Chronic Lymphocytic Leukemia (CLL)
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- Опубліковано 6 тра 2024
- Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/chr...
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Chronic Lymphocytic Leukemia (CLL). CLL is a type of cancer that affects the blood and the bone marrow. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Chronic Lymphocytic Leukemia (CLL) Introduction
0:55 Hematopoiesis Pathway
5:36 Pathophysiology
17:49 Diagnostic Approach to CLL
26:27 Treatment
33:49 Comment, Like, SUBSCRIBE!
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That’s what my mom has, she got diagnosed with it on April 1, 2015. She waited treatment wise until January of 2021. She ended up doing immunotherapy for 5 months back in April of 2021. After her last treatment, she now has follow ups monthly to as of right now once every three months. She takes ibrutinib everyday along with acyclovir twice a day for shingles and celebrex for arthritis in her knees
How old is your mom , since my dad got diagnosed these past week
@@greedysourceofgod4819 young, mid 50s
You aren’t made to wait for treatment, a lot of times at the time your diagnosed there maybe no need for any kind of treatment right away unless something is going on where the cancer isn’t active per say and, that’s why your mom didn’t do or receive treatment till 2021! Example, I was diagnosed with CLL at the age of 42, however, I didn’t need treatment till 3 yrs later and, it wasn’t for the fact, I had to wait a certain period before, I got treated, the cancer was not active or rather nothing was going on till then, that required a reason to get any treatment!
She must be one strong woman. My husband was put on Ibrutinib and it put him in the hospital for nine days. They had to change to Calquence, and he did better on that.
@@sonyafox3271that's what she meant. She waited for treatment because the stage of the cancer wasn't yet at the point of treatment. It is not about being active..but stages of development as clearly explained in the video. Stage 0 you do nothing. Just wait... Etc etc
If I had teachers like you, I might have gone to med school. I recently learned that my wife has CLL. Even though I'm not in the medical field, I want to learn everything I can about her condition and your talks are absolutely amazing! One of the worst things of a disease is the unknown, and you have done so much to help me understand her situation. Thank you, thank you, thank you.
Yes, very good instructor. Just got my diagnosis yesterday. Will be looking for lots of information. Good luck go wife.
you already helped me in physiology and now a few years later in clinical oncology. you're the best
thank you so much really appreciate all the work you put into these lectures 💐💐💐
Have had CLL but never had it really explained to me. Now I have a much greater understanding. Thank you.
You are so amazing!! I cannot stop bragging about your lectures to all my med student friends. ❤
Tons of thanks for such an outstanding tutorial
❤brilliantly presented lecture, so helpful and easy to follow, thank you guys x❤
love how well you explain these complex concepts! this lecture really helped me with my research paper. keep being amazing! how do you know so much about so much?
i'm a biomed. student and these videos really help me understand hematology better
Every word will not be enough to thanks you right
Thanks for every thing that you do here
Your effort will not ever fogetten ❤
Thanks for your supporting❤❤❤❤
The love of my life got CLL as the result of exposure to Agent Orange when he was serving on two different Navy aircraft carriers during the Vietnam War. We lost him in February of 2023, after cancer took his bladder and prostate (not uncommon for CLL patients), as well as multiple skin cancers - all going on in his body at the same time. If you or someone you love has CLL, don’t postpone treatment. And God bless you.
Love this! I'm learning so much.
Yay 🎉🎉 I’ve been waiting for CLL thank you ❤
I appreciate all the efforts you have done for these incredible whiteboards..
Amazing explanation, I really appreciated your countless effort to bring this high quality education for free.
I really dunno how to thank you, ur such an angel God sent to us , thank u so much for posting ur videos and these amazing info for free, ur amazing bro , love ya ❤!
You are the best doctor worldwide
Thank you, so proud of you 👏 🙌
Thank you! Love your videos.
Amazing content.Basics explained very nicely.
Thank you for this most informative video!!!
Wonderful incredible outstanding idea of coming up with such UA-cam channel. Millions and probably more than that support your channel and they say between them that it’s helpful even though they don’t comment here. Keep up with this job. Your channel is no. 1 ranked in my opinion.
Just been diagnosed with CLL so I'm just trying to understand it thank you
Great info, great teacher🙌
These are great lectures; so helpful
Please do us myeloproliferative neoplasms
Thank you for your hard work ❤❤
Good job Prof Zach
Thank you so much 🙏❤
I have atypical CLL with multiple paraneoplastic syndromes starting with a massive Pulmonary Embolism with cor pulmonale in 2108 spent a week in the ICU. Most of my paraneoplastic syndromes have been neurologic. I have found that oncologists seem to know very little about paraneoplastic syndromes and just ignore my symptoms. I never get any answers and have to research everything myself. I delt with almost a year of appendicitis level lower abdominal pain with no help or answers. It seemed to be a vascular type pain which fit angioedema in my colon which is occassionaly seen with CLL. I have seen peripheral angiodema in the past and the pain was identical to what my patients complained of. I am trying to figure out how to get oncologists to listen, or find an oncologist who knows atypical CLL.
I am looking for help and get none. I also get no answers, which is very frustrating. I have to research everything myself to get answers. My oncologists don't even try. It is extremely frustrating! I have had to find treatments on my own with no help from oncologists.
thank you for your supporting us please we need explanation about chronic myelogenous leukemia ❤❤❤
our great teacher thank you
Sir u are really a diamond of the medical science ...loves u a lot ....keep supporting us sir we need ur help❤❤❤
Wow keep uploading thanks 😊
I was just diagnosed with CLL. (Feb. 2024) I am not symptomatic yet and will be living near MD Anderson in Texas. Should I consider a clinical trial for CLL? I am relatively young (not yet 65 yrs old) Thank you for all you do! God Bless!
u said "please" so sincerely that i liked the video before watching eyes teared
Amazing! Tyssm Zach
amazing video as always
Please make a video on tissue it's really helpful for me and many other medical students. It's a humble request Zach 🥺
Perfection as always
Great overview of CLL! For the pathogenesis: it is true that we are not sure about the origin of the CLL, but scientific community agrees that some mutations on key genes are involved in the genesis of this malignant disease (familial CLL is also occuring in a small % of the population, and investigation is ongoing to try to find the correlation of certain genetic makeup with the CLL appearence). Importantly, we know for sure, based on preclinical studies to which I also contribute to, that the B-cell receptor signaling (BCR) is playing a role in the pathogenesis and progression of CLL.
thank you for fabulous lesson. Your lecture is indispensable for me
Thank you very much ❤
Brilliant well presented thank you.
thank you for the video!!
Thank You🙌🏽
Thank you for the video
Thank you so much Zack you are the best
❤
谢谢您！🌸
RN here recently diagnosed with CLL/SLL under investigation for large B cell lymphoma, need a FISH study(you didn’t mention)
Now I know Im Rai 2 symptomatic with the typical B symptoms. Recent 50 lbs weight loss in 6 mths, lots of abdominal symptoms and pain.
FYI My other presenting initial symptom was thoracic back pain spinal cord compression along with the lymphocytosis . Thats a big problem. Knowledge is power!
Fantastic lecture Im gonna send it to my GP😂❤Thank you!!
@maggieensley8819 your story sounds like mine. I have had a weird rash for 1.5 years. It was called psoriasis, but nothing helps. Now it's on my back. Recently got intracellular nutrient test back and shows anemic. I've struggled with fatigue. So, next step is bloodwork. Has anyone experienced rashes? I am in my early 60's.
Thank you !
Thank u ninja You're the best bcz of u I wanna be neurologist ❤
Thank you so much ❤❤❤❤❤❤
Thank you very very much
thank you zach
Best video on CLL ever!
Your video was really informative, but... chemo is on it's way out for all cll treatment since ibrutinib came on the scene. When was this video made? And no mention of high risk cll subset (p17 del, tp 53 mutation) which renders chemo ineffective.
Maybe i'm wrong but you look under the weather in this video. Hope you are doing well. You are an incredible teacher! God bless you!! Prayers your way!
Thank you for the video really appreciate it, I tried reading Davidson but didn’t understand
THANK YOU ❤❤
Thanks so much sir
Thank you so much
thank you very much doctor
Thank you❤️
ur awesome, i am a hematology fellow and the ASH SAP is complicated i need someone to simplify it for me so thank you for that really
Thank you 😊
Thank you so much sir…….
You are an absolute legend ❤️
Watching from Nairobi, Kenya. Nice video prof, am gaining a lot from you and now it's almost 5yrs since I started your lessons. Ninja Nerd...... please give us certificates 😂😂 and we pay for it.
Brilliant
Great job man ❤❤❤❤❤ proud of u you are doing such a great job for medical students all over the world I really respect u want to meet u once in my life if I was alive ❤❤❤❤❤❤❤❤❤❤❤❤
am from africa , ghana your videos help me alot
شكراً ❤
AMAZING!!!
I have to watch this 10 more times to get it all down, but my mom was just diagnosed at 74. We meet with her med team tomorrow. Ill have lots of questions for them because of the knowledge in this video. Im armed and ready to fight! (With knowledge) xxoo thank you to the creator of this video.
Thank you so much. I graduated in pharmacology 20+ years ago, but am unfortunately having to revisit this topic due to my wonderful aunt having been diagnosed with CLL. I want to feel useful, or come armed with some information. She’s now been taken off chemotherapy because it wasn’t having enough of an effect given the horrendous side effects she was experiencing. Could I ask you - is bone marrow transplant ever an option for the older population with this disease? I’m a registered bone marrow donor, and would get a hole drilled into my femur without anaesthetic if it meant my Auntie could live a normal life again. She might be 77, but she was fit and formidable before this, and she deserves better. All the best, Siân
Please do an overview video on leukemias and lymphomas.
I am jealous of u bro, great work ❤ we hope you have a great life with lot of beautiful blessings ❤
thanks Dr
Thank you for this videoo!
Justo lo que estoy estudiando ahora ❤❤❤
A legend indeed
THANKS A LOT 🫶🫶🫶🫶🫶
You said please twice. So here I am.
and I get to say a big thank you!
My dad was diagnosed with this a few years back... The theory from his doctor is it was due to Agent Orange exposure in Vietnam. Very interesting video!
thank you!
Very Useful Bravooo your soo Good ❤️❤️
Love you Doc😘
Good bless you …….❤
LOVE!!! thanks
Thank you
love these
The best videos on Leukemia's😊
You are amazing❤️🥰
Thanks
I love this man
You teach better than my lecturer
Namaskar, Doc