Hello, I am a Paramedic in NJ. I randomly chose a video to post under, but I have spent countless hours reviewing your videos, often taking notes, to help the night pass by during "downtime". Thank you for the commitment you've made to making them.
Your videos are very helpful. I am a paramedic and RN and they have increased body understanding of so many body systems. I appreciate your investment of time and hope to see more videos!! Thank you!!
Thank you so much for helping me understand the finer aspects of renal physiology! I HATED it as an undergrad as i didn't understand it. Now as a Masters student, i had no choice but to learn... thanks so much!
Thanks for this very good presentation of the mechanism of diabetic nephropathy but it will be good if you include treatment of different stages of diabetic nephropathy .
would it be possible for you to create a video dealing with URINALYSIS? and what type of findings would you expect to find in urine dipstick and under microscope for a patient with different types of renal disease, such as glumerolonephritis, TN, diabetic nephropathy and others? IT WOULD BE MOST APPRECIATED
From all sources I've gathered concerning this, only similar thing ive found is stage one. The rest of the stages are different from every source and now i don't know what is true and what is not😳
i do appreciate of your work, understand it more,but i am not pretty clear about mesangial physiology! i wish i can see it more from your video! oh,if it possible for you to upload the pulmonary disorder and its pathophysiology? i think i am capable to understand by your video than other's. thanks before hands!
Hi. Is the biggest cause of Diabities high blood sugar and high glucose. Does the High Bp damages the blood vessels of the kidneys leaving them ineffective over long period of high bp?
my second question is that we classify renal failure into 5 main classes according to the GFR of the patient in CKD 5 the GFR is less the 15ml/min so will all these patient's develop uremic syndrome?
what is the role of podocytes in the pathophysiology of diabetic nephropathy.?? and please can u suggest the recent globally accepted classification of diabetic nephropathy
Just to add to the wonderful explanation: Increase in GFR initially is caused due to hyalinization of efferent arteriole,which causes vasoconstriction---predisoposes to hyperfilteration injury Meanwhile non enymatic glycosylation of the basement membrane of the glomerules causes injury and leads to proteinuria esp. called as microalbuminuria. ACE inhibitiors prevent the cond'n as efferent arterilole are under Angiotensin 2 control,which causes vasoconstriction, thus giving an ACE would cause dilation of the hyalinzed efferent arteriole nd improve the GFR as well as hyperfilteraion injury.
ace inhibitor works on those with this condition provided that the dose is higher than normal and creatinine is between 1.3 to 2.0. it can completely reverse it at those levels with no need for dialysis later on.
HI i found your video quite helpful. but was wondering if you could explain kamilstain wilson lesion/nodule my interpretation of it is because of increased mesangial proliferation in response to mesangial and glommerular dammage the mesangial cells proliferate and eventually form small nodules known as kamelstein wilson nodules? wondering if i'm correct cheers
Also why does the efferent arteriole constrict? you mentioned free radicals, but what is the reasoning for the efferent arteriole wanting to constrict? or why do the free radicals cause this?
Hello, first of all great videos thank you! My question is about the 5 stages.....at stage 2 you said that people will start developing proteinuria does that also correlate to the GFR being mildly decreased? Along with stage 3 and the hematuria will the GFR be moderately decreased?
That explains it in type 2 diabetes. Type 1 is as I'm sure you know characterized by complete lack of insulin. And yet they develop diabetic nephropathy just as well. In type 2s it is due to a heterogenous group of diseases, dislipidemias, HTN...in addition to to diabetes. In type 1 there is only one initiating factor -that it shares with type 2. Is it the effect of hyperglycemia that causes the nephropathy in this case?
In diabetes type 2 there is a decreased sensitivity and so increased resistance to insulin causing the beta cells of the pancreas to secrete more insulin. That is why often their treatment initially involves drugs that increase sensitivity or decrease resistance, but due to continuous stimulation of the beta cells at some point they get damaged and exhausted, and treatment then often includes insulin therapy. atleast that what I understand from it..
Hello, I am a Paramedic in NJ. I randomly chose a video to post under, but I have spent countless hours reviewing your videos, often taking notes, to help the night pass by during "downtime". Thank you for the commitment you've made to making them.
Thanks for your feedback and thank you for watching.
Your videos are very helpful. I am a paramedic and RN and they have increased body understanding of so many body systems. I appreciate your investment of time and hope to see more videos!! Thank you!!
Thanks for your feedback and thank you for watching.
Where have you been all this time? Your videos are so simple to understand and I understand the information much better than when I read my books :-)
Thank you so much for helping me understand the finer aspects of renal physiology! I HATED it as an undergrad as i didn't understand it. Now as a Masters student, i had no choice but to learn... thanks so much!
You're welcome!
Complex topic simplified to a considerable extent.
Thanks for the feedback!
Thanks for this very good presentation of the mechanism of diabetic nephropathy but it will be good if you include treatment of different stages of diabetic nephropathy .
Appreciate the feedback!
would it be possible for you to create a video dealing with URINALYSIS? and what type of findings would you expect to find in urine dipstick and under microscope for a patient with different types of renal disease, such as glumerolonephritis, TN, diabetic nephropathy and others? IT WOULD BE MOST APPRECIATED
From all sources I've gathered concerning this, only similar thing ive found is stage one. The rest of the stages are different from every source and now i don't know what is true and what is not😳
thank you very much Dr. Andrew, the video is explained properly
You're welcome!
i do appreciate of your work, understand it more,but i am not pretty clear about mesangial physiology! i wish i can see it more from your video! oh,if it possible for you to upload the pulmonary disorder and its pathophysiology? i think i am capable to understand by your video than other's. thanks before hands!
thank a lot sharing yours knowledge
You're welcome!
Hi. Is the biggest cause of Diabities high blood sugar and high glucose. Does the High Bp damages the blood vessels of the kidneys leaving them ineffective over long period of high bp?
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
my second question is that we classify renal failure into 5 main classes according to the GFR of the patient in CKD 5 the GFR is less the 15ml/min so will all these patient's develop uremic syndrome?
solid,,absolutely clear
Thank you so much!
Hello. Ur fan from India. Very thankful for ur efforts. GOD bless u :)
This was SO HELPFUL!!!
thanks for this great and helpful information but i got a question please , does hypertensive nephropathy affect mesangium ? and if not ,why?
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
what is the role of podocytes in the pathophysiology of diabetic nephropathy.?? and please can u suggest the recent globally accepted classification of diabetic nephropathy
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
Thank you so much,this was pretty helpful
You're welcome!
Just to add to the wonderful explanation:
Increase in GFR initially is caused due to hyalinization of efferent arteriole,which causes vasoconstriction---predisoposes to hyperfilteration injury
Meanwhile non enymatic glycosylation of the basement membrane of the glomerules causes injury and leads to proteinuria esp. called as microalbuminuria.
ACE inhibitiors prevent the cond'n as efferent arterilole are under Angiotensin 2 control,which causes vasoconstriction, thus giving an ACE would cause dilation of the hyalinzed efferent arteriole nd improve the GFR as well as hyperfilteraion injury.
ace inhibitor works on those with this condition provided that the dose is higher than normal and creatinine is between 1.3 to 2.0. it can completely reverse it at those levels with no need for dialysis later on.
Thanks for the wonderful input
Appreciate the comment on this
HI i found your video quite helpful. but was wondering if you could explain kamilstain wilson lesion/nodule my interpretation of it is because of increased mesangial proliferation in response to mesangial and glommerular dammage the mesangial cells proliferate and eventually form small nodules known as kamelstein wilson nodules? wondering if i'm correct
cheers
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
@@HealthEdSolutions are you for real fool. I posted that question almost 10 years ago. I am a specialist doctor now.
Also why does the efferent arteriole constrict? you mentioned free radicals, but what is the reasoning for the efferent arteriole wanting to constrict? or why do the free radicals cause this?
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
@@HealthEdSolutions I asked EIGHT... YEARS... AGO... lol...
Hello, first of all great videos thank you! My question is about the 5 stages.....at stage 2 you said that people will start developing proteinuria does that also correlate to the GFR being mildly decreased? Along with stage 3 and the hematuria will the GFR be moderately decreased?
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
That explains it in type 2 diabetes. Type 1 is as I'm sure you know characterized by complete lack of insulin. And yet they develop diabetic nephropathy just as well. In type 2s it is due to a heterogenous group of diseases, dislipidemias, HTN...in addition to to diabetes. In type 1 there is only one initiating factor -that it shares with type 2. Is it the effect of hyperglycemia that causes the nephropathy in this case?
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
why there is increased level of angiotensin 2 in DM?
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
Thank you for your videos. do you have a video about chronic kidney disease?
Thanks Richel for the support. More videos being released weekly!
In diabetes type 2 there is a decreased sensitivity and so increased resistance to insulin causing the beta cells of the pancreas to secrete more insulin. That is why often their treatment initially involves drugs that increase sensitivity or decrease resistance, but due to continuous stimulation of the beta cells at some point they get damaged and exhausted, and treatment then often includes insulin therapy.
atleast that what I understand from it..
thank you for the great explanation! Your videos are very helpful.
You're welcome!
Are all the functions of human kidneys basically the same in animals such as fish, dogs, cattle birds and other animals?
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
Could you go more in depth into how hyperglycemia damages the nephron?
Man you are awesome i love you ! :)
Thanks for your feedback and thank you for watching.
vasoconstriction of efferent arterioles decrease glumerular pressure and filtration
Thanks for your input!
great video :-)
Could you please tell me how non enzymatic glycosylation and hyaline arteriolosclerosis relate to diabetic nephropathy?
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
That was so clear thank you so much
You're welcome!
sound?
subscribing ! :)
You ARE A-Mazing
Thanks for your feedback and thank you for watching.
Thank you, this was so useful :)
You're welcome!
Thank you :)
You're welcome!
you rock !
Appreciate the support!