I know its fucking confusing, bcoz no one is starting it frm the basic, i have made video too on the same topic, watch it once i hope it will help you..and pls comment if it does..or any doubt..
When calculating the membrane potential for when the membrane is permeable to multiple ions, why is it that when I do the Goldman equation using the information in your video I get -83mV rather than what you got which was -86mV? I did this: Vm = -61.5 x log( ((150 x 0.9) + (10 x 0.01) + (0.001 x 0.01) + (103 x 0.08)) / ((5 x 0.9) + (142 x 0.01) + (5 x 0.01) + (4 x 0.08)) ) = -83mV
excellent, excellent video! I was wondering though, why was the calcium +2 intracellular concentration was not 0.0001? in the video it is listed as 0.001
Thanks , when k+ move to outsid by channel , are the particles of Na+ inter in the same time !? and How it do that , by diffusion!? what is name the process in which particles move from low concentration To highe concentration?!
I do get it but I still cannot get how in guyton did they got the answer -86 millivolts for the exclusive contribution of Sodium and Potassium on RMP in Chapter 5.
Say *what* ? What do you mean by, " the negative charge of K ions remains positive" ? Where do you get that there *is* a *negative* charge of K ions? Can you point to a time stamp which refers to your question?
This is amazing!! I'm have zero intuition for biophysiology but you made it as clear as glass. Thanks for breaking it down into baby steps!! Love your simple but comprehensive diagrams.
well I believe many of you speed up the movie to 1.25 or 1.5x to make it faster to really save time. I did too. As a result, I have to turn it to 1x and play again. Still I dont understand :(
Thanks for another great video! Would have preferred a more conceptual rather than a mathematical explanation though, as well as an explanation of the role of the NaKATP pump and its contribution to the resting membrane potential.
Yes, I agree, it's not so good to just *mention* the Na/K pump, and then say nothing *about* it! I think it simplifies to: the Na/K pump helps maintain the *concentration gradient* , while the *leak channels*, in relation to *both* the concentration gradient *and* the (sort-of opposing) electrostatic gradient, are what balance out to yield the resting membrane potential.
Yeah, they *don't* explain that at all. They do present some interesting information (ie, ion concentration values). They *mention* the Na K pump, but do *not* explain its role in maintaining membrane potential. Not good! And while they *mention* an 'inward rectifier channel', they don't *explain it* at all!
@@dannichols6261 It would be great if they did but I think this video is targeted at people who already have a good understanding of passive and active transport systems. UA-cam is great, there are a lot of videos that cover that in depth. I would watch them and go back to this one. Hope this helps :)
What is the resting membrane potential of excitable cells is close to the equilibrium potential of potassium because. Potassium leak channels makes membrane more permeable to potassium at rest
Deema, there are two opposing factors causing the jumping in & out of the cell, the concentration gradient, and the electrostatic gradient. They each have a different 'power', sort of like two muscles in your arm, one pulling and the other pushing, and the result would be a position of *balance* between the two forces. So even though there are multitudes of ions jumping in and out of the cell, there is eventually a *balance* overall which yields the ...resting potential. So the *rest* is a matter of *dynamic balance* .
I was always taught that the cell's overall resting membrane potential is closer to -70 mV. Can you explain why this value is different that the -86 mV that you calculated? Thank you so much! This video was SO helpful!
What exactly do you mean? There isn't just 'one' concentration gradient, they each have their own concentration gradient, as each is present in differing amounts inside and outside the cell. I think you *might* mean that the Na/K *pump* might only function to prevent cell swelling (though I don't think that's true), but I'm not sure what you mean that *their* main job is to prevent cell swelling (that's why I think you are referring to the Na/K pump, not the ions themselves).
Thanks, Neha! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on UA-cam? Check it out here: bit.ly/2u35D6J
One thing I’d like to add to this is permeability. At rest without any voltage propagating(action potential) the cell is very permeable to potassium so the summation of these will decrease the effect of calcium, sodium, and chloride a lot and only affect the potassium slightly. GHK equation
best video I've seen on ionic basis of resting potentials! thank you, I've been searching and this one is the easiest to follow along and explains the equations/gradients the best
osmosis! this video is brilliant !! I've read about this topic from endless sources but I've never felt until now that I've truly grasped the concept. Thank you so much for your work. I've watched at least 90% of your pathology videos and honestly After Robbins and Porth you have made my life so much easier! thank you
This helped SO MUCH, especially during COVD-19 where learning things on your own from the university is a bit more difficult to understand on your own, when someone is not lecturing these bulky ideas to you. Great Video!
this is so great, the book i used just glances over most of this to jump to the action potentail. and i was struggeling to understand how the consentration and charges worked.
my prof has a PhD in neuroscience from harvard and ive listened to him explain this numerous times and never understood it but this video made me understand it finally. ty
This video seemed so simple, I was brand new to this formula a couple of weeks ago. So I kept watching it, but once i slowed the speed right down - then it started kicking in! thank you so much!
Thank you, Leticia! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on UA-cam? Check it out here: bit.ly/2u35D6J
i never understood the resting memb. potential but now ... i still don't understand it
mohammed just memorize it 🤷🏽♀️
I know its fucking confusing, bcoz no one is starting it frm the basic, i have made video too on the same topic, watch it once i hope it will help you..and pls comment if it does..or any doubt..
@@Apratim98 Thank you! I just checked out your video and it was really helpful! Thankfully I checked the replies.
Lol, We are on the same boat Mohammed... and I can’t memorize something that I don’t have a basic understanding of...
Me too
Wow, you make everything SO simple. i was stuck on a couple concepts here, clear 100%!
I find your Osmosis is so clear and easy to remember. I want to be a part of your osmosis. Can't i?
Very helpful thank you! Its hard teaching yourself this when you are taking online classes because of this quarentine
Hii
THANK YOU!
When calculating the membrane potential for when the membrane is permeable to multiple ions, why is it that when I do the Goldman equation using the information in your video I get -83mV rather than what you got which was -86mV? I did this: Vm = -61.5 x log( ((150 x 0.9) + (10 x 0.01) + (0.001 x 0.01) + (103 x 0.08)) / ((5 x 0.9) + (142 x 0.01) + (5 x 0.01) + (4 x 0.08)) ) = -83mV
The first calculation for Potassium is incorrect. It should be -82.8 and not -81.0 as stated in the video.
excellent, excellent video! I was wondering though, why was the calcium +2 intracellular concentration was not 0.0001? in the video it is listed as 0.001
Thank you, this was VERY helpful! ^_^ Loved it.
It is the nicest video i've ever watched !! Thank u :*)
Including the constant field equation would be useful here!
Great video
Physiology! Great!
great . thank you
Very nice
Thanks , when k+ move to outsid by channel , are the particles of Na+ inter in the same time !? and How it do that , by diffusion!? what is name the process in which particles move from low concentration To highe concentration?!
EXcellent guys. but why such vague jumping from one topic to other all of a sudden?
Bro you told wrong that Ca +2 is extra cellular fluid instead of intra cellular fluid. 0:37
I do get it but I still cannot get how in guyton did they got the answer -86 millivolts for the exclusive contribution of Sodium and Potassium on RMP in Chapter 5.
By using the Goldman equations and the given values in the book.
Why is the charge of Cl ions flipped while the negative charge of K ions remains positive?
Say *what* ? What do you mean by, " the negative charge of K ions remains positive" ? Where do you get that there *is* a *negative* charge of K ions? Can you point to a time stamp which refers to your question?
i still don’t get why chloride’s membrane potential is negative
yraa g smjh hi nhi aai
i still don't understand
This is amazing!! I'm have zero intuition for biophysiology but you made it as clear as glass. Thanks for breaking it down into baby steps!! Love your simple but comprehensive diagrams.
Great, I had been waiting on Physiology from Osmosis for a long time! Thank you!
well I believe many of you speed up the movie to 1.25 or 1.5x to make it faster to really save time. I did too. As a result, I have to turn it to 1x and play again. Still I dont understand :(
Thanks for another great video! Would have preferred a more conceptual rather than a mathematical explanation though, as well as an explanation of the role of the NaKATP pump and its contribution to the resting membrane potential.
Yes, I agree, it's not so good to just *mention* the Na/K pump, and then say nothing *about* it! I think it simplifies to: the Na/K pump helps maintain the *concentration gradient* , while the *leak channels*, in relation to *both* the concentration gradient *and* the (sort-of opposing) electrostatic gradient, are what balance out to yield the resting membrane potential.
Could you explain what's the role of the Na K pump in calculating the resting membrane potential?
Yeah, they *don't* explain that at all. They do present some interesting information (ie, ion concentration values). They *mention* the Na K pump, but do *not* explain its role in maintaining membrane potential. Not good! And while they *mention* an 'inward rectifier channel', they don't *explain it* at all!
@@dannichols6261 It would be great if they did but I think this video is targeted at people who already have a good understanding of passive and active transport systems. UA-cam is great, there are a lot of videos that cover that in depth. I would watch them and go back to this one. Hope this helps :)
I don’t understand ☹️
Thank you so much, I wish I found this prior to the test. I would have got these answers right. Damn>
That was a great piece of work!
pro trick : watch series on flixzone. I've been using them for watching all kinds of movies these days.
@Gunner Princeton Yea, have been using flixzone} for since november myself :D
@Gunner Princeton yea, I've been watching on flixzone} for since december myself :)
you explain good, and understandable mostly, just all of them number towards the end is a lot and a lil confusing
What is the resting membrane potential of excitable cells is close to the equilibrium potential of potassium because.
Potassium leak channels makes membrane more permeable to potassium at rest
Why CL is more concentrated outside the cell than inside??? Plz
isn' t the nerst forlmula with an ln and not a log? because thats what i am learning
who can it rest when K+ keeps freaking jumping in and out of the cell
Deema, there are two opposing factors causing the jumping in & out of the cell, the concentration gradient, and the electrostatic gradient. They each have a different 'power', sort of like two muscles in your arm, one pulling and the other pushing, and the result would be a position of *balance* between the two forces. So even though there are multitudes of ions jumping in and out of the cell, there is eventually a *balance* overall which yields the ...resting potential. So the *rest* is a matter of *dynamic balance* .
Could anyone explain me from where 61,5 comes in 4:40 ?
wow great! Will you guys eventually also do lectures on neuroanatomy/physiology?
we dont fuck with that shit. We are going in on female vag anatomy next!!
We're mostly focusing on pathology still, for now.
I was always taught that the cell's overall resting membrane potential is closer to -70 mV. Can you explain why this value is different that the -86 mV that you calculated? Thank you so much! This video was SO helpful!
Na and k only contributes 4% to the concentration gradiant, their main job is to prevent cell swelling.
What exactly do you mean? There isn't just 'one' concentration gradient, they each have their own concentration gradient, as each is present in differing amounts inside and outside the cell. I think you *might* mean that the Na/K *pump* might only function to prevent cell swelling (though I don't think that's true), but I'm not sure what you mean that *their* main job is to prevent cell swelling (that's why I think you are referring to the Na/K pump, not the ions themselves).
I lkie the way he explains and the presentation is always very nice to watch n clear .
Thanks, Neha! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on UA-cam? Check it out here: bit.ly/2u35D6J
curious: is this true across all of life? Same for bacteria, plants, fungi?
One thing I’d like to add to this is permeability. At rest without any voltage propagating(action potential) the cell is very permeable to potassium so the summation of these will decrease the effect of calcium, sodium, and chloride a lot and only affect the potassium slightly. GHK equation
woww you start physio, Thank of billions...
Thank you so much. 2024 and video is one of the most helpful lessons 😍😍😍
Glad it was helpful! ❤️
best video I've seen on ionic basis of resting potentials! thank you, I've been searching and this one is the easiest to follow along and explains the equations/gradients the best
Inward rectifier K+ channels pump K+ to inside! Not like leak K+ channels that allow to go to outside
osmosis! this video is brilliant !! I've read about this topic from endless sources but I've never felt until now that I've truly grasped the concept. Thank you so much for your work. I've watched at least 90% of your pathology videos and honestly After Robbins and Porth you have made my life so much easier! thank you
Thanks so much! It would be awesome if you and your friends could review us on our Facebook page. facebook.com/pg/OsmoseIt
Only video across globe that clearly explains resting membrane potential and equilibrium potential.
Thank you sir 😊
Happy to help 💖
very helpful ! thank u
THANK YOU SO MUCH 💜 SO HELPFUL 💜🥺💜💜💜 THANK U 😭💘💜💜
You're so welcome!
Awesome content and i like it so much :DDD
hi.. can u explain the resting membrane potential during cardiac surgery.. the usage of cardioplegia to stop the heart..
Brilliant video! Thank you very very much!
You're very welcome! 😊
If K+ gets in through electrostatic gradient what Is the benefit of pump then its confusing
This helped SO MUCH, especially during COVD-19 where learning things on your own from the university is a bit more difficult to understand on your own, when someone is not lecturing these bulky ideas to you. Great Video!
Erik Plumeda so true
for the first time i understood. thank you.
want to ask that in guyton the equation has inside/ outside but the equation in video is shows outside/inside. kindly guide me with this thing.
Really amazing ........iam really appreciate your great and fruitful work....thanks🙏
You made it quite clear! Thanks!
Very nice video sir , but generally why potassium is more transferred to out side?
makes so much sense now lol
Thaankkkk uuuu♥️♥️
She came she saw she contoured.... irritating 🙄🙄
I want to get a really high usmle. Do you have a strategy for that?
this is so great, the book i used just glances over most of this to jump to the action potentail. and i was struggeling to understand how the consentration and charges worked.
Thanks! 🙏🏼
I UNDERSTAND NOW!
i got screwed on my boards regarding this when i got my bachelor's in patient transporter
that was useful thankyou
please do more physiology videos I'll be grateful for that
Great physiology
Its really great understand! Thanks for making awesome video.
Very good explanation, keep posting videos like this :D
Thank you this is soo helpful
thank you for this clear explanation!! i have subscribed to your channel and will definitely explore more!!!
Hi Tengku! Glad you enjoy our video! Hope you'll like our other videos too! ❤️
my prof has a PhD in neuroscience from harvard and ive listened to him explain this numerous times and never understood it but this video made me understand it finally. ty
Wow! We're glad that our video was able to help! 🙏🏼 ❤️ 😊
Excellent!😍
It would really means a lot and nice if you guys upload dailyy one video consecutively!please.......!!!!
We wish we could! Right now we don't have the funding to do that, but we hope one day we will!
This video seemed so simple, I was brand new to this formula a couple of weeks ago. So I kept watching it, but once i slowed the speed right down - then it started kicking in! thank you so much!
Most welcome! 😊
This was really helpful.
That's nice to know! 💕
E don be 😂
are the values of each ions here constant?
This is the best video on membrane potential 😉glad to have discovered this channel 🙂😌
Welcome aboard! Hope you'll also enjoy our other videos! 😊 🙌🏼 🥰
I may just pass PT school because of you sir
is there a vedio for donnan membrane equilibrium
Thank u :)
I have a way better grasp on this now ty
And i get exams on thursday
you're the best, explained it better than my uni professors
Thanks for the feedback! 🙌🏼
Thanks you saved me a lot of time.
awesome
Thank you so much, i finally understood this 🥳
Glad it helped! ❤️
Unexplainable!!!
Unbelievable!!!
Thanks🤗🤗🤗
Great video ! thank you again Osmosis
Thanks for Arabic translation
Please upload a video on DIC
disseminated intravascular coagulation
We will eventually! You can vote for upcoming videos by becoming a Patreon subscriber. www.patreon.com/osmosis
OHHHH
Neuron resting potential
This helps me to understand the topic better.✌
We're glad our video was able to help, Ayesha! Thanks for letting us know! 🥰
Woow!! Thank you so much for this video!! Awsome explanation
Thank you, Leticia! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on UA-cam? Check it out here: bit.ly/2u35D6J
Good
very well explained, Great Job ☺☺
Thanks, Mustafa! 😊