To prevent catching fire one should remain a bubble of argon or nitrogen above the reagent in the syringe. This helps to make the pressure in the syringe equal to atmospheric pressure in the laboratory.
Chemistry is just absolutely amazing. I think of the greats that pioneered these methods by the seat of their pants, many suffering grave injury from the slightest mistake. Alfred Nobel's brother Emil, for example, from working out the safe synthesis and handling of nitroglycerin. Amazing how we are masters of materials to this degree. Awesome video thanks for presenting.
You can also pull in some air from the solution after you have your desired volume, this ensures that you wont have a spillage when you transfer the reagent and prevents dead volume.
Thanks! I remember the anguish of transferring t-butyl lithium while I was in graduate school. If only I had been smart enough to think of this system!
First I assembled the aparatus for the reaction and flushed it with Argon. I had a rubber seal over one arm of the reaction flask which was made of dental dam material. I lubricated, lightly, the barrel of a 50 cc glass syringe with silicone grease and attached an eight inch 18 ga needle. The commercial t-butyl lithium came in a rubber stoppered bottle so I could stick the needle into the bottle and withdraw the contents. Then it was simple to penetrate the rubber on the flask arm to inject the solution. The needle dribbled during transfer so little drops of flame dribbled out, scaring the caca out of me. If I had been thinking straight I should have taken it to another lab that had glove boxes and an inert atmosphere. @@Assassin_Aura
To prevent catching fire one should remain a bubble of argon or nitrogen above the reagent in the syringe. This helps to make the pressure in the syringe equal to atmospheric pressure in the laboratory.
Very detailed and nice tips you shared regarding transferring dry solvent and reagents!
Chemistry is just absolutely amazing. I think of the greats that pioneered these methods by the seat of their pants, many suffering grave injury from the slightest mistake. Alfred Nobel's brother Emil, for example, from working out the safe synthesis and handling of nitroglycerin. Amazing how we are masters of materials to this degree. Awesome video thanks for presenting.
Argon is your friend. Its a little more costly than N2 but since its heavy it displaces the air and leaves a blanket of inert gas over your reaction.❤
You can also pull in some air from the solution after you have your desired volume, this ensures that you wont have a spillage when you transfer the reagent and prevents dead volume.
Thanks! I remember the anguish of transferring t-butyl lithium while I was in graduate school. If only I had been smart enough to think of this system!
I dare not go near T-BuLi
May I ask how you did it then?
First I assembled the aparatus for the reaction and flushed it with Argon. I had a rubber seal over one arm of the reaction flask which was made of dental dam material.
I lubricated, lightly, the barrel of a 50 cc glass syringe with silicone grease and attached an eight inch 18 ga needle. The commercial t-butyl lithium came in a rubber stoppered bottle so I could stick the needle into the bottle and withdraw the contents.
Then it was simple to penetrate the rubber on the flask arm to inject the solution. The needle dribbled during transfer so little drops of flame dribbled out, scaring the caca out of me.
If I had been thinking straight I should have taken it to another lab that had glove boxes and an inert atmosphere.
@@Assassin_Aura
Thanks!!!👍👍👍👍👍👍👍