Remyelination research in Multiple Sclerosis
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- Опубліковано 8 лип 2024
- Myelin is a fatty protein that forms a sheath around the axons of nerve cells - the part of the cell that transmits messages to other nerve cells. Damage to myelin (or demyelination) caused by multiple sclerosis interrupts or blocks nerve messages. In the earlier stages of MS, oligodendrocytes can often repair areas of damaged myelin - a process known as remyelination. As MS becomes more established, these cells stop functioning or are killed off and myelin is not repaired, resulting in increasing disability.
The good news is that research is beginning to identify potential remyelination treatments which are being tested in clinical trials. In this Q and A we chat with Dr Nick Cunniffe about some of the research that has been done and what is in the pipeline for remyelination research.
For more information about remyelination have a look at our website mstrust.org.uk/a-z/nerve-cell... - Наука та технологія
It’s very good to hear that there is research into remylination and very encouraging to MS sufferers like myself
gives me hope for my future years of life to see MS isn't being forgotten about
Wow this is so fascinating. I think MS research deserves way more recognition, the progress just in the past couple years is amazing.
had severe ON and haven't recovered after 6 months - I am considering doing a combination of fasting and taking clemastine for a couple months (the fasting to mimic metformin) combined with exercise to boost Treg - I can't wait another 2-4 years to maybe get some results. The research is fantastic and I am amazed at the ingenuity and dedication of everyone involved, but to a patient these results are still painfully slow. Surprised there is not a broader interest in remyelination as this would surely be beneficial to anyone over the age of 60 - perhaps assist in general cognitive decline for everyone not just people with MS. Thank you MS Trust + Dr. Nick, great interview. :)
Is there a study?
Interesting. Gold was used in treating Rhematoid arthritis. Perhaps there’s a connection to MS
Do you know of any Clinical Studies for my son with Cerebral LEUKODYSTROPHY?
We are a multiple sclerosis charity and so this is outside of our area of knowledge. It may be worth contacting the MLD Support Association UK www.mldsupportuk.org.uk/ who support people affected by metachromatic leukodystrophy and will know what research is happening.
You can also find a list of recent and current trials around the world on the Clinical Trials website at clinicaltrials.gov/ct2/results?cond=Cerebral+LEUKODYSTROPHY
anything new on metformin/clemastine trials ?
The start of the study was delayed by the pandemic, but the first of the 50 people they are aiming to enroll started on the study in April 2022 (multiplesclerosisnewstoday.com/news-posts/2022/04/26/clinical-trial-enrollment-metformin-clemastine-myelin-repair-multiple-sclerosis/)
The treatment will last 24 weeks, and the intention is to have gathered all the data by October 2023. There's a little bit more about the trial on the Cambridge University website at www-neurosciences.medschl.cam.ac.uk/jones-coles-group/ccmr2-a-trial-of-metormin-and-clemastine-as-remyelinating-drugs-in-ms/ and also on the ClinicalTrials site at clinicaltrials.gov/ct2/show/NCT05131828 (this latter includes the eligibility criteria)
Would like to join.
Any research into cheap treatments for remyelination using Lion's Mane mushrooms? Animals have responded well and have shown regrowth of myelin, correct? Oh that's right...there isn't any big money like $125,000 per person per year in that kind of treatment. Never mind.
this research has been terminated due to numerous adverse effects
An update of the five treatments mentioned in the video (as of December 2022):
Bexarotene - the video explains why this drug wasn't taken beyond the completion of the initial trial due to is side effects, though the research did indicate that remyelination is possible - www.mstrust.org.uk/a-z/bexarotene
Anti-lingo-1 (Opicinumab) - this trial was discontinued, not because of side effects but because the drug wasn't proving any more effective than placebo - www.mstrust.org.uk/a-z/opicinumab-anti-lingo-1-biib033
Nanocrystalline Gold - these trials are still ongoing, with results possibly appearing in 2023 - clinicaltrials.gov/ct2/show/NCT03993171
Clemastine/metformin - the Cambridge trial was further delayed by Covid but began recruiting participants in March 2022. It will be running throughout 2023, with results possibly in 2024 - www-neurosciences.medschl.cam.ac.uk/jones-coles-group/ccmr2-a-trial-of-metormin-and-clemastine-as-remyelinating-drugs-in-ms/