Pathophysiology of Diabetes Mellitus
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- Опубліковано 25 сер 2024
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Description of pathophysiology of type 1 and type 2 diabetes, and a discussion of complications.
Mr. Wolf..
You are the sole reason why I am passing Patho right now. I don't even listen to my teacher in class. I jot down some notes of diseases and processes that we cover, and then when I get home...I pray to god that you have covered them in a tutorial!
THANK YOU!
Thanks for the feedback!
I'm so thankful for all of your videos. It's like going to class without having to leave my room. I've learned so much.
Thanks for the feedback! We will be rolling out new lessons soon. Keep watching, we appreciate the support!
Just wanted to say I love these videos, they are so helpful to me as I go through nursing school!
Thank you! Glad they were helpful!
Just watched this 10 years after you posted, thanks
You are a great lecturer and easy to understand. Wonderfully helpful explanation of the pathophysiology behind diabetes. I am a 2nd year nursing student your videos are really helping me. Thank you.
Mr. Wolf great lecture and explanation for the DM.. Plus the expected outcomes of both are an added bonus!! Cellular K and serum differences are awesome!!
Thank you
Thanks Conrad!
Thank you so much! I have an exam on the endocrine system today in Pathophysiology and you have made DM so much easier to understand. Wow!
Thanks for watching!
You are very good at explaining this. I didn't feel like you were talking over-my-head, so I was able to enjoy this video and come away with a really good understanding of the material. I really appreciate that!
Thanks Robin!
thank you! your videos are always helpful from my A&P classes and now nursing classes
You’re welcome. Glad you found it helpful!
Instructor here. Thanks for showing me some easier ways to explain this to students.
You’re welcome. Glad you found it helpful!
I always have difficulty understanding Type 1 and type 2 diabetes especially in-depth of pathos. Watching your video makes it so much easier to understand and fun to watch. Thank you so much for your great videos.
You’re welcome. Glad you found it helpful!
Great Video explaining Diabetes Mellitus watched them several times before taking my test in this system this was so helpful thank you!
Thank you for the kind words!!
Amazing video!! I think this is my first time that I've actually enjoyed pathophysiology!
Regards from a Kuwaiti PhD student, cardiac rehab specialist, at Swansea University, UK
Fatimah
Thank you for the support!
Late clinical complications are:1 Macrovascular complications, eg larger blood vessels like coronary and cerebral arteries may become prone to occlusion. 2 Microvascular complications-damage to small vessels eg fine capillaries in eye and kidney causing retinopathy and nephropathy respectively. 3 Microvascular damage to blood vessels in skin may cause lesion- dermopathy and 4 Peripheral nueropathy where peripheral nervous tissue mainly sensory nerves can become progressively damaged.
Thank you sir ... this is a very nice lecture to understand the the two types of diabetes and the long term effects
Thanks for watching:)
nice lecture, easy to understand, thank you
Thanks for watching!
a great video and very helpful. thank you.
Very clearly explained on how compications occur and what goes on.. SUPERRRRRRRRRRRRRR
Thank you!
Thank you so much for posting these videos. I feel a lot better about taking Patho this coming semester.
You’re very welcome!
nice lecture and very helpful especially in africa where we are lacking medical lecturers
Glad it was helpful!
Hey, thanks this video has helped me understand the difference between type 1 and type 2 diabetes.
+ John Kamau
Thanks for watching John!
Thanks for watching Channel!
i wish my teacher is YOU !! .. this would be soo much easier for me not sleeping in classes.... and understanding everything!! thanks for ur videos really help... please post some more!! =)
Thank you!
GOOD. I learnt more in this 25 minute video than I did in my entire semester for cardiometabolic (4th year uni) about diabetes.
Failed my practical because I gave a dismal answer to the client in why they are at risk of diabetes (with PAD, HTN and dyslipidemia). I guess I would answer that now as; as you have high levels of circulating fatty acid due to your dyslipidemia diagnosis, this causes increased inflammatory hormones which damage 2nd messenger system that works to release insulin. How would I link this back to HTN and PAD though?
Awesome feedback! Appreciate hearing such great feedback:)
This is very well, and simply explained. Thank you for the video.
Great explanation sir
Wow! I'm glad I found this before my test!!
Thank you so much!
Great work indeed. Thanks for sharing. Need of the hour as diabetis is increasing like anything now in India.
Thank you so much for such a simple and thorough explanation. I just wish you were my instructor for all of my classes! Thank you again.
wow...you are an excellent educator and i like your explanation really. would you mind please telling my how to access to your power points or handouts?
Thank you very much
Brilliant for My Remedial A&P Studies
Glad it helped!
Great lecture Dr. Wolf. You are really helping by uploading these videos.
Thanks so much!
great vid! indeed, a helpful one especially for us nursing students to fully understand DM. thanks!
Thank you for tuning in!
C-peptide, a component of proinsulin (precursor to insulin) declines in DM1. It apparently plays a protective role in preventing beta cell destruction; therefore less C-peptide will accelerate decline in beta cells. The autoantibodies and cytotoxic T cells will continue to destroy beta cells unabated.
McCance & Huether, 2010 - pathophysiology: a biologic basis for disease in adults and children - pg. 748
Great video thanks for helping me study for my exams in a non text book way. My question would be how does exercise affect insulin levels.
Thank you Dr. Wolf. I wish you were my professor
Thank you Diem!
Very good lesson
Thanks for the feedback! We will be rolling out new lessons soon. Keep watching, we appreciate the support!
Hi, where would Hyperglycemia fall in? is hyperglycemia part of type 2 diabetes?
Hello Dr. Wolf
Thank you for this video it is very helpful.
Thank you.
Thank you Kevin!
Great video.
Thank you.
Was left wondering why the video finished so abruptly though.
You’re welcome. Glad you found it helpful!
Very good work.
The high glucose level will form plaques on the wall of blood vessel and it makes blood vessel hard (arteriosclerosis), this will cause poor blood circulation, and high glucose concentration serves as food to the bacteria.
thank you. I don't know how I will remember all this stuff!
You’re welcome. Glad you found it helpful!
I did appreciate the video, but don't forget the simple stuff. like osmotic effects.
No mention of the three "P's"??? The typical early indicators of diabetes are Polyurea, Polydipsia, and Polyphagia. (Urinating frequently, Thirst, and hunger).
Another osmotic effect is increased intra-ocular pressure.
Thank you for sharing your feedback. The Health Ed Solutions team is happy you found the lesson helpful!
Great lecture sir
Thank you so much!
easy to understand, can I embed this video on my blog?
Triglycerides are derived not only from fats in the diet but also sugar (carbs and simple), alcohol, and excess calories in general. I think it's important to note this so as not to demonize fats in the diet specifically. Please correct me if I'm wrong.
Thank you for sharing your feedback.
Great and informative video.
Thank you!!
You are amazing sir. Make some more tutorials to help us please v
Thanks for the feedback! We will be rolling out new lessons soon. Keep watching, we appreciate the support!
Good information
Glad it was helpful!
awesome video. ....
Thanks for your feedback and thank you for watching.
insulin is secreted from beta cells in the form of pro-insulin (insulin+c-peptide)
then it splits into insulin & c-peptide
so,estimation of c-peptide level in the blood can be an indicator for endogenous insulin level
as estimation of insulin level cant determine whether it is the insulin secreted from pancreas(endogenous) or it is insulin therapy (exogenous)
Excellent, thank you...
Thank you 🙏🏼
Mr. Wolf, You said FFA causes increased cytokines and inflammation which may be cause for inhibiting the second messenger system. My question is, why wouldn't anything that causes increased levels of cytokines and inflammation do the same thing? How can you pinpoint only Free Fatty Acids as the cause and in the same note claim it's from the processes that FFA induce? Multiple other stimuli have the same inflammatory affect, no?
Great question. We will check with Dr. Wolf and see what his input is. Thanks for watching!
Excellent!!!!!
Thank you!
Great video!!! Highly recommended along with his other videos to medics.
Thanks so much!
Well made, thanks doc.
Thanks for watching!
hello there i was wondering if you could explain the reason why ketoacidosis is more pronounced in type I diabetics rather then type II, i was think because of complete lack of insulin in type I the patient is more likely to burn the fats while in type II even though there is insulin resistance some tissues in the body show some response to the insulin so ketoacidosis doesn't manifest to the same extent. hope you can clear up my understanding
Thanks for the question. We will ask Dr. Wolf and see what he says!
you my friend are a genius.! i love all your videos. makes it so easy to understand
You’re welcome. Glad you found it helpful!
I thought type 1 one was juvenile diabetes and was diagnosed in childhood, therefore I did not believe people whe claimed to have a combination of both type 1 and 2 especially when the type 2 lifestyle was glaring evident and the diagnosis came in late teen or adult years. However, from what you have said I can see the possibility. Can a Pt have both types and do adults get type 1
Thanks for the question. We will ask Dr. Wolf and see what he says!
very informative thank you
thanks for the review
Thanks for watching!
thank you
You're welcome and thanks for watching!
This made me cry because complicated diabetes killed my mom.
The third main type of diabetes is gestationaI diabetes, which is a condition that women can get when they are in the second trimester of pregnancy. About 4 percent of aII pregnant women wiII deveIop gestationaI diabetes. UnIike Type 1 and Type 2 diabetes, gestationaI diabetes wiII disappear after the baby is born ..........
Thanks for your input Kelly!
Is there a second part?
Thanks for the vid BTW
Thanks for the question. We will ask Dr. Wolf and see what he says!
thank you for this amazing lecture
You’re welcome. Glad you found it helpful!
Thank you, very easy to understand. Animations really helped
You’re welcome. Glad you found it helpful!
Are arthereomas causing trouble with the microvessals in the kidney? Some renal problem that is causing the hyperglycemia in the first place?
Thanks a lot for this lecture. Really helped me :)
You’re welcome. Glad you found it helpful!
Very nice
Thank you!
Brilliant video! Thanks for sharing :)
Was just wondering if you also happened to know the link between Type 1 Diabetes and HLA types DR3 and DR4?
Great video!!!!
Thank you:)
Hi thanks a lot. Can I ask are the neurological complications eg sensory loss in the feet die to reduce BS to nerves and they die? Thanks
Thanks for the question. We will ask Dr. Wolf and see what he says!
excellent
Thanks!!
excellent!
Thank you!!
Andrew, as always legendary videos. You should add more information on about me section ... give more info of who you are and what you did ... just saying
Well done!
Thank you!
Finally Its clear! Thank you
Thanks Belinda!
I'll take the survey if you are still in need of participants - the pop-up at the end of the video does not open a URL for some reason.
Thanks so much!
Hi! How do you do these video? I mean what program or application are you using? I was hoping to use this on a school presentation.
Thanks for your inquiry. The whiteboard lessons are created using a Wacom Bamboo tablet. Thanks for watching!
Dear Andrew, i'm a bit lost here.. Shouldn't it be the other way? Hyperosmolarity stimulates vasopressin secretion and therefore the patient will experience polydipsia, with polyuria as a consequence? thanks for yor support! btw.. i love the twix bar guy! he rocks!!! thank u!
Thanks for the question. We will ask Dr. Wolf and see what he says!
hello sir!!..thankyou for ur video.i have a doubt.sir,how can hyperinsulinemia compensate the high blood glucose levels when the problem is with secondary messenger system? i mean,the high or low levels of insulin are not gonna regulate glucose levels as the problem is with insulin resistance.
Thanks for the question. We will ask Dr. Wolf and see what he says!
what about do action of insulin producing hypoglycaemia ???
Thanks for the question. We will ask Dr. Wolf and see what he says!
Great video. Type 1 diabetes is due to HLA chromosome 6. Type 2 is due to uterine malnutrition (Barker hypothesis). Can I feauture this in my educational youtube channel?
Absolutely, thanks for tuning in Dr. UA-cam!
The video is great. Where is tge rest of the video?
Thanks for the feedback! We will be rolling out new lessons soon. Keep watching, we appreciate the support!
sir..how does DM patient experienced polyuria, polydipsia and polyphagia?
Thanks for the question. We will ask Dr. Wolf and see what he says!
really great video. sir how does polyphagia occur in diabetic patients?
Thanks for the question. We will ask Dr. Wolf and see what he says!
Where is the next lecture after this?
More to come!
Isn't normal potassium K+ levels 3.5-4.5 and sodium levels Na 135-145?
Thanks for the question. We will ask Dr. Wolf and see what he says!
i think i may be confusing two different terms
I really appreciate that!
But sir, why the video doesnt continue till the end ?!! when somebody enters your room & u say Hold on Please, the video ends, but u didnt explain the CONTROL... !!!
Thanks for watching! New edited version coming soon!
amazing as usual, thanx alot 😊
You’re welcome. Glad you found it helpful!
It seems like even if the body was making extra insulin you would still have diabetes if the cell isn't able to uptake the glucose... I don't understand how the increased insulin is useful at taking care of the glucose.
This is a very good video Mr Wolf, but I have the same question with Sara Leland. If the second messenger system of the liver cells in prediabetic condition (type 2 DM) is blocked, how the patient can compenzate just fine? Since the glucose transporters on the plasma membrane of the hepatocytes do not brink the glucose molecules in the cytoplasm. How the patient can have a normal glucose level in the blood at this prediabetic state? I am looking forward for your reply... Thank you :-)
Great question. We will check with Dr. Wolf and see what his input is. Thanks for watching!
Hi Dr. Wolf, These videos are so helpful!
I am trying to get ready for my final in Patho and can't figure out what pathway is activated in the kidneys to increase urine and excrete the additional serum K+ during DKA? Is it the RAAS?
Thank you!
Thanks for the feedback! We passed it along to the Health Ed Solutions board!
Thanks so much
amazing
I guess I'm quite off topic but does anybody know a good website to watch newly released series online?
@Angel Lee lately I have been using Flixzone. You can find it by googling =)
@Orlando Grayson Yup, I have been using flixzone for since march myself =)
@Orlando Grayson thanks, signed up and it seems like they got a lot of movies there :D I appreciate it !
@Angel Lee Glad I could help xD
If they get the whole pancreas taken out what happens when the other parts of the pancreas produces things like enzymes ect.
Passed this question along to the medical review board :)
Very nice video Andrew...
Can you tell me more about including potassium in diet? and is DKA common in Type -1 or 2?
Thanks for watching! We’ve passed along the question to the Health Ed Solutions medical review team!
How does hypo and hyper glycaemia effect type 1 & 2?
Thanks for the question. We will ask Dr. Wolf and see what he says!