I love how Joel holds that heart like he was handed someone's newborn baby. Lol This technology is so cool, I can't wait to see where it goes from here.
Yeah this could possibly be use to create an entire race of super beings that would ultimately destroy all of mankind. I'm just not that excited to see the creation of something that ultimately could be misused by the evil people of this world. I think we are a the point where we are too smart for our own good and to dumb to realize it.
Randall Cromer at this point just do your best to add to the positives in humanity. There’s no stopping the research, just beating the next country/lab to it. We’re in multiple arms races all at once. I just hope the “good guys” develop the tech first and can implement protective legislation.
@@randallcromer66 Pretty sure AI bots are far greater a threat. Superhumans are cool and all but are still just fleshsacks with slow electro-chemical processing and reaction times.
The Sci-Fi TV Show Space Above and Beyond uses "Tanks" or "Nipple Necks" for their slave labor. Specially bred clones to serve as cloned human servants. It would actually be cheaper to have robotics replace much of what companies like Amazon and UPS do.
I’m actually really curious on how they’re gonna be able to 3D print smooth muscle in the future. It’s one thing to print a vein or an artery that just acts like a hose and that it, it’s another thing entirely to print something that functions like an actual organ. Cant wait to see if they can pull it off or not.
I think that what they are printing here is closer to a scaffold that will let the muscle cells grow into the right shape. Sort of like a mold, but instead of the material being inside the mold, it slowly replaces the mold material with cells.
T Ray maybe something like how they are printing silicone air muscles? They have a mandrel they print it on instead of just a flat bed. Basically there’s a lathe in place of the pint bed, they have a stretched matrix over a tube, then print on the matrix and slide off when done
Currently working on towards my Biomedical Engineering degree, this was a great overview! Great info, thanks so much for shedding some light on our field! ❤️❤️❤️
Don't know why anyone would Downvote this, it's a great presentation for it's intended Target Audience. Maybe a shame the models weren't more visible but seeing those microfine blood vessels was amazing. Nice work, both of you, & Lulzbot
I was legit tearing up thinking about the implications of this technology. Thinking about all the lives it will be able to save when it is fully realized. And I think Joel was able to see that too. He was so excited for the future. And so excited to bring it to us. Thank you Joel, and thank you to everyone working to make this technology real.
I am actually working on my master thesis right now (using bioprinters) and I try to find out how the forces in the different needles impact the viability of the cells that are printed.
@@N3tech Depends what material you are printing with but normally all the printed compounds are chosen specifically for biocompatability (not only to not be toxic, but also to provide printed cells with survival signals etc. that ensure that the cells will proliferate and form functional tissue). Also all the temperatures that you use of course have to be around 37°C to keep the printed cells at their optimal conditions.
I'm guessing that by "forces" you mean things like the flowrate, driving pressure, needle inside diameter, plus the physiochemical properties of the solution the cells are suspended in. It kind of reminds me of 50 years ago when heart-lung bypass machines were being developed, it was necessary to contend with similar issues when pumping blood through long tubes by squeezing it through roller pumps that physically damaged the red blood cells. Wishing you success in your work.
@@BrenzMarie The "force" is mainly the shear stress and the most important parameters for this inside a 3D bioprinter are the viscosity of the cell-laden hydrogel, the internal geometry of the "extruder", the inner needle diameter and maybe the hydrostatic pressure driving the hydrogel through the nozzle.
Excellent presentation, Joel. I'm so glad you took Lulzbot up on their offer and shared your experience. All the work this rag-tag community of 3D printing pioneers has put in by printing figurines, toys, little monsters and even more 3D printer parts is starting to pay off. I think we can look back even now and realize how important those fun early days were in terms of laying the foundation for serious applications of 3D bioprinting. If you have the chance someday, please do a follow-up on this topic.
we need a pallet BIO to attach to the lulzbot BIO so it can selectively print scaffolding tissues, muscle cells, & support goo (or 3 syringes, retractable) if you could extrude both collagen and support goop couldn't you print larger and more complex structures layer by layer, without pushing your needle through and around an existing tub of support goop, which I imagine distorts whatever is printing in there
@@MeNoOther I believe induced pluripoent stem cells (iPSCs) will be the future when it comes to cultivating every kind of necessary cell type to print from patient-specific cells :)
Great video, Joel ! I have always been fascinated by 3D printers, but I never have the chance to get my hands on one... Until a couple of months ago. It was exactly bio-printing, that got me into the universe of 3D-printing. Before being introduced to the bio-printer, we had to learn PLA/ABS printing on the Creality CR-10S-pro. I learned 3D modelling (Blender was my program of choice, instead of Fusion360), I had to struggle with bed-leveling and adhesion issues and all the stuff that a noob has to face :D Your channel has been very helpful and inspirational on my way! I finished the bio-printing module last week and this video is very special to me - feels like "back to the roots" and it's a reminder that the tutorial is over and the real challenge awaits. Thank you !
This is why I love 3d printing, in the right hands it can make a massive difference to society! that said I can't see this tech being able to print a fully working heart yet unless it can print muscles and there's no guarantee that a patient could take a synthetic organ due to allergies or their body treating synthetic organ as a foreign body and attack it.
Awesome video! :) I used FRESH printing for my master thesis and now continue with it during my PhD. I think it is far more advanced than normal Bioprinting techniques! Nice to see it explained for a broader public here. I think though that it should be mentioned that this is still quite far from actually making functional organdies ;) People like to exaggerate a bit and then they think they can print themselves a new heart in a few years.
Awesome Tech from an equally Awesome company! Can't wait to see what they do next. Sure, their machines are expensive, but the research and design is top-notch. Thanks for the video Joel and Sean!
Groundbreaking tech! I've been looking forward to seeing a Bioprinter review for the community. Looking forward to seeing all the applications in the real world. Also, the fact that it's open source is even better! This means more companies will be able to make similar products as a less expensive price.
Your tooltip @12:48 is incorrect. A micron is a thousandth of a millimeter, not millionth. Hair measurement is correct though. A nanometer is 1/10000ths (what carbon nano tube wall thicknesses are caculated in)
Yeah - I'm guessing the thought was "millionth" due to the fact that micron really is 1 millionth... of a meter. I think that's why we generally called it micrometer in physics rather than micron, given the fact you have the base measurement (meter) and the fraction (micro/millionth) explicitly stated. Less confusing.
There is a Ted talk with a 3d printed kidney and about 10-15 years ago they used a lexmark bubble jet printer to print a heart valve. It was printed in layers, stacked and grown together in a petri dish. When they tested it, it worked a lot like what you saw.
In the future there wont be a difference between the original organ and a printed one. The latter might even be "younger" as the reprogramming process of "old" cells to stem cells which are used to make the cells for the organs, resets some of the aging markers in cells.
12:14 it's a honest to goodness heart. (YOU CAN SEE THE INFILL) I think it's an important distinction to make that these are just shapes and 3d printing functional organs if possible would be years away. These are mostly just shapes and test prints. Not harping on lulzbot it's just the hype in the bio industry is on a next level.
Within a week Lulzbot is ready to change the world with the Bio, and laying off the majority of their employees. Sounds like they need that life support!
Any reason we couldn't use a container printed at the same time as a similar biodegradable gel and our model as a new support method for general 3D Printing
@@ChrisD__ I would be happy with a printed cornia. It would be great if it could be a mini heads up display as well for Augmented reality and have other useful functions.
@@shivalwolf I need a new retina, I would happily take a eye with -a light field mode.- Nevermind I meant this! ua-cam.com/video/8FC6udrMPvo/v-deo.html
This is amazing! Think about the applications and how this can change clinical testing that animals are normally used for? Also, think about all those soft prints that can be created with this... epoxies, etc... Just awesome!
When is this coming out? I'm confused about it being open source and then Lulzbot shows a professional looking bio-printer. Would love to get into this!
So cool to see they're getting in to a different kind of printing space :) No doubt going to be a big thing not only for them, but for science in general, cos no doubt this will cost significantly less than the machines that existed in the market so far! (wow... I typed this before even getting to the discussion of price, thinking they wouldn't perhaps reveal it, but wow... that's INSANELY cool to think it's that cheap! I was expecting it'd be at least 10-20k!)
I could easily see this printing goblet cells for an artificial gut within the year, those guys under the right condition could make a little small intestine out of those (not from zygote) stem cells
This video contained some exciting information. I had no clue something like this could be dumbed down to where it could be understood by myself and be open source. Then within days LULZBOT announced they are closing their doors. WTF LULZBOT. You could have passed on doing this stuff and kept the doors open
Organovo has been doing this for at least 4 years already. Owned in USA, but built in Australia. My friends here are printing kidney organoids already.
I was a master's student in the lab that created FRESH. It's cool to see this work in UA-cam videos.
Amy Powers That’s super cool!
Amy can this be used to print penile tissue? I need to know for uh, reasons
Jake Mitch I would imagine its designed to print anything with the right modifications. Have fun. :)
@@greenthizzle4 leme guess, you're circumsised and turn on the water too hot?
Rmdhn na, just want a foot long instead of an average 6ish inches
Awesome. Sent this to some friends who are literally doing this stuff for their PhD.
Sent it to my colleagues too! I am working on my master thesis in this research area.
@@sintoxic How does one get into this? Trying to write my grad school applications this month...
I just love how genuinely excited and happy Joel is for everything, in a completely non-annoying way. Never change, sir.
that canadian awkwardness is starting to rub off on me lol
Have they printed a collagen benchey yet
Never trust any 3d printer until you see a benchy
I want him to print a sphincter lolz
Yes! We need a bio benchey!
I love how Joel holds that heart like he was handed someone's newborn baby. Lol
This technology is so cool, I can't wait to see where it goes from here.
2039: Jeff Bezos: *3d printing an entire human workforce*
Elon musk: *builds an iron man suit*
Yeah this could possibly be use to create an entire race of super beings that would ultimately destroy all of mankind. I'm just not that excited to see the creation of something that ultimately could be misused by the evil people of this world. I think we are a the point where we are too smart for our own good and to dumb to realize it.
Randall Cromer at this point just do your best to add to the positives in humanity. There’s no stopping the research, just beating the next country/lab to it. We’re in multiple arms races all at once. I just hope the “good guys” develop the tech first and can implement protective legislation.
@@randallcromer66 Pretty sure AI bots are far greater a threat. Superhumans are cool and all but are still just fleshsacks with slow electro-chemical processing and reaction times.
The Sci-Fi TV Show Space Above and Beyond uses "Tanks" or "Nipple Necks" for their slave labor. Specially bred clones to serve as cloned human servants. It would actually be cheaper to have robotics replace much of what companies like Amazon and UPS do.
I’m actually really curious on how they’re gonna be able to 3D print smooth muscle in the future. It’s one thing to print a vein or an artery that just acts like a hose and that it, it’s another thing entirely to print something that functions like an actual organ. Cant wait to see if they can pull it off or not.
I think that what they are printing here is closer to a scaffold that will let the muscle cells grow into the right shape. Sort of like a mold, but instead of the material being inside the mold, it slowly replaces the mold material with cells.
I mean it’s the future, they’re GOING to pull it off, it’s just a matter of what’s going to allow that next big jump to be made.
I think it is harder to install that print than actually print it.
Александр Алексеев kinda like how the stem cells cost more than the machine haha
T Ray maybe something like how they are printing silicone air muscles? They have a mandrel they print it on instead of just a flat bed. Basically there’s a lathe in place of the pint bed, they have a stretched matrix over a tube, then print on the matrix and slide off when done
Currently working on towards my Biomedical Engineering degree, this was a great overview! Great info, thanks so much for shedding some light on our field! ❤️❤️❤️
Don't know why anyone would Downvote this, it's a great presentation for it's intended Target Audience. Maybe a shame the models weren't more visible but seeing those microfine blood vessels was amazing. Nice work, both of you, & Lulzbot
I was legit tearing up thinking about the implications of this technology. Thinking about all the lives it will be able to save when it is fully realized. And I think Joel was able to see that too. He was so excited for the future. And so excited to bring it to us. Thank you Joel, and thank you to everyone working to make this technology real.
Its all fun and games till your heart delaminates
Got me to chuckle nicely
Same
Or till your stomach dissolves itself from the acids in it
I actually laughed out loud, thanks for that ☺️
I am actually working on my master thesis right now (using bioprinters) and I try to find out how the forces in the different needles impact the viability of the cells that are printed.
That's awesome good luck with that! Are there issues with biocompatibility using bio prints?
@@N3tech Depends what material you are printing with but normally all the printed compounds are chosen specifically for biocompatability (not only to not be toxic, but also to provide printed cells with survival signals etc. that ensure that the cells will proliferate and form functional tissue). Also all the temperatures that you use of course have to be around 37°C to keep the printed cells at their optimal conditions.
I'm guessing that by "forces" you mean things like the flowrate, driving pressure, needle inside diameter, plus the physiochemical properties of the solution the cells are suspended in. It kind of reminds me of 50 years ago when heart-lung bypass machines were being developed, it was necessary to contend with similar issues when pumping blood through long tubes by squeezing it through roller pumps that physically damaged the red blood cells. Wishing you success in your work.
@@BrenzMarie The "force" is mainly the shear stress and the most important parameters for this inside a 3D bioprinter are the viscosity of the cell-laden hydrogel, the internal geometry of the "extruder", the inner needle diameter and maybe the hydrostatic pressure driving the hydrogel through the nozzle.
Excellent presentation, Joel. I'm so glad you took Lulzbot up on their offer and shared your experience. All the work this rag-tag community of 3D printing pioneers has put in by printing figurines, toys, little monsters and even more 3D printer parts is starting to pay off. I think we can look back even now and realize how important those fun early days were in terms of laying the foundation for serious applications of 3D bioprinting. If you have the chance someday, please do a follow-up on this topic.
we need a pallet BIO to attach to the lulzbot BIO so it can selectively print scaffolding tissues, muscle cells, & support goo (or 3 syringes, retractable)
if you could extrude both collagen and support goop couldn't you print larger and more complex structures layer by layer, without pushing your needle through and around an existing tub of support goop, which I imagine distorts whatever is printing in there
"THIS IS SO COOL!!... What is it?"
"World first 3d printed human shape!"
Joel: "........Can I eat it?"
😂
It's truly incredible what is available now, and will be in the near future!
Thanks Joel.
Very interesting progress! Let’s hope the work can continue...
I wonder if I can still update my filament order to include some stemcells and alginate
Dont forget the collagen and muscle fiber
@@MeNoOther I believe induced pluripoent stem cells (iPSCs) will be the future when it comes to cultivating every kind of necessary cell type to print from patient-specific cells :)
Great video, Joel !
I have always been fascinated by 3D printers, but I never have the chance to get my hands on one... Until a couple of months ago. It was exactly bio-printing, that got me into the universe of 3D-printing. Before being introduced to the bio-printer, we had to learn PLA/ABS printing on the Creality CR-10S-pro. I learned 3D modelling (Blender was my program of choice, instead of Fusion360), I had to struggle with bed-leveling and adhesion issues and all the stuff that a noob has to face :D Your channel has been very helpful and inspirational on my way! I finished the bio-printing module last week and this video is very special to me - feels like "back to the roots" and it's a reminder that the tutorial is over and the real challenge awaits.
Thank you !
Wow it's really amazing that the technology of the 3d printing reached very high level.
Thanks for the videos. Respect from Saudi Arabia
This is why I love 3d printing, in the right hands it can make a massive difference to society! that said I can't see this tech being able to print a fully working heart yet unless it can print muscles and there's no guarantee that a patient could take a synthetic organ due to allergies or their body treating synthetic organ as a foreign body and attack it.
Awesome video! :) I used FRESH printing for my master thesis and now continue with it during my PhD. I think it is far more advanced than normal Bioprinting techniques! Nice to see it explained for a broader public here. I think though that it should be mentioned that this is still quite far from actually making functional organdies ;) People like to exaggerate a bit and then they think they can print themselves a new heart in a few years.
Very cool Joel, so awesome to see where 3D printing is going, DIY things, Buildings, Bridges, BIO. So exciting, thanks for bringing this to us.
Back in 2012-2013 i remember seeing someone having a blader 3D printed using the same technology
Joel... I have never seen you geek so hard on 3D printing. (love it)
And this application of 3D printing is amazing.
Another very good bioprinter is the inkredible + , they use it in the institute of macromolekular chemistry in Freiburg
This is a very interesting time to be alive, looking forward to all the applications coming
Great stuff Joel. Always wondered how bio 3D printing worked. See you in Maryland on Saturday!
Incredible technology. It will help so many people survive. I hope though that it doesn’t get into the hands of people that are going to abuse it.
the container cant be deep, right?
bro Joel you are amazing and so is your editor
Mario Alfonso thank you!
Awesome Tech from an equally Awesome company! Can't wait to see what they do next. Sure, their machines are expensive, but the research and design is top-notch. Thanks for the video Joel and Sean!
Groundbreaking tech! I've been looking forward to seeing a Bioprinter review for the community. Looking forward to seeing all the applications in the real world. Also, the fact that it's open source is even better! This means more companies will be able to make similar products as a less expensive price.
I had no idea 15 min away from me was bio printing at CMU!
I misread cmu as another word with those letters. God help me.
Your tooltip @12:48 is incorrect. A micron is a thousandth of a millimeter, not millionth. Hair measurement is correct though. A nanometer is 1/10000ths (what carbon nano tube wall thicknesses are caculated in)
Yeah - I'm guessing the thought was "millionth" due to the fact that micron really is 1 millionth... of a meter. I think that's why we generally called it micrometer in physics rather than micron, given the fact you have the base measurement (meter) and the fraction (micro/millionth) explicitly stated. Less confusing.
Oh my gosh. Looks like Sean already fixed it???
@@RegularOldDan Cant say they dont pay attention to comments xD
There is a Ted talk with a 3d printed kidney and about 10-15 years ago they used a lexmark bubble jet printer to print a heart valve. It was printed in layers, stacked and grown together in a petri dish. When they tested it, it worked a lot like what you saw.
i wonder how durable are the bio prints are compared to natural vessels.
In the future there wont be a difference between the original organ and a printed one. The latter might even be "younger" as the reprogramming process of "old" cells to stem cells which are used to make the cells for the organs, resets some of the aging markers in cells.
12:14 it's a honest to goodness heart. (YOU CAN SEE THE INFILL) I think it's an important distinction to make that these are just shapes and 3d printing functional organs if possible would be years away.
These are mostly just shapes and test prints. Not harping on lulzbot it's just the hype in the bio industry is on a next level.
Depends. At UQAM they printed a slice of bacon and the muscles could still react
This, guys....omg. thank you!!!!!
"This is SO COOL!...What is it?"
This was fantastic! Want to see more soon!
Within a week Lulzbot is ready to change the world with the Bio, and laying off the majority of their employees. Sounds like they need that life support!
A medical bot that has LUL in the name? I love it.
What is the durability factor of these organs?
What are the next steps
Wow, I can print replacement body parts... does it print sausage shapes, uh..a friend wants..to.. know...😕
Jazz you say my name?
Jazz I’ve got all my wobbly bits
can't wait to print my next heart or kidney! I hope we get that far in our lifetimes!
Can you use it to print brains for American and British politicians?
To think this video still has only 50k views has to indicate that the UA-cam algorithm is going haywire again.
Blackofnight I couldn’t agree more!
Thanks for the heart Joel 😁
*doctor does awkward face*
Soo the layers shifted and now your new artery is leaking.
I'm gonna be a bummer but I think the way it works is it makes like, a map for stem cells to follow and differentiate
@@ari_wastaken more like a resin printer. It places cells and hope that they stick together and grow a little
ah shit imma get broke again
Awesome stuff Joel! 😃👍🏻👊🏻 ...... I'm going to need some new parts in a few years! 🤞🏻🤞🏻
I was wondering what Lulzbot was up to... Very cool to see something making use of that support gel I saw a while back.
Any reason we couldn't use a container printed at the same time as a similar biodegradable gel and our model as a new support method for general 3D Printing
I'm a simple man. I see Joel in my notifications, I watch and like.
Joel you have to get this printer when its released for your collection.
Watching this reminds me of the 80s and the introduction of the Jarvik Artificial Heart, this is a step in a Good Direction
Cool wonder if there is any food applications? I've used agar and calcium for spherication in cooking. Cool video 👍
the outro screen should read "SIGN UP FOR EXCLUSIVE HIGH FIVES!" ;)
I had collagen cross linking done to my left eye. Its not fun.
It won't be long until we can print new eyes.
@@ChrisD__ I would be happy with a printed cornia. It would be great if it could be a mini heads up display as well for Augmented reality and have other useful functions.
@@shivalwolf I need a new retina, I would happily take a eye with -a light field mode.- Nevermind I meant this! ua-cam.com/video/8FC6udrMPvo/v-deo.html
@@shivalwolf I'd be over the moon just to have more "normal" eyes.
Awesome tech going on there! Can't wait for them to bring this more mainstream!
This is amazing! Think about the applications and how this can change clinical testing that animals are normally used for? Also, think about all those soft prints that can be created with this... epoxies, etc... Just awesome!
I heard this was delayed and I'm sad they're having problems.
This is incredible!!!! It’s great how excited he is too😂
The best organ donor.
🤯🤩🤩🤩🤩😍😍😍😍 This is freaking awesome. Let's start 3d scanning our organs.
If you are still in Colorado can you ask when my printer is going to be repaired?
Since they laid off 80% of their workforce a couple of weeks ago - who knows?
Rip lulzbot.
Wow Joel it was really informative, thank you
Does this mean that we can finally 3D print girlfriends?
3D printed catgirl waifus very soon
Well of course. She will be at a nice height of 2" tall!
Joebus100 so you can basically print a small fleshlight?
@@greenthizzle4 *Just the right size*
epic gamer moment
this is a drinking game any time you hear the word YES take a drink
When is this coming out? I'm confused about it being open source and then Lulzbot shows a professional looking bio-printer. Would love to get into this!
Bram it’s very very close to launch. We just didn’t hear the exact date before we had to publish the video! But SOON.
Did they explain the whole open source thing? I'm really interested since I'm pursuing a career in this field
Very cool stuff.
YESSSSSS! this was a fun video. :)
Jake the Dog in the background at 6:40 thinking he's slick. I see you.
The scale?
Yup lol couldn't unsee it
So cool to see they're getting in to a different kind of printing space :) No doubt going to be a big thing not only for them, but for science in general, cos no doubt this will cost significantly less than the machines that existed in the market so far! (wow... I typed this before even getting to the discussion of price, thinking they wouldn't perhaps reveal it, but wow... that's INSANELY cool to think it's that cheap! I was expecting it'd be at least 10-20k!)
I could easily see this printing goblet cells for an artificial gut within the year, those guys under the right condition could make a little small intestine out of those (not from zygote) stem cells
Where are their models sourced
this is cool for making it also opensource
To anyone who doesn't think this is cool, have a heart!
...and a lung, and an extra kidney, and a...
Yes this is great but could it back fire
"It is so cool! what is it?" Lol
I love your excitement
No one:
3DPN: Can I eat it?
Scientist Guy: ...yes.
This video contained some exciting information. I had no clue something like this could be dumbed down to where it could be understood by myself and be open source. Then within days LULZBOT announced they are closing their doors. WTF LULZBOT. You could have passed on doing this stuff and kept the doors open
I fucking LOVE science. This is absolutely revolutionary!!!
Organovo has been doing this for at least 4 years already. Owned in USA, but built in Australia. My friends here are printing kidney organoids already.
Kieran Short can they print me some extra penile tissue You think?
I can't even get my Lulzbot Mini 2 to print plastics? Are you sure they are up for this?
Joel's 'mini me', but this is truly amazing tech.
Holy shit! Real life Frankenstein Now this is RAD!!!! 🧟♀️💖👏👍
Eventually this technology will allow you to print a new body when yours wears out. That is pretty insane.
What's the intro bgm
can you make a tiny person with it
6:39, that scale on the left looks like Jake the dog is spying on you guys...
Hey Joel I met you at reprap errf Idk it was my first time there but it was cool even tho you probably don’t remember me
Awesomeness! Super mini ✋
THIS IS AWESOME!!!!!
Dude. So close to star trek replicators
3-d printing orbeez is next!
But can you print fake living fleshlights with it
Very useful tech.
" Behind me , next to me , to my side "
Make up ur mind man
👍😂
3D Printing Nerd lool didnt know you'd reply 😂😅 love your stuff man keep it up ! 👍🏻