Fluvoxamine: a $4 Antidepressant That Reduces COVID 19 Hospitalizations
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- Опубліковано 21 тра 2024
- Roger Seheult, MD of MedCram on how Fluvoxamine Maleate, an inexpensive SSRI medication FDA approved in 1994, was shown to reduce COVID 19 hospitalizations and deaths in a recent randomized placebo controlled trial published in the Lancet. Fluvoxamine (Luvox) was also compared to other medications such as ivermectin, metformin, and hydroxychloroquine in the trial. This is Update 138 in the MedCram Coronavirus Series
(This video was recorded on November 1, 2021)
TOPICS IN THIS VIDEO INCLUDE:
00:00 What is Fluvoxamine, how is it working to treat COVID-19 patients, and how did we get here?
00:42 JAMA Study from Nov. 2020: Fluvoxamine vs. Placebo and Clinical Deterioration in Patients with Symptomatic COVID-19
01:27 Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI): How do SSRIs work?
02:37 History of Fluvoxamine and known side effects
03:39 Why would researchers try an SSRI (Fluvoxamine) for COVID-19? Revisiting the role of Reactive Oxygen Species (ROS) and inflammatory factors
08:03 Breaking down the data from the smaller JAMA study on Fluvoxamine
10:36 Large-scale TOGETHER COVID-19 clinical trials: Is there a medication already in use that could be repurposed for SARS-CoV-2 treatment?
12:11 Medications studied in TOGETHER trial: Hydroxychloroquine, Lopinavir/Ritonavir, Metformin, Ivermectin, Doxazosin, Interferon Lambda, and Fluvoxamine
13:36 Ivermectin trial data
14:07 Fluvoxamine trial data: statistically significant at preventing hospitalization
Roger Seheult, MD is the co-founder and lead professor at www.medcram.com/?Y...
He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.
LINKS / REFERENCES:
Fluvoxamine in the treatment of anxiety disorders (PMC) | www.ncbi.nlm.nih.gov/pmc/arti...
Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial (Lancet) | www.thelancet.com/journals/la...
Who We Are (Together Trial) | www.togethertrial.com/who-we-are
The Sigma-1 Receptor in Cellular Stress Signaling (Frontiers in Neuroscience) | www.frontiersin.org/articles/...
All coronavirus updates are at MedCram.com (including more discussion on the COVID delta variant, fluvoxamine maleate, serotonin syndrome, fluvoxamine 100 mg, vaccine randomized trial and more).
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Why are fluvoxamine and other low cost / less invasive treatments seemingly only starting to appear now, rather than from the outset? What medical / scientific reason were expensive and invasive and IP protected treatments like vaccines and remdesivir pushed, highlighted, funded and kept in the public discourse while cheaper pills were largely swept under the rug? Shouldn't the policy have been to prevent hospitalization first and then mass immunity, if even possible, after that?
This channel has been my go to for the whole pandemic. Really really helpful.
We give this to our covid pts. I mostly work in the ICU, not the covid floor. (So severity is severe where I most commonly work). It doesn't seem to clinically make a difference in outcomes, but I am always happy for any research that will improve ANY covid symptoms! Thank you!
No BS. Most trustworthy UA-cam medical channel of Covid-19 hands down.
Doctor, what's going on with ivermectin, a detailed lecture on this medicine will be very helpful. You're doing wonderful job, been watching the updates since February 2020.
If you look at the together trial they stopped enrolling in the ivermectin arm because there was no benefit.
Finally understanding how “the mitochondria is the powerhouse of the cell” is useful for clinical medicine! Never thought this day would come!!
Thank you for all the information. I took fluvoxamine when I had Covid before the 7 day infection period and it definitely helped to prevent a cytokine storm. My symptoms were mild because of it.
Dr. Seheult not only possessed a wealth of medical knowledge, but also has the ability to make a dummy like me to understand the complex matter rather clear. Well done Dr. and much appreciated.
Thank you for all you do to help us non medically trained humans understand such a complex subject matter.
God bless you Sir 🙏 🇬🇧 😁
There’s like what 18 different studies about ivermectin that cured my 90-year-old mama that has lots of medical issues
Hopefully we're only talking about usage for a short time period. SSRIs really have side effects that can mess a person up.
Imagine if the entire country embraced the post exposure treatment protocol from FLCCC. Might actually be able to reach herd immunity through recovered individuals and vaccine booster participants.
Doctor, it's hard to fathom how this study shuts down ivermectin as ineffective when there are other studies that show it being very effective when dosed correctly and in the right infection cycle. This study, did it include the use of zinc in the HCQ as its function of an ionophore? If not that is counterproductive and if so then whatever happened to the data that zinc can shut down viral reproduction if used correctly and early? These studies with exact opposite results are confusing at best and frustrating to mystifying at worst. One has to wonder about confirmation bias or other factors because it's not coming off as logical.
Thanks for this. The explanation was the best I have heard on most any medical situation.
I love the way you explain things. It makes very difficult things understandable even for someone with little knowledge in the areas of medicine and biology. Thank you!
Congratulations from Venezuela!!! Extraordinary, coherent and very complete explanation of another very important medical tool to help save lives...Many months ago, doctors in South Africa have reported the use of FLUVOXAMINE to reduce the devastating effects of the cytokin attacks that create blood clots (thrombi), that avoid oxígeno and nutrients from reaching the brain and all other vital organs, causing parálisis or death....
I am surrounded by healthcare people and have been amazed and grateful listening to you, Doctor more than ever before. Please continue.
Now THIS is exciting.
I am a very mainstream doctor, and follow the standard NIH guidelines. And this study on Fluvoxamine looks convincing to me.
I appreciated seeing how fluvoxamine might work at the cellular level with COVID-- great video.
Thanks to Dr RS doing his meticulus analysis of relevant & credible studies/published papers etc., saves me TIME as a healthcare provider. This is the ONLY channel I recommend to colleagues. But I also follow Kiwi Dr. Sam.
Thank you for piecing this down and putting it back together
Good info. Question: Did the HCQ arm of the trial include increased Zinc dosing? HCQ is an ionophore for Zinc that may reduce replication. It would be ineffective without Zinc. Most trials assess HCQ alone and that is not the usage that is recommended in HCQ protocols.
Such a great channel... I am so happy I found it.
Thanks so much for the content ♥️
Great info, thank you for taking the time to put this together and present it to the public
Thank you so much. This could prove useful for lowering the pressure on the health care system.
As always very informative and awesome presentation. I wish I could have had a doctor like Dr Seheult teaching biology at school. His explanations are extensive and really give you an insight into how powerful the cell machinery is, how it can be hijacked and what treatments are available to doctors and their patients to treat all sorts of diseases. Thank you for the wonderful work you and your team do everyday to make us a more informed public.
What happened to BOTH hydroxychloroquine and Ivermectin? I thought there were studies/ clinical experiences all over the world that these were saving millions of lives! Very confused. I just got COVID-19. NOT certain what to do!
Super information Dr S. Thank you🇨🇦
Great explanation of the drug mechanism and results. One question- is there any dependency to fluvoxamine? Any plunge in mental health after it’s short term use? What about subgroup populations that are already on anti anxiety/ anti depression meds?
Thank you very much for your video's and information. Very helpful, have watched many of your videos on UA-cam. Thanks again, be safe, happy holidays.
I feel smart after listening to you..
YAY! Thank you Dr Medcram and Team Medcram!!
YAY previously approved medications work against Covid-19!
Finally! A well respected Doctor and channel is addressing repurposed drugs!
Actually we talked about Hydroxychloroquine before it was thing to talk about.
It’s drawback is the word cheap. Like ivermectin it will be ignored or attacked by health leaders and the press.
So I have asthma, which puts me at high risk, and I have been taking Zoloft for 5 years straight, which is in the same drug class; max dose of 200 mg daily. I still ended up going to the hospital because of COVID-19 for symptoms such as coughing up blood and being unable to breathe. Even if they are in the same drug class, how different is the mechanism of action for fluvoxamine to have a better impact than the other SRRIs.
Thank you for the information.
Tiny correction: Glycolysis happens in the cytosol, not in the mitochondria. Otherwise, excellent as usual
True that.
Why would anyone give this video a thumbs down?
Thank you for an informative video. Interestingly, we have seen more post-COVID-19 patients with anxiety disorder symptoms. I wonder would Luvox be helpful for post-COVID-19 patients and long haulers?
Very well presented for the lay person to understand. Thank you.
Excellent video!
Very encouraging to see some positive results for treatment of COVID.
I have enjoyed all your videos and am definitely better informed.
Thank you.
How about Fluoxetine, Prozac generic? Any similarities?
Such a short term benefit should not overlook the research that has implicated long term Fluvoxamine as a dementia risk. Dr. Campbell also sung the praises of Fluvoxamine without mentioning the dementia aspect. There is far too much casual antidepressant use in society akin to the overuse of antibiotics. When considering a new repurposed drug the risk/benefit analysis needs to include whether or not an already existing therapeutic is safer and more effective. That indeed is the case as Ivermectin seems superior on all counts, most notably a much better safety profile. So why consider a drug that messes with brain chemistry when there's a better alternative? This doesn't make a lot of sense.
Very clear, as usual.
So I suppose the doctors won’t prescribe it and if they do the pharmacist won’t fill the prescription
Happy to see you again Dr seheult❤️😊
Very interesting video Doc. Now I am wondering if giving Fluvoxamine with another med such as Molnupiravir would work even better at reducing symptoms of COVID-19? Anyway, thanks for keeping us up to date on treatments for COVID! Let's hope that they can get this under control sooner than later!
Excellent study and info.
Excellent summary, thank you
this is so informative and easy to understand, thank you!
Thank you for these videos. You make it clear and it's easy to learn.
Thank you Doc,your information is explained so well ...
Thank you! 👍
So I might be able to brew saffron in my tea instead of taking Fluvoxamine............Dr. Greger says Saffron is as good as Prozac. Prozac seems similar to Fluvoxamine. Love drinking saffron in Earl Grey tea and it's already in my kitchen.
Awesome. Thanks for describing the biological plausibility that led to the trial. I just happened on Fluvoxamine yesterday as being good for 'long covid' as well. Thanks again gor sharing.
Since there have been many SSRI’s that have come to market since Prozac, have other SSRI’s been looked at to determine their ability to affect the mitochondrial receptor that calms down the other receptor?
Thanks a lot doc for a very informative and important , good content lecture.
Would be interesting to know if other SSRIs (or SNRIs) have the same effect. There are so many now!
The dose that has shown this result agaunst covid is 200 mg daily for 10 days.
The terapeutic dose is 50-100 mg daily, and usually you start with a lower dose during the first weeks with SSRIs becauae the side effects the first days can be bad. Imagine that on a person that is already feeling bad
I dont know
Fluvoxamine has the highest S1R affinity of the SSRIs. Likely why it was chosen. Followed by sertraline and fluoxetine. (And S1R is in the endoplasmic reticulum.)
With the mitochondrion
www.ncbi.nlm.nih.gov/pmc/articles/PMC5603014/
Someone with depression was probably really glad they were already on that pill lol
This is so impressive!!!!!! Thank you so much for explaining it to us. Really amazing.
Would be intresting to see a side by side comparison between Fluvoxamine and Molnupiravir. Both in terms of eficasy but as well in terms of cost of treatment.
Thank you. Highly informative. Could other SSRIs have the same effect?
Good clear presentation thanks. Would be intersting to see a trial done in vaccinated pts.
Brilliant studies.
I wonder if Fluoxetine (Prozac) gives the same benefits as well.
Obrigada Brasil!
Thank you, Brazil 🇧🇷!
Exciting development!
Thank you MedCram!!
thank you, info that I needed to know.
Great to know, but not necessarily good news. Ivermectin has similar capabilities, but no medical practitioner I know is willing to prescribe either off-label any more.
Does anybody wonder why?
Novavax has a vaccine that is more effective that those of Pfizer and Moderna, and has considerably less risks of adverse effects than those of Pfizer and Moderna, but the FDA has slowed down its approval process -- even though Phase III was successfully completed and the FDA has issued a statement to the effect that people who took the Novavax vaccine in the trial are considered to be fully vaccinated. Japan has already negotiated hundreds of millions of doses of the Novavax vaccine, but it looks like the Novavax vaccine may never be used in the USA, and instead we are hearing about the 3rd, and 4th jabs of the Pfizer and Moderna,.I recently heard someone saying we may have to take a shot every year going forward.
Does anybody wonder why?
Thank you for a look into this Study...Explanation of conclusions etc were clear.
Thank you DR,. SHEHEULT
Were the participants vaccinated in the trial with Fluvox…. Thank you for sharing such valuable information
Steve Kirsch was championing the use of fluvoxamine on the dark horse podcast back in April. Used to relieve brain fog and long Covid.
Great video! Dr Seheult, please talk about aspirating (drawing back on the plunger) when administering the vaccine. Dr John Campbell has been saying this for months on his UA-cam channel. Miopericarditis.
Yay for generics!
Thank you for the info! Very interesting.
I'm a psychiatric nurse and think I have some valid input here. The dosage is huge so the high rate of non compliance is not a shock as side effects such as nausea, vomiting, and anything sexual are a huge quality of life hit. I would not expect the compliance rate to improve, but I wouldn't worry about it because if it fails due to nausea all that is really lost is today's lunch and $4 worth of Prozac.
As far as the black box goes so few covid patients are under the age of 25 the simplest answer is don't prescribe it to patients 25 and under.
This is really promising news for developing nations and insurance companies because the cost of other therapeutics like monoclonal antibodies is through the roof and the supply is very limited.
Interesting! Good to know.
Thanks
My question is. Where the participants vaccinated? Thank you for the valuable info you are sharing
Very Nicely Done! Thank You. (Hopefully I will Never Need Any treatment). I feel responsible to keep informed on behalf of my family, who are somewhat oblivious & Uninformed. I'll share and save, just in case someone decides to use their brain...🙂🙏❣
My fully vax momma (not my choice, The first shot in February almost killed her. Very upset that they decided to give her 2nd shot in April.
My 90-year-old mother who is in a nursing home has had congestive heart failure few years and low functioning kidney for years and she’s been on hospice since February of this year because she almost lost her life with the first Covid shot.
Last week She got Covid from her nursing home roommate, The night before Halloween she tested positive she skirted Covid for so long but they gave her a flu shot I’m sure that triggered & lowered her immune system ?
I talked to her doctor & I was adamant and so is my family about her going on ivermectin along with whatever else he was going to do possibly even monoclonal antibodies but he said she’ll have to leave the facility for that so that’s not gonna happen. Well he put her on ivermectin Tuesday afternoon within 12 hours of ivermectin her fever was gone. (this was the third day her fever was gone). She was congested really bad for two days (6&7) they gave her all kinds of decongestants push fluids and on the 6th day they gave her monoclonal antibodies after all they found somebody to come in and give it to her.
Now today is the 10th day and looks like she’s beat COVID!!! Thank God her congestion is almost gone she hasn’t had a fever since that 3rd day! Thank you Jesus!
By the 11th day we got word she’s out of the Covid unit and back at her favorite spot sitting at the bar at the nurses desk chatting up everybody who comes by! By the way I’m in California so it was shocking that the doctor even agreed that he would give it to her. I told him I remember the facility had a scabies outbreak two months ago I’m pretty sure that you have ivermectin on hand. Now, In my opinion when I heard about the “so-called scabies outbreak” I think it was just their way of ordering a lot of Ivermectin in my humble opinion!!
I’m high risk and my doctors office wouldn’t even consider it. They told me they don’t do anything unless you get bad symptoms
Early treatment with therapeutics saves lives! More therapeutics must be available early!!!
Great clear explanation of those trials. Thanks. It explains clearly for me two aspects of the FLCCC early treatment protocol. First also why ivermectin was abandoned.. because acc to the FLCCC it is only effective as an anti viral in the first few days of infection whereas this trial could start up to 7 days post infection. The FLCCC early treatment protocol says that if ivermectin is not showing effectiveness after two days for you, to then take Fluvoxamine. With Fluvoxamine having some more serious side effects, I can see the sense in not having to take it unless you need to, hence ivermectin the safe drug first.
I’m sure they could do sub group analysis on ivermectin and see if earlier treatment led to a signal. They abandoned the study completely because there was no signal.
I went to the emergency room to inquire about monoclonal antibodies and was told they are not very effective against the omicron varient of covid and was given a prescription for Fluvoxamine instead. I took two tablets the next day and the following night I could not sleep a wink and had a world class case of diarrhea. I initially thought these were symptoms of my covid getting worse until I read that sleeplessness and diarrhrea are side effects of Fluvoxamine. I was actually sleeping rather well and had no diarrhrea before I took the drug. As soon as I stopped taking the drug I was back to normal. I felt that getting a good nights sleep was more important then running to the bathroom every 20 minutes all night long and then being exhausted all the next day on top of being sick. How good can that be for you...
Could you tell me if citalopram has a similar effect? Everyone in my household has had covid except for me. All the adults including me have been double vaccinated
Thanks Doc!
Thank you
Wonderful.
I am curious what would be Dr. Seheult's opinion regarding Bromhexine.
All these videos, interesting and to be further investigated.
Has there been any trials with hydroxychloroquin or ivermectin?
I was prescribed Fluvoximine and ivermectin months and months ago by my FLCCC affiliated internet doc. Glad to see others coming around. Better late than never, I guess. Unless that is you’re already dead.
They recommended a 50 mg dose. This study endorses a 100 mg dose.
The almost complete silence of discussion regarding ambulatory care has been deafening. Thank you for bucking the trend. One question, how does prescribing something the CDC list among serious comorbidities do anything other than worsen outcomes? CDC cited anxiety and treatment for depression as the second greatest comorbidity next to obesity, .28 vs. .30 respectively. Could it have something to do with the irrational fear regarding this virus creating some psychosomatic effect and if so perhaps blowing thing so seriously out of proportion has been a serious comorbidity in and of itself.
There is something that this medication you're talking about and hydroxychloroquine and Ivermectin have in common and that is that they all reduce inflammation (think pneumonia) plus I don't think a lot of these tests are using the proper doses of Ivermectin.