I'm sorry, but I honestly think she explained it really well. You have a talent of explaining ma'am. Clear, concise, and short. Keep up the excellent work. And no, your voice is not as others have said, it's great! Thanks for helping me prep for my MCAT :D
First of all you have an amazing voice, secondly the way you break it down it is so understandable and i am an engineer. Thank You very much you have been very helpful.
I have been learning a lot about nutrition and how the body works so I can take better care of medical issues. Your videos fill a lot of missing pieces and are very understandable. Keep up the good work. Great voice!
These videos are amazing! They present the information with the perfect level of complexity and depth, and they are so incredibly thorough-they are an invaluable resource for me as a nutrition coach. And for the record, the narrator’s voice is lovely 😊
I sincerely hope you are a teacher because you are brilliant at it!!! Thank you so much for the generous time you spent doing this. I've subscribed and you will be my go to for all things biochem.
This video is amazing :). Thank you so much for taking the time to produce this video. I am fairly impressed by how you have simplified the information such that it is readily understandable by laymen like me. I always wondered how fat is digested in our body.
Thank you very much. I had a very hard time understanding walls of scientific words on the internet, but this video is way easier to understand. You help me with my homework a real lot.
Omg it is soooo helpful thank you so much. I'm a French medical student and it helped me a lot understanding my lessons for my finals thank youuuuu! Btw, i love your voice!!!
Ignore the ignorant comments from the guys who watch too much porn. Great video, very helpful, clear and concise with the right amount of detail. Nothing distracting or annoying about your voice.
When medium chain fat is absorbed directly into the blood, does it go in as a triglyceride or is it broken down into fatty acids? The name of the MCT oil suggests that the trig. are entirely short, but natural substances like milk have mixed trig. and also work for quick energy delivery.
I find her voice soothing. Well organized and informative video. At 3:41 she says that, "our body secretes something called bile from the liver." This is incorrect. The bile is produced in the liver but stored and secreted from the gallbladder.
-Thanks for the Great Explanation , But Doesnt the Pancreatic Lipase Cleave Ester bonds of C1 and C3 , and leaves Fatty acid of Carbon 2 unchanged ? And shouldnt Bile Salts Provide a Micelles for Transport of Fatty acids and Monoglycerol into the enterocyte ? . Thanks :)
I am in the middle of viewing this video, and am thinking, "I really like this instructor." She explains everything clearly and concisely. I am also thinking, "Hmm, I really like the voice." I quickly check out some comments, and see that some have the opposite opinion. I am a guy, so I don't know, I really like this instructor's voice. Soothing, relaxing, but clear and bright at the same time. It's true that the voice alone can tell us whether we will like a person or not. For example, for me, when it comes to radio station hosts, generally speaking, the Jazz station hosts have the most pleasant and interesting voices.
Isn't it lipase only hydrolyzes the ester-bond in the carbons 1 and 3 of TAG? so the resulting products are 2 free fatty acids and a 2-monoacylglycerol? Just asking :) thanks for the vid though. its helping me a lot
Does this mean that all our consumed fats get absorbed and transported before reaching the large intestine? If they don't. What would cause this lack of absorption and are they just considered waste and excreted at that point? Your videos are incredibly informative by the way, I'm just extra curious
Are the FAs of the C2 on the glycerol backbone cleaved? I thought they were left on the glycerol backbone, and then absorbed, and then once inside the endothelial cells, repackaged? Also, before entering the blood, don't the chylomicrons go to the liver first? There were a few details of this video that I thought were misrepresented, but other than that, thank you so much for the video. The way you described everything was easy to understand.
Great process summary. I have a question. When lecithin or Phosphatidylcholine is used as a carrier to encapsulate a nutrient, is the release of this nutrient triggered in the first encounter with the lipase molecule or in the second encounter with the lipoprotein lipase in the blood?
Very nice presentation. However, the packaging of TAGs is not made inside a protein molecule. Instead, the TAG are surrounded by a phospholipid layer (purple circles). These phospholipids have polar head groups (phosphocholine) and hydrophobic tails (fatty acids). On this layer (facing the aqueous environment) several proteins are attached.
Congratulation for the video, is very well done and really helped me, but I have a question: at 2:45 you've said "colesterol backbone" (or that's what I heard, if it's me, please excuse me for bothering you)...shouldn't it have been "glycerol backbone"?
•Triglycerides are hydrophobic and therefore it can’t be absorbed in the small intestine 1. Fatty droplets are formed (triglycerides are grouped) 2. Bile emulsifies fat molecules in smaller pieces to allow the Lipases to act upon fat molecules (break down of triglycerides to fatty acids) 3. Reformation of triglycerides in intestinal cells 4. Packaging of triglycerides by a carrier molecule called a lipoprotein to transport it. (Triglycerides inside the lipoprotein forms Chylomicron) 5. Chylomicron enters in lacteal because its fenestrations are bigger than the capillaries’ 6. Chylomicron travels through lymphatic system until lymphatic thoracic ducts, draining into veins. (Next video)
It really does! I would love to learn the information but after about 10 minutes it goes from words to an irritating sound that my brain just can’t handle anymore no matter how important the information is. I know it’s me and should be ignoring it but wow yes.
This video missed digestion of medium chain and shorter fatty acids through the portal vein and is perhaps using a restricted definition of what is "fat".
I confuse this pathway with that of re-esterification😭 as the chylomicrons are transferred to the lacteals enter the lymphatics, not the portal vein😭😭 (in monogastrics)
*Some points you missed* Remember fatty acids dont simply diffuse into enterocytes in the intestine. They are absorped by *facilitated diffusion* , they are assisted by FABPs (fatty acid binding proteins) located at the enterocyte membrane. Another factor aiding the diffusion gradient/ translocation of fatty acids and monoacylglycerols from the micells and into the enterocyte is the rapid re-esterification of long-chain-fatty-acids into 2-MAG into triacylglycerols already happening inside the enterocyte (completed by the enzyme acyl-CoA-cholesterol acyltransferase, ACAT). Speaking of cholesterol, cholesterol also associates within micelles and are similarily absorbed by a different *sterol* -carrying protein in the enterocyte membrane. However much less cholesterol is absorbed this way (about 40% compared to 90% in fatty acids and MAGs), this is because cholesterol is reabsorped in the ileum together with bileacids in a salvaging hepatic circulation system designed for the liver to re-use cholesterol in the making of bileacid.
@@CitriReg What a strange comment. His videos are meant for education. It is only fitting for health professionals watching to add to the level of sophistication so that viewers can aid each other in learning the topics that are presented.
I really wanna huge u after seeing ur explanation cause I understand perfectly from u ❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤😻 I'm going to complete this huge great explanation in the 2nd video 🚶♀️🚶♀️🚶♀️🚶♀️
I'm sorry, but I honestly think she explained it really well. You have a talent of explaining ma'am. Clear, concise, and short. Keep up the excellent work. And no, your voice is not as others have said, it's great! Thanks for helping me prep for my MCAT :D
ليا1ق9نوزتهدظتااالةقفغظظنتتلبباتاغت0
First of all you have an amazing voice, secondly the way you break it down it is so understandable and i am an engineer. Thank You very much you have been very helpful.
I have been learning a lot about nutrition and how the body works so I can take better care of medical issues. Your videos fill a lot of missing pieces and are very understandable. Keep up the good work. Great voice!
This is so far the best explaination . Detailed but precise. Lol. I just fell in love with learning the process.
This is the clearest and most coherent explanation of this process I have come across. My professor explained it terribly.
These videos are amazing! They present the information with the perfect level of complexity and depth, and they are so incredibly thorough-they are an invaluable resource for me as a nutrition coach. And for the record, the narrator’s voice is lovely 😊
No idea what people mean about your voice... Seems like people can never be happy. Thanks for the video! I needed this.
it's a fake, high piched, cringy, anoying voice, simple as that
It's shitty voice trying hard to vocal fry . It's irritating to hear
I just found this video looking up fat metabolism, and all I see is four years of mean comments about a nice, normal voice.
Thank you so much for helping me understand stand this material for Human nutrition. Love when I understand what someone is teaching.
I sincerely hope you are a teacher because you are brilliant at it!!! Thank you so much for the generous time you spent doing this. I've subscribed and you will be my go to for all things biochem.
You Guys are doing an awesome service.. Thank You so much
Your voice is beautiful, and you also explained it clearly. Keep up the great work!
This video is amazing :). Thank you so much for taking the time to produce this video. I am fairly impressed by how you have simplified the information such that it is readily understandable by laymen like me. I always wondered how fat is digested in our body.
The voice motivates me more to learn. keep going.
your voice is so lovely! thanks !!!!! this was very clear and your explanation was very genuine
Thank you very much. I had a very hard time understanding walls of scientific words on the internet, but this video is way easier to understand. You help me with my homework a real lot.
LOVE YOUR VOICE , IT MAKES ME CONCENTRATE , AND YOU HAD THE BEST EXPLANATION EVER !!!!!!! YOU`RE THE BEST , TACTICAL TEACHER . THANK YOU .
There is a major mistake.... Its PacMan and not MacMan. 😬
macman loooool
IRK?
it's a Big Mac burger, makes sense... lol...
Also, it's an imaginary Pac Man
Milenial mistake for sure.
wow, 45 minutes of reading condensed into 5 minutes (if watching 2x). Good job.
Omg it is soooo helpful thank you so much. I'm a French medical student and it helped me a lot understanding my lessons for my finals thank youuuuu!
Btw, i love your voice!!!
I can't stop laughing at that sudden "is" on that sentence around the middle point of the video.
😂😂 i repeat it lots of times
6:14 😂
You are a great teacher. Appreciate the free lessons. #gratitude
Great video! God bless anyone who liberates knowledge
It's not just the voice, it's the enunciation as well.
dont mock her lithp
Ignore the ignorant comments from the guys who watch too much porn. Great video, very helpful, clear and concise with the right amount of detail. Nothing distracting or annoying about your voice.
When medium chain fat is absorbed directly into the blood, does it go in as a triglyceride or is it broken down into fatty acids? The name of the MCT oil suggests that the trig. are entirely short, but natural substances like milk have mixed trig. and also work for quick energy delivery.
I did not find the voice annoying, it was actually very clear.
I find her voice soothing. Well organized and informative video. At 3:41 she says that, "our body secretes something called bile from the liver." This is incorrect. The bile is produced in the liver but stored and secreted from the gallbladder.
-Thanks for the Great Explanation , But Doesnt the Pancreatic Lipase Cleave Ester bonds of C1 and C3 , and leaves Fatty acid of Carbon 2 unchanged ?
And shouldnt Bile Salts Provide a Micelles for Transport of Fatty acids and Monoglycerol into the enterocyte ? . Thanks :)
Vayne Manson you are right
u r makin my job easier.. thanku for al ur informative videos!!
I am in the middle of viewing this video, and am thinking, "I really like this instructor." She explains everything clearly and concisely. I am also thinking, "Hmm, I really like the voice." I quickly check out some comments, and see that some have the opposite opinion. I am a guy, so I don't know, I really like this instructor's voice. Soothing, relaxing, but clear and bright at the same time. It's true that the voice alone can tell us whether we will like a person or not. For example, for me, when it comes to radio station hosts, generally speaking, the Jazz station hosts have the most pleasant and interesting voices.
Excellent explanation about this fascinating process, well done !
Isn't it lipase only hydrolyzes the ester-bond in the carbons 1 and 3 of TAG? so the resulting products are 2 free fatty acids and a 2-monoacylglycerol? Just asking :) thanks for the vid though. its helping me a lot
My Lady Rose Queturas I thought so too
Does this mean that all our consumed fats get absorbed and transported before reaching the large intestine? If they don't. What would cause this lack of absorption and are they just considered waste and excreted at that point? Your videos are incredibly informative by the way, I'm just extra curious
I thought the burger was a ufo trying to catch the good gentleman’s attention. I like your illustrations. 😊
Good information. The part about lacteals I didn't know before. Thanks.
now understood properly, very beautifully explained thank you soo much
Are the FAs of the C2 on the glycerol backbone cleaved? I thought they were left on the glycerol backbone, and then absorbed, and then once inside the endothelial cells, repackaged? Also, before entering the blood, don't the chylomicrons go to the liver first? There were a few details of this video that I thought were misrepresented, but other than that, thank you so much for the video. The way you described everything was easy to understand.
Excellent piece of work.
Great process summary. I have a question. When lecithin or Phosphatidylcholine is used as a carrier to encapsulate a nutrient, is the release of this nutrient triggered in the first encounter with the lipase molecule or in the second encounter with the lipoprotein lipase in the blood?
Very nice presentation. However, the packaging of TAGs is not made inside a protein molecule. Instead, the TAG are surrounded by a phospholipid layer (purple circles). These phospholipids have polar head groups (phosphocholine) and hydrophobic tails (fatty acids). On this layer (facing the aqueous environment) several proteins are attached.
Congratulation for the video, is very well done and really helped me, but I have a question: at 2:45 you've said "colesterol backbone" (or that's what I heard, if it's me, please excuse me for bothering you)...shouldn't it have been "glycerol backbone"?
she said "glycerol" mate. Cheers.
It actually sounds like cholesterol..but I'd want to assume she said glycerol..since we all know it's a triglycerol head. End of story.
•Triglycerides are hydrophobic and therefore it can’t be absorbed in the small intestine
1. Fatty droplets are formed (triglycerides are grouped)
2. Bile emulsifies fat molecules in smaller pieces to allow the Lipases to act upon fat molecules (break down of triglycerides to fatty acids)
3. Reformation of triglycerides in intestinal cells
4. Packaging of triglycerides by a carrier molecule called a lipoprotein to transport it. (Triglycerides inside the lipoprotein forms Chylomicron)
5. Chylomicron enters in lacteal because its fenestrations are bigger than the capillaries’
6. Chylomicron travels through lymphatic system until lymphatic thoracic ducts, draining into veins.
(Next video)
Great explanation. Thanks for your great and hard work.
Are the lipoproteins mentioned that carry the fats, LDLs?
Beautiful voice!...AND AN INCREDIBLE WORK!!!
people are actually hating on her voice? i really like her voice haha
This is so concise and clear. Thank you.
Thank you. This lesson was helpful
Very clear, concise & extremely informative. Do you have similar lectures on carbohydrates and proteins?
So is does your body break down the cheeseburger fat differently than say, a fresh salmon fat?
wow thanks a lot excellent video
anyone can tell which part of America is this voice from?
NICE VIDEO AND ALSO NICE VOICE.
Awesome vid.
sooo sweet voice. couldnt concentrate properly. have to listen again. but got the zyst.
Amazing explanation!!
you are an amazing lady!!
اريد المقطع مترجم
Great video :)
Great Video, thanks a lot
Very well explained. Thank you!
Beautiful voice!
I'd pay for you to spell "chessburger" 100 times. Really.
Great explanation as well, thanks!
How many hours of fasting for the fat cell storage to un-store the fatty acids & triglyceride and back into the blood stream for use?
For weight loss? I don't know but probably a lot of hours because even if you don't eat, the human body has BACKUPS to ATP production😂😂😂 like🙆🙆🙆 wow.
Great explaination
Very helpful !!! Thanks a lot...
hi really love the drawing and explanation.
does any body know were is she drawing everything, like the program or where?
lol thanks
Best video
so how does eating fat give you high cholesterol?
I know this isn't the point.... but did she say MacMan?
The voice will lead me do my phD in Biochemistry. :p
The fret, very suggestive
Very nice and simple! thank you :)
Fantastic!
thank u for my life
Very nice, thank you so much ❤️
I love this
Excellent!
Its a beautiful voice
Its the lisp for me
thanks! helped me a lot
does the voice really matter....? really?
+Sam Enck It shouldn't matter, but holy shit the way she talks bothers the shit out of me I couldn't focus.
it's really annoying
Yes
It really does! I would love to learn the information but after about 10 minutes it goes from words to an irritating sound that my brain just can’t handle anymore no matter how important the information is. I know it’s me and should be ignoring it but wow yes.
Very clear, thank you.
thanks the explanation..
The unnecessary use of "kind of" dozens of times during the whole video is kind of unnerving.
that was a ton on information
IS
is this?
Amazing voice....❤️
What is that weird, unearthly groaning sound playing over the title card?
This video missed digestion of medium chain and shorter fatty acids through the portal vein and is perhaps using a restricted definition of what is "fat".
I confuse this pathway with that of re-esterification😭 as the chylomicrons are transferred to the lacteals enter the lymphatics, not the portal vein😭😭 (in monogastrics)
*Some points you missed*
Remember fatty acids dont simply diffuse into enterocytes in the intestine. They are absorped by *facilitated diffusion* , they are assisted by FABPs (fatty acid binding proteins) located at the enterocyte membrane. Another factor aiding the diffusion gradient/ translocation of fatty acids and monoacylglycerols from the micells and into the enterocyte is the rapid re-esterification of long-chain-fatty-acids into 2-MAG into triacylglycerols already happening inside the enterocyte (completed by the enzyme acyl-CoA-cholesterol acyltransferase, ACAT). Speaking of cholesterol, cholesterol also associates within micelles and are similarily absorbed by a different *sterol* -carrying protein in the enterocyte membrane. However much less cholesterol is absorbed this way (about 40% compared to 90% in fatty acids and MAGs), this is because cholesterol is reabsorped in the ileum together with bileacids in a salvaging hepatic circulation system designed for the liver to re-use cholesterol in the making of bileacid.
congrats mate you want a trophy
@@CitriReg What a strange comment. His videos are meant for education. It is only fitting for health professionals watching to add to the level of sophistication so that viewers can aid each other in learning the topics that are presented.
Lost in ur voice n forgot about the explination :v ...
LOL
+Hamizi Oussama wtf bro hahaha
yeah :D
same here
😂😂🙈
❤️❤️❤️
6:14 What even.
Mac Man?
👍👍👍👍👍
I really wanna huge u after seeing ur explanation cause I understand perfectly from u ❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤😻 I'm going to complete this huge great explanation in the 2nd video 🚶♀️🚶♀️🚶♀️🚶♀️
Wait so there are chylomicrons in your lungs?
Would’ve been nice if it was detailed from mouth to rectum rather than just explaining the breakdown that occurs in the small intestines
Who's macman
Its pac-mans brother who eats a lot of Big Macs
the voice couldn't be more female :)