Bench to Bedside: Myelination 1 - Myelination, Remyelination and Multiple Sclerosis - Mikael Simons

www.ibiology.org/human-diseas...
Improving our understanding of nerve cell myelination and remyelination in both animal models and humans may to improve treatment for demyelinating diseases such as multiple sclerosis.
Part 1: Myelination, Remyelination and Multiple Sclerosis: During multiple sclerosis, the myelin sheath around axons is destroyed and nerve function is lost. Yet sometimes a few lesions undergo remyelination. Why? And how can this be improved?
Part 2: Neuropathology of Multiple Sclerosis: Better understanding of the brain pathology that correlates with the progression of multiple sclerosis may improve diagnosis and treatment.
Talk Overview:
Multiple sclerosis (MS) is a debilitating autoimmune disease in which immune cells infiltrate the central nervous system and attack the myelin sheath surrounding axons. Dr. Simons explains that myelin is necessary for signal conduction by nerve cells and for the metabolic support of axons. Demyelination results in axonal loss and formation of lesions in the brain. A small percentage of MS lesions are capable of remyelination following steps similar to axonal myelination during normal development. Since lesion remyelination correlates with reduced neurodegeneration, Simons and his colleagues strive to understand why remyelination occurs in only a small number of MS patients and to identify drugs that may promote it.
MS begins as a disease of intermittent episodes with recovery in between. With time, however, MS changes to a progressive disease with increasing disability. In her talk, Dr. Stadelmann explains that studies of MS brain lesions have identified specific changes that occur with disease progression. For example, chronic MS lesions contain many fewer oligodendrocytes than do early lesions. Since oligodendrocytes produce the myelin sheath that surrounds axons, drugs that stimulate the migration and establishment of oligodendrocytes in lesions may increase axonal remyelination and improve the prognosis of MS patients. Stadelmann also explains that brain lesions can be caused by conditions other than MS, such as neuromyelitis optica. Improved studies will help to correctly diagnose and treat these distinct diseases.
About Mikael Simons:
Dr. Simons’ research focuses on developing new ways to promote remyelination of damaged axons in demyelinating diseases such as multiple sclerosis (MS). To reach this goal, his lab strives to better understand the cellular processes underlying myelin formation in normal development.
Simons received his MD from the University of Heidelberg and did his residency in neurology at the University of Tübingen. He joined the University of Göttingen in 2004 and, in 2016, he moved to Munich to become Director of the Institute of Neuronal Cell Biology at the Technical University, and the German Center for Neurodegenerative Diseases.
Learn more about Dr. Simons’ research here:
www.neuroscience.med.tum.de/in...
About Christine Stadelmann:
Dr. Stadelmann is a Professor and Deputy Director of the Institute for Neuropathology at the University of Göttingen Medical Center. Her studies focus on inflammatory diseases of the central nervous system including multiple sclerosis and neuromyelitis optica. She is particularly interested in understanding which pathological events correlate with disease progression.
Learn more about Dr. Stadelmann’s research here:
www.neuropathologie.med.uni-go...

[@Jan2844]

Glad to see UA-cam has such rich content. Being Medical student I really like the high quality content of this channel.

[@sirranhaal3099]

Quite a succinct lecture from a clear expert. Thank you.

[@rockykeim5018]

I am in North Carolina, US and suffer from CMT (Charcot-Marie-Tooth Disease) Demyelination. How can I learn more about the remyelination of the nerve tissue in my legs, feet, and hands?

[@watersoilearthfire7216]

Omega 3 fish oil and almond milk that you made it by yourself. Avocado and MCT oil Take Vitamin B/ ask doctor for Benfothiamine or Vitamin B injection and take fresh veg and berries. Take care of your food and if possible use Oxygen assist breathing machine for elder to increase oxygen in the itssue also will help.

[@elijahmbanks]

What do you eat or what vitamins help the body remyelinate?

[@pedrorodriguez7122]

elijahmalik b fish oil omega 3 krill oil walnuts. Olive oil with cod liver oil helps not necessarily a cure.b vitamins also

[@alexanderpadalka5708]

🗽

[@ramazan9857]

I'm 21 years old I don't want to be disabled