Factors Affecting Drug Absorption: Rotue Specific Factors || Pharmacokinetics, General Pharmacology

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Rotue-specific factors affecting drug absorption:
In the oral route, the degree of ionization affects how much portion of the drug, is available for absorption. However, most of the drug is absorbed from the intestine, regardless of ionization, because of the higher surface area of the intestine. For the same reason, gastric emptying increases absorption. Degradation, and extrusion, decrease the absorption of some drugs. The presence of food, and concurrently given drugs, also affect the absorption. First-pass metabolism decreases the bioavailability of some drugs. Gastrointestinal diseases also affect absorption. In the subcutaneous and intramuscular routes, heat, and exercise increase absorption, by increasing blood flow. On topical administration, abrasion on the surface, increases absorption. Bioavailability in the intravenous route is 100%, and nothing can affect this!
Chapters
00:00 Introduction
00:32 Degree of ionization
04:32 Gastric emptying
04:57 Degradation
05:21 Extrution
05:48 Prences of food in GIT
06:48 Concurrent drugs
07:11 First pass metabolism
07:57 Gastrointestinal diseases
08:24 Heat & Exercise
08:44 Abrasion on the surface
09:09 Summary
Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

[@lydiabasimbe2617]

Thanks Soo much it's of great help

[@definitedaku4443]

Sir please make video on second gas effect and diffusion hypoxia please

[@NonstopNeuron]

Nice suggestion. Will try making that as soon as possible. Thanks.

[@milagirl01]

Thank youuu🥰❤️

[@Habsnation]

What about stress ?

[@NonstopNeuron]

What do you think?

[@raghavwalker77]

Can you also please tell some easy tricks to remember drugs names?

[@NonstopNeuron]

I also struggled a lot with drug names. But I haven't created memory tricks. So I don't have any such tricks to share. I revised over and over and it worked for me. At times I would go through only the names of drugs in different groups, try to recall drugs from different groups randomly, etc. Also over time as we learn more about the details regarding the drug, remembering its name becomes automatic. Ohh yaa... One particular problem for me in the beginning was that I couldn't remember even the entire word. Like from peracetamol, I could recall only "para"😅. For that problem I used to break down the word and remember them i.e. para-ceta-mol. I wish that you don't have this issue but if it is, this was my trick.

[@NonstopNeuron]

In the above comment, you might have noticed that I am still struggling with spellings😅😅😅

[@montazaraldujeili2475]

❤❤❤❤

[@saikrishnasurajbavirisetty7804]

🥳