Diabetes Mellitus (Part-10) Mechanism of Action of Sulfonylurease | Antidiabetic Drugs | Diabetes

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Diabetes mellitus is a disorder in which blood sugar (glucose) levels are abnormally high because the body does not produce enough insulin to meet its needs.
Type 1 Diabetes Mellitus
In type 1 diabetes (formerly called insulin-dependent diabetes or juvenile-onset diabetes), the body's immune system attacks the insulin-producing cells of the pancreas, and more than 90% of them are permanently destroyed. The pancreas, therefore, produces little or no insulin. Only about 5 to 10% of all people with diabetes have type 1 disease. Most people who have type 1 diabetes develop the disease before age 30, although it can develop later in life.
Type 2 Diabetes Mellitus
In type 2 diabetes (formerly called non- insulin-dependent diabetes or adult-onset diabetes), the pancreas often continues to produce insulin, sometimes even at higher-than-normal levels, especially early in the disease. However, the body develops resistance to the effects of insulin, so there is not enough insulin to meet the body’s needs. As type 2 diabetes progresses, the insulin-producing ability of the pancreas decreases.
Complications of diabetes
(1) Brain, causing a stroke
(2) Eyes (diabetic retinopathy), causing blindness
(3) Heart, causing a heart attack
(4) Kidneys (diabetic nephropathy), causing chronic kidney disease
(5) Nerves (diabetic neuropathy), causing a decreased sensation in feet
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One of the most appreciatable teacher of pharmacology...

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best n my fav teacher of pharma

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[@aman-themotivater9431]

Apke samjhane ka tarika best h

[@kmunursinglecturesbyyasiru1334]

Appriciated Sir
Your teaching Method are very impressive and Understanding I am BSN Student i understand and Learned Pharma From you Sir
Long Live And May Allah bless you
Sir Plzz Make A Videos Lectures on Drug Dose Calculation
Love from Pakistan ❤💖

[@solutionpharmacy]

Thank you so much for your kind feedback. We have already uploaded a dose calculation video

[@चीको]

This made the topic really easy. Thank you so much Sir👏

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[@hiyapatel7992]

U r the best teacher👍👍keep it up sir!!!

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[@vihaansinghdhami908]

Brilliant Explaination!

[@swarnalatamohapatra2044]

Lots of thanks to sir for easy MOA of DM

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[@UmairSpeaks1631]

Thankyou sir for making the mechanism so easy.

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Most welcome

[@yasaswinisaladi8001]

Mecahnism was made easy...diagram. .tq🙌

[@solutionpharmacy]

Thank you

[@devesh7061]

Very good explanation

[@sambitdas5065]

Outstanding explain sir 🙏 thank you so much sir 🙏🙏🙏🙏🙏🙏

[@manishgoswami1770]

Great sir🙏🙏🙏🙏

[@solutionpharmacy]

Thank you

[@shivampaswan5989]

Awesome explanation sir 😊

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Thank you so much for your

[@SaurabhYadav-cl3tv]

Thanku sir very easily define ❤

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Thank you

[@satyampatel9829]

Easiest explanation ❤️

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[@umakantgupta251]

very good sir THANKS for everything

[@abidurrahman3421]

Nice explanation

[@ashuhooda1012]

thank u so much sir

[@AmanKumar-wz1bb]

Great teaching style sir.

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[@komalsingh1205]

Very nicely explained Sir👍

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[@yashsherasiya6392]

Otherwise sir your explanation is too good to understand the topic 👍👏

[@akashappu4211]

Nice sir 💥💥🙂

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[@vijaygoel2402]

Thanks for sharing the content s, very deeply and well explained, Namaskar 🙏

[@user-wk2gp3tu8h]

Very nice explaination ❤️😊😊🙏🏻🙏🏻

[@solutionpharmacy]

Thank you

[@drnehanegi221]

Thank you sir 👏

[@arjundakhore8382]

Thank u sir 🤗

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My pleasure

[@dunnajayasri1787]

Easily understand ..👍

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[@pravinpatel7657]

Thanks sir

[@kishansaradhara2436]

Dil se aapko Tq

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My pleasure. Thank you so much for your feedback

[@lalitsaini2408]

Very nice sir

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Thank you

[@sagarrahangdale8857]

Tysm sir...😊

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My pleasure

[@BITTUKUMAR-eb9oy]

Very nice sir 👌 👌 👌 👌 👌 👌 👌

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Thank you

[@bpharmacy5608]

Nice sir

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Thank you

[@kishansaradhara2436]

Tq sir ji

[@VickyAbhi7]

MOA 3 number sir thoda explain kr dijiye video cut gaya hai to waha samgh nahi aaya

[@masrurakhatun4765]

Thanku is a small word for ur explanation !! And efforts !! Again thanku Sir❤❤ !! Sukria ❤ . Someone -- say .too boring pharmacology!! Le ..my ans .... 😅 Kavi solution pharmacy se padke dekho 😎

[@solutionpharmacy]

Thank you so much. Aapk asupport hame aur achha karne ke liye motivate karega. Thank you 🙏

[@harshshrivastava8010]

Sir plz clear your last point about diuretics

[@solutionpharmacy]

Sure i will. Which point. Please mention time of the video.

[@Tradezonetrading]

Sir to the point padhaiye na

[@desajidrohan654]

Sir, No explanation about it"s indication , contraindication and Adverse effect ?

[@solutionpharmacy]

Actually our lectures are based on concepts of MOA.

[@kumarabhi969]

Sir this whole activity of sulfonylurease takes place in any cell of the body or this is specific to pancreatic beta cells...?

[@solutionpharmacy]

Body

[@sushilpal8434]

But Sir, SU facilitating the insulin release, which only produce in pancreatic Beta Cells, then How SU can act on whole body cell.??

[@solutionpharmacy]

That will transfer to blood and blood moves everywhere

[@yashsherasiya6392]

Sir in this k+atp channel block ,so influx of k+ ion not move into cells ,so cells start new channel open is ca+2 for stabilized the cell and ca+2 ion is responsible for the secretion of insulin

[@akshaydhawale1999]

Sir in this diagram of sulphonyl urease sir you sad calcium channel opens and depolarisation starts and release insulin from granules so my question is Insulin is produced by beta cell so from where insulin come in target cell

[@solutionpharmacy]

Its endocrine

[@abdulhameedaryoubi808]

Sir is this the cell of the pancreas of Beta cell .?

[@DB-ec9hh]

Sir adverse effects of drugs ki series be upload karona.

[@solutionpharmacy]

ADR ka video hai

[@utkarshupadhyay8840]

Good afternoon sir
Sir kindly make video on mechanism of action DDP4 INHIBITOR ,
I'll be very thankful for you

[@abdulhanan7431]

DPP4 Video...????

[@thegirlblog4816]

Sir normal case m bhi to potassium efflux ho rha h Nd depolarisation nhi ho rha to fr hum diabetes m potassium efflux q block kr rhe h

[@ooloty]

Deplorization happens when potassium moves out if we close its channel how the depolarization will occur?

[@farahnaz9764]

Sir jb ap digarm darw kar k samjaty to bhout zida samj ai jata ha

[@solutionpharmacy]

Thank you

[@mahamjaved160]

Displace SU from protein binding mean???

[@solutionpharmacy]

Means it will release sulf. from binded protein

[@pragyajain1236]

Sir what will be the answer if this question
Tolbutamide increase -
Insulin synthesis
Sensitivity of receptor
Number of insulin receptor
All

[@user-wk2gp3tu8h]

Why ca+2 is responsible for Insulin release ?

[@solutionpharmacy]

They triggered the depolarization and thus release initiated

[@dineshsaini9085]

Sir which type of glut transporter is used by ß cells because different books shows different glut transporters.

[@rishikeshjaiswal4304]

Glut 2 B cell, other body cell glut 4

[@reshmareshma6137]

Sir plz respiratory system ki vedio bnauo....

[@solutionpharmacy]

Next semester me aaega

[@reshmareshma6137]

Sir plz pura define karna for pharmaciat exam... Dose and length parts

[@beingtricky4405]

Sir why calcium influx cause insulin secretion.

[@solutionpharmacy]

They have triggering and contraction ability

[@akshaydhawale1999]

Or the process of potassium atp blocker operates in only beta cells

[@ayurstudies2264]

Y influx of calcium causes increase in insulin??

[@solutionpharmacy]

They trigger endocytosis

[@Ajay.Shishwal]

Sir aap jada details m chle jatay ho esliye topic jada bda ho jata h

[@solutionpharmacy]

Ajay ji sabki alag alag need hai.

[@akshaydhawale1999]

For release

[@ajitsinha1033]

sulfonyl urea

[@barakib7127]

Dr. when insulin is increase glycogen is also increase am i right plz explain?

[@solutionpharmacy]

No

[@khushbookhalidasheikh8835]

hloo sir anticancer ke notes bnake upload krdo plzzz

[@solutionpharmacy]

khushbookhalida sheikh We do not provide notes of all topics. But trying to do so in future

[@khushbookhalidasheikh8835]

@@solutionpharmacy sir ap bhut hi jada accha smjhate ho plz anticancer ke bhi notes bna do

[@solutionpharmacy]

khushbookhalida sheikh Thank you. Jaldi suru hoga wo topic

[@adeshkhandekar5481]

Sir ek to aap KD tripathi se padhai nahito dusare book se padhai dono mix maat karo confusion ho raha hai please request 😊

[@solutionpharmacy]

Are bhai sahab aapko KDT padhna hai ki pharmacology ? Aapke liye KDT ekmatra mahan kitab ho sakta hai hamare liye 1 kafi nahi hai, hum Kai book book use karte hain ek chapter ke liye, aur aapko pata nahi ki KDT bhi use karte hain.

[@adeshkhandekar5481]

@solutionpharmacy sir mai DI ka prepration karata hu so muze kd tripathi imp hai nahi to aap suggestion dijiyega mai kaha se kar sakata hu please reply

[@farahnaz9764]

Sir muj notes chaya

[@solutionpharmacy]

Video hi hai usse aap notes bana samte hain ya Facebook me jaiye waha notes hain

[@mohitjaiswal1141]

Sir u skip 3rd point

[@solutionpharmacy]

May be due to mistake

[@manthannandha131]

There is a mistake
You used word sulfonylurease
In place of sulfonylurea
Plz correct it..
By the way video is good 👌

[@solutionpharmacy]

Thank you and sorry for that if it took place.

[@Ajay.Shishwal]

Most important adverse effects vo to aapne karvaae hi nhi

[@solutionpharmacy]

ADR xan be done by students. Already informed

[@mayankmehendiratta999]

i think glycogen level increase on increase insulin

[@solutionpharmacy]

Yes upto limit.

[@mohitjaiswal1141]

But in this video the insulin level inc. and glycogen level dic. How?

[@shade7552]

@@mohitjaiswal1141 that's glucagon not glycogen....sir hve corrected it

[@Evermore_324]

Thanks sir🙏

[@vivekyadav-gk1bo]

Good explanation sir

[@mohitchhabra8106]

Thanks sir

[@durgeshsingh6447]

Thanks sir