"if you torture the data long enough, it will confess to anything" - Ronald Coase, not surprisingly an economist.
@@scottmiller2591 That's a good quote to remember. Thanks
I looked up the Fatty 15 product and found that it is being offered at the ridiculously high price of $3 per capsule. That is a huge red flag.
Dr. Brad
You are correct in your assessment in regards to fatty 15.
If you look at their web site, they list a different address for their returns that they shut down in 2020. Fatty 15 has no actual store front.
So where is this product manufactured?
Dr. Brad, please keep digging into these unscrupulous vitamin claims.
thanks Brad, an excellent investigation and illustration of the supplement hype cycle
Vit C was helpful in lab rats with CMT neuropathy but didn't work in humans with CMT
Definition of vitamin is?
Most Vitamin C supplements are unstable. Unless they use a stabilized slow release version I don't think anyone knows what it's capable of.
Which is sad. No one does the leg work on anything.
@@darkhorseman8263 Simply get real V-C ! Pine needles are loaded with real C and makes for a excellent tea and saves you money!
awaiting more research. early days but are getting some good results after 2 months.
Do two teaspoons of Ghee per day (very tasty). It has the same amount of C 15 as the Fatty 15 supplement.
Right... or put a little cream in your coffee, or have a little cream cheese. "Deficiency" cured.
I do one ounce of cheddar cheese in my salad. It has the same amount of C15 plus it is high in spermidine.
I have a few grams of butter on a slice of seed bread fron trader joes for lunch and dinner. A total of 22 carbs and some protein too.
Cream in coffee or tea blocks absorbion of beneficial polyphenols
Unlike this video here is a valuable comment.. note that if you study the fatty15 site it is targeting the vegans.. aka those who refuse milk and such other foods..
Excellent to receive this type of information Brad.
Dr Brad is HUGELY on point here, however, there are molecules that have almost no strong human peer reviewed documentation, yet they have been known over the centuries and in various countries around the world. Thanks, Brad.
There are also many examples of snake oil that have existed for centuries. This is why strong human peer reviewed documentation matters: separating fact from fiction.
Such as?
People also believed in witches for a long time. That doesn’t make them real. Could be placebo.
What I did after reading all the "C15 papers" I could find - simply make a more concerted daily effort to getting grass-fed dairy products, goat/sheep milk products, and/or grass-fed beef. Near as I can tell, about 2 ounces a day of such cheese or butter, 4 oz of such beef, or a couple cups a day of such whole milk meets the "RDA" (assuming/if such a thing truly exists for C15). Any one of those in nominal amounts each day should do the trick, and since all of those are all healthy unprocessed foods with beneficial Omega 3 profiles as well - as long as I keep it all within daily calorie thresholds there is no downside risk if the whole thing turns out to be bullocks. :)
What about the saturated and trans fat content? What about the associations of animal protein with cancer and autoimmune diseases (established with strong statistical significance in epidemiological studies documented in the China Study?)
What about them? Sure, there are people with allergies or vegan that may wish to avoid. I would suggest anyone that believes proper health maintenance must include 100% avoidance of any level of saturated fat consumption is not fully or properly informed. For example; C15 itself - to any extent it truly is essential - is a saturated fat. And somehow, if the research is to be believed, that saturated fat became “essential” to proper cellular health over the course of at least a few hundred thousand years of evolution (if not millions), despite the absence of a magic pill…
Wonderful comment.. unlike this video.. he miss the point that vegans are the ones lacking and the target is not the suppliment it is the statement that c15 may be an essentially nutritient.. he is a misguided and misleading good information
I'm so glad you go against the mainstream health-UA-cam-channel trend with pushing supplements by sowing fear and instead stick to medical research on humans.
Thx for covering Fatty 15, haven't been able to find an objective review since it's release a while back. It's super expensive as well.
Listen to latest Dave Asprey podcast. The person behind it is on it and mentions where you can get links to research. Up to you to decide then.
Don't forget that Dr Brad was pro resvératrol just a few years ago after he'd drunk the David Sinclair Koolaid (as had many of us, admittedly). Even at that time there was research around which dissed it.
Ozempic is a good example of what will happen if someone comes out with something that actually works as well as its advertised. You're gonna hear about it very quickly
Ozempic also calls bowel obstruction. And you're not hearing about that yet, are you?
I am very skeptical of supplements and medicine what’s popular isn’t working you got to find little known things to get any benifit. They don’t advertise things that help no money in dead people no money in healthy people.
thank you so much for this really informative video🤗
I’m in my 50’s and most of my family has died from Alzheimer’s. Because of this and my age, I started taking neuro hacking supplements a few years ago. I had a full physical about 5 months ago and was told my liver enzymes were spot on for good health. 4 months ago, I added the supplement uridine after watching some videos on it. A month ago I ended up spending several days in the hospital with fatty liver disease. They said one of my numbers is supposed to be under 100, but was now over 2100. I started reading about each supplement I take and found that in some, uridine can cause this. I stopped taking all supplements completely. I feel more clear minded now than I have in years. I’m going to steer clear of supplements for the foreseeable future.
Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden
www.ncbi.nlm.nih.gov/pmc/articles/PMC5349792/
Contrary to observations in industrial populations, older adult E4 carriers with high parasite burdens either maintained or showed slight improvements in cognitive performance, whereas non-E4 carriers with a high parasite burden showed reduced cognitive performance. Being an E4 carrier is the strongest risk factor to date of AD and cognitive decline in industrial populations
If you're afraid of Alzheimers then you need good sleep, daily exercise, and a solid diet. If supplements help at all (a big "if"), then their effects are marginal compared to sleep, exercise, and diet.
I was looking forward to this from you. Thank you ❤
Excellent information 👍
Thank you Dr. Stanfield for the insightful, well organized analysis.
Nice one Dr Brad, I reached a similar conclusion.
"All of this is complete bollocks" 🤣
Love it.
@@phaedrusalt You have to have the intelligence to know the difference between the two.
Actually many ingredients that make a cake taste better also make a stew taste better... Adding black chocolate to the sauce of a beef stew like Daube or Boeuf Bourgignon is an old trick of french cooks, cinnamon also adds flavor. More general, adding sugar to savory dishes in general makes them better, as does adding a bit of salt to many sweet desserts and cakes. Adding butter to both will also make them simultaneously tastier and unhealthier...
WRONG. Butter is extremely healthy.
creatine is just about the only supplement that matches the hype and I’ve been around for 60 years so few really pan out to your point don’t chase every new thing doctor oz was the biggest offender every week a new miracle, food or pill for me this is a particularly good video thank you
There’s a few others.
@@michaelmcgee335VERY few... and they generally only apply to small populations or to unique situations.
I appreciate the information. I had taken this product before and it did nothing for me. I even put that on a post of this product on facebook. Some had even taken this for a year and it did nothing for them as well. I hope this video makes it around so others know not to take this product.
And if it IS found to be effective, guess what? A pharmaceutical company will say that it is extremely beneficial for a particular ailment and will apply with the FDA for it to be sold by prescription only.
It depends. Astaxanthin from BioAstin got FDA-approved but can still readily be bought without prescription.
Seems like some supplements companies are just as bad for the public as pharmaceutical companies.
I heard that some idiot at Harvard tried that with NMN, a variant of niacin.
bullshit, there are plenty of supplements with proven efficacy that are still cheap and available (Creatine, Taurine, Glycine, NAC and many other)
I am glad I waited. I was one of the people that took the information about C15 to heart. But I never bought any. I was thinking a bit in the direction of eating those types of fish those dolphins ate. But I have a question, on your video. You showed white compressed pills, but how can those contain fats?
Thanks Brad! You are my go to guy for common sense medical analysis.
Excellent review. Thank you for making a video about this. This supplement seemed "fishy" to me because of the lack of controlled human evidence.
Summary.
It's like:
- trying to turn a sketch into a full colo[ur] painting
- finding a new ingredient that makes a cake taste better
- finding a shiny object on a beach
- a polished pitch
- a magician performing a trick
- a mechanic telling you your car has a made-up problem
- selling tickets to a concert
- crying wolf
Perfect summary, no need to watch the video anymore
@@phaedrusalt Many painters' sketches are, come to think of it. It's like a stillborn metaphor.
Having taken Fatty 15 for 5 months now my HDL is the highest it has ever been, my before & after blood test prove it. This was the reason I started it. Also fasting Insulin went from 15 to 6.6. I will keep on taking it and will test again at the end of the year. For now my biomarkers are moving in the right direction if that changes then I will change my supplements.
Maybe you’ve changed something else too ??
I believe his job is to deter you from something that may work. He does this all the time.
@@MegaWandak Oh? And why would he do that?
I’m taking it to. I am seeing and feeling much better. 59 and getting morning erections again. How’s that for a scam? I’ll take the scam.
@@MegaWandak True, I feel this way about Brad. Only focuses on single facts about substances that have been studied vastly in many areas like resveratrol.
I have obtained a letter from the National Archives that Stephanie Venn-Watson wrote back in 1977 when she was just 5 years old. She wrote to the United States Congress demanding they modify the dietary guidelines to exclude dairy fat. AND THEY DID JUST THAT! The same exact year, her future husband wrote to Sardian sheep farmers in broken-Italian and asked them to consume adundant amounts of their pecorino cheese to obtain high levels of C15:0. Their plan? 45 years later compare Sardians with high levels of pentadecanoic acid to Americans with almost none, pen some wild story and publish it in a peer-reviewed journal, then create a supplement. And it worked...ALMOST. If it hadn’t been for the New Zealand medical Magnum P.I. (you just need to grow a crumb catcher, Brad) they would have gotten away with it! Thanks for the cracking the case! By the way, I would love to try the supplement you're pushing on your website (the Dr. Brad Stanfield Micro Vitamin for a cool $39.99) in order to reep the "18% smoother skin" benefit. Would you recommend I have my rough skin tested prior to taking it and then again after 3 months? What would that test be, exactly? Thanks, Julian
Yes, supplements must be research science based and have pharmaceutical level quality control, even then they dont work for everyone in the same way, just as drugs don't always too .
love your analogy re sub group analysis : if you torture the data enough you can get the result you want to hear
Please do a video on reversing hair loss and greying
And reversing hypothyroidism!
What a fantastic and eye-opening video, Dr. Stanfield! 🌟 Your breakdown of the supplement hype cycle is not just timely but essential in a world where "miracle cures" seem to pop up faster than a TikTok dance trend.
It's fascinating (and a bit alarming) how the supplement industry has mastered the art of storytelling. They’ve turned marketing into a high-stakes game of "who can sell the most hope." I mean, if I had a dollar for every time I saw a supplement marketed as the "next big thing," I could probably fund my own clinical trial! 💸
Your point about TEDx talks being used as platforms for unvetted claims is particularly striking. It’s like watching a magician pull a rabbit out of a hat-impressive, but you have to wonder where that rabbit came from! 🐇✨ Just because someone is on a stage doesn’t mean they’re not just selling smoke and mirrors.
And let’s not forget the irony of it all: we’re often told to "trust the science," yet many of these supplements lack the rigorous research that would make any scientist proud. It’s like being served a gourmet meal that looks amazing but is made entirely of air-satisfying to the eyes, but not so much for the stomach! 🍽
For anyone looking to navigate this minefield, your advice on seeking out supplements with proven health benefits is golden. It’s a reminder that sometimes the best "supplement" is a balanced diet and a good night’s sleep. Who knew that the real miracle cure was just a well-rounded lifestyle?
Thanks for shedding light on this important topic, and for keeping us all informed and entertained! Looking forward to your next video-maybe something on the "real" benefits of kale? 😉🥬
Just as bad as the pharmaceutical companies
The problem to solve is that in this case a parallel study on humans could take several hundred years. So how do we deal with that as empiricists?
We don’t. That’s how.
We don’t.
Watch: "C15 Fats: What No One is Telling You [7 Studies Later]" and "C15 Fats: Better than Omega-3s? Scientist Explains", by the UA-camr: Physionic
Physionic's Credentials:
- Ph.D. in Molecular Medicine (Cell Physiology)
- Masters in Exercise Physiology
- 10 Years Experience in Laboratory Work
- Previous American College of Sports Medicine Certification
- Non-Degree in Nutrition Science (1.5 years undergraduate education)
- Classroom Professor (T.A. in 2015) in Health, Nutrition, and Physiology since 2016
Great video. I bought into the hype because of the interview with Stephanie Venn Watson. She seemed so sincere and the dolphin story and the Sardinian (humans) story. She may be sincere and the marketing people took over and over hyped the product. The fatty 15 people say they have a double blind placebo human trial of 20 people taking their pills and 10 control people taking placebos with good results on the 20 people. I wish Brad had talked some about the Sardinians and the human trials, otherwise it was a great video.
Yes, this aligns with my experience as a consumer. Not a science person but usually curious about things, I like to find the evidence for claims and it is often very much like was described here: “in animal studies …. Scientists found in mice that ….” Listening to many of the presentations you find on UA-cam, there are great leaps in logic. You often read the “10 best foods/supplements for people with (insert condition)” and when you read through said list, it is full of hyperbole, making tenuous links such as Vitamin C is an antioxidant therefore prunes, which are high in vitamin C can reduce3 inflammation. Can sound convincing. Going through a few health conditions myself, I’ve become very alert to the points described here relative to that hype cycle. Some articles look like they have actually made links to scientific research and will provide the links (knowing most people wont read them but just accept the fact that “it must be true then”) that are actually related to something else. The dosage of supplements is also concerning to me. There needs to be regulation of the supplement industry.
Good content, Brad!
Fantastic, we need much more like that! Thank you!
Timely video, brother - time to put a spotlight on Urolithin-A, if you haven't already.
Timely misleading please do your own research about c15 and ignore fatty 15.. totally different
Would your grandma need to do resistance training to get the health benefits from creatine?
There's emerging evidence that creatine may be neuroprotective as well as increase muscle endurance. There's no downside to taking it, and plenty of indications of potential upside, I think everyone should take 5-10 grams/day.
Well it may be my so called placebo effect trait from Ancestry, but on day 32 the hair on my arms is getting thick, sex changes - more ejaculate, slightly better sleep. Better mood. I am 70. Also started taking astragalus though as well. I have looked hard for the papers from 2012, nada. It does make me suspicious about a scientific journey vs. greed. But if it can lower mTor which is unproven, it might escape all those patents and just be added back into milk.🎉 My hearing loss may be improving due to that new form of autophagy. But there are other variables that may be involved.
Almost all from taurine to rapamycin start off and are primarily based on animal studies. The data on dogs who live 12 years more or less is not even out. You too push your own supplements based on the weakest of non randomized trials on multivitamins. And I get it that you too need to get hits for your UA-cam. So you either take a non conflicted educational role or you stop making yourself look better than the others. Everything imho out there is more or less personal opinions that are attempting to be monetized
Also while what makes a cake taste good may make a stew taste better it also may make it worse. Similarly, the supplement may worsen our health. So literally no reason to take it, it gives hope but also risks.
Execellent video, Dr Brad. Cutting through the wellness BS is important work. I’d be interested to know your opinion of naturopathy, a practice that seems to rely on prescribing any number of supplements to treat patients.
Hi brad, don't you offer any discount code from your supplements? I am thinking of switching and putting my trust in you. I usually buy them separately from do not age.
Are the compounds from natural foods or plants?
If I had a nickel for every time something called "fatty" tried to scam me I'd have two nickels this year, which isnt a lot but its weird that it happened twice.
Aaawww tell me you didn't buy the coin
Lmao
Seems like palmitoleate + apigenin could be a healthy combination. Improved insulin response without higher risk of fatty liver, hopefully, with the apigenin added.
I hear you Dr Brad, never heard you angry like this saying “bollocks” love it 😊
The statement about the subgroup analysis doesn’t make sense. You say: ‘even in the subgroup analysis, which is a risky thing to do in a small trial anyway, there was still no statistically significant difference’. Smaller N gives less power. If a result is statistically significant, this is despite small sample size and power. It’s only ‘risky’ in that you need a large effect size to see p < 0.05. And the Kruskal-Wallis p value in the table is 0.01, which is significant at alpha = 0.05. Did they set it at 0.05 or are you referring to a result reported elsewhere?
Thank you for this review.
Hello Doctor - looked at your brand for psyllium husk - is not organic. Some brands indicate organic and third party tested. Is to costly? Or really not needed or benefit if organic brand?
Oh no!! I just bought this supplement because it was promoted many times on the podcasts. Will not buy this again!
Don't throw it out. Take a blood test before and after, it may work!
@@jaimearaque8503 ok. I will that
I see that you take psyllium husk for digestive health. Could you comment on recent research that says beta glucans (found in mushrooms, seaweed, barley and oat husks) are even better for gut nutrition than insoluble fiber like psyllium?
But you push yours…How we know your stuff works
Brad, I listen to you, and I do listen.
I saw an interview with SVW and my intuition red flags were going up. Something about her doesn't feel right. I've been looking at various channels to get more info and appreciate this caution. I eat grass fed butter so I don't think I need a supplement unless it has more human data.
I have taken C15 and C17 several times and it seems to give me a reduction in stress hormones. I find it quite useful after a long day of work. My libido also increases .
Great video!
Everyone loves dolphins. I’m going to find the secret component in bamboo shoots because everyone gushes over panda bears.
Thank you Brad!
Thanks a lot for this video. Just in time, as I was on the point of ordering some C15
If you are a dolphin eat butter and cheese.
Dr. Stephanie Venn Watson is an interesting person with, indeed, great insight. Also notable is her entrepreneur mind. She seems to know how to put the results of her work into an ingenious new business. I understand that when she and her team discovered the role of C15 in the well-being of the dolphins, she attributed the lack of C15 to the changing nutrition of the animals. In other words, according to her, in the past those dolphins would have had sufficient C15 to thrive. Therefore, for millennia dolphins have received all the needed C15 from the right diet. What humans need is to eat a healthy diet rich in saturated fats from dairy. Look at the centenarians of Sardinia. They seem to have enough of the C15 in their system without any supplement. They apparently get all their C15 from eating dairy product from raw goats and sheep’s milk pasturing on the grass of high mountains tops. I modestly believe that we can get the C15 we need from the proper diet rich in dairy saturated fats and the meat of those animals. Just have cheese high in C15 daily, and a rack of lamb regularly!
Excellent video! 👏👏👏
Not surprising at all. I've noticed that - seemingly - you can find a study that says just about anything you want on the NIH website. The NIH is a participant in all of this. The supplement heroes like David Sinclair have a lot in common with people like "pharma-bro" Martin Shkreli and the rest of the supposedly "legitimate" pharmaceutical industry. They just operate in different channels and they know how much they can bend the rules in each market - pharmaceutical or supplements.
I’m a 54 year old runner and C15 took away my aches. Sooooo…you’re going to eat your words when you get older Mr. Stanfield. Just wait.
Both Brian Johnson and Dave Pasco both take it as far I can see.
It's just Dave Pasco... Sorry...
Consumer Labs is ONE MAN.
Thank you Dr. Stanfield! I almost purchased their product :( It has been touted on so many podcasts! Honesty and understanding are thoroughly lacking on so many other podcasts!
me too
I did and it’s making a big difference in my health.
I falled for it 😢😅, huge thanks for the knowledge and general eye opening!
I made comment regarding the product to them and they refunded my money immediately.
Thank you very much for this.
Hi Dr. Brad. In my country there is a supplement including all these "Kreatin, L- Karnitin, L-karnosin, Taurin, Silimarin ,Pirolokinolin Kinon, Likopen, B1, B2, B5, B7, B9,B12, Vit A, Zinc, Selenium, Manganese". Do you recommend such a supplement for long term use?
Here to see if any one else experienced nausea and vomiting from taking fatty15. I just canceled my subscription. I have had terrible nausea since I started taking this a week ago.
Interesting report. What about Urolithin A ?
Could you let us know your view on hydrogen water and hydrogen generating effervescent tablets .
Thank you Brad
If this is true I'd hope for a class action law suite to stop this from happening
Thank you Dr Brad
Do you also make videos about medicines produced by pharmaceutical companies, that are allowed to do their own approval trials and which get approved by the FDA based on these 'trials' and which turn out to be extremely harmful (sometimes even deadly) after they are given to patients? This is well documented 'standard practice' in medicine today (I am sure you know). That would make a much more important video than this 'hype' thingie clip. The 'false hope'- scenario is much more valid for many 'approved' drugs, so why this aggrieved excited tone for just another insignificant supplement that probably has no or fewer side effects than those approved medications. Or are you just trying to convince us of something else? Please explain .
A fatty acid ending in zero is saturated.
mice dolphins humans --- all mammals --- but very different metabolisms and diets- thanks Dr.Brad Stanfield ... you are treasure imho
I use to sleep 7 hours 50% of the time and 6 hours the other 50 %.
Now (C15) I sleep 70% of the time for 8 hours and remaining 30 % I sleep for 7 hours!! THANK YOU FATTY 15!!!!
Well for NMN and other NAD+ booster there have been results for people with very low NAD+ levels, like glaucoma patients with very low NAD+. It very well could be same for C15:0 that it is beneficial in cases were levels are very low. But we would need a longer trial with a lot of people with initial and further levels measured.
I just tried it. It ruined my sleep. When it was promoted to enhance sleep.
I have been sleeping horribly since taking fatty15. I was sleeping quite well before it. So disappointed since sleep is so imperative to good health. I feel even worse now.
i bought the hype, and started adding butter to my coffee, i get the same amount of C:15 that's in the pills and a creamer coffee...i have no idea what this does to my body but my coffee tastes better
How do you know you vet 100mg of c15 in a tablespoon of butter?
@@pattersonellen i googled food sources for Pentadecylic acid or C15...it works out to about 13-14 grams of butter (1/2 ounce)
Wow buen video, excelente para tener criterio con la industria de la publicidad ( en realidad criterio con todo 😮). Espero que pronto esté excelente canal tenga su versión en español.
Thank you, Brad standfield. You have saved me a lot of money as I quit taking n. M andrez Vera troll as promoted by David Sinclair. I was about to buy this as I had listened to their pitch at least twice. Thank you for your honesty and your help in our journey to stay healthy and live a long life
This fatty15 sounds interesting. I hadn’t heard of it. Going to try a bottle.
Well I feel bamboozled 😅 Thank ouy for critiquing the literature. 👍
I heard AG1 was a scam as well.
Check some videos about the owner. A professional scammer
I tried it. So far it's like snake oil or placebo. I have not noticed any actual impact posiive or negative.
Now what about Sinclair? Did Sinclair invent this model of patent backed snake oil? Is it deliberate?
Does epithalon work for anti aging? It is supposed to have telomere lengthening properties. Or is it not worth the money?
Thanks for a great overview and presentation. We should probably always be careful with new molecules and wait for good human double blind placebo controlled studies.
I believe the same thing happened with CoQ10