Dear All For captions, Please click on the 'CC' button next to the gear icon at the right-hand-side bottom. This is one of the most watched video on MHC with your support. The audio is bit fast so please use the captions for better understanding. Click this link to Subscribe ua-cam.com/users/biologyexams4u If you find this useful; please, subscribe support and share...thank you so much:) Watch our new video: First Line of Defense of Immune system 8 minute summary @ Stay safe and stay blessed:)
You are doing a phenomenal job with your videos! The explanations are concise and the diagrams are descriptive but also easy to understand. Thank you for sharing your knowledge and don't bother about all the people complaining about the accents. They need to learn to have an open mind because they are missing out on wonderful teachers like you! Subscribed
so perfect , I understood very much , the show was very exciting. thanks for the smart lesson .. and I love the comparing you showed , because it's help me to understand what is MHC I and what is MHC II
great video! I "liked" it. i have a question--if I were to make a bacteria-based vaccine, would the bacterial antigens be expressed EXCLUSIVELY on MHC class 2? and your video says that MHC class 2 interacts mainly with helper T cells, but does that mean it does not interact with CD8+ cytotoxic T cells at all? How does the CD4+ helper T cell decide what is a self-antigen and what is a foreign invader?
This was fantastic man! Very well explained and kept it simple. Do not pay attention to the losers posting silly comments. Just focus on the positive comments and the likes. Keep them coming and thank you!!
You said that MHC class 2 presented peptides from a virus but doesn't MHC class 2 only present peptides that are taken up by the cell (exogenous)?? Because viruses replicate within the host so they are endogenous and can only be presented by MHC class 1?
sararahxx Really sorry for this late reply. This depends on the nature of virus entry into the cell. If the the virus coat remains outside, any antigenic particle recognized by the cell will be presented on MHC class II for interaction with Th cells for more effective immune response. If the virus entered the cell is intact, then often antigenic peptides of the viral protein coat is presented on MHC Class II.
I don't think that the reason for different MHC alleles is so that the immune system can recognize foreign cells. It is just a side effect because organ transplantations never occured in the evolution. Instead, it is rather the fact that pathogens can adapt to an allele and this gives a selection pressure (for both, the pathogen and the immune system). In fact, this is the gene with the most variability among mammals. It can even give immunity, e.g. some individuals are immune to HIV for this reason...
Dear Revin Really appreciate your encouraging words and a great boost to do more. I am in mad love with the subject immunology. Just dropping the link of our immunology videos.. ua-cam.com/play/PLpKNQ2U3np9gi5gW5MkgCyJG5QcwFHy6l.html Hope this will help. Thank you so much once again :)
People complaining about the accent... Understanding smart people from all parts of the planet is a life skill you'll need to learn to succeed in biotech (or in life).
Dear All
For captions, Please click on the 'CC' button next to the gear icon at the right-hand-side bottom. This is one of the most watched video on MHC with your support. The audio is bit fast so please use the captions for better understanding. Click this link to Subscribe
ua-cam.com/users/biologyexams4u
If you find this useful; please, subscribe support and share...thank you so much:)
Watch our new video: First Line of Defense of Immune system 8 minute summary @
Stay safe and stay blessed:)
You are doing a phenomenal job with your videos! The explanations are concise and the diagrams are descriptive but also easy to understand. Thank you for sharing your knowledge and don't bother about all the people complaining about the accents. They need to learn to have an open mind because they are missing out on wonderful teachers like you! Subscribed
"Each individual has specific MHC/HLA proteins just like fingerprints". Thank you so much! It was very difficult until I see your explaining.
i feel like i am on plane listening to captain.
NU House your welcome :)
haha me too
lmfaoo!
😂😂😂 same here!
LOL
Excellent Video! very precise, fast and on point, thank you so much.
Welcome... Thanks for the support... Your comment really a motivation to do more
This Malayali guy did an excellent job of explaining this concept, thank you!
wonderful video! You made everything seem so clear.
Thank you so much!
thank you very helpful, great way to present side by side, keep up the great work
rainbow
Great clear explanation on their differences. Thanks so much!
great video! things are more clear now, thank you
Great video. It helped to consolidate my knowledge and will definitely help in my upcoming exam. Thank you!
Really glad to know that it helped. Thank you so much for the visit and comment
Great video - thank you so much! I finally get it!!!!
It was a great help!! Thank you so much!
this video helped me a lot,,clear and to the point...thank you so much
this was great thank you so much - current 2nd year medic and you helped so much!
Really happy that the video helped... Thank you so much.. Please Subscribe and share:)
so perfect , I understood very much , the show was very exciting. thanks for the smart lesson .. and I love the comparing you showed , because it's help me to understand what is MHC I and what is MHC II
Dear A1Turkish
Really value your comment and very happy to know that it helped. Definitely a motivation to do more. Thank you so much for the support
Simple n easy covering all imp points, thank you
Thank you very much , it was very helpful !
great video! I "liked" it. i have a question--if I were to make a bacteria-based vaccine, would the bacterial antigens be expressed EXCLUSIVELY on MHC class 2? and your video says that MHC class 2 interacts mainly with helper T cells, but does that mean it does not interact with CD8+ cytotoxic T cells at all? How does the CD4+ helper T cell decide what is a self-antigen and what is a foreign invader?
This was fantastic man! Very well explained and kept it simple. Do not pay attention to the losers posting silly comments. Just focus on the positive comments and the likes. Keep them coming and thank you!!
Thank you Nikhil for your encouragement. really a motivation to do more.
i got the notes what i needed!thankyou sir.
Thank you this was very helpful!
thank u sir, i got exactly what i wanted from this topic
Nice explanations, superb...
feel like I'm on a flight listening to the announcements... lol but great explanation!
thank you :) clarified very well
Excellent Video!
Thanks!
IT WAS VERY HELPFUL thannnk you
amazing even useful for medschool..!
this was amazing!
Easy to understand and very helpful, thankyou! :3
You're very welcome!
Sharing our immunology playlist for your reference :shorturl.at/fjT01
Thank you so much:)
Thankyou for this video
THANKS GOOD DESCRIPTION
NEW YORK
3/3/2015
genius, man! really!
Great motivation to do more.... Thanks a lot
Thank you!!
.. thanqqq sir.. its really grt vdo
Very nice. Thank you
thank you
Thank you sir, very useful
thanks for your clear and precise explanation..nice work :)
Very thanks
Thank you
Its realy help full for me.
Good clear explanation
amazing!
It's very great and helpful thank you 💐💓💓
You're so welcome!
Thanks
You said that MHC class 2 presented peptides from a virus but doesn't MHC class 2 only present peptides that are taken up by the cell (exogenous)?? Because viruses replicate within the host so they are endogenous and can only be presented by MHC class 1?
sararahxx
Really sorry for this late reply. This depends on the nature of virus entry into the cell. If the the virus coat remains outside, any antigenic particle recognized by the cell will be presented on MHC class II for interaction with Th cells for more effective immune response. If the virus entered the cell is intact, then often antigenic peptides of the viral protein coat is presented on MHC Class II.
Thank you so much.
Welcome... Thanks for the support
thank you
But the t cell recognition domain is alpha 3 ?
Tq u so much sir..keep sharing n stay safe
welcome and Thank you for the visit....Stay Safe:)
It is really useful, thanks.
The accent is a little bit difficult to understand.
i don't know what you are saying
Thanks alot
Welcome... Thanks for the support
I don't think that the reason for different MHC alleles is so that the immune system can recognize foreign cells. It is just a side effect because organ transplantations never occured in the evolution. Instead, it is rather the fact that pathogens can adapt to an allele and this gives a selection pressure (for both, the pathogen and the immune system). In fact, this is the gene with the most variability among mammals. It can even give immunity, e.g. some individuals are immune to HIV for this reason...
Execllent
very nice thank you so much
Welcome to @biologyexams4u. Thank you so much for the nice words Ranjit :)
Where tha mhc class 1 activate?
This is medical college level points . Really good explanation
Dear Revin
Really appreciate your encouraging words and a great boost to do more. I am in mad love with the subject immunology. Just dropping the link of our immunology videos..
ua-cam.com/play/PLpKNQ2U3np9gi5gW5MkgCyJG5QcwFHy6l.html
Hope this will help. Thank you so much once again :)
nic one sir😃😃
super sir
Once inside the cell, these viruses _____ (at 2:40) I couldnt understand it.
+Sandra XO 'these viruses is degraded into antigenic peptides'
Thank you!
Ignore the ignorant comments from the uncultured swines. Great video and great explanation.
thank you it is helpful but toooo fast
A+
Really an inspiration to do more.....Thank you so much for the visit and comment
biologyexams4u You speak very well. I was able to watch the videos at twice speed. The information was concise and to the point.
hard to understand :(
A plus
MHC Class II is not with respect to viruses, it's mainly bacteria.
nice pictures to help but like everybody else said you need to work on your speech
You sound like the gupta that works at the gas station down the street
...enjoy your flight👀
Thank you for your sincere words and I enjoyed the comment. Definitely will improve vocal quality in future videos. Thank you:)
thank you so much for this... 😃
People complaining about the accent... Understanding smart people from all parts of the planet is a life skill you'll need to learn to succeed in biotech (or in life).
thanks you so much my dear brother
very difficult to understand, very thick accent.
Video is great but the accent is painful
cant understand you at all
cant understand
go read a book but looks like you had trouble understanding that too, seeing as you are here :)
speak english, please..