IgG4 Related Disease
Вставка
- Опубліковано 31 тра 2024
- 2:21 Five key takeaways about IgG4RD.
4:09 IgG4RD is an inflammatory autoimmune disease.
4:50 Fibrotic vs. inflammatory lesions.
6:13 Organs typically affected by IgG4RD.
8:51 IgG4 are common, but not always present.
10:05 Treatment for IgG4
11:56 New treatments are being evaluated.
IgG4 Related Disease
Recorded April 2023
If you’re living or loving someone with IgG4-Related Disease (IgG4-RD), what do you need to know? How is this condition related to vasculitis? In this webinar, rheumatologist Zach Wallace, MD, MS, breaks down the fundamentals of this complex, rare immune-mediated condition that-if left untreated-can cause fibro-inflammatory lesions nearly anywhere in the body as well as irreversible organ damage. He explains what it is, how it’s diagnosed, and the best tips and strategies for treating and managing the disease. He also answers some common (and uncommon) questions from people affected by IgG4-RD.
Introducing Dr. Zach Wallace 0:18
Elevated IGG4 levels are seen in repeated covid vaxxed patients. Mergeonmics does an interesting job of presenting this association.
I’ve heard the same. As this is a recently acknowledged phenomenon associated with the C-19 vaccine, there is a lot of interest developing in this topic. Perhaps the vasculitis foundation could do a video elaborating on this topic.
Indeed!
Yup, in people boosted with mRNA (Pfizer or moderna) but not adenovirus ones
Perhaps the IGG4 production is to avert extreme immuno response. Maybe a natural offset to prevent a cytokine storm. The downside might be an overly suppressed immune response to the underlying cause.
How likely is it that the Vagus nerve could be a target for this particular inflammatory process?
Thank you for this presentation which helps me understand my situation. I was initially diagnosed with pancreatic cancer, but after a biopsy the diagnosis was autoimmune pancreatitis, IGg4. My treatment was Prednisone and Rituximab. The IGg4 destroyed the insulin producing cells in the pancreas, and resulted in Type 1 diabetes. This is successfully managed with a daily low dose of insulin and diet and I lead an active healthy life at 75. I am grateful for the knowledgeable and supportive medical community.
I am sorry to hear that your insulin producing cells were destroyed by the IGg4 but glad that you were accurately diagnosed and promptly treated and that you are leading an active and healthy life. There are so many amazing people who research and treat these conditions. We at the Vasculitis Foundation are very grateful for them as well.
I'm a Moderna 3 jab victim who was never infected before vaccination. My last jab was in October 2021. Today I received a Labcorp test quantifying IgG subclasses. My result is below.
Total IgG is 925 reference range is 603 to1613
IgG1 is 484 reference range is 248-810
IgG2 is 247 reference range is 130-555
IgG3 is 44 reference range is 15-102
IgG4 is 94 reference range is 2-96
I assume the result is nonspecific to SARS-CoV-2. Subclass 4 exceeds subclass 3. Subclass 4 is elevated at 10.2% of the total. I follow a carnivore diet. My last jab injured but didn't disable. I've fasted for 72 hours three times since I was injured.
everyone here too scared to talk about the link with IgG4 and the subject we are not allowed to talk about.
I would say it's a mischaracterization to categorize doctors & researchers who are involved in IgG4 research, as being too scared to talk about the link with IgG4 and the Covid vaccine. In fact, there is much ongoing research right now looking into how the Covid virus and the Covid vaccine may impact autoimmune diseases including IgG4. Research takes a lot of time and Covid and the Covid vaccine are still both very new from a research timeline standpoint. I would say researchers are unwilling to speculate until they have more, accurate information. I wish you could meet many of the amazing researchers who are trying to learn more about vasculitis and other autoimmune diseases. I can guarantee that after you met them you would realize just how much they care and just how hard they are working to help prevent and cure diseases not cause them.
Research into how the vaccine may impact autoimmune diseases? I’m confused, the science was declared a couple of years ago, the vaccine is safe and effective and anyone who has any questions is a dangerous idiot conspiracy theorist. Researchers and scientists should have said they need more time for research when it mattered and mandates were being pushed. They lost a lot of trust and respect along with doctors as a group.
Just tested positive for IgG4-RD. I've had a wide range of symptoms. Saw 4 different specialists who were trying to figure it out. It was the GI doctor who caught it in blood work 5 months after the first symptoms presented. I do believe that it's vaccine related in my case, but I have nothing to back it up of course. I just know I've always been healthy and after the vaccine I get hit with IgG4. I started Prednisone yesterday, prescribed by the GI doctor. What's interesting is my primary care physician previously prescribed Prednisone for a course of 5 days based on some of my symptoms. The GI doctor has me on a slightly higher dosage. Thank you for making this video. It seems like there are only a few doctors taking an interest in this disease which is discouraging. This is an awful disease and to get hit with something like this has been devastating to say the least.
We are so sorry to hear about your diagnosis. We are glad you are getting the treatment you need and that you found the information in this video to be helpful. There is some research (in the very early stages) being done into links between vasculitis, IgG4 related diseases, and Covid infections and the Covid vaccine. Unfortunately we don't currently have a lot of IgG4 resources on our website but if you join our mailing list you would receive information about upcoming webinars and research some of which might be related to this topic. www.vasculitisfoundation.org/subscribe-to-vf-e-news/
You could also join our online support community to connect with others who have IgG4 related diseases.
www.inspire.com/groups/vasculitis-voices/
Have you ever had mononucleosis or have you came down with West Nile or dingy fever did you ever have does other things that you can have that can make high inflammatory markers before covid they're not talking about this though
Inoculation shots can do it all of the inflammatory inoculation shots can do it too in my case I have been fighting this high inflammatory disease since 2017 they haven't done nothing it took them to 2019 to do the IGG test it was high they just let me suffer because I guess all of the doctors are too stupid
Is unbelievable that they just now started looking when mononucleosis has been doing this to people for over 60
I had shingles I had a heart attack before I was 23 years old and I'm 60 years old now
I have iga vasculitis from last 5 years continuously skin lesions without any remission and im just 22. Wishing for a miracle now.
I am so sorry that you're having such a tough time. I was off my feet for nearly six months. I hope that you are being treated at the best teaching hospital in your area. I am praying for you 🙏🏻
We also hope your healthcare team is able to find a treatment that will help you get some relief. The Vasculitis Foundation has additional resources you may find helpful including information on online virtual support groups that can be found on our website vasculitisfoundation.org
You can also sign-up for our Enews and receive emails about upcoming educational webinars and conferences as well as information on research. www.vasculitisfoundation.org/subscribe-to-vf-e-news/
You may also find this video about IgA vasculitis helpful ua-cam.com/video/gTPBAhTY7nc/v-deo.html
And here's some information from our website about IgA vasculitis. www.vasculitisfoundation.org/education/forms/henoch-schonlein-purpura/
Call upon Jesus
Go carnivore it’s worth a try 👍👍
The mRNA gene 🧬 therapy causes igG4 is become abnormal and unstable in the body after administration.
The first two shots but especially any boosters to follow.
Merogenomic did a video on 20 children with increased elevated Igg4 . After the mRNA gene therapy GMO product. That can't be a good thing..
Hi can you tell me something more about it pls . my igg4 is super high .
The lesions on my legs were so painful 😢 I had IgA HCC. I got kidney damage. I am in Massachusetts. I am looking for more information and I'm hoping you can help me.
Punch biopsy done. Six months it took to get rid of it.🥺
I would love for you to talk about my type of vasculitis. Apparently it is rare.
We do have information on IgA vasculitis including this video ua-cam.com/video/gTPBAhTY7nc/v-deo.html
This information on our website www.vasculitisfoundation.org/education/forms/henoch-schonlein-purpura/
I'd also suggest reaching out to our patient support coordinator using this contact us form and she can help connect you with resources in Massachusetts. www.vasculitisfoundation.org/about/contact-2/
Mergeonmics.
I now take 8000iu of vitamin D3 and my chest pains have become calmed down considerably.
Glad that is helping you.
Remember to take Vit k2 with your D3. As without it calcification of the arteries can occur. So I’m told and I’m no expert. But I found this out on my journey 👍
I have a igg4 patient, 38% ratio, i took rituximab 1 mg vial 3 injection, so my igg4 level decrease,
Now a days my sgpt level 125 and abdomen pain ，back pain
What can i do
We are not doctors so cannot give medical advice. We strongly urge you to see your rheumatologist and report your symptoms of abdominal and back pain to them.
Hi how are you doing? Is everything better?
With increased IgG4 does that affect the other antibodies effectiveness? Maybe why vaxxed get repeat infections?
Unfortunately, I don't know how increased IgG4 impacts the effectiveness of other types of antibodies. Here's a link to an article that contains information which partially addresses your question www.science.org/doi/10.1126/sciimmunol.adg7327
Introduction is longer then disease
I have a high range of IGG4
We'd recommend consulting a rheumatologist if you have not done so yet.
Hi can we talk about igg4 disease. I am new to this disease 😢 I am 35 yrs old mother of 4 kids and very very scared. Did you had any more test for igg4? Any biopsy or I don't know.... anything.... I will have biopsy on July . I don't know what to do ,what to think just crying at the moment. How high is your igg4 tell me pls
Can igg4rd cause tinitus?
Hi. That's a great question. I was able to find an article where someone did a review of all of the published research/case study papers on IgG4-RD looking for impact on the ears. Here is what they found. "Results: Nineteen cases of IgG4-RD with mastoid bone involvement were reported in the literature, the earliest appearing at the beginning of the previous decade. Most frequent symptoms included hearing deterioration, tinnitus and otalgia." It does look like some people with IgG4 related diseases have experienced tinnitus.
Source: www.mdpi.com/2076-3417/12/16/8353#:~:text=Results%3A%20Nineteen%20cases%20of%20IgG4,was%20restricted%20to%20otologic%20manifestations.
I am unvaccinated, but developed tinnitus during covid. It has subsided a little since.
@@vasculitisfoundation TY for the data I think there maybe still the mitigating factor of the" cause" of the igg4rd For example,if igg4rd were caused by the vaccine elevating igg4 along with what we now know how the vaccine can mimic some symptoms of covid such as tinitus Therefore,if acquired that way,along with the igg4r would be tinitus
@@J123Tilley Tinitus is often a symptom of covid infection Glad you recovered from it
Wi fi can!
great news after taking four jabs any comment??
Vitamin D helps
We are so glad you found something that helps you.
Hi Do you have igg4 disease?