The Future of Early Cancer Detection? | Jorge Soto | TED Talks
Вставка
- Опубліковано 4 жов 2024
- Along with a crew of technologists and scientists, Jorge Soto is developing a simple, noninvasive, open-source test that looks for early signs of multiple forms of cancer. Onstage at TEDGlobal 2014, he demonstrates a working prototype of the mobile platform for the first time.
TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more.
Find closed captions and translated subtitles in many languages at www.ted.com/tra...
Follow TED news on Twitter: / tednews
Like TED on Facebook: / ted
Subscribe to our channel: / tedtalksdirector - Наука та технологія
Amazing.. We need this in the UK, I have lost too many family member's to Cancer.. It need's to change and hopefully this is the way forward.. But we need it now!! I shall keep following this and ensuring people know it's out there.. Thanks
Jorge Soto and his team are an inspiration to humanity. To give this technology away for the good of "mankind" is a beautiful sentiment. I only hope now it will aid those in need.
As a survivor who has been missed diagnosed initially (which pushed me towards stage 2b by the time I was properly diagnosed) this has made me so happy...AND it's open source. Incredible.
WHERE CAN I SUPPORT THIS!?
My mind has been blown by how incredible this project is. We need to spread the word.
***accurate and affordable test that has the potential to dramatically change how cancer procedures and diagnostics have been done ... You only need one milliliter of blood and a relatively simple array of tools ... it can be routinely diagnosed at the very early stages ***What a promising statement! Loud applause! And where is it all in 6 years??
Wow open source! May god bless this man and his team and may his aunt recover too..this isreal research coming from the heart
like like like like like.... Georgeus.... wonderful invention and investigation .... those guys are awesome they deserve a Nobel prize and all the support of medical community
I totally agree with you
As soon as I saw the title to this TED talk, I was automatically interested. Sadly, cancer runs in my family, and it always will unfortunately. I lost both of my grandparents to breast and lung cancer. Soto's talk hits home for me. Two of my aunts have also been diagnosed with breast cancer in the past as well. Meaning, when I am older I will have to get mammograms more often than the average woman.
The way Jorge Soto started off his talk made me feel sad, yet also frustrated at the same time. He talked about how his aunt never smoked, drank, and played sports for more than half of her life. Which led me to my question, why her? Now, that doesn't go to say that I wish cancer upon certain people, because I don't. However, it sounds like she took care of her body, and cared for. Yet she ended up with cancer, why? I have always thought cancer hits those who don't see it coming, or you don't expect it to happen to. Which is sad, yet true.
He also made a point that due to her lifestyle, that is why it took the physicians almost six months to properly diagnose her. I am not saying that they were in the wrong, because I wouldn't have assumed it was cancer right from the start, but six months seems like a LONG time! Exactly why when she was diagnosed she was already stage three. Have it being 2017 (2014 was when this video was published), one would assume that cancer would be one of the top things to check for would be cancer.
Later on in the talk, it was mentioned that that a blood sample could potentially be used to detect early signs of cancer cells. if that is the case, that would be ground-breaking. I say that because more than usual, when people are diagnosed with cancer it is when the cancer has already reached either stages three or four. Which in other words, a point of no return.
Not many people mention the word "affordable" when discussing the term "cancer". However at the end of Soto's talk, he talks about a clinical trial that is more affordable for patient's and their families. When someone is diagnosed with cancer, it can become a financial burden to the family that is affected.
Overall, I agree with more than one point that Jorge brought up throughout his talk. I felt that he did a very good job, and felt that the non-invasive blood test sounds like a great idea.
Brilliant!!!! Not an open source. Great idea.
***** They are still in very early stages or research and development, it's not even an alpha version yet, just the first prototype.
You all are correct. It's not open source. I thought I heard him say it. Misunderstood. Thanks for the correction.
Thank you TED for these informative speeches. I love everyone I see on stage. I love this "coming together-ness". Humanity needs minds like these.
Just shared this on facebook. Such an incredible discovery. The mind is an incredible thing, and BRAVO to those scientists who work so diligently for the good of mankind! This is very exciting! Congrats to all involved and thank you for your genius.
we're going to need much more frequent Nobel prizes given out.
Excellent news!!! This will change too many lives!!! Thanks to Jorge Soto and his team!
Sounded too good to be true, did some research:
Turns out only the device (basicly a camera stand) is "open source". The actual tests happening in the little pippetes are patented by Miroculus (according to their website). So it totally depends on them and their investors how "cheap" this actually gets in the end. It's likely that more patents are involved too.
Secondly he didn't say how the actual test procedure works. Only how the results get photographed and processed. Is it as simple as pouring a few drops of blood into this? How does it need to be prepared? Can a normal doctor do this (quickly) or do you need proper lab equipment? Do doctors need to buy this from Miroculus aswell?
Thirdly the images get sent to one single knowledge-based system for processing. This opens a whole new can of worms concerning patient data privacy. Will you be able to send your test in anonymously? Or are we basicly creating a huge biometric database of everyone?
So yeah. I'd not celebrate yet. It's not gonna be a thing for a couple years anyway. But i sincerely hope they aren't lying and actually have something good. Fingers crossed.
Enhorabuena, Chile, Panama, Mexico, Israel, Grecia buen trabajo!! KEEP GOING ON!!
Great news to us.. Cancer is way too common to be ignored. It comes to people who are young now. When older time it was more a sickness associated more with old age. Thanks for making it more transparent for us. Wishing u and team success in your research
It is a new approach to detect and differentiate between different subtypes of cancer, Happy we've started to do it in Egypt
Simple, short, sweet! I like this talk!
WHAT AN HONOR FOR MEXICO YOU ARE JORGE!
CONGRATULATIONS!!!!!
Thanks Ted to doing that journey. I have no cancer and i hope i will never have but i know that infortunately maybe can happen . But if you continue whit updating this new revolutionary BioTecnology i hope that billion of people will have a more longer life and more happy memories whit the friends . I appreciate this amazing work and just hold on . Greets TED
Very important talk. Though, I was hoping to hear about the software techniques used to classify the samples. It's fascinating to think of all the mathematical, computer theoretic, and physics discoveries that led to the development of the software that makes all this possible. Support basic research.
How can someone dislike this?
@Jorge Soto this story really touched me, i will tell my family and friends ^-^. don't stop here do a kickstarter perhaps?! is there anywhere online i (we) can follow your progress?
"Oh, no! It's available worldwide thanks to 3D printing and it's open-source! Curse them!" - says every pharmaceutical company everywhere. lol
2018 now.. what happening with this project?!? the web site miroculus.com not show any details about it!
it's alrady 2016, why, why does it take so long!
because it doesn't work!
amazing guys..all the very best..!!
This is incredible.
As a medical student, I think this can easily have a profound impact on patients. Although it seems simple enough, there are so so many complexities involved with this research, and I think we're still at least a decade out of reach for its practical use. He says it's sensitive, but how specific is it? Just because a test can detect all cancer doesn't mean it should be used. There are problems with false positives as well, since they can cause unnecessary harm in the form of added stress, unnecessary procedures and treatment. I do think tests like this are the future, and I hope it comes sooner than I think it will.
Im sure that when cancer gets detected this way, there would be a follow up examination. They're not just blindly going to cut people open.
If it can detect cancer in 90% of people who have cancer, but detects another 20% extra in people who don't have cancer, it's still a good way of detecting it early. It doesn't mean that the 20% who don't have cancer are going to get cancer treatment immediately.
This is amazing.
Thank you.
Goosebumps!
What a amazing technology. When will it be available to the public worldwide?
+Calo Q. The trick is making a chip that just needs a drop of blood or similar. I worked miRs on my thesis, it's still a good five years away.
Thank you for the response. Wonderful tech.Kasarii
Early cancer detection is an urging issue in todays healthcare and there are still many steps to take. I am curious about the data on sensitivity and specifity of mRNAs. Then I am curious about how he intended to implement the device: There are (blood test) biomarkers available for screening (i.e. PSA for prostate cancer - one of the most common cancer in men, which is quite specific as well). So I ask myself what makes his project a novelty - the easy-to-use approach? The overall-availability? The cloud-networking approach? I wish good success to him and I hope that his projects will be fruitful, heading towards early detection and treatment initiation by doctors.
It is a novel approach because it can supposedly detect any type of cancer with one blood test without having to rely on symptoms or family history for guidance. If this discovery is true, which I have no particular reasons to doubt, it is a revolution in cancer detection.
I'm curious to see how much does it take for his team and all the research to mysteriously disappear...
Thank you. To everyone working on this world altering project, I solute you. SCIENCE FTW.
A lot of the really cool stuff I see on Ted I find is really in the early development stages. This talk makes this look like a slam dunk detection system but conspicuously leaves out how far into the future we'll see this as a common tool used in hospitals. how far off is this to actually being implemented in most working medical facilities? What hurdles are left to gain governmental approval?
I don't think the main hurdle is government approval. It is finding all the different kinds of micro RNA patterns because there are just so many! Its going to take a year or two or maybe more for this to get going.
ya but we don't need a comprehensive test for all cancers even if it finds only one quickly and inexpensively it should be implemented.
Amazing Idea man, thank you!!! Jorge Soto
Hats off man!
Fantastic work!
That's fantastic.
great advanced work
This is a great idea. What is happening with this technology today? This video was done in 2014. Do we have any advances in the last 4 years?
this vid saved me cancer :)
Awesome!
This could be huge.
dr soto parabéns,por este grande avanco,so espero que aqeles que querem reduzir a populacao nao querem sabotar o seu conjunto,os cumprimentos do mexico por esta descoberta
The test grid is only 8x12, so you only need an 8x12 resolution camera. Any $1 webcam from ebay would do it.
It could also just be done in a hand-held device, as tiny as a diabetic's blood sugar monitor.
Not exactly. Better cameras are more capable of discerning between colours and light levels. It sounds like that would be very important to the results.
Using the smartphone, while silly on many levels, also gives a very well defined set of camera capabilities that make careful calibration less necessary. It is clearly possible for them to use less expensive cameras and build a more self contained unit but using smartphones is kind of the big thing right now. They probably just don't have a design engineer on the team.
Amazing presentation, but he didn't really explain exactly how the device works, I'd love to know that.
Me too, but it will be open source. We'll be able to read all the project data.
RenanzinhoSP Sweet.
He's looking at the types of MicroRNA (miRNA) in the blood.
It's kindof like searching through the local landfill, analyzing people's thrown-out paperwork and reciepts, to get an idea of how many people are (for example) actively committing tax fraud. Every activity has a specific signature. If you find a lot of receipts for paints and paper, you may conclude that there's a lot of artists in the area. If you find a lot of receipts for bullets and bombs, maybe you've got a military situation on your hands.
MicroRNA is like the thrown-out paperwork. By analyzing it, you can figure out what the cells in the body are doing. Different types of cells emit specific signatures or patterns of MicroRNA, and cells with cancer also have specific signatures.
The various vials in his device each contain a unique mix of chemicals which only react with specific types of MicroRNA, if you add that MicroRNA into the vial it will glow, how fast and how bright it glows can tell you how much of the MicroRNA is in the vial. The camera then looks at the vials, in a controlled lighting environment (that's why it's in a closed box). This allows the speed and brightness information of the vials to be converted into simple data, which can be graphed. The graph is like a signature, which tells you if you have cancer, and what type it is.
Over time, we'll discover more signatures, and be able to identify more cancers.
Maybe it was the time limit?
Nyx Gypsy That's what I'm guessing, it's a complicated subject haha. But I've been getting some very helpful responses to my original comment, so I think I understand how it works now.
Thank You God!
God bless his soul
@9:35 he says that the test is accurate. If so what's its sensitivity, specificity and positive predictive value for various types of cancers? And can it distinguish between nonprogressive, gradually progressive, and highly progressive cancers?
Hi please help what's the name of this device and is it available to buy? Where can I find more information online?
Fantastic. I know what early detection means.
Amazing!
I want one ASAP
I consider this project such an important advance in the early diagnosis of diseases that can be found at a molecular level involving transcriptomics. I would like to know if this microRNAs are going to be useful only for a preventional detection or if in a nearly future this 20-25 nucleotides could be modified not just only to prevent a disease but to eradicate it directly from our DNA.
Is this diagnostic capable of use also for another pathologies or is it only for cancer?
Has probably been bought and shelved by now. Haven't heard any more about this since this video was made !!!
If it's open source, where can I find it? I can't find it in google right now
That's because this, as is often the case in many TED talks, is merely an idea. Vaporware is what it is.
aw ok
Will this be able to be used for the detection of Alzheimer disease also?
He is so altruistic to make this great innovation open source.
I would love to know the name of the program he used to show the different types of cancer/diseases and their matching dysfunctional gene expression. Anyone know the name or where I can get my hands on it?
Not sure what specific software he used, but look up "mindmap software" and you'll find several versions (many of which are free to use).
I also would like to know
you guys can find it here:
d3js.org/
Click on "See more examples" and look up for "Concept network browser".
Thanks :-)
This simple, noninvasive, and awesome open-source test in combination using CBD's and other alternative treatments would ultimately be ideal, as opposed to the mostly expensive and unsuccessful radiation and chemo.
Deserving of a Nobel for Medicine, imho. Probably won't get one while anyone involved is still alive, though.
WOW!
I really get what it's like to see someone stating their opinion or belief that completely opposes your own. The truth is there is no point in commenting back and I did, for a long time, even while I knew, completely and consciously it wouldn't amount to anything. So here's something to make your lives easier; don't comment against people, comment for people or for yourself. And something for the atheists specifically. One day the universe will just end and therefore nothing will ever matter. Ever.
Wow!
عمل عظيم
How can we help?
wow!
Is Tony Montana giving this TED Talk? #nohate
Early cancer detection or diagnoses has no relation to mortality rate. Number one rule in epidemiology. But interesting video.
Really? Do you have any sources for that? That's quite a surprising claim, given that early stages of cancer often haven't metastasised so can be treated far more effectively, not just with surgery but also molecular treatments (such as inhibition of autophagy and apoptosis) that aren't effective in later stages of cancer.
I read it in my medical textbook a while ago. Here is an article that may provide some information. www.score95.com/blog/blog/usmle-trends-in-cancer-incidence-and-mortality/ But yeah early detection of cancer will not decrease mortality rate. Especially if the cancer cell has reached Anaplasia, It is not reversible and quite abnormal at this point.
+Ajs00 Did you contradict your self? At this point? Mortality rate for all is 100% but when is key. So no, time does play a huge role.
Cancer detection is a multi-stage process. Once in a while cancer is found by chance but most of the time from screening. The final stage of cancer diagnosis depends on an Oncologist's(it is a branch of medicine that deals with the prevention, diagnosis, and treatment of cancer) judgment.
On the contrary, if it's speculated that you have cancer, the doctor may prescribe certain "cancer blood tests" or other "lab tests", for example, an investigation of your urine or a biopsy of a suspicious area where cancer is speculated.
Read More: www.allin122.com/2018/10/cancer-detection-and-treatment.html
Detection democratise its cool, just try to share you info of the clouds with many other places. NSA and big pharma corp may trash your ideal approach. Remember cancer treatment is a huge business.
Is it me or is patent/copyright taking a U-turn here? :D
100%
How do videos of Kardashians have millions of views but a video of early cancer detection only 50k. Man on man our societies priorities...
People are f’kin stupid.
Who on earth thumbs down this? Let me guess...you don't like that he uses an iPhone?
lol I have accidentally thumb things down but if anything it would be someone making a lot off of cancer patients.
microRNA expression pattern recognition and correlation with existing published literature in the cloud, this is indeed miroculus ;)