@@medcatmcat haha yea, I noticed yesterday when I was going through the HY MCAT playlist! It just came after this video lol. Thanks for all your work man! Super helpful!
Wow, this video is literally a lifesaver! I’ve been trying to understand how to read my gene mutation results and even after talking to 4 different genetic counselors I haven’t been able to get a concise answer about my specific variant. I’ve learned more from this video than I have talking to multiple experts. Very straight forward and informative!
i’ve searched high & low for this topic because i’ve seen it on almost every single one of my practice exams 🤡🤡 thankful to have come across your video..
Great video, I'm so glad I discovered your videos for some review a month before my test date! I just have a question-- How come we would classify Y64S as conservative? Especially considering tyrosine has a ring. How would much emphasis is placed on structure vs overall function (like the ability to be phosphorylated) Thank you:)
That's a great question! The tricky part about nonconservative vs. conservative is that in the real world, there isn't going to be that binary categorization-it's more of a spectrum depending on the situation. I put Y64S as conservative for two reasons: 1) they are both polar, uncharged amino acids, and 2) they both have a hydroxyl functional group. It is entirely possible that based on a specific protein structure that serine would not conserve the same function as a tyrosine, but without that context, we could probably assume that it is likely to be conservative.
Lens/mirror video is in the works (it's gonna be a long video, or a playlist), and I'll get started on specific gravity! Feel free to comment on any of my videos if you want to see any other topics.
Just released a video on specific gravity!📕 ua-cam.com/video/RKVcqS-7xXE/v-deo.html Thanks for the request and feel free to let me know what else you'd like to see!
Hi, Thanks for the video. For example 'W701I' and 'Y64S', I did follow your logic that it's likely a conservative mutation since it's nonpolar AA to another nonpolar AA, but I was wondering if you could elaborate on your explanation since W and Y are both aromatic AAs? Would this ever be nonconservative due to the loss of aromaticity?
Hi, great question! You're correct that it's possible that the loss of aromaticity could lead to a nonconservative mutation (e.g. if we were relying on aromatic ring stacking, or pi-stacking, and replaced something aromatic with alanine, for example). That being said, for purposes of the MCAT, stick to the broad categories for conservative vs nonconservative. If you take it to the extreme, one could argue that a change from leucine to isoleucine could affect a specific enzyme's function, but you would have to know the enzyme and what role that specific amino acid was playing in the role of the enzyme, etc, which would be beyond the scope of the MCAT. They really just want you to know polar, nonpolar, basic, and acidic.
Helpful mnemonic for the stop codons: U Are Annoying, U Are Gross, U Go Away (UAA, UAG, UGA, respectively)
Love it! I have this in one of my other videos, though I forget which one.
@@medcatmcat haha yea, I noticed yesterday when I was going through the HY MCAT playlist! It just came after this video lol. Thanks for all your work man! Super helpful!
Wow, this video is literally a lifesaver! I’ve been trying to understand how to read my gene mutation results and even after talking to 4 different genetic counselors I haven’t been able to get a concise answer about my specific variant. I’ve learned more from this video than I have talking to multiple experts. Very straight forward and informative!
Thank you; I'm glad I could be of help!
i’ve searched high & low for this topic because i’ve seen it on almost every single one of my practice exams 🤡🤡 thankful to have come across your video..
Thank you!
WOW. Very intelligent approach to understanding topics and prepare for the test
Glad it was helpful! Thank you!
@@medcatmcat where is your acid base video. It says unavailable
Thank you!
You're welcome!
very helpful. thank you
You're welcome!
Great video, I'm so glad I discovered your videos for some review a month before my test date! I just have a question-- How come we would classify Y64S as conservative? Especially considering tyrosine has a ring. How would much emphasis is placed on structure vs overall function (like the ability to be phosphorylated)
Thank you:)
That's a great question! The tricky part about nonconservative vs. conservative is that in the real world, there isn't going to be that binary categorization-it's more of a spectrum depending on the situation.
I put Y64S as conservative for two reasons: 1) they are both polar, uncharged amino acids, and 2) they both have a hydroxyl functional group. It is entirely possible that based on a specific protein structure that serine would not conserve the same function as a tyrosine, but without that context, we could probably assume that it is likely to be conservative.
@@medcatmcat Thannks for your explanation !
Do we need to memorize the different codons that code for the same amino acid so we can know what type of mutation something is?
No, absolutely not! Though you do need to memorize your amino acids. The only codons you need to know are the start codon and the three stop codons.
Can you do lens/mirror problems and specific gravity problems.
Lens/mirror video is in the works (it's gonna be a long video, or a playlist), and I'll get started on specific gravity! Feel free to comment on any of my videos if you want to see any other topics.
Just released a video on specific gravity!📕 ua-cam.com/video/RKVcqS-7xXE/v-deo.html
Thanks for the request and feel free to let me know what else you'd like to see!
Informative ❤
Glad it was helpful!
Hi, Thanks for the video.
For example 'W701I' and 'Y64S', I did follow your logic that it's likely a conservative mutation since it's nonpolar AA to another nonpolar AA, but I was wondering if you could elaborate on your explanation since W and Y are both aromatic AAs? Would this ever be nonconservative due to the loss of aromaticity?
Hi, great question! You're correct that it's possible that the loss of aromaticity could lead to a nonconservative mutation (e.g. if we were relying on aromatic ring stacking, or pi-stacking, and replaced something aromatic with alanine, for example). That being said, for purposes of the MCAT, stick to the broad categories for conservative vs nonconservative.
If you take it to the extreme, one could argue that a change from leucine to isoleucine could affect a specific enzyme's function, but you would have to know the enzyme and what role that specific amino acid was playing in the role of the enzyme, etc, which would be beyond the scope of the MCAT. They really just want you to know polar, nonpolar, basic, and acidic.
@ Wow, thank you for your prompt and detailed reply! It clears my confusion completely.
thank you so much
Of course!
Nice 👍
Thank your Boris! Very cool.
please more short valuable videos
Thank you! Will do.