We need more doctors like this guy. Many believe MAOIs went obsolete but they have the potential to help so many people. We need more research and possibly new MAOI drug development.
7:50 "Jigerry Pokery methods" LOL! Also, I never put the edema/pyridoxine deficiency together. Thanks for clarifying. I am interested to see if it helps. Thanks for everything you do, Ken.
I was on Nardil for around 3 years and it stopped being effective, It took me 4 months to taper off and I’m just about a week away from being off of it. The withdrawals have just started and it’s hell on earth. I’m going to ride out the storm for as long as I can. If this doesn’t end sooner than later I might have to surrender and be on it for the rest of my life. I’ve had severe anxiety and depression before but this is significantly worse than anything I’ve been through in the past.
I’ve been experiencing that really badly lately to the point I can’t even finish what I’m saying sometimes or think of what to say because my brain never allows me to say what I want to because of social anxiety. I also get jittery and shake like a leaf when people are watching me do something, does Nardil help with physical symptoms of anxiety like this also? It also feels physically painful to make eye contact or say hi to someone I know first that I see. I can only awkwardly engage them if they talk to me first. For me it’s not just some anxiety in social situations. It’s literally debilitating to the point it makes me act like something is extremely wrong with me out of nerves and anxiety even though I’m “normal” in my head. I’m wondering if Nardil would work for a more severe case of social anxiety like this and what your experience is?
Nardil used to be the only thing that worked for me. I'm back on it after being free of any anti-depressant for year...and it is doing nothing but making be foggy. So I learned that Pfizer changed the formula back in 2003. Isn't there any way we can get the old formula back?
Great video Ken, I am so grateful for your work and that you still continue to share your knowledge even after retiring. WIthout it I may never have been prescribed to Parnate by my psychiatrist who told me to check out your work. Really hoping that Australia doesn't discontinue parnate like it has nardil. Just looked at the symptoms of B6 deficiency and I think it's time for me to see a dietician aswell so thx for mentioning that in the video.
Australia has NOT discontinued Nardil. Nardil has always been available in Australia, just the suppliers have been changed, since the UK Factory (Recipharm Ashton-under-Lyne solid dose manufacturing facility) who were manufacturing it for around two decades shut down.
@@Jack_Callcott_AU Dr. Ben Mitchell (Brisbane) or Dr. Ian Matthews (Mapleton) If you want an MAOI, generally stay away from psychiatrists and see a good GP. If you show you are educated about MAOIs and are mature and responsible, they generally should prescribe one. Unfortunately, psychiatrists are generally more close-minded than GPs, but, ironically, often don't know more about MAOIs than GPs!
@@anlace3447 Thank you very much An lace. I have already asked my GP but he refused to prescribe saying that he didn't consider himself sufficiently qualified. I am, I think, well-educated about MAOIs. I was on Nardil for a year and Parnate for 10 days, also I have read a lot about MAOIs including Dr Gillman's work. The last psychiatrist I saw hadn't even heard of Parnate. Thanks again!
Nardil literally saved my life. It is the limitless pill. But unfortunately when I take it now the PEA effect is so intense I can’t get the anti-anxiety effect from it anymore. It takes a long time for MAOI disinhibition to be removed from the system, I will eventually take Nardil again but for now I will cope with Clomipramine.
What is PEA? Dr Gillman, could you please explain? I need for anxiety as well as depression. SNRIs were to stimulating for me. Does this mean Nardil won’t help my anxiety?
Make sure the clomipramine’s been out of your system for at least two weeks before you start phenelzine. Clomipramine’s one tricyclic that really can’t be combined with MAOIs.
The solution for me is to take methylphenidate some 10 minutes before Nardil. Its weak, but still relevant, allosteric inhibition of the noradrenaline transporter (NET) is enough to prevent most of the PEA from entering the neuron and displacing NE from the storage vesicles. As thus it attenuates the stimulatory and mood de-stabilizing effect from Nardil. A very low dose of atomoxetine, desipramine or nortriptyline should do the job as well. Also, make sure your dose of Nardil is not too high so as not to inhibit 100% of the MAO. It needs some free MAO available in the gut to form phenylethylidenehydrazine (PEH) and inhibit GABA-T in the CNS.
@@marc2377 people who end up on a combination of tricyclic and MAOI drugs tend to be very interesting. It takes a lot of independent strength and commitment to get to that point.
@@marc2377 Thank you for this, I was literally searching everywhere to fix this PEA phenomenon. I tried so many different tactics but nothing worked. Will try this and report back.
Can you recommend a cross taper schedule from Nardil (45mg) to Parnate. I read your article about cross-tapering but didn't see a recommended schedule.
I'm on Nardil. I'm on the Lupin version/manufacturer. Many people say that is the superior version compared to the others, because it's the closest to the original Parke Davis Nardil.
@@elizabethriley9897 yes, just get a script through a doctor first. it comes through a distributor called Generic Health. Throughout the "shortage" I could always get enough Nardil, no problems at all!
@@psychotropicalresearch5653 still titrating. (A little over two weeks on) Up to 75mg now. I definitely have noticed a slight uptick in mood and have gotten out of the house again to do basic tasks. (Panic disorder lead to a sort of agoraphobia-ish situation) Anxiety definitely lower than before I started.
@@psychotropicalresearch5653 also on a somewhat unrelated note, it just so happens my psychiatrist is familiar with your work. I’ve asked him about not using nifedipine in case of a hypertensive crisis and using beta blockers to help with orthostatic hypotension should it come to that. The ladder piqued his interest and said he would do some research on it which I thought was cool.
More and more people are getting known about this and it’s hopeful. I’m going to contact Dr Gillman very soon. Hope it helps with AvPD even if my hope about treating it is about 50%.
Hi Dr! :) I just went back on Nardil after another, (as you were very likely already aware of), supply shortage shock. I’ve been on Parnate on and off over the years but Nardil for me definitely is “THE ONE”, most likely due to what you’ve already covered and that it has a more anxiolytic effect. And it’s not a subtle one either! Just an FYI and testimonial and thanks once again for your honourable crusade you are leading on behalf of us treatment resistant types!
I was thinking when I was looking at your other videos You should do a Nardil video And then here it is instantly My question is , how did you read my mind just now and make a 23 minute video I wanted now, a year ago
Thanks for the video! Would Methylene blue be effective for depression, in particular if you have severe cognitive symptoms (impaired focus, reading comprehension and memory)?
Probably not terribly effective because specific MAO-A inhibitor's tend not to be very good for depression, e.g. Moclobemide, and there isn't a suitable preparation for medical use except the experimental preparation being used for Alzheimer's
Hello...Could Nardil helps social anxiety and if Parnate failed on me. Would Nardil be a medicine to think about? I have borderline, adhd, anxiety and depression and ocd and other doc said shizo affective I even tried ketamine... Im so desperate. My brain isnt functioning anymore.
Nardil made my anxiety worse in the two weeks I tried it. I couldn’t handle it and had to stop it. I wished it worked for me because anxiety is my major concern
that's a shame, when it makes anxiety worse within 2 weeks, it usually is a good predicator it will work great for anxiety. Made my anxiety worse at start, but after 6 or 7 weeks all was gone, and great antidepressant effect.
Dr Gillman sir do you think Parnate would be a better option for very severe social anxiety disorder, panic disorder and Pure O type OCD if Nardil isn’t available in my country ?
Been on Nardil for 8 weeks now and am very disappointed. I had such high hopes for this medication. Since starting it I have experienced nothing but trouble. Insomnia, extreme dizziness, nausea, agitation, worse depression and fatigue.
These difficulties, fortunately, put you in the minority. Most patients get less side-effects with these drugs and many of the other drugs they have previously tried. But everyone is different so it may be appropriate for you to explore other alternatives if you feel you really need drug treatment.
Could you make a video discussing sleep issues when using MAOI's, particularly their potent effects on sleep structure? Or for antidepressants in general for that matter...
@Adrian Simmlekark the MAOI effect is irreversible and relatively long-lasting, but there may be other effects, for instance on TAA receptors, which could modulate dopaminergic mechanisms and account for the above interesting observations. And yes, it is very good for migraine. I've had many patients who have been completely free from migraine since starting TCP.
Hi Dr. Will doctors prescribe this in the UK? Or will i have to go too a psychiatrist? Ive tried every SSRI/SNRI and other medications and treatments. And still in severe anxiety 24/7
I couldn't understand the video because I don't speak English. I have been using antidepressants for 8 years, but I have not benefited from any of them. In Turkey, only Azilect and mao-a Moclobemid are mao inhibitors. 50 years ago, my grandmother, like me, lived with depression for 7 years and finally recovered with a mao inhibitor she used. 50 years ago there were mao inhibitors in Turkey, but now there is only rasagiline and moclobemid. I've been using Azilect 1 mg for 6 days now. If that doesn't work, I don't know what to do. Azilect is a selective mao-b inhibitor but I wonder if it would be as effective as Nardil
@@psychotropicalresearch5653 Thanks for your answer. I suspect anxiety. I'm going to try anxiolytics in the next few days. I hope it works because even as little as 0.5mg/10 of Xanax made me feel good now. I'll leave Azilect for now. If that doesn't work, I'll write you an email from the web. Is it possible?
@@myilmaz314 Aga şimdi tam olarak şikayetin nedir? Ben de yıllarca depresyon diye düşündüm, antidepresanlarla gittim ama yemedi. Sonra antienflamasyon tedavisi uyguladım ve acayip, sihir gibi çalıştı. Kortizol seviyemi düzenledim ve bdnf düzeyini artırdım. Ara ara kaygı gene oluyor ama kendimi işime verebiliyorum. Ketamin tedavisine kadar yolu var bunun. İnatçı olursan çözülür.
Hey Dr. Gillman. I understand that when using an MAOI, one has to be very mindful of eating foods containing tyramine. What sort of diets do you find your patients tend to gravitate towards when on an MAOI? Can someone be on a carnivore diet or keto diet when taking an MAOI?
Hello Doctor, another Great video Have you had any feedback from your patients about Pfizer Nardil not being as good since the reformulation in 2003? This would make for a great video , as nobody knows why they reformulated it and if is as good as the original Or is it just a urban B.S. legend gone viral As drug Company's tend to make medications better with new data, formulations and technology not worse
you probably wont read this or respond dr Gillman, but are there any MAOIs at all that are non-prescription that are worth trying? im talking syrian rue, polygala tenuifolia, passionflower (and others?). would be great if you could touch on this in a future video. thank you for your work
Try Moringa Oleifera. Add niacin If you want to potetiate it but be careful with the BP response. Also pay attention to low levels of vitamins, particularly B6.
@@psychotropicalresearch5653 forum (noun): a place on the internet where people can leave messages or discuss particular subjects with other people at the same time The UA-cam comments sound like a forum to me. And someone else can reply to my question.
As you please. I am simply advising you that, as you will see for yourself if you look at the volume of comments, this is not a high traffic forum where people give each other advice. If that is what you want then you might be better off joining one of the Reddit groups. If you're not well-schooled in this sort of thing, I am not, then you could ask advice from Philip at PsychoTropical
There's a doctor who said he prefers it over SSRIs for bipolar depression but as last resort when mood stabilizers, ect and antipsychotics haven't brought relief.
I don't know why selegiline would be less effective if dosed high enough to substantially inhibit mao-a. Whether it's less effective or not is an important question because (unfortunately) it's the only maoi available in some countries.
@@johns966 we would expect it to be effective (at 20 -40 mg) but it's a question of efficacy versus tolerability and higher doses may cause more side-effects, but it's definitely a reasonable option in the situation you describe
@@johns966 I have been on oral Selegiline for approximately 8 weeks (I am not entirely sure on how long, I’m not near my calendar to check when I started it). I was on 10mg for a few weeks, 15mg for a few more and recently I was put onto 20mg daily and I haven’t noticed much of a difference in my depression or my anxiety to be honest, but I also haven’t experienced any side effects, except for some very minor occasional postural tachycardia (no hypotension or hypertension) and worsened insomnia. My energy levels have maybe increased ever so slightly. But my mood is still incredibly low. I see my psychiatrist in a month and I am hoping he will agree to put me onto 30mg, we discussed it at my last appointment and he said it could possibly be ok, but I could tell he was hesitant, because as we know, the oral dose for depression is really not known, but I’d hate to give up now, that I’ve come this far, because a few things I have read say that 30mg might be necessary. But I haven’t had any issues with other medication interactions or any food interactions etc. And the side effects have been next to none. No weight gain and no sexual dysfunction, in fact, my sex drive has increased. If I do go to 30mg and it doesn’t show any improvement after sometime, I think I will cease it at that point. I definitely I am giving it enough time too, as I said, it’s been at least 8 weeks so far, maybe even longer, it’ll be another month before I see my psychiatrist again too. I wish I could find more videos and reviews on oral Selegiline for depression! 🙏🏻❤️
Viagra’s the answer to a lot of sexual dysfunction caused by antidepressants. Bethanechol may or may not help. Those obviously weren’t your only side-effects but it just helps to know that at least some side-effects can be treated directly.
@@jacob042 excellent point Jacob, I don't know if there's any quality data about this (give details if you know of any), but certainly a few members of my international expert group report they have found this helpful.
For everyone here looking for help with their anxiety/depression be extremely careful with Nardil. I'm not sure who is benefitting from this push of pro MAOI information but they have seriously intense side affects which will make you wish you never took em. Inability to sleep, extreme muscle spasms, jolts of anxiety, bruxism, unrine retention. These side affects do not go away. On top of those, there are temporary side affects like mania, paranoia, extreme fatigue. Please be wary of the MAOI Reddit as well.
I haven’t seen experiences like yours to be common at all. Everyone reacts uniquely to these chemicals. If yours was common they wouldn’t be as successful as they’ve been and all this despite the unique considerations of diet and blood pressure
I am really thinking about going the TCP, phenelzine route. I never, ever, experienced any mood improvement from the (many)SSRI's and SNRI's that I have taken. The best they gave me was a relief from severe anxiety. That makes bad depresion less bad, but you still feel like life is an ordeal you just have to power through. The only mood improvement I *ever* got from the deep feelings of pointlessness and lack of excitement for things that have characterized my life since I was a little boy was from a strong DRI. Methylphenidate and amineptine fit much better than descriptions of "antidepressants" than the SSRIs and the SNRIs. Even caffeine is better than the SSRIs to improve your mood, although caffeine makes you feel even more depressed and shitty a few hours latter when it wears out. The problem is, DRIs are highly controlled due to abuse problems, so getting them is no longer possible for me. For several years of my life, I've had constant suicidal thoughts. Do you know what it's like waking in th morning and having nothing but negative feelings from the moment you wake up? Nothing but feelings of apprehension, angst, that terrible things are about to happen, and a general lack of interest in engaging in anything. Like everything is completely boring and uninteresting and that you don't get anything from doing anything. You feel drained, like any action that you do, from speaking to walking to even going to buy food is exhausting. You antecipate all the terrible things that can happen to you if you try to do those things, and that even if nothing bad happens who cares? It sucks. It sucks to do those things. You have that moment of sel-realization that what you have is not just a "little sadness". You realize that thinking about how terrible you feel is constant, happens every day all day long and makes you exhausted. I suffer from massive inflammatory diseases and auto-immune diseases from how stressed I am at being myself. I have been thinking consistently about ending my life for the past 6-7 years. The only reasson why I don't do it is because of my cowardice and high anxiety which stops me from it. But thinking about killing yourself every day for years is not a "little sadness". I came to the conclusion that *I am sick* . People tell you all the time that you come across to them as miserable, as a sinkhole of sadness. And of malaise. But you tell yourself that it just normal feelings of sadness. It's hard to accept that it is not normal sadness and general lack of interest in things, and that you will be better when things are better for you. But even if things go well for you, you are still sad and finding everything pointless I didn't want to take the non-selective MAOIs because I am sesnitive to tyramine and I fear having a stroke or death. But I figure I will end up killing myself eventually if I remain like I am so, so I have nothing to lose. MAOIs appear to be only slightly better than SSRIs for normal depression, but they apparently are *significantly* superior to the SSRIs when the depression is bad. So I will give it a shot. I feel like I am in a prison of flesh.
It sounds like Nardil will be a good option for you and in view of your higher level of symptoms and distress it seems a very obvious choice. Note, you may get useful information and support from the Reddit type forums which you probably know about it already, the very small number of people looking at this comment thread will not likely produce a useful support for you.
@@psychotropicalresearch5653 Thank you. I tried to get a presciption for Ritalin from a psychiatrist, but he wasn't having any of it. He wanted to prescribe me for the 100th time a SS(N)RI that never did anything for me but help me sleep when my anxiety was very bad. But these SS(N)RIs never made my feelings of pointlessness and sadness go away. I told that I only ever had a mood lift from DRI, but he treated me like a junkie that wanted an excuse to get high. I told him I was going to take only 2 pills a day, one in the morning and one in mid afternoon, but he wasn't having it.He said that "MP is for ADHD and obesity. It's not an antidepressant.". I said that it was the only thing that relieved my lack of joy in engaging in things, but he pretty much kicked me out of his office as if I were a junkie looking for a fix. Getting phenelzine is nigh-impossible for me in my country. Only TCP available. They say that Parkinson's drugs usually help people like me as well.
I agree with Ken. Nardil sounds like it would be good for you (given the anxiety component to your illness), if you choose to try it. Keep in mind, however, that it generally has a slower onset than other Ad's (up to 8-12 weeks even), and most people require a minimum dose of 60mg (dose guideline is generally 1mg/kg) It is often very very helpful, although you may have quite a few start up side-effects. These generally fade away in time, although some may linger. Read many of the success stories on the "Ask a Patient" review site. Please remember, too, that the chance of a stroke on MAOI's is extremely low, and the "MAOI diet" is often exaggerated. I do not recommend this, but i personally know many who have been on Nardil for decades and who have never taken any notice of the diet, and they have not had one problem. However, Ken has a very good "MAOI diet" list on his webpage. I would be much more afraid of depression and anxiety, than some minor changes to your diet and a few side-effects.
@@anlace3447 Thanks. Nardil(phenelzine) is not available in my country. I would have to import it, and the legal and financial problems in doing that are significant. Ideally, I would take an SSRI combined with a DRI. That gives the same anti-anxiety, anti-depressant effect without the risks of MAOI. But DRIs are very controlled and difficult to get. Doctors don't like prescribing drugs that work like cocaine!
@@petercoderch589 I literally typed a response on this page. I am going through the same thing right now... you will see it if you sort by most recent.
We need more doctors like this guy. Many believe MAOIs went obsolete but they have the potential to help so many people. We need more research and possibly new MAOI drug development.
Absolutely.
7:50 "Jigerry Pokery methods" LOL! Also, I never put the edema/pyridoxine deficiency together. Thanks for clarifying. I am interested to see if it helps. Thanks for everything you do, Ken.
I was on Nardil for around 3 years and it stopped being effective, It took me 4 months to taper off and I’m just about a week away from being off of it. The withdrawals have just started and it’s hell on earth. I’m going to ride out the storm for as long as I can. If this doesn’t end sooner than later I might have to surrender and be on it for the rest of my life. I’ve had severe anxiety and depression before but this is significantly worse than anything I’ve been through in the past.
@@quiksilver7373 - how long were you on it?
Hey Anonymous! How's it going with your withdrawals? Wish you the best luck!
@@FoxinTaiwan - Things are going much better, thanks for asking.
Parnate stopped working for me at the 3 year mark a while back
Did you go back on it? My withdrawal from 60mg to 45mg has made me reinstate.@@ThePinnacle415
Marplan is available in the UK, I'm prescribed it on the NHS
HOW
Did you get through to such an awful beurocracy as the NHS ?
They refused anything other than ssri/snri (etc) for me
Thank you Dr. Gillman for sharing these very informative and helpful videos! I appreciate it so much!
I’ve been experiencing that really badly lately to the point I can’t even finish what I’m saying sometimes or think of what to say because my brain never allows me to say what I want to because of social anxiety. I also get jittery and shake like a leaf when people are watching me do something, does Nardil help with physical symptoms of anxiety like this also? It also feels physically painful to make eye contact or say hi to someone I know first that I see. I can only awkwardly engage them if they talk to me first. For me it’s not just some anxiety in social situations. It’s literally debilitating to the point it makes me act like something is extremely wrong with me out of nerves and anxiety even though I’m “normal” in my head. I’m wondering if Nardil would work for a more severe case of social anxiety like this and what your experience is?
Please reply sir I don't have any other depression. nardil can relief my social phobia and glossophobia .
@@bhrigu_kalita128yes
Nardil used to be the only thing that worked for me. I'm back on it after being free of any anti-depressant for year...and it is doing nothing but making be foggy. So I learned that Pfizer changed the formula back in 2003. Isn't there any way we can get the old formula back?
I'm not sure about that but what about trying a similar maoi? Like parnate?
There are many things you can do to try to make it emulate pre 2003. I have info for you
@@meridethmattwrite please
Great video Ken, I am so grateful for your work and that you still continue to share your knowledge even after retiring. WIthout it I may never have been prescribed to Parnate by my psychiatrist who told me to check out your work. Really hoping that Australia doesn't discontinue parnate like it has nardil. Just looked at the symptoms of B6 deficiency and I think it's time for me to see a dietician aswell so thx for mentioning that in the video.
Hey, for how long have you been on Parnate? Any positive/negative changes?
Australia has NOT discontinued Nardil. Nardil has always been available in Australia, just the suppliers have been changed, since the UK Factory (Recipharm Ashton-under-Lyne solid dose manufacturing facility) who were manufacturing it for around two decades shut down.
Could someone please recommend a doctor in Brisbane who would prescribe Parnate. I'm sure I need it ,as it worked dramatically for me a long time ago.
@@Jack_Callcott_AU Dr. Ben Mitchell (Brisbane) or Dr. Ian Matthews (Mapleton)
If you want an MAOI, generally stay away from psychiatrists and see a good GP. If you show you are educated about MAOIs and are mature and responsible, they generally should prescribe one.
Unfortunately, psychiatrists are generally more close-minded than GPs, but, ironically, often don't know more about MAOIs than GPs!
@@anlace3447 Thank you very much An lace. I have already asked my GP but he refused to prescribe saying that he didn't consider himself sufficiently qualified. I am, I think, well-educated about MAOIs. I was on Nardil for a year and Parnate for 10 days, also I have read a lot about MAOIs including Dr Gillman's work. The last psychiatrist I saw hadn't even heard of Parnate. Thanks again!
Nardil literally saved my life. It is the limitless pill. But unfortunately when I take it now the PEA effect is so intense I can’t get the anti-anxiety effect from it anymore. It takes a long time for MAOI disinhibition to be removed from the system, I will eventually take Nardil again but for now I will cope with Clomipramine.
What is PEA? Dr Gillman, could you please explain?
I need for anxiety as well as depression. SNRIs were to stimulating for me. Does this mean Nardil won’t help my anxiety?
Make sure the clomipramine’s been out of your system for at least two weeks before you start phenelzine. Clomipramine’s one tricyclic that really can’t be combined with MAOIs.
The solution for me is to take methylphenidate some 10 minutes before Nardil. Its weak, but still relevant, allosteric inhibition of the noradrenaline transporter (NET) is enough to prevent most of the PEA from entering the neuron and displacing NE from the storage vesicles. As thus it attenuates the stimulatory and mood de-stabilizing effect from Nardil.
A very low dose of atomoxetine, desipramine or nortriptyline should do the job as well. Also, make sure your dose of Nardil is not too high so as not to inhibit 100% of the MAO. It needs some free MAO available in the gut to form phenylethylidenehydrazine (PEH) and inhibit GABA-T in the CNS.
@@marc2377 people who end up on a combination of tricyclic and MAOI drugs tend to be very interesting. It takes a lot of independent strength and commitment to get to that point.
@@marc2377 Thank you for this, I was literally searching everywhere to fix this PEA phenomenon. I tried so many different tactics but nothing worked. Will try this and report back.
Can you recommend a cross taper schedule from Nardil (45mg) to Parnate. I read your article about cross-tapering but didn't see a recommended schedule.
Worked for me until the shortage. Went into protracted withdrawal and can't take anything now. Beware of shortages!
I'm on Nardil. I'm on the Lupin version/manufacturer. Many people say that is the superior version compared to the others, because it's the closest to the original Parke Davis Nardil.
i find Lupin awesome!
How do i get lupin version please ? Is this through your pharmasist? Thx!
@@elizabethriley9897 yes, just get a script through a doctor first. it comes through a distributor called Generic Health. Throughout the "shortage" I could always get enough Nardil, no problems at all!
@@anlace3447 thx so much, appreciate you replying. 😇
If you're in the UK, you want Neon Healthcare version
@@elizabethriley9897
I’ve been getting severe panic attacks almost daily. Many times multiple times a day especially when driving. Hoping nardil will help me.
Good chance it will, keep us updated
Very good chance that it will. Slow and steady wins the race. Woke up to 45 mg as a minimum, some people need 60 or 90
@@psychotropicalresearch5653 still titrating. (A little over two weeks on) Up to 75mg now. I definitely have noticed a slight uptick in mood and have gotten out of the house again to do basic tasks. (Panic disorder lead to a sort of agoraphobia-ish situation) Anxiety definitely lower than before I started.
Stick with it and give it plenty of time. 75 is usually enough but some people do you need a little more@@nealcastagnoli6185
@@psychotropicalresearch5653 also on a somewhat unrelated note, it just so happens my psychiatrist is familiar with your work. I’ve asked him about not using nifedipine in case of a hypertensive crisis and using beta blockers to help with orthostatic hypotension should it come to that. The ladder piqued his interest and said he would do some research on it which I thought was cool.
More and more people are getting known about this and it’s hopeful. I’m going to contact Dr Gillman very soon. Hope it helps with AvPD even if my hope about treating it is about 50%.
Did it help ? :)
I'm in the same boat.
Hi Dr! :) I just went back on Nardil after another, (as you were very likely already aware of), supply shortage shock.
I’ve been on Parnate on and off over the years but Nardil for me definitely is “THE ONE”, most likely due to what you’ve already covered and that it has a more anxiolytic effect. And it’s not a subtle one either!
Just an FYI and testimonial and thanks once again for your honourable crusade you are leading on behalf of us treatment resistant types!
The cause is progressing, do donate to support if you are able
@@psychotropicalresearch5653 Excellent news! When I’m first able to I’ll definitely do what I can! 👍
I was thinking when I was looking at your other videos
You should do a Nardil video
And then here it is instantly
My question is , how did you read my mind just now and make a 23 minute video I wanted now, a year ago
I do not know and cannot understand, that video is usually only available to people who have donated at least $10,000
Thanks for the video!
Would Methylene blue be effective for depression, in particular if you have severe cognitive symptoms (impaired focus, reading comprehension and memory)?
Probably not terribly effective because specific MAO-A inhibitor's tend not to be very good for depression, e.g. Moclobemide, and there isn't a suitable preparation for medical use except the experimental preparation being used for Alzheimer's
Hello...Could Nardil helps social anxiety and if Parnate failed on me. Would Nardil be a medicine to think about? I have borderline, adhd, anxiety and depression and ocd and other doc said shizo affective
I even tried ketamine... Im so desperate. My brain isnt functioning anymore.
Yes
Nardil made my anxiety worse in the two weeks I tried it. I couldn’t handle it and had to stop it. I wished it worked for me because anxiety is my major concern
that's a shame, when it makes anxiety worse within 2 weeks, it usually is a good predicator it will work great for anxiety. Made my anxiety worse at start, but after 6 or 7 weeks all was gone, and great antidepressant effect.
@@anlace3447 yeah I wish I could have held on but it was so intense I couldn’t
@@bustingatdaseems lowering the dose would have been a good idea.
Anxiety is the -¹ of grace. Grace is acceptance. Anxiety is resistance. Both depend on the same energy
Dr Gillman sir do you think Parnate would be a better option for very severe social anxiety disorder, panic disorder and Pure O type OCD if Nardil isn’t available in my country ?
Not possible to predict from the available information, but it may be worth a try
Been on Nardil for 8 weeks now and am very disappointed. I had such high hopes for this medication. Since starting it I have experienced nothing but trouble. Insomnia, extreme dizziness, nausea, agitation, worse depression and fatigue.
These difficulties, fortunately, put you in the minority. Most patients get less side-effects with these drugs and many of the other drugs they have previously tried. But everyone is different so it may be appropriate for you to explore other alternatives if you feel you really need drug treatment.
Don't listen to "Dr." Gillman. Many have issues with this medication and the side affects are much more intense then SSRIs and other medications
What about Selegiline?
Could you make a video discussing sleep issues when using MAOI's, particularly their potent effects on sleep structure? Or for antidepressants in general for that matter...
@Adrian Simmlekark It only lasts about 5 or 6 hours, tops. At least in my experience.
@Adrian Simmlekark the MAOI effect is irreversible and relatively long-lasting, but there may be other effects, for instance on TAA receptors, which could modulate dopaminergic mechanisms and account for the above interesting observations. And yes, it is very good for migraine. I've had many patients who have been completely free from migraine since starting TCP.
Parnate insomnia...
Hi Dr.
Will doctors prescribe this in the UK? Or will i have to go too a psychiatrist?
Ive tried every SSRI/SNRI and other medications and treatments. And still in severe anxiety 24/7
That depends entirely on the individual doctor concerned
I couldn't understand the video because I don't speak English. I have been using antidepressants for 8 years, but I have not benefited from any of them. In Turkey, only Azilect and mao-a Moclobemid are mao inhibitors. 50 years ago, my grandmother, like me, lived with depression for 7 years and finally recovered with a mao inhibitor she used. 50 years ago there were mao inhibitors in Turkey, but now there is only rasagiline and moclobemid. I've been using Azilect 1 mg for 6 days now. If that doesn't work, I don't know what to do. Azilect is a selective mao-b inhibitor but I wonder if it would be as effective as Nardil
Would you like to email me via website
@@psychotropicalresearch5653 Thanks for your answer. I suspect anxiety. I'm going to try anxiolytics in the next few days. I hope it works because even as little as 0.5mg/10 of Xanax made me feel good now. I'll leave Azilect for now. If that doesn't work, I'll write you an email from the web. Is it possible?
Aga n'aptın, çözebildin mi?
@@ergenekonualkslayanliberal1077 malesef işe yaramadı
@@myilmaz314 Aga şimdi tam olarak şikayetin nedir? Ben de yıllarca depresyon diye düşündüm, antidepresanlarla gittim ama yemedi. Sonra antienflamasyon tedavisi uyguladım ve acayip, sihir gibi çalıştı. Kortizol seviyemi düzenledim ve bdnf düzeyini artırdım. Ara ara kaygı gene oluyor ama kendimi işime verebiliyorum.
Ketamin tedavisine kadar yolu var bunun. İnatçı olursan çözülür.
Hey Dr. Gillman. I understand that when using an MAOI, one has to be very mindful of eating foods containing tyramine. What sort of diets do you find your patients tend to gravitate towards when on an MAOI? Can someone be on a carnivore diet or keto diet when taking an MAOI?
It's all on the website, consult, read away, and email me via the website, or preferably Skype me, if further explanation is required
@@psychotropicalresearch5653 but make sure to pay you first for your Skype call
How is it for anxiety? I had to quit Parnate because it was making me too anxious.
Buy it, I presume you mean nardil. In which case the answer is often very good as explained in the video
Hello Doctor, another Great video
Have you had any feedback from your patients about Pfizer Nardil not being as good since the reformulation in 2003?
This would make for a great video , as nobody knows why they reformulated it and if is as good as the original
Or is it just a urban B.S. legend gone viral
As drug Company's tend to make medications better with new data, formulations and technology not worse
Will Nardil help with anxiety at a 15 mg does? How dangerous is tianeptine with Nardil
Possible, try it. Re Tiranë-tine, no information
@@psychotropicalresearch5653 Thanks so much!
At 45mg Nardil, I'm struggling with urine hesitancy, daytime somnolence, anorgasmia, muscle jerks. What can be done about these side effects?
For some people those side effects reduce after 3 months. Did they reduce for you
Bethanechol can kill the urinary hesitancy. Viagra and clonazepam may or may not help with your anorgasmia and jerks.
you probably wont read this or respond dr Gillman, but are there any MAOIs at all that are non-prescription that are worth trying? im talking syrian rue, polygala tenuifolia, passionflower (and others?). would be great if you could touch on this in a future video. thank you for your work
No, just too weak to have any effect
Try Moringa Oleifera. Add niacin If you want to potetiate it but be careful with the BP response. Also pay attention to low levels of vitamins, particularly B6.
Thoughts on Vilazodone, Moclobemide and Mirtazapine?
Keep reading the website and you will learn learn and there isn't room to repeat it all here!
@@psychotropicalresearch5653 Found the search bar, that works well. But couldn't find anything on Vilazodone, Maprotiline, or amoxapine?
Is phenelzine recommended for patients with bipolar disorder? What about psychotic patients?
This is not a forum in which such a question can be addressed
@@psychotropicalresearch5653 forum (noun): a place on the internet where people can leave messages or discuss particular subjects with other people at the same time
The UA-cam comments sound like a forum to me. And someone else can reply to my question.
As you please. I am simply advising you that, as you will see for yourself if you look at the volume of comments, this is not a high traffic forum where people give each other advice. If that is what you want then you might be better off joining one of the Reddit groups. If you're not well-schooled in this sort of thing, I am not, then you could ask advice from Philip at PsychoTropical
@@psychotropicalresearch5653 I love you
There's a doctor who said he prefers it over SSRIs for bipolar depression but as last resort when mood stabilizers, ect and antipsychotics haven't brought relief.
I'm anxious 1 so nardil fits i thinks
Yes, quite possibly
Please do Selegiline :D there aren’t many videos on that. Especially oral Selegiline.
I have done a video on 'other MAOIs' which will be posted as and when and if Heidi is able to do it
@@psychotropicalresearch5653 thank you so much
I don't know why selegiline would be less effective if dosed high enough to substantially inhibit mao-a. Whether it's less effective or not is an important question because (unfortunately) it's the only maoi available in some countries.
@@johns966 we would expect it to be effective (at 20 -40 mg) but it's a question of efficacy versus tolerability and higher doses may cause more side-effects, but it's definitely a reasonable option in the situation you describe
@@johns966 I have been on oral Selegiline for approximately 8 weeks (I am not entirely sure on how long, I’m not near my calendar to check when I started it).
I was on 10mg for a few weeks, 15mg for a few more and recently I was put onto 20mg daily and I haven’t noticed much of a difference in my depression or my anxiety to be honest, but I also haven’t experienced any side effects, except for some very minor occasional postural tachycardia (no hypotension or hypertension) and worsened insomnia.
My energy levels have maybe increased ever so slightly.
But my mood is still incredibly low.
I see my psychiatrist in a month and I am hoping he will agree to put me onto 30mg, we discussed it at my last appointment and he said it could possibly be ok, but I could tell he was hesitant, because as we know, the oral dose for depression is really not known, but I’d hate to give up now, that I’ve come this far, because a few things I have read say that 30mg might be necessary.
But I haven’t had any issues with other medication interactions or any food interactions etc.
And the side effects have been next to none.
No weight gain and no sexual dysfunction, in fact, my sex drive has increased.
If I do go to 30mg and it doesn’t show any improvement after sometime, I think I will cease it at that point.
I definitely I am giving it enough time too, as I said, it’s been at least 8 weeks so far, maybe even longer, it’ll be another month before I see my psychiatrist again too.
I wish I could find more videos and reviews on oral Selegiline for depression! 🙏🏻❤️
Nardil, whats the Dil?
Got so many sides from nardil. Couldnt climax for 2 months. Torture
Viagra’s the answer to a lot of sexual dysfunction caused by antidepressants. Bethanechol may or may not help. Those obviously weren’t your only side-effects but it just helps to know that at least some side-effects can be treated directly.
Except, Nardil makes you really fat and looks to be a Type 2 diabetes facilitator. It’s great for mood, but I’m not happy with what it did to me.
Hello Lizzy so good to hear from you, yes that is a major problem for many as I have said in the past, but it works for some.
Metformin!
@@jacob042 excellent point Jacob, I don't know if there's any quality data about this (give details if you know of any), but certainly a few members of my international expert group report they have found this helpful.
Could this be due to B6 depletion, a characteristic of hydrazines, as Dr. Gillman points in his website?
@@jacob042 metformin did nothing for weight gain in my case
For everyone here looking for help with their anxiety/depression be extremely careful with Nardil. I'm not sure who is benefitting from this push of pro MAOI information but they have seriously intense side affects which will make you wish you never took em. Inability to sleep, extreme muscle spasms, jolts of anxiety, bruxism, unrine retention. These side affects do not go away. On top of those, there are temporary side affects like mania, paranoia, extreme fatigue. Please be wary of the MAOI Reddit as well.
I have never had a more miserable time on a pill then Nardil and there is a strong push to only show the positives of this medication.
Your knowledge and experience of this complex subject are probably insufficient for you to be able contribute any clarificatory comments.
I haven’t seen experiences like yours to be common at all. Everyone reacts uniquely to these chemicals. If yours was common they wouldn’t be as successful as they’ve been and all this despite the unique considerations of diet and blood pressure
@@psychotropicalresearch5653 and you are a pill pusher who couldn't care less about others and is financially gaining from this
@@marial3231 I have definitely read others with similar experiences
I am really thinking about going the TCP, phenelzine route. I never, ever, experienced any mood improvement from the (many)SSRI's and SNRI's that I have taken. The best they gave me was a relief from severe anxiety. That makes bad depresion less bad, but you still feel like life is an ordeal you just have to power through. The only mood improvement I *ever* got from the deep feelings of pointlessness and lack of excitement for things that have characterized my life since I was a little boy was from a strong DRI. Methylphenidate and amineptine fit much better than descriptions of "antidepressants" than the SSRIs and the SNRIs. Even caffeine is better than the SSRIs to improve your mood, although caffeine makes you feel even more depressed and shitty a few hours latter when it wears out. The problem is, DRIs are highly controlled due to abuse problems, so getting them is no longer possible for me.
For several years of my life, I've had constant suicidal thoughts. Do you know what it's like waking in th morning and having nothing but negative feelings from the moment you wake up? Nothing but feelings of apprehension, angst, that terrible things are about to happen, and a general lack of interest in engaging in anything. Like everything is completely boring and uninteresting and that you don't get anything from doing anything. You feel drained, like any action that you do, from speaking to walking to even going to buy food is exhausting. You antecipate all the terrible things that can happen to you if you try to do those things, and that even if nothing bad happens who cares? It sucks. It sucks to do those things.
You have that moment of sel-realization that what you have is not just a "little sadness". You realize that thinking about how terrible you feel is constant, happens every day all day long and makes you exhausted. I suffer from massive inflammatory diseases and auto-immune diseases from how stressed I am at being myself. I have been thinking consistently about ending my life for the past 6-7 years. The only reasson why I don't do it is because of my cowardice and high anxiety which stops me from it. But thinking about killing yourself every day for years is not a "little sadness". I came to the conclusion that *I am sick* . People tell you all the time that you come across to them as miserable, as a sinkhole of sadness. And of malaise. But you tell yourself that it just normal feelings of sadness. It's hard to accept that it is not normal sadness and general lack of interest in things, and that you will be better when things are better for you. But even if things go well for you, you are still sad and finding everything pointless
I didn't want to take the non-selective MAOIs because I am sesnitive to tyramine and I fear having a stroke or death. But I figure I will end up killing myself eventually if I remain like I am so, so I have nothing to lose. MAOIs appear to be only slightly better than SSRIs for normal depression, but they apparently are *significantly* superior to the SSRIs when the depression is bad. So I will give it a shot. I feel like I am in a prison of flesh.
It sounds like Nardil will be a good option for you and in view of your higher level of symptoms and distress it seems a very obvious choice. Note, you may get useful information and support from the Reddit type forums which you probably know about it already, the very small number of people looking at this comment thread will not likely produce a useful support for you.
@@psychotropicalresearch5653 Thank you. I tried to get a presciption for Ritalin from a psychiatrist, but he wasn't having any of it. He wanted to prescribe me for the 100th time a SS(N)RI that never did anything for me but help me sleep when my anxiety was very bad. But these SS(N)RIs never made my feelings of pointlessness and sadness go away. I told that I only ever had a mood lift from DRI, but he treated me like a junkie that wanted an excuse to get high. I told him I was going to take only 2 pills a day, one in the morning and one in mid afternoon, but he wasn't having it.He said that "MP is for ADHD and obesity. It's not an antidepressant.". I said that it was the only thing that relieved my lack of joy in engaging in things, but he pretty much kicked me out of his office as if I were a junkie looking for a fix.
Getting phenelzine is nigh-impossible for me in my country. Only TCP available. They say that Parkinson's drugs usually help people like me as well.
I agree with Ken. Nardil sounds like it would be good for you (given the anxiety component to your illness), if you choose to try it. Keep in mind, however, that it generally has a slower onset than other Ad's (up to 8-12 weeks even), and most people require a minimum dose of 60mg (dose guideline is generally 1mg/kg) It is often very very helpful, although you may have quite a few start up side-effects. These generally fade away in time, although some may linger. Read many of the success stories on the "Ask a Patient" review site.
Please remember, too, that the chance of a stroke on MAOI's is extremely low, and the "MAOI diet" is often exaggerated. I do not recommend this, but i personally know many who have been on Nardil for decades and who have never taken any notice of the diet, and they have not had one problem. However, Ken has a very good "MAOI diet" list on his webpage. I would be much more afraid of depression and anxiety, than some minor changes to your diet and a few side-effects.
@@anlace3447 Thanks. Nardil(phenelzine) is not available in my country. I would have to import it, and the legal and financial problems in doing that are significant. Ideally, I would take an SSRI combined with a DRI. That gives the same anti-anxiety, anti-depressant effect without the risks of MAOI. But DRIs are very controlled and difficult to get. Doctors don't like prescribing drugs that work like cocaine!
@@petercoderch589 I literally typed a response on this page. I am going through the same thing right now... you will see it if you sort by most recent.