This was really helpful :) I'm a new PhD student starting a project about targeting GPCR-mediated extracellular acid sensing by tumor cells and I'm just starting to learn why GPCRs are such common targets of drugs. In the future, maybe the exact GPCRs responsible for binding protons can be identified and targeting them can limit tumor cells from positively responding to the low acidity conditions they generate!
Very interesting! Is it through immunotherapy? I would imagine targeting it with small molecules would be hard without knowing much about your target.. I’m learning so much about the GPCR as well mostly on a structural level. Good luck with your PhD:)
Thank you for this valuable work 😊
This was really helpful :) I'm a new PhD student starting a project about targeting GPCR-mediated extracellular acid sensing by tumor cells and I'm just starting to learn why GPCRs are such common targets of drugs. In the future, maybe the exact GPCRs responsible for binding protons can be identified and targeting them can limit tumor cells from positively responding to the low acidity conditions they generate!
Very interesting! Is it through immunotherapy? I would imagine targeting it with small molecules would be hard without knowing much about your target.. I’m learning so much about the GPCR as well mostly on a structural level. Good luck with your PhD:)
Can you please share the reference for the last picture shown in the video? (30% ...),
Can you recommend me a book which covers this topic in detail