Ischemic stroke (mechanism of disease)

This is a flowchart on ischemic strokes, covering the etiology, pathophysiology, and manifestations.
ADDITIONAL TAGS:
Risk factors / SDOH
Cell / tissue damage
Structural factors
Ischemic stroke
Medicine / nosocomial
Infectious / microbial
Biochem / molecular bio
Immunology / inflammation
Signs / symptoms
Tests / imaging / labs
Metabolic / hormonal
Genetics / hereditary
Flow physiology
Pathophysiology
Etiology
Manifestations
Insufficient cerebral blood flow (hypoperfusion)
Ischemia
Infarction or other neuronal injury
Dislodged emboli occludes cerebral blood vessel
Embolic stroke (20%)
Afib: uncoordinated atrial contractions
Blood stasis → clot
Ventricular aneurysms
CAD / MI
Rheumatic heart disease
Endocarditis → infectious emboli
VTE (DVT)
R→L shunt (PFO, ASD)
Paradoxical embolism
Atheroemboli, such as at carotid bifurcation aortic arch
Blood clot formation inside blood vessel
Thrombotic stroke (40%)
Athero- sclerotic plaque
Exposure of subendothelial collagen
Formation of thrombus (20%), commonly at branch points
HTN
T2DM
Chronic hypertensive vasculopathy
Lipohyalinosis of small vessels → occlusion (lacunar stroke, 20%)
Global cerebral ischemia
Systemic hypoperfusion (affecting watershed areas)
Shock
(Insulinoma →) hypoglycemia
(Respiratory arrest →) hypoxia
Weakness / paralysis
Paresthesias (“pins and needles” sensation)
Aphasia (can’t comprehend and/or formulate language)
Dysarthria (impaired motor articulation)
Impaired consciousness
Nausea, vomiting
Headache
Seizures
Sudden onset of focal neurological deficits
Nonspecific symptoms

[@pryn5116]

Thank you so much,very helpful guide... waiting for next one on this topic

[@Ali-007pn]

Could you kindly provide us with the links to each paragraph and mind map you have created in form of pictures so that we can save them? That would be much appreciated.

[@yusufildabxasan]

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