I would love to see more of your lectures. I understood you well and this helped smooth out some knowledge gaps I was having when reading research journals on the topic. Great visuals used. Thank you!
an excellent presentation. i have long wondered why the cell goes to the trouble of making all that mRNA only to turn right around and destroy it. His explanation starting circa forty-one minutes is most thought-provoking in regards to that question. iBiology lectures rock!
A lot of Nobel Prizes are granted many years after their discovery. One of the reasons is that it takes time for an idea to be accepted by the scientific community and recognised as important. If an idea is brand new, applications for such discovery will most likely not exist yet. Great ideas are like great wines: it takes time.
Getting a grasp on how much room there is to maneuver on the inside of a cell from the perspective of these agents is somebody's task in terms of animations, to true scale. Maybe it's out there, but havent found it yet. And, I want to see it in real time then slow motion. Report back here on completion. You have one day.
Mr. Bartel, what is the method scientists are using to manipulating the DNA and RNA in human beings or others? I'm so happy I accidentally found your channel, I immensely enjoyed your videos. Thank you Mr. Bartel
The Nobel Assembly at Karolinska Institutet has today decided to award the 2024 Nobel Prize in Physiology or Medicine jointly to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
thomas underhill both CAS and ARGONAUTE are endonuclease protein. mode of function is same but homology is difficult to assume. you can run pBLAST for that
Hello sir , Ryt now I'm pursuing my masters in biochemistry as the my research work is on microRNAs I have to complete the work before deadline but I'm stuck in the part of target prediction of miRNAs by using bioinformatic tools ,by the way I'm using target scan for prediction but I'm unable to analyse the data it Will be very nice if you can help me that means a lot and I assure you that I will acknowledge you in my thesis work , thank you.
Greetings. Professor Bartel, thanks for your lecture which I'll watch in a few minutes; do you believe that bacteria infected with a lambda phage that carries highly expanded CAG repeats could produce a restriction enzyme that could be used later in vivo, to excise highly expanded CAG repeats in brain cells of carriers of Huntington disease?
OK. Now I feel stupid again. It has been awhile since I studied transcription and translation and I had not been keeping up with all of the developments. I had a superficial understanding of micro RNAs, which appear to potentially be important in my research. Now I know how much I do not know.
hello prof your teaching is excellent and im higly intrested in genetic engineering and molecular biology .....plzz recommend top books for very topics..thank you!!!
At 19:35, he attributes cognition to evolution, speculating that it must be preserving microRNA’s “for some reason”. This belies a fundamental misunderstanding of evolution, which is the religious belief that life has no cognitive Creator or Designer. What this proves is that he knows that the existence of life is intentional and his attributing it to evolution is inherently dishonest. They all fall into the trap of giving the glory and credit for the creation of life to something that is hopelessly incapable of it.
people like him makes the beauty of science!
How lucky I'm to watch these lectures free of cost.
Really amazing presentation about miRNAs.
He seemed like he was being held at gunpoint, never the less, that was a great presentation
Teach us about MicroRNAs or else!
pahahahahaha
this comment is funny 🤣🤣
Am I the only one?
these researchers are so brilliant! i hope to join their ranks someday
And? Did you do it? 😁
@@michaelf.8131very rude of you michael
These classes help me a lot, this is really open science, greetings from Chile where i am doing my PhD program, i am colombian.
I so much enjoy to see our gurus in "person" ... Thanks for this video !
I am a medical doctor and this lecture is a revelation of sorts to me -- I never thought about RNA regulation of gene expression
Sir ! 🙏
Great job! We need more of people like you who can explain the complicated in a simple way to understand. God bless you
Which god ?
Fantastic explanations without nonsense 3d animations and unneeded graphics
Very informative and easy to understand. Thank you so much for taking the time to put this together- much appreciated!
I would love to see more of your lectures. I understood you well and this helped smooth out some knowledge gaps I was having when reading research journals on the topic. Great visuals used. Thank you!
an excellent presentation. i have long wondered why the cell goes to the trouble of making all that mRNA only to turn right around and destroy it. His explanation starting circa forty-one minutes is most thought-provoking in regards to that question. iBiology lectures rock!
Wonderful presentation, a person who are going to get some knowledge about miRNA thanks to David in 2020.
High quality as I expected. Thanks Proffesor David Bartel
you do such a wonderful job sir...thank you from the land down under.
If this was known for the last 10 years then why it's discovery is now being awarded the Nobel prize?
A lot of Nobel Prizes are granted many years after their discovery. One of the reasons is that it takes time for an idea to be accepted by the scientific community and recognised as important. If an idea is brand new, applications for such discovery will most likely not exist yet. Great ideas are like great wines: it takes time.
You are awesome... How simply he makes things understandable...
Getting a grasp on how much room there is to maneuver on the inside of a cell from the perspective of these agents is somebody's task in terms of animations, to true scale. Maybe it's out there, but havent found it yet. And, I want to see it in real time then slow motion. Report back here on completion. You have one day.
perfect presentation. I liked all it especial the part about plant
Very very interesting, This will be all the medical treatments very soon, or already are
Dare I say the king of miRNAs
Very concise and inclusive. Thank you.
enjoy the learning about the functional inference from conservation.
Thank you very much David Bartel.
Mr. Bartel, what is the method scientists are using to manipulating the DNA and RNA in human beings or others?
I'm so happy I accidentally found your channel, I immensely enjoyed your videos.
Thank you Mr. Bartel
you found the ibiology channel covering a diverse array of biological topics, not his channel. 😊
You seemed a bit nervous but I loved your explanation, it was intelligent and easy to understand . Thank you!!!!!!!!
you're beautifull
Thanku so much sir for such awesome series of lectures on miRNA's. 👍
Great! Thank you very much for comprehensive explanation.
Will the mirna seed region always be the same for for the all the genes that it targets ?
The Nobel Assembly at Karolinska Institutet has today decided to award the 2024 Nobel Prize in Physiology or Medicine jointly to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
QQQ Could this mean GM food plants might be missing in some protein production processes? Thanks for sharing your knowledge 🙏!
this is awesome! Thank you so much!
I really love this lecture.😻
I'm so sorry that I'm not good at English to decsribe how I felt this is great😂
very nice presentation , please make a presentaion on effect of MiRNA on pregnancy
is there any homology between RISC complexes and CRISPR CAS ?
thomas underhill both CAS and ARGONAUTE are endonuclease protein. mode of function is same but homology is difficult to assume. you can run pBLAST for that
holy hell, I never even knew about pBLAST!!! that thing is so cool!!!
THANKS!!!
welcome
Hello sir , Ryt now I'm pursuing my masters in biochemistry as the my research work is on microRNAs I have to complete the work before deadline but I'm stuck in the part of target prediction of miRNAs by using bioinformatic tools ,by the way I'm using target scan for prediction but I'm unable to analyse the data it Will be very nice if you can help me that means a lot and I assure you that I will acknowledge you in my thesis work , thank you.
Amazing thank you Dr. Bartel!
Greetings. Professor Bartel, thanks for your lecture which I'll watch in a few minutes; do you believe that bacteria infected with a lambda phage that carries highly expanded CAG repeats could produce a restriction enzyme that could be used later in vivo, to excise highly expanded CAG repeats in brain cells of carriers of Huntington disease?
It's a perfect video. thank u very much.
Great lecture! Thanks
Nice sir excellent concept I like u most
Thank you very much! It's fascinating!
Fantastic explanation!!,
Excellent presentation!
Great presentation. easy to do.
this is blowing my mind... 8bp is all it takes?
great lecture
Great Video
Many Thanks
Thank you. Very interesting
great video! thank you David
I love your lecture sir
great talk to understand miRNA
help me, my english is fad and I need that information to an investigation I'm doing, but nose if it's available in Spanish
yes of course, read the book The Cell, from Cooper.
si, claro, lee el libro La Celula, de Cooper
OK. Now I feel stupid again. It has been awhile since I studied transcription and translation and I had not been keeping up with all of the developments. I had a superficial understanding of micro RNAs, which appear to potentially be important in my research. Now I know how much I do not know.
many thanks ... very informative...
keep up the good work
correction of my previous comment: the explanation begins at about 30 minutes
hello prof your teaching is excellent and im higly intrested in genetic engineering and molecular biology .....plzz recommend top books for very topics..thank you!!!
Alberts et al Molecular Biology of the Cell; Lodish et al Molecular Cell Biology; Watson et al Molecular Biology of the Gene...
Thank you alot!!!!
Thank you!
very informative. thank you
At 19:35, he attributes cognition to evolution, speculating that it must be preserving microRNA’s “for some reason”. This belies a fundamental misunderstanding of evolution, which is the religious belief that life has no cognitive Creator or Designer. What this proves is that he knows that the existence of life is intentional and his attributing it to evolution is inherently dishonest. They all fall into the trap of giving the glory and credit for the creation of life to something that is hopelessly incapable of it.
fantastic
impressive！
Thank you sir
@20:23 Mind blown.
super biologist about miRs
excellent introduction
thx!
awesome
Great.
clear
Thank youuuuuuuuuu
wow!!
More 3d animations!
he is soooo cute！
Thomas Steven Hall George Thomas Deborah
please!!!!!!!
MicroRNA should be represented as "μRNA".
The robust south korea biosynthetically treat because shadow bizarrely melt given a present possibility. unaccountable, wakeful degree
Those technologies should be forbidden. 🙈
Great presentation!
Amazing presentation!