INFLAMMATION Part 3: Leukocyte Activation - PHAGOCYTOSIS

In this short tutorial i have described the the basics of process of leukocyte activation and described PHAGOCYTOSIS in detail.. Visit ilovepathology.com/ for more topics in Pathology!
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What NEXT? After recruitment of leukocytes
To recognize the microbes/necrotic cells/foreign bodies
Activation of Leukocytes
Phagocytosis & intracellular Killing
What NEXT? After recruitment of leukocytes
To recognize the microbes/necrotic cells/foreign bodies
Activation of Leukocytes
Phagocytosis & Killing
How these stimuli are recognized by the PHAGOCYTES?
PHAGOCYTIC RECEPTORS
Mannose receptors Bind terminal mannose & fucose residues of glycoproteins & GlycolipidsThese sugars are found in walls of microbesNot found in mammalian cells
Scavenger receptors Bind modified LDL particles
Opsonin receptors
Recognize opsonins
Opsonin: antibody that renders bacteria and other cells susceptible to phagocytosis, IgG, C3b, Mannose binding lectin
What happens when leukocytes are activated?
Phagocytosis
Destruction of Phagocytosed Microbes & dead cells;By Reactive oxygen & nitrogen species& lysosomal enzymes
Destruction of extracellular microbes & dead cells;By forming extracellular “traps”
Production of chemical mediators;Amplify inflammation
Phagocytosis A process
Which involves the recognition , engulfment and digestion of
Microbes, dead cells an foreign bodies
Greek word
Phagein, meaning "to devour" kytos, meaning "cell", and -osis, meaning "process")
Also referred to as “cell eating”
kILLING: Occur in neutrophils and Macrophages
By
Reactive oxygen species
Reactive nitrogen species
Lysosomal enzymes
The killing occur in phagolysosomes thus avoiding damage to cell’s cytoplasm and nucleus
REACTIVE OXYGEN SPECIES
Produced by NADPH Oxidase (Phagocyte oxidase)
Phagocyte oxidase is present in the membrane of phagosome and lysosome
Thus ROS, can be produced in lysosome and Phagolysosome

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it would really be helpful

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Thank you 😊 good luck 😊

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Good explanation sir.

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You present a good summary of Robbins which is enough for understanding the complex concept in a few simple words...

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Please make more videos

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God bless you
i feel now easy to study ROBBins

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Thanks for the kind words 😊

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wow! lots of information, Thank you very much..

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sir can you make videos on tumors(tumor growth, epithelial and non-epithelial tumors)

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Please make a video for chronic inflammation and tissue repair

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Please upload more videos also

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Plz make a vedio on chronic inflammation

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Thankss😁🙌

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Thank u so much sir, love your effortless explanation 😍 - student of veterinary science

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Very nice and simple vedio easy to understand the lecture thanks

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Thanks a bunch sir 🥺❤️

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Super explanation of phagocytosis

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Can make videos on chronic inflammation and Neoplasia.

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Thank you

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❤️❤️❤️❤️❤️❤️❤️VERY USEFUL

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Sir the microbe present inside the cell is killed along with the host cell...???

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Plz upload lecture on hematology plzzzzzzz"zz..
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comprehensive one

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........
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All the best

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Pls make on thrombosis ..

[@timmahembram1662]

I have a doubt.. in the 1st part of inflammation you already told about two receptors TOLL-LIKE RECEPTORS AND INFLAMMASOME. in this one you told us three more..so my question is whether both u told before and now are same with just different names or are different

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In this video explaining about receptors that are present on the phagocytes and previous lecture tells about toll like receptors and inflammasome are the receptors prsnt on epithelial cells or antigen presenting cells...

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Shukran

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Thank you 😊.Glad you liked it

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sir your videos are awesome.. Please also make videos on Immunology ...It's very long in robbins and Levinson ..please

[@ilovepathologyVijayPatho]

Glad you liked them 😊..shall surely try to cover immunology 👍

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Sir can i get the notes of whole acute inflammation topic please

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i want to like again...

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Chronic inflammation and healing videos Plzzz sir

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Please sir upload videos of others chap also

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Sure.thank you 😊

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chronic inflammation plz

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Plzz sir tell us about detail of chronic inflammation

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Reference?

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💜💜

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Time stamps
1:06 recognition

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Please hindi me kijiye this video please.