Vitamin-D (calcitriol) metabolism, Vitamin-D synthesis, biochemistry made easy, physiology made easy

vitamin d metabolism, vitamin d synthesis, vitamin d biosynthesis, vitamin d synthesis pathway, cholecalciferol vitamin d3, calcitriol functions
📍 Vitamin D3 is synthesized in the skin in response to sunlight exposure, while vitamin D2 can be obtained from certain foods and supplements. Vitamin D synthesis and metabolism are essential processes in the body for maintaining bone health and overall well-being.
📍 In first step, the primary source of vitamin D is sunlight. When your skin is exposed to ultraviolet B (UVB) rays from the sun, a precursor molecule that is present in the skin epidermis, called 7-dehydrocholesterol get converted into cholecalciferol, which is also known as vitamin D3, and it gets released into the blood.
📍 In second step, from the blood Cholecalciferol and also ergocalciferol gets transferred to liver. Once in blood, it is bound to vitamin D binding protein and then transported to liver. In the liver an enzyme '25 Hydroxylase' converts cholecalciferol and ergocalciferol to 25 Hydroxycholecalciferol which is also known as calcifediol.
📍 In last step, from the liver the 25 hydroxycholecalciferol is transferred to kidney. In the kidney an enzyme called, 1 alpha hydroxylase, converts 25 hydroxy-cholecalciferol to 1, 25 dihydroxycholecalciferol. This enzyme adds another hydrogen molecule to the 1st carbon atom. This is also called Calcitriol. This is the activated form of Vitamin D.
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Chapters:
0:00 - Vitamin-D (cholecalciferol)
0:38 - Vitamin-D metabolism (Vitamin-D synthesis) step-1
1:10 - Vitamin-D metabolism (Vitamin-D synthesis) step-2
1:52 - Vitamin-D metabolism (Vitamin-D synthesis) step-3
2:22 - Functions of Vitamin-D
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Disclaimer:
"Content is For Informational & Education Purpose Only, Creamed From Various Authentic Books of Pharmacy & Medicine. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition."