Vitamin D (calciferol): Sources, Synthesis, Metabolism, Functions, Deficiency ||
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- Опубліковано 12 кві 2020
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Vitamin D (calciferol): Sources, Synthesis, Metabolism, Functions, RDA, Regulation and Deficiency
Vitamin D (calciferol)
Characteristics
-------------------------
Active form: 1,25-dihydroxyvitamin D (1,25-(OH)2 D3, calcitriol)
Sources:
--------------
Ergocalciferol (vitamin D2): mushrooms, fortified foods (e.g., milk, breakfast cereals, formula), yeast (from ergosterol)
Cholecalciferol (vitamin D3)
Synthesized in the skin (stratum basale) when exposed to UV light
Fortified foods (e.g., milk, breakfast cereals, formula), fatty fish (liver), egg yolks
Vitamin D synthesis
--------------------------------
Liver: cholesterol → 7-dehydrocholesterol (provitamin D3)
Enzyme: cholesterol dehydrogenase
Skin
Storage of 7-dehydrocholesterol
Cleavage of 7-dehydrocholesterol via irradiation with UV light → cholecalciferol (in the stratum basale of the skin)
Liver: hydroxylation of cholecalciferol to 25-hydroxyvitamin D (25-OH D3, calcidiol; activated vitamin D2)
Kidneys: 1α-hydroxylase hydroxylates 25-hydroxyvitamin D → 1,25-dihydroxyvitamin D
Transport to target cells: vitamin D-binding protein (DBP)
Storage: mainly in adipose tissue as 25-hydroxycholecalciferol
Regulation of vitamin D synthesis: via regulation of 1α-hydroxylase activity in proximal convoluted tubule
↓ Calcium, ↓ phosphate, and ↑ PTH → ↑ 1α-hydroxylase activity → ↑ 1,25-dihydroxyvitamin D biosynthesis
↑ Calcium, ↑ phosphate, and ↑ 1,25-dihydroxyvitamin D → ↓ 1α-hydroxylase activity → ↓ 1,25-dihydroxyvitamin D biosynthesis
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Unthwoods
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Keep making short and sweet videos like this. Thank you. All the best
Thank you, I will
Great lecture .. very short still covers all aspects .. excellent job it was time saving
Tysm 😊
Thanku so much sir!
This was very helpful. 💓👍
Very informative, thank you for sharing.⚕️🌞
Thank you Sir for this video.....
This information is lucrative for us thanks you
Thanks sir for that valuable video
thank you. it helped a lot
Great sir💖
Абалдееееть😍класс. Спасибо
Excellent summary. Thank you
Glad you enjoyed it!
Your vídeos are the BEST guys!
Thank u so much
excellent vedio full of pure knowledge
well 100/100
Nice info. Dr.tqs for sharing such useful info.
Great video very informative
Thank you Doctor Bhanu
Doc I have low levels at 25 then I started vit d3 at 4000iu with k2 and my body doesn’t respond well at all I get more anxiety cold sweats etc what should I do ?
Sir U r the best
Swaad aa gaya 👌
Thank u Sir ❤️
Thanks Sir ji for your information about it 👌🏼💐🎉💕🙏🏼
Ur most welcome
At what time is best for sunbathing for vitamin D production in our body..? What's the duration time for sunbathing..? Is it harmful at mid day sunlight exposure to skin..?
Super video ☺
Thank you so much Sir 😌
Thank you so much for videos😇👍
Glad you like them!
Can we get (synthesise) vit D if we stand in sunlight with shirt/T-shirt? Or is direct sunlight on skin required? Also guide for morning sunlight or anytime?
better without shirt/t-shirt. Time frame is before 11:00 am and after 18:00 pm to ensure safe UV exposure.
Thank u sir..Keep it up
Keep watching
Does vitamin d3 deficiency cause any ear broblem or feet burning?????
good English👍👍
Thank you so much sir🙏
So nice of you
How are Vitamin D supplement made? Are they vegan? Are they mostky defived from ovine sources? Is the Vitamin D made by our body through sunlight exoosure really sufficient? Halibut and cod liver oils contain both Vitamin A and Vitamin D - won’t we overdose on the Vitamin D? Which part of the sheep are Vitamin D supplemebts detived? The liver? What about halal issues? I have more questiojs but please kindly answer thress pressing questions first. Thank you
Loved ❤️ from Pakistan 🇵🇰
Thank you Indian or Pakistani man!!
Your videos are very helpful
My pleasure, iam indian
If you have a vitamin D deficiency and start taking supplements what is the prognosis for improvement in bone density? Can you increase your bone density even if you are an adult? I have a vitamin D deficiency + osteopenia 😢
Awesome 👌
Thanks
Welcome 😊
sir.this deffiency is coursed for buring sensation to lower back
Thank you sir
Welcome
GOD bless you aour teacher
Tysm
Very good job
Thank you so much 😀
Is it normal a fatty liver can synthesize vit d
Very informative video..Thanks sir
Sir I'm surching for your Vitamin b 12 vedio
Very soon
❤sir
gud
❤
Which cells of kidney release 1-hydroxylase enzyme???
100IU and 400IU is literally nothing.
You need atleast 1000-5000IU
what's the difference between "literally nothing" and "nothing"? Why add the word "literally" is it scientific or just stupid talk. Mr. Akash. Looking forward to your explanation.
Stupid question.@@ryanm.5381
U need 60 k in a week or a month and10000 iu in a day or a week
👍❤👍❤👍❤👍❤
Hmm
Plz handi ya urdu ma b batya kary.....sab ko english ni ati sir..
A pro
هههههههههههه ألف شكر
So maybe a leep but let's say you radiate someone with EMPs over time say 20 years. You'd leach their body and the kids would develop bone deformities like rickets. Also sudden increase in radiation would increase permeability of the intestinal lining causing nausea and vomiting with excess Vit D absorption. Then loss of Vit D due to hemorrhagic vasculitis of the radiation. If you wanted to do WW3. That's one way to do it.
Sar hindi me video banaiv
Some sweet sweet disinformation.... where are your credible references sir ? writing in the description what you said in your video is not a source
really ?
I mean… he’s saying whitamin D… so how ever its defined he may yet be correct 😭
Bhag makarpada difardi bgfghv
Sir I didn't you to be so Meaningless
Hindi nahi aati lagta teko
haan nai aatha hai
How are Vitamin D3 supplement made? Are they vegan? Are they mostky defived from ovine sources? Is the Vitamin D made by our body through sunlight exoosure really sufficient? Halibut and cod liver oils contain both Vitamin A and Vitamin D - won’t we overdose on the Vitamin D? Which part of the sheep are Vitamin D supplemebts detived? The liver? What about halal issues? I have more questiojs but please kindly answer thress pressing questions first. Thank you