Optical Methods in Neuroscience: Calcium Imaging, Optogenetics
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- Опубліковано 12 вер 2024
- This video introduces the most commonly used, modern approaches to use light to record and manipulate the activity of neurons in the brain. Because the only thing neuroscientists love more than neurotransmitters is lasers.
The methods I highlight include calcium imaging, voltage imaging, and ways to manipulate neural activity using light with optogenetics. I also discuss the advantages, limitations, and interpretations of these methods.
Playlist for all videos in series: • Introduction to Neuros...
Professor Bing Wen Brunton
www.bingbrunton.com
27:26 Professor Brunton is so incredible that she can stop talking about the current subject, go to the next as if it was nothing. And these are very advanced topics. Thank you very much for the content, professor.
So you finally back good to see you
Very nice overview of calcium imaging and optogenetics!
Hi Bing, I'm slowly but surely making my way through this whole series and can I just say -- thank you so much! I've always been passively interested in neuroscience and this course is the perfect balance of clarity and depth. Every time a new complex graphic or series of equations pop up on screen, I feel that gut-wrenching "is this where I get lost?" feeling, and yet by the end of the slide I walk away with perfect understanding. No easy feat!
A couple of questions for you if you don't mind:
1- The field of optogenetics sounds as insanely interesting as you portray it, the specific targeting capabilities are sure to have wild medical applications in the future. Forgive me if this is a stupid question, but with precise viral targeting and promoters to bind to dopaminergic or serotoninergic targets, could it be possible to one day modulate attention/motivation/mood with targeted light therapy in humans?
2- The story behind Karl, Ed and Zhuo-Hua is super interesting - would you mind if I shared about 4-minutes of this video in a series of trainings I'm conducting on scientific writing and the importance of describing significance in your paper/grant?
Thanks again, looking forward to the next lectures!
Thank you for the kind words! Glad the material is connecting with your interests.
Re (1) Great question! It is not impossible. But we'd have to get some light inside the skull. This may require implanting a light source, or some fiber optic cables.
Re (2) Please feel free to forward any part of the video! Thanks :-)
Thank you very much
I appreciate your great effort ❤
Go on
Hello Bing, the information about imaging data sources being publicly available is very interesting. Could you recommend to someone outside of neuroscience community what are the places to follow to find such sources, where are they published? Would you recommend following any particular researchers / labs / social web platforms?
Using this opportunity - big kudos for putting up these lectures, they are absolutely fantastic and inspiring.
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There is a low frequency background noise, that makes it difficult to listen to with headset.
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Thank you very much
I appreciate your great effort ❤
Go on
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