In addition to the upcoming human trials mentioned, there is the PEARL trial (Participatory Evaluation of Aging with Rapamycin for Longevity) in association with AgelessRx.
Thank you for updates on Rapamycin, Dr. Matt! I’ve been following your research for some time. I am on Sirolimus, along wit low dose of Tacrolimus as an organ transplant recipient. You mentioned multiple times in series of videos about degree of sickness of organ transplant recipients referring to them as “very sick people”. I want to object against it. I received kidney and pancreas transplant due to juvenile DM that reversed diabetes since 2005. Now I’ve been on vegan diet for 17 years with no red meat for over 27 years. I eat one to two meals per day, work out daily, have not taken a single day off work for the last two years, I also do other modalities like sauna and meditation. I am NOT a sick transplant patient. I am surrounded by people who did not undergo transplantation but much sicker being significantly overweight/obese, lethargic, hardly dragging feet, having no energy for even getting off their chairs all day. Please, avoid referring to us as “very sick” folks. I love your work and the work of Professor Mickail Blagosklonniy! Thank you and SPASIBO to Dr. Misha! Vseh lyubliu! 😘💗🙏👍
No, he didn't say that. Why did you misquote him by adding the key word "very" in your statement? Here's the full quote from the 11:16 mark: "There are some side effects in that context. Of course those are sick people taking immunosuppressants in addition to rapamycin." Other corrections: - He does not refer multiple times to the degree of their sickness. - He is not addressing you specifically, nor all transplant patients. He is referring to a specific cohort of subjects in those specific clinical trials to show why rapamycin picked up a certain reputation. Are you saying you were in those trials? Are you saying that you had exactly the same clinical conditions as they did? As you are right to point out, not all transplant patients have the same degree of health problems, and some are in far more severe states than others. They most certainly had some differences from you. Your personal experience story can still be helpful (actually, far *more* helpful) and is worth sharing without resorting to false statements. But as it is, one would be reasonable to question what other information may be misrepresented in your report so as to support your view. Your points are more persuasive and better made when your quotes are more accurate.
Cheers Matt, robust presentation, are you suggesting that a one treatment period protocol has a strong possibility of a positive outcome, what dose and period might hit that target?
Thanks for posting Matt. On slides 7/8 there are two rapamycin treatments listed: 8mg/kg and 126ppm. How do these compare to the 5mg per week in Mannick’s studies? Was 8mg/kg a total dose of the entire treatment?
*FWIW.....my weight 190lb, 6'1" height I take 6mg once a week. I eat one grapefruit 1 hour before, then take the rapamycin with sardine's in olive oil. The grapefruit and fat base food increase the amount absorbed.*
@@josepho5055 unfortunately, you're not taking 6mg/week! You're taking *far* more than that because of the effects of the grapefruit juice on CYP450. Be careful!! Because you take it with grapefruit juice, you may be getting 15-20mg, and possibly much more! Rapamycin normally has low oral bioavailability and the amounts prescribed take that into consideration. The side-effects from higher doses of rapamycin are referenced in this presentation, and the presenter often refers to lower doses as being more beneficial because of that. Also note that the grapefruit juice continues to exert about 50% of its effects 24 hours after you take it. Since it will also increase the levels of many, many other meds and supplements, you should consider its multiplying effects on those as well. Some side-effects of certain meds even include 'torsades', a very dangerous, easily lethal heart rhythm. (link below mentions torsades in relation to grapefruit juice & certain drug interactions). I admire the thoughtfulness of trying to 'hack' absorption this way, but do realize (and hopefully others reading this will realize) that there are many potentially unhealthy or life-threatening consequences that may follow when levels of supplements or meds are much higher than was prescribed/intended. Bioperine is another absorption enhancer that can cause problems of this kind; it may be safe for one med or supplement while it dangerously increases the levels of another supplement/med taken on the same day. Helpful to remember that more is not always better, and sometimes, more is much worse. Wishing you the best of health. References: (please note, the links below turned up on a 5 second google search, not an exhaustive study of the topic; as such, there may be more important aspects or newer data to consider than what I have linked to below. My goal is just to raise awareness about the seriousness of the wide-spread effects of CYP450 inhibitors & hopefully people can do their own research & get expert advice for their own situations...) Regarding grapefruit juice on absorption/CYP450: www.ncbi.nlm.nih.gov/pmc/articles/PMC3589309/ Regarding rapamycin oral bioavailability (pharmacokinetics, etc.): pubmed.ncbi.nlm.nih.gov/11523724/
Not necessarily. Consider thymic senescence, which may lead to inflammaging. If one can reverse senescence, this rejuvenated (non-immunosuppressed) portion of the immune system can lead to a decrease in chronic inflammation.
A trustworthy, calm and down to earth scientist… a pleasure to listen thank you
You did and absolutely terrific job making this video. Thank you - much appreciated…I have subscribed!
In addition to the upcoming human trials mentioned, there is the PEARL trial (Participatory Evaluation of Aging with Rapamycin for Longevity) in association with AgelessRx.
Nice presentation Matt!
Thank you for updates on Rapamycin, Dr. Matt! I’ve been following your research for some time. I am on Sirolimus, along wit low dose of Tacrolimus as an organ transplant recipient. You mentioned multiple times in series of videos about degree of sickness of organ transplant recipients referring to them as “very sick people”. I want to object against it. I received kidney and pancreas transplant due to juvenile DM that reversed diabetes since 2005. Now I’ve been on vegan diet for 17 years with no red meat for over 27 years. I eat one to two meals per day, work out daily, have not taken a single day off work for the last two years, I also do other modalities like sauna and meditation. I am NOT a sick transplant patient. I am surrounded by people who did not undergo transplantation but much sicker being significantly overweight/obese, lethargic, hardly dragging feet, having no energy for even getting off their chairs all day. Please, avoid referring to us as “very sick” folks. I love your work and the work of Professor Mickail Blagosklonniy!
Thank you and SPASIBO to Dr. Misha! Vseh lyubliu!
😘💗🙏👍
No, he didn't say that. Why did you misquote him by adding the key word "very" in your statement?
Here's the full quote from the 11:16 mark:
"There are some side effects in that context. Of course those are sick people taking immunosuppressants in addition to rapamycin."
Other corrections:
- He does not refer multiple times to the degree of their sickness.
- He is not addressing you specifically, nor all transplant patients. He is referring to a specific cohort of subjects in those specific clinical trials to show why rapamycin picked up a certain reputation. Are you saying you were in those trials? Are you saying that you had exactly the same clinical conditions as they did? As you are right to point out, not all transplant patients have the same degree of health problems, and some are in far more severe states than others. They most certainly had some differences from you.
Your personal experience story can still be helpful (actually, far *more* helpful) and is worth sharing without resorting to false statements. But as it is, one would be reasonable to question what other information may be misrepresented in your report so as to support your view.
Your points are more persuasive and better made when your quotes are more accurate.
Cheers Matt, robust presentation, are you suggesting that a one treatment period protocol has a strong possibility of a positive outcome, what dose and period might hit that target?
Keep going man
Thanks for posting Matt. On slides 7/8 there are two rapamycin treatments listed: 8mg/kg and 126ppm. How do these compare to the 5mg per week in Mannick’s studies? Was 8mg/kg a total dose of the entire treatment?
If you yourself decided to self-experiment on rapamycin, what dosage you'd use?
*FWIW.....my weight 190lb, 6'1" height I take 6mg once a week. I eat one grapefruit 1 hour before, then take the rapamycin with sardine's in olive oil. The grapefruit and fat base food increase the amount absorbed.*
@@josepho5055 thx, thats interesting to me. What ist the reason for eating the grapefruit? Acid-components?
@@sr.9402 GF turn off an enzyme in the intestines. Will make the rapamycin absorber more in the blood stream.
@@josepho5055 does grapefruit help with absorption with other supplements
@@josepho5055 unfortunately, you're not taking 6mg/week! You're taking *far* more than that because of the effects of the grapefruit juice on CYP450. Be careful!! Because you take it with grapefruit juice, you may be getting 15-20mg, and possibly much more! Rapamycin normally has low oral bioavailability and the amounts prescribed take that into consideration.
The side-effects from higher doses of rapamycin are referenced in this presentation, and the presenter often refers to lower doses as being more beneficial because of that.
Also note that the grapefruit juice continues to exert about 50% of its effects 24 hours after you take it. Since it will also increase the levels of many, many other meds and supplements, you should consider its multiplying effects on those as well. Some side-effects of certain meds even include 'torsades', a very dangerous, easily lethal heart rhythm. (link below mentions torsades in relation to grapefruit juice & certain drug interactions).
I admire the thoughtfulness of trying to 'hack' absorption this way, but do realize (and hopefully others reading this will realize) that there are many potentially unhealthy or life-threatening consequences that may follow when levels of supplements or meds are much higher than was prescribed/intended. Bioperine is another absorption enhancer that can cause problems of this kind; it may be safe for one med or supplement while it dangerously increases the levels of another supplement/med taken on the same day.
Helpful to remember that more is not always better, and sometimes, more is much worse.
Wishing you the best of health.
References:
(please note, the links below turned up on a 5 second google search, not an exhaustive study of the topic; as such, there may be more important aspects or newer data to consider than what I have linked to below. My goal is just to raise awareness about the seriousness of the wide-spread effects of CYP450 inhibitors & hopefully people can do their own research & get expert advice for their own situations...)
Regarding grapefruit juice on absorption/CYP450: www.ncbi.nlm.nih.gov/pmc/articles/PMC3589309/
Regarding rapamycin oral bioavailability (pharmacokinetics, etc.): pubmed.ncbi.nlm.nih.gov/11523724/
8 mg/kg rapamycin increases lifespan. This is like 376 mg rapamycin in a 47 kg human
I think thats 8mg/kg of food .... that was given!
Its mouse, divide dose by 12...
Inflammaging requires immune suppression
Not necessarily. Consider thymic senescence, which may lead to inflammaging. If one can reverse senescence, this rejuvenated (non-immunosuppressed) portion of the immune system can lead to a decrease in chronic inflammation.
@@MarcusAsaro Nice reply, reversing the age of the immune system and the body more broadly would solve inflammaging. 👍
nobody told me he had a youtube channel!
How do I get it?
Most people who take it for geroprotective effects get it via off-label prescription from their doctor.
where can you get this?
If you can convince your doctor they can write an off-label prescription.
You look a little younger compared to past appearances…
I cringe everytime that I hear "Gold Standard". So many times it is a lie or just status quo.
First comment and subscriber number 6