I think this is grape news! I'm tempted to rush out and buy a grape grape extract, but I'm not sure the results so far are raisin enough to act on it...
A couple of years ago university of Colorado did quite some research of grape seed extracts. Primarily in relation to prostate cancer. Now we might have gained greater understanding of a new mechanism at work.
I love your mice as well as your thorough and detailed explanations. I also appreciate your skepticism and pointing the areas where research is still needed. Thank you for sharing.
Dear Miss Eleonor Sheekey please edit the under titles so that, at least, the compounds mentioned are properly expressed in text. We are not all so well versed in your specialty. I am an old K-12 educated, unskilled, retired, non-professional but I do love your videos. Thank you.
You shouldn't mix nmn or nr with senolytics, best is to separate them. For example a week of taking quercetin mixed with fiestin and then the week after move to nmn and nr (mixed) with TMG all taken every other day as well as d3, pqq and at night after the last meal of the day - spermidine. in off days take akg with d3, at night - spermidine. Every once in a while (several months) switch to senolytics week again.
Consider only doing the senolytics in a hit and run fasion. I'm doing quercetin + fisetin once a month for 3 days and now I'm planning to do GSE the same way but separated from the other senolytics. Meaning "high" dose senolytics every other week.
Meanwhile you cant even find grapes with seeds anymore. I remember eating grapes with seeds alot like 2 decades ago. Now they're all deseeded. But the complete package like nature intended it to be eaten is with seed. There are alot of beneficial compounds in the seeds including the fibre. Which is exactly what you want with fructose from the grape.
I like your excellent, highly technical videos describing fairly complicated ideas in a concise way with humor and pictures and charts to fill in the details in a grape way, pun intended.
You mentioned piperlongumine as having senolytic properties. Life Extension Magazine (March 2021) reported on the combination of piperlongumine with luteolin as autophagy activator. I wonder what would happen if spermidine were added to the mix? Anyway I love your videos. Keep up this great work.
I think we're in for exciting times once we start studying the combined effects of multiple longevity interventions. The potential for synergy is huge.
Back in the 1990s I tried 6000mg of green grape seed every day for the anti aging effects and after two weeks I noticed that my airways which I didn't know were previously restricted became unrestricted. Fast forward to early 2000s I had long stopped taking the grapes seed and stopped eating potatoes, after two weeks my airways had become less restricted exactly as if I were taking the grape seed.
My nails have been growing like wild since I quit potatoes years ago, and I was already in my 60s. They had also sped up some years prior when I quit grains.
Grape seed extract has been an important antioxidant and health promoting compound, known for many years. This is maybe just another thing they found that makes it work so well. I use Terry Naturals GSE, it is a low molecular weight, low tannin GSE, so it is absorbed better, performs better, and is easier on the digestive system.
I just added GSE from Terry Naturally because of this report. From what little I read there are many potential benefits and no (?) detriments. Not too expensive and worth trying was my thought.
I like the fact that all these supplements are readily available and affordable. Grape Seed + cinnamon + Curcumin. The only thing extra you really need is AKG, Zinc, D3 and Niacin. Love your videos, and ultra cool voice. Not sure if you tracking Greg Fahy's Thymus Rejuvenation studies. I think apart from checking the epigenetic clocks, thymus rejuvenation should be tracked in all these studies, especially human studies. The thymus is key for extending health span.
Magnesium, selenium, vitamin B- complex extra B-9(folate) DHA, EPA, ALA, CoQ10, L-tyrosine, L-phenylalanine, L-tryptophan, etc. Their are a lot of precursors.
Interestingly, I have been taking Grape Seed Extract for like 10 years now, without paying much attention to it. This because it is added to a Resveratrol supplement I have been taking for a long time. At least I can say it does no it have a significant side effect. Maybe I should stop it from time to time, to give the senolytic effect a little rest. Maybe the company producing this supplement knew something was there of interest many years ago already.
I found out something about grape seed extract back in 1996. Can't remember what exactly. Back then their was a lot of incomplete and sometimes conflicting information.
But isn’t this the same story of Resveratol? They said it was the fountain of youth and I took it for years. It was so expensive, I spent so much money on it and then they said it does not work, so all my money went down the drain.
Isn't the problem with procyanidins that they barely get absorbed in humans and only the metabolites from gut bacteria make it into the blood in relevant amounts. It's similar to catechins iirc
Paper says GSE is a senolytic at high doses, and a senomorphic at lower doses. (Page 2). The study even gives the dose, but that is in vitro. What would the dosage be, in vivo? Given the efficacy of GSE in reducing the SASP as a senomorphic agent, we next interrogated the potential of this natural product in killing senescent cells at higher concentrations by acting as a senolytic. SA-β-Gal staining indicated that senescent cells were eliminated at a GSE concentration of 0.75 μg ml−1 (Fig. 1a,b). At 3.75 μg ml−1 GSE, a plateau of 20% senescent cell survival was reached. It would be nice to use fisetin as a senolytic (hit and run), and daily GSE as a senomorphic, until the next dosage of fisetin.
Thanks for that, Juan. I know I'm asking some sort of guessing but, for achieving this senomorphic effect, do you have any thoughts on how much mg of oral grape seed extract? (Good quality source.)
I’ve been taking supplement like alpha lipoid acid and grape seed extracts for more than a decade for their ‘antioxidant’ potential. A few years ago I also added curcumin for joint health and resveratrol for aging support. Good to see some of these showed some kind of senolytic activities in the study shown here. I’d be extremely interested to know if they will work synergistically, or cancel each other out.
What kind of grapeseed extract? There are a huge variety of grapes. What exactly do you get when buying GSE? Concord grapes? And on a side tangent, I believe quercetin has poor bio-availability. If so, would taking it with something like olive oil improve the bio-availability? I've been pouring a tablespoon of olive oil, dropping the supplement into the spoon and consuming both. Not sure this is really doing anything. I do this for other supplements as well. Thanks and I love your science show. BTW, there actually is pine bark extract via Bulk Supplements on Amazon.
Chris Masterjohn says quercetin bio-availability is greatly improved when paired with sunflower lecithin. I would bet that many of these polyphenols, ie fisetin, apiginin, etc... would be better absorb that way. I sometime use lecithin, olive oil and occasionally a a few drops of DMSO for better absorption. I don't have a test to know whether it's working or not, though...
As implied in the video you might want to stay clear of anti oxidants when consuming GSE for the senolytic effect. Olive oil is a pretty strong anti oxidant I think.
@@randallhesse5011 David Sinclair is kinda barking up the wrong tree with Resveratrol and its analogues like Piceatannol. Its activates sirtuins via detoxification pathways, not directly. Activating them via collateral damage is inefficient. It is of minor help, but there are substances that activate sirtuins directly. Slave and Master ossilators of circadian rhythm and epigenetic quality control. Simple Exogenous and Endogenous signalling molecules. I could take or leave Piceatannol. Ive got cheaper, easier ways of doing what it does.
I love your grape humour and hope that grape seed proves it's senolytic potencial, because it's abundant and cheap as a supplement. I personally consider trying it on. In your opinion, is it worth combining it or mixing with other senolytics as fisetin or quercetin?
So is it good to high dose fisetin and GSE when your fasting or one meal a day to maximise their effect….because when your over eating and exercising on those days they will be countered
I don't know how they listed them in that order, but it was not by senolytic effect. The bars show the amount of senolytic cells measured. The lower a red bar the better.
Resveratrol should be renamed SinclairMillionairatrol. So many reasons 🤑 to be skeptical in this field. Thankful for the ethical doctors and scientists!
GSE has many, many studies with purported benefits, which may or may not be related senescence. GSE is also seemingly less expensive than fisetin. There are many more compounds within GSE beyond PCC1 which may have benefits unrelated to senescence.
I am curious whether lowering estrogen would be a good thing or bad thing in the context of your question. As a side note, soy phytoestrogens seem to inhibit estrogenic effects by fitting into the "high-water mark" estrogenic receptors better than they fit into the "main signal" estrogenic receptors.
I've started putting 1/5 teaspoons of grape extract powder in my green tea twice a day. Hoping this will have positive effects on my general health and longevity. Are there better ways to increase bioavailability? By the way, I love the illustrations and the puns 🤣
FUNCTIONAL innovative medicine or purely hypothetical longevity ? Brilliant thankyou BUT what we need is not longevity so much as innovation made applicable or useful in mainstream affordable medicine and other treatments which can reverse , treat or effectively ameliorate damage , having suffered from toothe lossw and two recent bad cycling accidents rehabing I am left with disabling side effects which add to psychological and social burden ie cannot pass driving test , I need compounds eye drops which will reverse protein aggregration in my lens , I need benign approach to dupytrens I need eetc as do many people , YET grape seed extract is promising People generally need to function better not necessarily improve longevity which is highly speculative at best .
Procyanidin C1 looks to me like another one of those big flat molecules that remind me of some antibiotics and preservatives. I can't help but wonder if the mechanism of action is actually inhibiting division of rapidly dividing cells like bacteria. en.m.wikipedia.org/wiki/Procyanidin_C1
A grape new discovery or a sour disappointment?
I think this is grape news! I'm tempted to rush out and buy a grape grape extract, but I'm not sure the results so far are raisin enough to act on it...
A couple of years ago university of Colorado did quite some research of grape seed extracts. Primarily in relation to prostate cancer. Now we might have gained greater understanding of a new mechanism at work.
I don't extractly peel any raisin to vine. I juice like to seed grape results from currant studies.
I heard about this through the grapevine
What do you think about extra virgin olive oil?
I love your mice as well as your thorough and detailed explanations. I also appreciate your skepticism and pointing the areas where research is still needed. Thank you for sharing.
Adding Grape seed extract to my longevity stack after this podcast , thanks.
Nice, what else do you have in that stack?
You explained this soo well!
Thanks!
Agree
The explanation was so grape!
It's grape that you actually had the courage to tell that joke
That is fantastic news. I hope the promise holds. Thanks for all your hard work.
Love your delivery. Dense & complete thoughts in rapid succession. Brill.
Dear Miss Eleonor Sheekey please edit the under titles so that, at least, the compounds mentioned are properly expressed in text. We are not all so well versed in your specialty. I am an old K-12 educated, unskilled, retired, non-professional but I do love your videos. Thank you.
PCC1 + Fisetin with fenugreek seed + NMN + Pterostelbene + Bio Curcumin with black pepper + AKG combo 🔥 my immortality protocol 😁
You shouldn't mix nmn or nr with senolytics, best is to separate them. For example a week of taking quercetin mixed with fiestin and then the week after move to nmn and nr (mixed) with TMG all taken every other day as well as d3, pqq and at night after the last meal of the day - spermidine. in off days take akg with d3, at night - spermidine. Every once in a while (several months) switch to senolytics week again.
@@yuvalkapellner2551 take pqq at night might be bad idea
@@yuvalkapellner2551 Hi, thanks.Im wondering if it backed by since to not mix nmn or nr with senolytics or just your view?
Consider only doing the senolytics in a hit and run fasion. I'm doing quercetin + fisetin once a month for 3 days and now I'm planning to do GSE the same way but separated from the other senolytics. Meaning "high" dose senolytics every other week.
@@johnnielsen5493 Have you heard of EMIQ version of quercetin?
Meanwhile you cant even find grapes with seeds anymore. I remember eating grapes with seeds alot like 2 decades ago. Now they're all deseeded. But the complete package like nature intended it to be eaten is with seed. There are alot of beneficial compounds in the seeds including the fibre. Which is exactly what you want with fructose from the grape.
Doesn't nature rather intent though, that you just swallow the seed without chewing on it and spread it "after"wards?
What ever you said is true ,because I have been using the grape seeds for a long time to reverse damages and there are other benefits too.
I love this channel but I'm jeaous of mice, it seems that everything extends their lifespan. They're going to live forever.
I like your excellent, highly technical videos describing fairly complicated ideas in a concise way with humor and pictures and charts to fill in the details in a grape way, pun intended.
I have been taking grapeseed extract every day for two years.
You mentioned piperlongumine as having senolytic properties. Life Extension Magazine (March 2021) reported on the combination of piperlongumine with luteolin as autophagy activator. I wonder what would happen if spermidine were added to the mix? Anyway I love your videos. Keep up this great work.
If you want truly powerful Senolytics and Autophagy enhancers, 3,4 or 4,4-dimethoxychalcone.
@@darkhorseman8263 a drug?
I think we're in for exciting times once we start studying the combined effects of multiple longevity interventions. The potential for synergy is huge.
Back in the 1990s I tried 6000mg of green grape seed every day for the anti aging effects and after two weeks I noticed that my airways which I didn't know were previously restricted became unrestricted. Fast forward to early 2000s I had long stopped taking the grapes seed and stopped eating potatoes, after two weeks my airways had become less restricted exactly as if I were taking the grape seed.
My nails have been growing like wild since I quit potatoes years ago, and I was already in my 60s. They had also sped up some years prior when I quit grains.
That’s interesting.
Grape seed extract has been an important antioxidant and health promoting compound, known for many years. This is maybe just another thing they found that makes it work so well. I use Terry Naturals GSE, it is a low molecular weight, low tannin GSE, so it is absorbed better, performs better, and is easier on the digestive system.
I use the same brand! been taking it for a couple of years. Terry always has excellent products
You’re great! Love your mice!
I just added GSE from Terry Naturally because of this report. From what little I read there are many potential benefits and no (?) detriments. Not too expensive and worth trying was my thought.
I like the fact that all these supplements are readily available and affordable. Grape Seed + cinnamon + Curcumin. The only thing extra you really need is AKG, Zinc, D3 and Niacin. Love your videos, and ultra cool voice. Not sure if you tracking Greg Fahy's Thymus Rejuvenation studies. I think apart from checking the epigenetic clocks, thymus rejuvenation should be tracked in all these studies, especially human studies. The thymus is key for extending health span.
if you take niacin you need betain, if you take d3 you need k2 and magnesium
Magnesium, selenium, vitamin B- complex extra B-9(folate) DHA, EPA, ALA, CoQ10, L-tyrosine, L-phenylalanine, L-tryptophan, etc. Their are a lot of precursors.
Cinnamon is high in Oxalates
Nice work!
Great information as always👍🏾🎉🙏🏽
Interestingly, I have been taking Grape Seed Extract for like 10 years now, without paying much attention to it. This because it is added to a Resveratrol supplement I have been taking for a long time. At least I can say it does no it have a significant side effect. Maybe I should stop it from time to time, to give the senolytic effect a little rest. Maybe the company producing this supplement knew something was there of interest many years ago already.
Interesting. Thanks for sharing.
I found out something about grape seed extract back in 1996. Can't remember what exactly. Back then their was a lot of incomplete and sometimes conflicting information.
Pondering the shape of the mice honestly made me think more than the awesome content of this video ;)
But isn’t this the same story of Resveratol? They said it was the fountain of youth and I took it for years. It was so expensive, I spent so much money on it and then they said it does not work, so all my money went down the drain.
At least this stuff (GSE) is super cheap and you might just need to take is for a few days every other week. That's money I'm willing to bet.
Always look at the used amounts in the studys (concentration). Resveratrol is absorbed very poorly, so most won't ever reach these concentrations.
Isn't the problem with procyanidins that they barely get absorbed in humans and only the metabolites from gut bacteria make it into the blood in relevant amounts. It's similar to catechins iirc
Paper says GSE is a senolytic at high doses, and a senomorphic at lower doses. (Page 2). The study even gives the dose, but that is in vitro. What would the dosage be, in vivo?
Given the efficacy of GSE in reducing the SASP as a senomorphic agent, we next interrogated the potential of this natural product in killing senescent cells at higher concentrations by acting as a senolytic. SA-β-Gal staining indicated that senescent cells were eliminated at a GSE concentration of 0.75 μg ml−1 (Fig. 1a,b). At 3.75 μg ml−1 GSE, a plateau of 20% senescent cell survival was reached.
It would be nice to use fisetin as a senolytic (hit and run), and daily GSE as a senomorphic, until the next dosage of fisetin.
Thanks for that, Juan.
I know I'm asking some sort of guessing but, for achieving this senomorphic effect, do you have any thoughts on how much mg of oral grape seed extract? (Good quality source.)
Wonder how it fairs against Pycnogenol (pine bark extract)?
I’ve been taking supplement like alpha lipoid acid and grape seed extracts for more than a decade for their ‘antioxidant’ potential. A few years ago I also added curcumin for joint health and resveratrol for aging support. Good to see some of these showed some kind of senolytic activities in the study shown here. I’d be extremely interested to know if they will work synergistically, or cancel each other out.
Might be good to add during a fast since fasting can increase autophagy.
Well done for this informative video.
What kind of grapeseed extract? There are a huge variety of grapes. What exactly do you get when buying GSE? Concord grapes?
And on a side tangent, I believe quercetin has poor bio-availability. If so, would taking it with something like olive oil improve the bio-availability? I've been pouring a tablespoon of olive oil, dropping the supplement into the spoon and consuming both. Not sure this is really doing anything. I do this for other supplements as well. Thanks and I love your science show. BTW, there actually is pine bark extract via Bulk Supplements on Amazon.
Chris Masterjohn says quercetin bio-availability is greatly improved when paired with sunflower lecithin. I would bet that many of these polyphenols, ie fisetin, apiginin, etc... would be better absorb that way. I sometime use lecithin, olive oil and occasionally a a few drops of DMSO for better absorption. I don't have a test to know whether it's working or not, though...
You can check out Enzymatic-Modified isoquercetin (EMIQ). It's a highly bioavailable form of quercetin, derived from rutin.
As implied in the video you might want to stay clear of anti oxidants when consuming GSE for the senolytic effect. Olive oil is a pretty strong anti oxidant I think.
You'd want to have your quercetin with either / and vitamin C or bromelain ( substance found in pineapple) to increase bio availability.
I have her Dr. Burg say take quercetin with a fat
Procyanidin B2 from Uncaria Tomentosa is pretty good, too. Gets rid of fat and upregulates genetic repair.
Good to know. Genetic repair. Is that anything like Piceatannol (2,3,3',4,5 transtetrahydroxystilbene) found in passion fruit seeds.
@@randallhesse5011 David Sinclair is kinda barking up the wrong tree with Resveratrol and its analogues like Piceatannol.
Its activates sirtuins via detoxification pathways, not directly. Activating them via collateral damage is inefficient.
It is of minor help, but there are substances that activate sirtuins directly.
Slave and Master ossilators of circadian rhythm and epigenetic quality control. Simple Exogenous and Endogenous signalling molecules.
I could take or leave Piceatannol. Ive got cheaper, easier ways of doing what it does.
I love your grape humour and hope that grape seed proves it's senolytic potencial, because it's abundant and cheap as a supplement. I personally consider trying it on. In your opinion, is it worth combining it or mixing with other senolytics as fisetin or quercetin?
hey, I saw your METFORMIN commercial!
So is it good to high dose fisetin and GSE when your fasting or one meal a day to maximise their effect….because when your over eating and exercising on those days they will be countered
My knee joints get quite sore and sensitive and prone to injuries for about a day to three days after a dose of fisetin.
is asxtanthin the strongest or the weakest senolytic on the graph at 3.27? I'm confused. why is astaxathin 1st on that chart?
I don't know how they listed them in that order, but it was not by senolytic effect. The bars show the amount of senolytic cells measured. The lower a red bar the better.
@@johnnielsen5493 thanks for clearing that up. Yeah would of been easier if they sorted it in order with the better results first.
Love your mice!
Resveratrol should be renamed SinclairMillionairatrol.
So many reasons 🤑 to be skeptical in this field.
Thankful for the ethical doctors and scientists!
Thumbs up, even with that horribly bad pun at the end! 😀
If Curcumine had that effect, is peperine+Curcumine going to have a x1000 times that effect? If so, I think I'm going in the right direction
Informative video. Would it be possible to add still shots of some of those charts in the comments?
I see Astaxanthin (which I take) I increases those sells. What does that mean for the body?
GSE has many, many studies with purported benefits, which may or may not be related senescence. GSE is also seemingly less expensive than fisetin. There are many more compounds within GSE beyond PCC1 which may have benefits unrelated to senescence.
True, though regarding the study it seems that pcc1 is the component that has senolytic activity
@@TheSheekeyScienceShow OK, so what is the concentration of pcc1 in straight GSE?
No mention of sirtuins unless I missed it in all the speed reading.
Awesome!
Any thoughts about this lowering estrogen? I believe it is a “natural” aromatase inhibitor.
I am curious whether lowering estrogen would be a good thing or bad thing in the context of your question. As a side note, soy phytoestrogens seem to inhibit estrogenic effects by fitting into the "high-water mark" estrogenic receptors better than they fit into the "main signal" estrogenic receptors.
why cant i take grape seed extract with vitamin c?
So, I'm curious; if Resveratrol is produced by grapes, are grape seeds just a higher concentration of Resveratrol?
I remained with this question too.
@@julioalexo Its always hard to get answers.
Thanks for the clear explanation!
Are there any important side effects to be on the lookout for with GSE?
I've started putting 1/5 teaspoons of grape extract powder in my green tea twice a day. Hoping this will have positive effects on my general health and longevity.
Are there better ways to increase bioavailability?
By the way, I love the illustrations and the puns 🤣
grape seed extract has already a very high bioavailability.
Green tea is high in Oxalates
What about Pine Pollen abstract? Can you look at that one please? Thank you
Grape seed and hawthorne berry everyday amazing for the body
What about people who say grapeseed oil is unhealthy as its inflammatory for one
bc its forms hardened trans fats under heat (even body temp) and its deprived of all the nutrients. Its propably trash
FUNCTIONAL innovative medicine or purely hypothetical longevity ?
Brilliant thankyou BUT what we need is not longevity so much as innovation made applicable or useful in mainstream affordable medicine and other treatments which can reverse , treat or effectively ameliorate damage , having suffered from toothe lossw and two recent bad cycling accidents rehabing I am left with disabling side effects which add to psychological and social burden ie cannot pass driving test , I need compounds eye drops which will reverse protein aggregration in my lens , I need benign approach to dupytrens I need eetc as do many people , YET grape seed extract is promising People generally need to function better not necessarily improve longevity which is highly speculative at best .
They have Grape seed extract in Monster Energy Drinks.
That means they'll extend my life, right?...... Right?
@@lightbeingpontifex You mean, Yes!!!
Possibly synergistic with fisetin.
Procyanidin C1 looks to me like another one of those big flat molecules that remind me of some antibiotics and preservatives. I can't help but wonder if the mechanism of action is actually inhibiting division of rapidly dividing cells like bacteria. en.m.wikipedia.org/wiki/Procyanidin_C1
Do you think you'd ever do a live Q and A?
Hello, Whats the application you use for making such video pleace? Thank you
Do the various senolytics cancel each other out ?
Nice
Great 😁👏
So.. can we just cook using grape seed oil to get PCC1?
don't know, but will develop wheat belly for sure
Grape video from a grape presenter
I like your accent.
What about an AI for men???